{"id":"https://openalex.org/W3196755571","doi":"https://doi.org/10.1016/j.neuroimage.2021.118550","title":"Convergent structural network and gene signatures for MRgFUS thalamotomy in patients with Parkinson's disease","display_name":"Convergent structural network and gene signatures for MRgFUS thalamotomy in patients with Parkinson's disease","publication_year":2021,"publication_date":"2021-09-01","ids":{"openalex":"https://openalex.org/W3196755571","doi":"https://doi.org/10.1016/j.neuroimage.2021.118550","mag":"3196755571","pmid":"https://pubmed.ncbi.nlm.nih.gov/34481084"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroimage.2021.118550","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2021.118550","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.neuroimage.2021.118550","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060959419","display_name":"Jiaji Lin","orcid":"https://orcid.org/0000-0002-3653-2389"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaji Lin","raw_affiliation_strings":["Department of Radiology, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China. Electronic address: jiaji90@outlook.com","Department of Radiology, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China. Electronic address: jiaji90@outlook.com","institution_ids":[]},{"raw_affiliation_string":"Department of Radiology, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104183271","display_name":"Xiaopeng Kang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210112150","display_name":"Institute of Automation","ror":"https://ror.org/022c3hy66","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112150"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaopeng Kang","raw_affiliation_strings":["School of Artificial Intelligence, University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100876, China; Brainnetome Center & National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China","Brainnetome Center & National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China","School of Artificial Intelligence, University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100876, China"],"affiliations":[{"raw_affiliation_string":"School of Artificial Intelligence, University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100876, China; Brainnetome Center & National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Brainnetome Center & National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210112150","https://openalex.org/I19820366"]},{"raw_affiliation_string":"School of Artificial Intelligence, University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100876, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085662985","display_name":"Yongqin Xiong","orcid":"https://orcid.org/0000-0002-2435-9064"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongqin Xiong","raw_affiliation_strings":["Department of Radiology, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008421021","display_name":"Dekang Zhang","orcid":"https://orcid.org/0000-0002-9711-6733"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dekang Zhang","raw_affiliation_strings":["Department of Radiology, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009119570","display_name":"Rui Zong","orcid":"https://orcid.org/0000-0002-0049-7227"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Zong","raw_affiliation_strings":["Department of Neurosurgery, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China"],"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050115004","display_name":"Xinguang Yu","orcid":"https://orcid.org/0000-0001-6898-3996"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinguang Yu","raw_affiliation_strings":["Department of Neurosurgery, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China"],"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032705088","display_name":"Longsheng Pan","orcid":"https://orcid.org/0000-0002-1033-1802"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Longsheng Pan","raw_affiliation_strings":["Department of Neurosurgery, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China. Electronic address: panls301@163.com","Department of Neurosurgery, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China"],"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China. Electronic address: panls301@163.com","institution_ids":[]},{"raw_affiliation_string":"Department of Neurosurgery, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009565631","display_name":"Xin Lou","orcid":"https://orcid.org/0000-0003-2980-5171"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xin Lou","raw_affiliation_strings":["Department of Radiology, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China. Electronic address: louxin@301hospital.com.cn","Department of Radiology, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China. Electronic address: louxin@301hospital.com.cn","institution_ids":[]},{"raw_affiliation_string":"Department of