{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:13:17Z","timestamp":1783051997881,"version":"3.54.6"},"reference-count":40,"publisher":"MIT Press - Journals","issue":"11","content-domain":{"domain":["direct.mit.edu"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Because number is an abstract quality of a set, the way in which a number is externally represented does not change its quantitative meaning. In this study, we examined the development of the brain regions that support format-independent representation of numerical magnitude. We asked children and adults to perform both symbolic (Hindu-Arabic numerals) and nonsymbolic (arrays of squares) numerical comparison tasks as well as two control tasks while their brains were scanned using fMRI. In a preliminary analysis, we calculated the conjunction between symbolic and nonsymbolic numerical comparison. We then examined in which brain regions this conjunction differed between children and adults. This analysis revealed a large network of visual and parietal regions that showed greater activation in adults relative to children. In our primary analysis, we examined age-related differences in the conjunction of symbolic and nonsymbolic comparison after subtracting the control tasks. This analysis revealed a much more limited set of regions including the right inferior parietal lobe near the intraparietal sulcus. In addition to showing increased activation to both symbolic and nonsymbolic magnitudes over and above activation related to response selection, this region showed age-related differences in the distance effect. Our findings demonstrate that the format-independent representation of numerical magnitude in the right inferior parietal lobe is the product of developmental processes of cortical specialization and highlight the importance of using appropriate control tasks when conducting developmental neuroimaging studies.<\/jats:p>","DOI":"10.1162\/jocn.2009.21399","type":"journal-article","created":{"date-parts":[[2009,11,23]],"date-time":"2009-11-23T18:41:37Z","timestamp":1259001697000},"page":"2627-2637","update-policy":"https:\/\/2.zoppoz.workers.dev:443\/https\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":104,"title":["Developmental Specialization in the Right Intraparietal Sulcus for the Abstract Representation of Numerical Magnitude"],"prefix":"10.1162","volume":"22","author":[{"given":"Ian D.","family":"Holloway","sequence":"first","affiliation":[{"name":"1Dartmouth College, Hanover, NH"},{"name":"2University of Western Ontario, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ansari","sequence":"additional","affiliation":[{"name":"1Dartmouth College, Hanover, NH"},{"name":"2University of Western Ontario, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"281","published-online":{"date-parts":[[2010,11,1]]},"reference":[{"key":"2021072900454102100_R1","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1162\/jocn.2006.18.11.1820","article-title":"Age-related changes in the activation of the intraparietal sulcus during nonsymbolic magnitude processing: An event-related functional magnetic resonance imaging study.","volume":"18","author":"Ansari","year":"2006","journal-title":"Journal of Cognitive Neuroscience"},{"key":"2021072900454102100_R2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.brainres.2005.10.083","article-title":"Parametric effects of numerical distance on the intraparietal sulcus during passive viewing of rapid numerosity changes.","volume":"1067","author":"Ansari","year":"2006","journal-title":"Brain Research"},{"key":"2021072900454102100_R3","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1097\/01.wnr.0000183905.23396.f1","article-title":"Neural correlates of symbolic number processing in children and adults.","volume":"16","author":"Ansari","year":"2005","journal-title":"NeuroReport"},{"key":"2021072900454102100_R4","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1371\/journal.pbio.0040125","article-title":"Functional imaging of numerical processing in adults and 4-y-old children.","volume":"4","author":"Cantlon","year":"2006","journal-title":"PLoS Biology"},{"key":"2021072900454102100_R5","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1162\/jocn.2008.21159","article-title":"The neural development of an abstract concept of number.","volume":"21","author":"Cantlon","year":"2008","journal-title":"Journal of Cognitive Neuroscience"},{"key":"2021072900454102100_R6","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1162\/jocn.2009.21246","article-title":"The role of right and left parietal lobes in the conceptual processing of numbers.","volume":"22","author":"Cappelletti","year":"2009","journal-title":"Journal of Cognitive Neuroscience"},{"key":"2021072900454102100_R7","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1073\/pnas.0600444103","article-title":"Discrete and analogue quantity processing in the parietal lobe: A functional MRI study.","volume":"103","author":"Castelli","year":"2006","journal-title":"Proceedings of the National Academy of Sciences, U.S.A."},{"key":"2021072900454102100_R8","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1162\/089892999563689","article-title":"Differential contributions of the left and right inferior parietal lobules to number processing.","volume":"11","author":"Chochon","year":"1999","journal-title":"Journal of Cognitive Neuroscience"},{"key":"2021072900454102100_R9","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.neuron.2006.12.025","article-title":"Notation-dependent and -independent representations of numbers in the parietal lobes.","volume":"53","author":"Cohen Kadosh","year":"2007","journal-title":"Neuron"},{"key":"2021072900454102100_R10","first-page":"1238","article-title":"Are numbers special? 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