{"id":"https://openalex.org/W2011628627","doi":"https://doi.org/10.1089/cmb.2007.0181","title":"Boolean Network Approach to Negative Feedback Loops of the p53 Pathways: Synchronized Dynamics and Stochastic Limit Cycles","display_name":"Boolean Network Approach to Negative Feedback Loops of the p53 Pathways: Synchronized Dynamics and Stochastic Limit Cycles","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2011628627","doi":"https://doi.org/10.1089/cmb.2007.0181","mag":"2011628627","pmid":"https://pubmed.ncbi.nlm.nih.gov/19119996"},"language":"en","primary_location":{"id":"doi:10.1089/cmb.2007.0181","is_oa":false,"landing_page_url":"https://doi.org/10.1089/cmb.2007.0181","pdf_url":null,"source":{"id":"https://openalex.org/S78571599","display_name":"Journal of Computational Biology","issn_l":"1066-5277","issn":["1066-5277","1557-8666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443"],"host_organization_lineage_names":["Mary Ann Liebert, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101567547","display_name":"Hao Ge","orcid":"https://orcid.org/0000-0003-0404-5268"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Ge","raw_affiliation_strings":["Centre for Computational Systems Biology and Mathematical Department, Fudan University, Shanghai, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Computational Systems Biology and Mathematical Department, Fudan University, Shanghai, P.R. China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041134334","display_name":"Min Qian","orcid":"https://orcid.org/0000-0002-6472-7693"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Qian","raw_affiliation_strings":["School of Mathematical Sciences, Peking University, Beijing, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematical Sciences, Peking University, Beijing, P.R. China","institution_ids":["https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0077,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.73924156,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"16","issue":"1","first_page":"119","last_page":"132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.9869999885559082,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9751999974250793,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/limit-cycle","display_name":"Limit cycle","score":0.7452361583709717},{"id":"https://openalex.org/keywords/markov-chain","display_name":"Markov chain","score":0.6090390086174011},{"id":"https://openalex.org/keywords/negative-feedback","display_name":"Negative feedback","score":0.5667092204093933},{"id":"https://openalex.org/keywords/limit","display_name":"Limit (mathematics)","score":0.516711950302124},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.5020885467529297},{"id":"https://openalex.org/keywords/synchronization","display_name":"Synchronization (alternating current)","score":0.48344525694847107},{"id":"https://openalex.org/keywords/stochastic-modelling","display_name":"Stochastic modelling","score":0.45574334263801575},{"id":"https://openalex.org/keywords/generalization","display_name":"Generalization","score":0.45397165417671204},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.4356902539730072},{"id":"https://openalex.org/keywords/stochastic-process","display_name":"Stochastic process","score":0.43520212173461914},{"id":"https://openalex.org/keywords/oscillation","display_name":"Oscillation (cell signaling)","score":0.42953944206237793},{"id":"https://openalex.org/keywords/markov-process","display_name":"Markov process","score":0.42697200179100037},{"id":"https://openalex.org/keywords/steady-state","display_name":"Steady state (chemistry)","score":0.4246538281440735},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.4180123209953308},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4168263077735901},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.4097396731376648},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.2648922801017761},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.24137461185455322},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.13331395387649536}],"concepts":[{"id":"https://openalex.org/C93357160","wikidata":"https://www.wikidata.org/wiki/Q1545916","display_name":"Limit cycle","level":3,"score":0.7452361583709717},{"id":"https://openalex.org/C98763669","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov chain","level":2,"score":0.6090390086174011},{"id":"https://openalex.org/C93586867","wikidata":"https://www.wikidata.org/wiki/Q62527","display_name":"Negative feedback","level":3,"score":0.5667092204093933},{"id":"https://openalex.org/C151201525","wikidata":"https://www.wikidata.org/wiki/Q177239","display_name":"Limit (mathematics)","level":2,"score":0.516711950302124},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.5020885467529297},{"id":"https://openalex.org/C2778562939","wikidata":"https://www.wikidata.org/wiki/Q1298791","display_name":"Synchronization (alternating current)","level":3,"score":0.48344525694847107},{"id":"https://openalex.org/C127491075","wikidata":"https://www.wikidata.org/wiki/Q7617825","display_name":"Stochastic modelling","level":2,"score":0.45574334263801575},{"id":"https://openalex.org/C177148314","wikidata":"https://www.wikidata.org/wiki/Q170084","display_name":"Generalization","level":2,"score":0.45397165417671204},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.4356902539730072},{"id":"https://openalex.org/C8272713","wikidata":"https://www.wikidata.org/wiki/Q176737","display_name":"Stochastic