Radiology, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China","institution_ids":["https://openalex.org/I2802939634"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5009565631","https://openalex.org/A5032705088"],"corresponding_institution_ids":["https://openalex.org/I2802939634"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":1.8494,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.879846,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"243","issue":null,"first_page":"118550","last_page":"118550"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6736888885498047},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.5055019855499268},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.49912285804748535},{"id":"https://openalex.org/keywords/dopaminergic","display_name":"Dopaminergic","score":0.49493592977523804},{"id":"https://openalex.org/keywords/thalamotomy","display_name":"Thalamotomy","score":0.45054376125335693},{"id":"https://openalex.org/keywords/human-brain","display_name":"Human brain","score":0.44531774520874023},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.3884628415107727},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.3184162378311157},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.25653505325317383},{"id":"https://openalex.org/keywords/deep-brain-stimulation","display_name":"Deep brain stimulation","score":0.18276715278625488},{"id":"https://openalex.org/keywords/dopamine","display_name":"Dopamine","score":0.15245243906974792}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6736888885498047},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5055019855499268},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49912285804748535},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.49493592977523804},{"id":"https://openalex.org/C2775841352","wikidata":"https://www.wikidata.org/wiki/Q1772023","display_name":"Thalamotomy","level":5,"score":0.45054376125335693},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.44531774520874023},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3884628415107727},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3184162378311157},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25653505325317383},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.18276715278625488},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.15245243906974792}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D019635","descriptor_name":"Neurosurgical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019635","descriptor_name":"Neurosurgical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019635","descriptor_name":"Neurosurgical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020329","descriptor_name":"Essential Tremor","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D020329","descriptor_name":"Essential Tremor","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D020329","descriptor_name":"Essential Tremor","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D025321","descriptor_name":"Surgery, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025321","descriptor_name":"Surgery, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025321","descriptor_name":"Surgery, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.neuroimage.2021.118550","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2021.118550","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},{"id":"pmid:34481084","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34481084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":null},{"id":"pmh:oai:doaj.org/article:a869a3a612cd41288b4e733d02c8f274","is_oa":true,"landing_page_url":"https://doaj.org/article/a869a3a612cd41288b4e733d02c8f274","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NeuroImage, Vol 243, Iss , Pp 118550- (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.neuroimage.2021.118550","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2021.118550","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2956015230","display_name":null,"funder_award_id":"81825012","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G372430656","display_name":null,"funder_award_id":"81730048","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W1740955462","https://openalex.org/W1946566023","https://openalex.org/W1966327575","https://openalex.org/W1977314903","https://openalex.org/W1978957620","https://openalex.org/W1980548655","https://openalex.org/W1981093360","https://openalex.org/W1981176642","https://openalex.org/W1990218919","https://openalex.org/W1990257603","https://openalex.org/W1991002654","https://openalex.org/W2003539800","https://openalex.org/W2005821483","https://openalex.org/W2019182054","https://openalex.org/W2025260963","https://openalex.org/W2028402362","https://openalex.org/W2038963685","https://openalex.org/W2053264733","https://openalex.org/W2055655674","https://openalex.org/W2077073169","https://openalex.org/W2083658929","https://openalex.org/W2100145912","https://openalex.org/W2100673126","https://openalex.org/W2101279164","https://openalex.org/W2105515675","https://openalex.org/W2126838454","https://openalex.org/W2127068730","https://openalex.org/W2133188546","https://openalex.org/W2139484893","https://openalex.org/W2