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Therefore, a direct link between emotion processing and moral judgment is still lacking. Here, vmPFC patients and control participants considered moral dilemmas while skin conductance response (SCR) was measured as a somatic index of affective state. Replicating previous evidence, vmPFC patients approved more personal moral violations than did controls. Critically, we found that, unlike control participants, vmPFC patients failed to generate SCRs before endorsing personal moral violations. In addition, such anticipatory SCRs correlated negatively with the frequency of utilitarian judgments in normal participants. These findings provide direct support to the hypothesis that the vmPFC promotes moral behavior by mediating the anticipation of the emotional consequences of personal moral violations.<\/jats:p>","DOI":"10.1162\/jocn.2009.21367","type":"journal-article","created":{"date-parts":[[2009,11,20]],"date-time":"2009-11-20T04:59:10Z","timestamp":1258693150000},"page":"1888-1899","update-policy":"https:\/\/2.zoppoz.workers.dev:443\/https\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":132,"title":["A Psychophysiological Investigation of Moral Judgment after Ventromedial Prefrontal Damage"],"prefix":"10.1162","volume":"22","author":[{"given":"Giovanna","family":"Moretto","sequence":"first","affiliation":[{"name":"1Universit\u00e0 di Bologna, Italy"},{"name":"2Centro studi e ricerche in Neuroscienze Cognitive, Polo Scientifico-Didattico di Cesena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"L\u00e0davas","sequence":"additional","affiliation":[{"name":"1Universit\u00e0 di Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia","family":"Mattioli","sequence":"additional","affiliation":[{"name":"3Spedali Civili, Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"di Pellegrino","sequence":"additional","affiliation":[{"name":"1Universit\u00e0 di Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"281","published-online":{"date-parts":[[2010,8,1]]},"reference":[{"key":"2021072900425949800_R1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nrn1884","article-title":"Meeting of minds: The medial frontal cortex and social cognition.","volume":"7","author":"Amodio","year":"2006","journal-title":"Nature Reviews Neuroscience"},{"key":"2021072900425949800_R2","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/14833","article-title":"Impairment of social and moral behavior related to early damage in human prefrontal cortex.","volume":"2","author":"Anderson","year":"1999","journal-title":"Nature Neuroscience"},{"key":"2021072900425949800_R3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1207\/S1532694205Barrash","article-title":"Acquired personality disturbances associated with bilateral damage to the ventromedial prefrontal region.","volume":"18","author":"Barrash","year":"2000","journal-title":"Developmental Neuropsychology"},{"key":"2021072900425949800_R4","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.geb.2004.06.010","article-title":"The somatic marker hypothesis: A neural theory of economic decision.","volume":"52","author":"Bechara","year":"2005","journal-title":"Games and Economic Behavior"},{"key":"2021072900425949800_R5","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1523\/JNEUROSCI.19-13-05473.1999","article-title":"Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making.","volume":"19","author":"Bechara","year":"1999","journal-title":"Journal of Neuroscience"},{"key":"2021072900425949800_R6","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1126\/science.275.5304.1293","article-title":"Deciding advantageously before knowing the advantageous strategy.","volume":"275","author":"Bechara","year":"1997","journal-title":"Science"},{"key":"2021072900425949800_R7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/cercor\/6.2.215","article-title":"Failure to respond autonomically to anticipated future outcomes following damage to prefrontal cortex.","volume":"6","author":"Bechara","year":"1996","journal-title":"Cerebral Cortex"},{"key":"2021072900425949800_R8","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1093\/brain\/123.6.1122","article-title":"Impaired social response reversal. 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