process","level":2,"score":0.43520212173461914},{"id":"https://openalex.org/C2778439541","wikidata":"https://www.wikidata.org/wiki/Q7106412","display_name":"Oscillation (cell signaling)","level":2,"score":0.42953944206237793},{"id":"https://openalex.org/C159886148","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov process","level":2,"score":0.42697200179100037},{"id":"https://openalex.org/C8171440","wikidata":"https://www.wikidata.org/wiki/Q903414","display_name":"Steady state (chemistry)","level":2,"score":0.4246538281440735},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.4180123209953308},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4168263077735901},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4097396731376648},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.2648922801017761},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.24137461185455322},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.13331395387649536},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/cmb.2007.0181","is_oa":false,"landing_page_url":"https://doi.org/10.1089/cmb.2007.0181","pdf_url":null,"source":{"id":"https://openalex.org/S78571599","display_name":"Journal of Computational Biology","issn_l":"1066-5277","issn":["1066-5277","1557-8666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443"],"host_organization_lineage_names":["Mary Ann Liebert, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Biology","raw_type":"journal-article"},{"id":"pmid:19119996","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19119996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computational biology : a journal of computational molecular cell biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W571141297","https://openalex.org/W586663512","https://openalex.org/W1490595428","https://openalex.org/W1498566120","https://openalex.org/W1521319613","https://openalex.org/W1650797637","https://openalex.org/W1884390770","https://openalex.org/W1973821009","https://openalex.org/W1979634817","https://openalex.org/W1979992647","https://openalex.org/W1994697081","https://openalex.org/W1995397995","https://openalex.org/W2003277232","https://openalex.org/W2008887283","https://openalex.org/W2010309246","https://openalex.org/W2014170738","https://openalex.org/W2022718411","https://openalex.org/W2033237792","https://openalex.org/W2053961182","https://openalex.org/W2056298390","https://openalex.org/W2064330613","https://openalex.org/W2069500900","https://openalex.org/W2073765202","https://openalex.org/W2078119846","https://openalex.org/W2085418817","https://openalex.org/W2087393141","https://openalex.org/W2088155512","https://openalex.org/W2112246162","https://openalex.org/W2112999165","https://openalex.org/W2117398609","https://openalex.org/W2128084896","https://openalex.org/W2152750766","https://openalex.org/W2155418451","https://openalex.org/W2323544027","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1995427843","https://openalex.org/W2042280983","https://openalex.org/W2888652631","https://openalex.org/W2321888438","https://openalex.org/W2369445029","https://openalex.org/W2026456043","https://openalex.org/W4320063126","https://openalex.org/W2417662900","https://openalex.org/W1987284827","https://openalex.org/W1996323220"],"abstract_inverted_index":{"Deterministic":[0],"and":[1,44,77,87,117,202],"stochastic":[2,114,125,138,208],"Boolean":[3],"network":[4,121,131],"models":[5],"are":[6,94],"built":[7],"for":[8,96],"the":[9,16,23,27,31,51,63,83,88,104,120,124,137,141,145,150,154,157,161,171,177,182,193,196,203,207],"dynamics":[10,65,116,122],"of":[11,15,26,47,62,100,108,123,144,156,179,195],"negative":[12,28,52],"feedback":[13,29,53],"loops":[14],"p53":[17,32,37,64],"pathways.":[18],"It":[19],"is":[20,34,55,140,165],"shown":[21],"that":[22,81],"main":[24,158,183,200],"function":[25],"in":[30,50,136,149,160,166,181,192],"pathways":[33],"to":[35,58,169,176,206],"keep":[36],"at":[38],"a":[39,59,97,133,189,198],"low":[40],"steady":[41],"state":[42,86],"level,":[43],"each":[45],"sequence":[46],"protein":[48],"states":[49,180],"loops,":[54],"globally":[56],"attracted":[57],"closed":[60],"cycle":[61,148,184,201],"after":[66,91],"being":[67,92],"perturbed":[68,93],"by":[69,118],"outside":[70],"signal":[71],"(e.g.,":[72],"DNA":[73],"damage).":[74],"Our":[75],"theoretical":[76],"numerical":[78],"studies":[79],"show":[80],"both":[82],"biological":[84,89],"stationary":[85],"oscillation":[90],"stable":[95],"wide":[98],"range":[99],"noise":[101],"level.":[102],"Applying":[103],"mathematical":[105],"circulation":[106,135],"theory":[107],"Markov":[109],"chains,":[110],"we":[111],"investigate":[112],"their":[113],"synchronized":[115,172],"comparing":[119],"model":[126,139],"with":[127,185],"its":[128],"corresponding":[129],"deterministic":[130,146,151],"counterpart,":[132],"dominant":[134,186],"natural":[142],"generalization":[143],"limit":[147],"system.":[152],"Moreover,":[153],"period":[155],"peak":[159],"power":[162],"spectrum,":[163],"which":[164],"common":[167],"use":[168],"characterize":[170],"dynamics,":[173],"perfectly":[174],"corresponds":[175],"number":[178],"circulation.":[187],"Such":[188],"large":[190],"separation":[191],"magnitude":[194],"circulations--between":[197],"dominant,":[199],"rest--gives":[204],"rise":[205],"synchronization":[209],"phenomenon.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-07-25T15:57:00.446498","created_date":"2025-10-10T00:00:00"}