140616469","https://openalex.org/W2142843434","https://openalex.org/W2148957121","https://openalex.org/W2152255412","https://openalex.org/W2156804553","https://openalex.org/W2157464285","https://openalex.org/W2167822639","https://openalex.org/W2168334242","https://openalex.org/W2239878504","https://openalex.org/W2260830658","https://openalex.org/W2355160806","https://openalex.org/W2411622228","https://openalex.org/W2516889512","https://openalex.org/W2517769867","https://openalex.org/W2520304945","https://openalex.org/W2570271466","https://openalex.org/W2587992172","https://openalex.org/W2590552552","https://openalex.org/W2599852392","https://openalex.org/W2614847871","https://openalex.org/W2615667960","https://openalex.org/W2746664600","https://openalex.org/W2765936263","https://openalex.org/W2789408335","https://openalex.org/W2792565280","https://openalex.org/W2800619871","https://openalex.org/W2889717585","https://openalex.org/W2902791275","https://openalex.org/W2951310155","https://openalex.org/W2952215064","https://openalex.org/W2952574438","https://openalex.org/W2961957244","https://openalex.org/W2965760658","https://openalex.org/W2974984553","https://openalex.org/W3017103339","https://openalex.org/W3093313331","https://openalex.org/W3096546069","https://openalex.org/W3098074707","https://openalex.org/W3099778492","https://openalex.org/W3212734140","https://openalex.org/W4255588241","https://openalex.org/W4389450057","https://openalex.org/W4401338748","https://openalex.org/W6671719220","https://openalex.org/W6731693446","https://openalex.org/W6838881207"],"related_works":["https://openalex.org/W3189709801","https://openalex.org/W2356669230","https://openalex.org/W154920111","https://openalex.org/W3181130790","https://openalex.org/W177724923","https://openalex.org/W2071134504","https://openalex.org/W4286702614","https://openalex.org/W1533456056","https://openalex.org/W2026888593","https://openalex.org/W2069844118"],"abstract_inverted_index":{"MRgFUS":[0,63,84,130,230],"has":[1],"just":[2],"been":[3],"made":[4],"available":[5],"for":[6,22,76,92,111,181,229],"the":[7,43,53,139,182,238],"1.7":[8],"million":[9],"Parkinson's":[10,79],"disease":[11,80],"patients":[12,81],"in":[13,58,99,124,241],"China.":[14],"Despite":[15],"its":[16,40],"non-invasive":[17],"and":[18,33,65,108,120,155,164,210,214,226],"rapid":[19],"therapeutic":[20],"advantages":[21],"involuntary":[23],"tremor,":[24],"some":[25],"concerns":[26],"have":[27],"emerged":[28],"about":[29,39],"outcomes":[30],"variability,":[31],"non-specificity,":[32],"side-effects,":[34],"as":[35],"little":[36],"is":[37],"known":[38],"impact":[41],"on":[42],"long-term":[44,56,220,239],"plasticity":[45],"of":[46,55,151],"brain":[47,59,100,104,140,170],"structure.":[48,101],"We":[49],"sought":[50],"to":[51,95,237],"dissect":[52],"characteristics":[54],"changes":[57,98],"structure":[60],"caused":[61],"by":[62,159],"lesion":[64],"explored":[66],"potential":[67],"biological":[68],"mechanisms.":[69],"One-year":[70],"multimodal":[71],"imaging":[72],"follow-ups":[73],"were":[74,179],"conducted":[75],"nine":[77],"tremor-dominant":[78],"undergoing":[82],"unilateral":[83],"thalamotomy.":[85],"A":[86],"structural":[87,203,224],"connectivity":[88,112],"map":[89],"was":[90,106,118,205,218],"generated":[91],"each":[93],"patient":[94],"analyze":[96],"dynamic":[97,221],"The":[102],"human":[103,169],"transcriptome":[105],"extracted":[107],"spatially":[109],"registered":[110],"vulnerability.":[113],"Genetic":[114],"functional":[115],"enrichment":[116],"analysis":[117],"performed":[119],"further":[121],"clarified":[122],"using":[123],"vivo":[125],"emission":[126],"computed":[127],"tomography":[128],"data.":[129],"not":[131,193],"only":[132,194],"abolished":[133],"tremors":[134],"but":[135,199],"also":[136,200],"significantly":[137,206],"disrupted":[138],"network":[141],"topology.":[142],"Network-based":[143],"statistics":[144],"identified":[145],"a":[146,219],"U-shape":[147],"MRgFUS-sensitive":[148],"subnetwork":[149],"reflective":[150],"hand":[152],"tremor":[153],"recovery":[154],"surgical":[156],"process,":[157],"accompanied":[158],"relevant":[160],"cerebral":[161],"blood":[162],"flow":[163],"gray":[165],"matter":[166],"alteration.":[167],"Using":[168],"gene":[171,197],"expression":[172],"data,":[173],"we":[174],"observed":[175],"that":[176,202],"dopaminergic":[177,227],"signatures":[178],"responsible":[180],"preferential":[183],"vulnerability":[184],"associated":[185],"with":[186,208],"these":[187,196],"architectural":[188],"alterations.":[189],"Additional":[190],"PET/SPECT":[191],"data":[192],"validated":[195],"signatures,":[198],"suggested":[201],"alteration":[204,225],"correlated":[207],"D1":[209],"D2":[211],"receptors,":[212],"DAT,":[213],"F-DOPA":[215],"measures.":[216],"There":[217],"loop":[222],"between":[223],"signature":[228],"thalamotomy,":[231],"which":[232],"may":[233],"be":[234],"closely":[235],"related":[236],"improvements":[240],"clinical":[242],"tremor.":[243]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4}],"updated_date":"2026-03-17T09:09:15.849793","created_date":"2025-10-10T00:00:00"}