{"id":"https://openalex.org/W4396627746","doi":"https://doi.org/10.1093/bib/bbae189","title":"SpatialCells: automated profiling of tumor microenvironments with spatially resolved multiplexed single-cell data","display_name":"SpatialCells: automated profiling of tumor microenvironments with spatially resolved multiplexed single-cell data","publication_year":2024,"publication_date":"2024-03-27","ids":{"openalex":"https://openalex.org/W4396627746","doi":"https://doi.org/10.1093/bib/bbae189","pmid":"https://pubmed.ncbi.nlm.nih.gov/38701421"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae189","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae189","pdf_url":"https://academic.oup.com/bib/article-pdf/25/3/bbae189/57390484/bbae189.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/3/bbae189/57390484/bbae189.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071349804","display_name":"Guihong Wan","orcid":"https://orcid.org/0000-0003-1100-4018"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guihong Wan","raw_affiliation_strings":["Department of Dermatology, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA","Laboratory of Systems Pharmacology, Program in Therapeutic Science, Harvard Medical School , Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Laboratory of Systems Pharmacology, Program in Therapeutic Science, Harvard Medical School , Boston, MA, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030146315","display_name":"Zoltan Maliga","orcid":"https://orcid.org/0000-0003-4209-7253"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zoltan Maliga","raw_affiliation_strings":["Laboratory of Systems Pharmacology, Program in Therapeutic Science, Harvard Medical School , Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Laboratory of Systems Pharmacology, Program in Therapeutic Science, Harvard Medical School , Boston, MA, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101793711","display_name":"Boshen Yan","orcid":"https://orcid.org/0000-0002-2445-1426"},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boshen Yan","raw_affiliation_strings":["Department of Biomedical Informatics, Harvard Medical School , Boston, MA, USA","Department of Dermatology, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Harvard Medical School , Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Dermatology, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037823374","display_name":"Tuulia Vallius","orcid":"https://orcid.org/0000-0002-3006-4887"},"institutions":[{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tuulia Vallius","raw_affiliation_strings":["Laboratory of Systems Pharmacology, Program in Therapeutic Science, Harvard Medical School , Boston, MA, USA","Ludwig Center for Cancer Research at Harvard, Harvard Medical School , Boston, MA"],"affiliations":[{"raw_affiliation_string":"Laboratory of Systems Pharmacology, Program in Therapeutic Science, Harvard Medical School , Boston, MA, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Ludwig Center for Cancer Research at Harvard, Harvard Medical School , Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109201199","display_name":"Yingxiao Shi","orcid":null},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yingxiao Shi","raw_affiliation_strings":["Department of Medicine, Dana-Farber Cancer Institute , Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Dana-Farber Cancer Institute , Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028028250","display_name":"Sara Khattab","orcid":"https://orcid.org/0000-0002-4724-258X"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Khattab","raw_affiliation_strings":["Department of Dermatology, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101973294","display_name":"Crystal Chang","orcid":"https://orcid.org/0000-0002-0647-7040"},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Crystal Chang","raw_affiliation_strings":["Department of Dermatology, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080075412","display_name":"Ajit J. Nirmal","orcid":"https://orcid.org/0000-0003-4139-0618"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ajit J Nirmal","raw_affiliation_strings":["Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA, USA","Laboratory of Systems Pharmacology, Program in Therapeutic Science, Harvard Medical School , Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Laboratory of Systems Pharmacology, Program in Therapeutic Science, Harvard Medical School , Boston, MA, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061562703","display_name":"Kun\u2010Hsing Yu","orcid":"https://orcid.org/0000-0001-9892-8218"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kun-Hsing Yu","raw_affiliation_strings":["Department of Biomedical Informatics, Harvard Medical School , Boston, MA, USA","Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Harvard Medical School , Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100739514","display_name":"David Liu","orcid":"https://orcid.org/0000-0003-0346-5033"},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Liu","raw_affiliation_strings":["Department of Medicine, Dana-Farber Cancer Institute , Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Dana-Farber Cancer Institute , Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085108299","display_name":"Christine G. Lian","orcid":"https://orcid.org/0000-0003-4626-1612"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine G Lian","raw_affiliation_strings":["Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074337248","display_name":"Mia S. DeSimone","orcid":"https://orcid.org/0000-0002-0042-6269"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mia S DeSimone","raw_affiliation_strings":["Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063426870","display_name":"Peter K. Sorger","orcid":"https://orcid.org/0000-0002-3364-1838"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter K Sorger","raw_affiliation_strings":["Laboratory of Systems Pharmacology, Program in Therapeutic Science, Harvard Medical School , Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Laboratory of Systems Pharmacology, Program in Therapeutic Science, Harvard Medical School , Boston, MA, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055719391","display_name":"Yevgeniy R. Semenov","orcid":"https://orcid.org/0000-0002-7387-3094"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yevgeniy R Semenov","raw_affiliation_strings":["Department of Dermatology, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA","Laboratory of Systems Pharmacology, Program in Therapeutic Science, Harvard Medical School , Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Laboratory of Systems Pharmacology, Program in Therapeutic