{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:21:03Z","timestamp":1785464463468,"version":"3.56.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":222,"URL":"https:\/\/2.zoppoz.workers.dev:443\/https\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1A5A2026045 2021M3H9A2085059 2021R1C1C2010716"],"award-info":[{"award-number":["2019R1A5A2026045 2021M3H9A2085059 2021R1C1C2010716"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HR21C1003"],"award-info":[{"award-number":["HR21C1003"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1A5A2026045 2021M3H9A2085059 2021R1C1C2010716"],"award-info":[{"award-number":["2019R1A5A2026045 2021M3H9A2085059 2021R1C1C2010716"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HR21C1003"],"award-info":[{"award-number":["HR21C1003"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cell\u2013cell interaction (CCI) is a crucial event in the development and function of multicellular organisms. The development of CCI databases is beneficial for researchers who want to analyze single-cell sequencing data or study CCI through molecular experiments. CCIs are known to act differently according to cellular and biological contexts such as cell types, gene mutations or disease status; however, previous CCI databases do not completely provide this contextual information pertaining to CCIs. We constructed a cell-cell interaction database (CCIDB) containing the biological and clinical contexts involved in each interaction. To build a database of cellular and tissue contexts, we collected 38 types of context features, which were categorized into seven categories, including \u2018interaction\u2019, \u2018cell type\u2019, \u2018cofactor\u2019, \u2018effector\u2019, \u2018phenotype\u2019, \u2018pathology\u2019 and \u2018reference\u2019. CCIs were manually retrieved from 272 studies published recently (less than 6 years ago). In the current version of CCIDB, 520 CCIs and their 38 context features have been manually collected and curated by biodata engineers. We suggest that CCIDB is a manually curated CCI resource that is highly useful, especially for analyzing context-dependent alterations in CCIs.<\/jats:p>\n               <jats:p>Database URL https:\/\/2.zoppoz.workers.dev:443\/https\/ccidb.sysmed.kr\/<\/jats:p>","DOI":"10.1093\/database\/baad057","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T16:40:08Z","timestamp":1691772008000},"source":"Crossref","is-referenced-by-count":9,"title":["CCIDB: a manually curated cell\u2013cell interaction database with cell context information"],"prefix":"10.1093","volume":"2023","author":[{"given":"Jin Young","family":"Noh","sequence":"first","affiliation":[{"name":"Department of Physiology, Ajou University School of Medicine , Suwon 16499, Republic of Korea"},{"name":"Department of Biomedical Science, Ajou University Graduate School , Suwon 16499, Republic of Korea"},{"name":"Ajou University Data Center for Biomedicine & Pharmacotherapeutics (AUDC-BMPT), Ajou University School of Medicine , Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae In","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiology, Ajou University School of Medicine , Suwon 16499, Republic of Korea"},{"name":"Department of Biomedical Science, Ajou University Graduate School , Suwon 16499, Republic of Korea"},{"name":"Ajou University Data Center for Biomedicine & Pharmacotherapeutics (AUDC-BMPT), Ajou University School of Medicine , Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hye","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Physiology, Ajou University School of Medicine , Suwon 16499, Republic of Korea"},{"name":"Department of Biomedical Science, Ajou University Graduate School , Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Ho","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Physiology, Ajou University School of Medicine , Suwon 16499, Republic of Korea"},{"name":"Department of Biomedical Science, Ajou University Graduate School , Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Hui","family":"Yi","sequence":"additional","affiliation":[{"name":"Ajou University Data Center for Biomedicine & Pharmacotherapeutics (AUDC-BMPT), Ajou University School of Medicine , Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hyun","family":"Lim","sequence":"additional","affiliation":[{"name":"Ajou University Data Center for Biomedicine & Pharmacotherapeutics (AUDC-BMPT), Ajou University School of Medicine , Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Been","family":"Myung","sequence":"additional","affiliation":[{"name":"Ajou University Data Center for Biomedicine & Pharmacotherapeutics (AUDC-BMPT), Ajou University School of Medicine , Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye Ju","family":"Shin","sequence":"additional","affiliation":[{"name":"Ajou University Data Center for Biomedicine & Pharmacotherapeutics (AUDC-BMPT), Ajou University School of Medicine , Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo Jin","family":"Shin","sequence":"additional","affiliation":[{"name":"Ajou University Data Center for Biomedicine & Pharmacotherapeutics (AUDC-BMPT), Ajou University School of Medicine , Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/2.zoppoz.workers.dev:443\/https\/orcid.org\/0000-0002-0916-893X","authenticated-orcid":false,"given":"Hyun Goo","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Physiology, Ajou University School of Medicine , Suwon 16499, Republic of Korea"},{"name":"Department of Biomedical Science, Ajou University Graduate School , Suwon 16499, Republic of Korea"},{"name":"Ajou University Data Center for Biomedicine & Pharmacotherapeutics (AUDC-BMPT), Ajou University School of Medicine , Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"key":"2023090910310615300_R1","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1007\/s13238-020-00727-5","article-title":"New avenues for\u00a0systematically inferring cell-cell communication: through single-cell transcriptomics data","volume":"11","author":"Shao","year":"2020","journal-title":"Protein 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Neurosci."},{"key":"2023090910310615300_R3","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaa183","article-title":"SingleCellSignalR: inference of\u00a0intercellular networks from single-cell transcriptomics","volume":"48","author":"Cabello-Aguilar","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2023090910310615300_R4","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/s41596-020-0292-x","article-title":"CellPhoneDB: inferring cell-cell communication from combined expression of\u00a0multi-subunit ligand-receptor complexes","volume":"15","author":"Efremova","year":"2020","journal-title":"Nat Protoc"},{"key":"2023090910310615300_R5","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and\u00a0analysis of\u00a0cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"key":"2023090910310615300_R6","doi-asserted-by":"crossref","DOI":"10.1186\/s13578-021-00635-z","article-title":"Applications and\u00a0analytical tools of\u00a0cell communication based on\u00a0ligand-receptor interactions at single cell level","volume":"11","author":"Ma","year":"2021","journal-title":"Cell Biosci"},{"key":"2023090910310615300_R7","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/carcin\/bgw085","article-title":"p53 functional deficiency in\u00a0human colon cancer cells promotes fibroblast-mediated angiogenesis and\u00a0tumor growth","volume":"37","author":"Hayashi","year":"2016","journal-title":"Carcinogenesis"},{"key":"2023090910310615300_R8","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.jhep.2020.05.039","article-title":"Single-cell transcriptomic architecture and\u00a0intercellular crosstalk of\u00a0human intrahepatic cholangiocarcinoma","volume":"73","author":"Zhang","year":"2020","journal-title":"J. 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