Science, Harvard Medical School , Boston, MA, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5055719391"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.9826,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.74082106,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"25","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6972469091415405},{"id":"https://openalex.org/keywords/multiplexing","display_name":"Multiplexing","score":0.5363619923591614},{"id":"https://openalex.org/keywords/source-code","display_name":"Source code","score":0.5346779823303223},{"id":"https://openalex.org/keywords/stromal-cell","display_name":"Stromal cell","score":0.5040901899337769},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"Tumor microenvironment","score":0.44984692335128784},{"id":"https://openalex.org/keywords/profiling","display_name":"Profiling (computer programming)","score":0.4339006543159485},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.36861342191696167},{"id":"https://openalex.org/keywords/tumor-cells","display_name":"Tumor cells","score":0.29488277435302734},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2223224937915802},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.16037937998771667}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6972469091415405},{"id":"https://openalex.org/C19275194","wikidata":"https://www.wikidata.org/wiki/Q222903","display_name":"Multiplexing","level":2,"score":0.5363619923591614},{"id":"https://openalex.org/C43126263","wikidata":"https://www.wikidata.org/wiki/Q128751","display_name":"Source code","level":2,"score":0.5346779823303223},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5040901899337769},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.44984692335128784},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.4339006543159485},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36861342191696167},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.29488277435302734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2223224937915802},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.16037937998771667},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae189","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae189","pdf_url":"https://academic.oup.com/bib/article-pdf/25/3/bbae189/57390484/bbae189.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38701421","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38701421","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11066940","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11066940","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11066940/pdf/bbae189.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae189","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae189","pdf_url":"https://academic.oup.com/bib/article-pdf/25/3/bbae189/57390484/bbae189.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3783488370","display_name":null,"funder_award_id":"K23AR080791","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4356752867","display_name":null,"funder_award_id":"R35GM142879","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6472984402","display_name":null,"funder_award_id":"W81XWH2110819","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4396627746.pdf"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1536690700","https://openalex.org/W1985861335","https://openalex.org/W2015009944","https://openalex.org/W2106489008","https://openalex.org/W2111349937","https://openalex.org/W2332292689","https://openalex.org/W2800392236","https://openalex.org/W2802206159","https://openalex.org/W2808814350","https://openalex.org/W2832881433","https://openalex.org/W2883287882","https://openalex.org/W2887091285","https://openalex.org/W2922020904","https://openalex.org/W2936119023","https://openalex.org/W2942448186","https://openalex.org/W3004640473","https://openalex.org/W3047106569","https://openalex.org/W3099559583","https://openalex.org/W3176444924","https://openalex.org/W3215932031","https://openalex.org/W4200538065","https://openalex.org/W4205817967","https://openalex.org/W4210583065","https://openalex.org/W4220854419","https://openalex.org/W4225563096","https://openalex.org/W4307687738","https://openalex.org/W4317434093","https://openalex.org/W4386022476","https://openalex.org/W4387336447","https://openalex.org/W6857064883"],"related_works":["https://openalex.org/W2980421756","https://openalex.org/W2161444195","https://openalex.org/W2589019771","https://openalex.org/W2314776203","https://openalex.org/W3118727544","https://openalex.org/W2985540061","https://openalex.org/W2406061890","https://openalex.org/W2185012154","https://openalex.org/W1987165109","https://openalex.org/W2104874568"],"abstract_inverted_index":{"Cancer":[0],"is":[1],"a":[2],"complex":[3],"cellular":[4,59],"ecosystem":[5],"where":[6],"malignant":[7],"cells":[8,17],"coexist":[9],"and":[10,15,41,60,81,93,111,125,142],"interact":[11],"with":[12],"immune,":[13],"stromal":[14],"other":[16],"within":[18],"the":[19,37,49,102],"tumor":[20,139],"microenvironment":[21],"(TME).":[22],"Recent":[23],"technological":[24],"advancements":[25],"in":[26,134],"spatially":[27],"resolved":[28],"multiplexed":[29,87,108],"imaging":[30],"at":[31,97],"single-cell":[32,88,109],"resolution":[33],"have":[34],"led":[35],"to":[36],"generation":[38],"of":[39,63,84,105,117,138],"large-scale":[40],"high-dimensional":[42],"datasets":[43],"from":[44,107],"biological":[45],"specimens.":[46],"This":[47,68],"underscores":[48],"necessity":[50],"for":[51,65,77],"automated":[52,103],"methodologies":[53],"that":[54],"can":[55,112],"effectively":[56],"characterize":[57],"molecular,":[58],"spatial":[61],"properties":[62],"TMEs":[64,85],"various":[66],"malignancies.":[67],"study":[69],"introduces":[70],"SpatialCells,":[71],"an":[72,131],"open-source":[73],"software":[74],"package":[75],"designed":[76],"region-based":[78],"exploratory":[79],"analysis":[80],"comprehensive":[82],"characterization":[83],"using":[86],"data.":[89],"The":[90],"source":[91],"code":[92],"tutorials":[94],"are":[95],"available":[96],"https://semenovlab.github.io/SpatialCells.":[98],"SpatialCells":[99,120],"efficiently":[100],"streamlines":[101],"extraction":[104],"features":[106],"data":[110],"process":[113],"samples":[114],"containing":[115],"millions":[116],"cells.":[118],"Thus,":[119],"facilitates":[121],"subsequent":[122],"association":[123],"analyses":[124],"machine":[126],"learning":[127],"predictions,":[128],"making":[129],"it":[130],"essential":[132],"tool":[133],"advancing":[135],"our":[136],"understanding":[137],"growth,":[140],"invasion":[141],"metastasis.":[143]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-03-11T14:59:36.786465","created_date":"2025-10-10T00:00:00"}
