{"id":"https://openalex.org/W2106418887","doi":"https://doi.org/10.1093/bioinformatics/btq473","title":"Improving performances of suboptimal greedy iterative biclustering heuristics via localization","display_name":"Improving performances of suboptimal greedy iterative biclustering heuristics via localization","publication_year":2010,"publication_date":"2010-08-23","ids":{"openalex":"https://openalex.org/W2106418887","doi":"https://doi.org/10.1093/bioinformatics/btq473","mag":"2106418887","pmid":"https://pubmed.ncbi.nlm.nih.gov/20733064"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btq473","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq473","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/20/2594/48852883/bioinformatics_26_20_2594.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/26/20/2594/48852883/bioinformatics_26_20_2594.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066274617","display_name":"Cesim Erten","orcid":"https://orcid.org/0000-0002-8149-7113"},"institutions":[{"id":"https://openalex.org/I132286405","display_name":"Kadir Has University","ror":"https://ror.org/03zzckc47","country_code":"TR","type":"education","lineage":["https://openalex.org/I132286405"]},{"id":"https://openalex.org/I4405392","display_name":"Bo\u011fazi\u00e7i University","ror":"https://ror.org/03z9tma90","country_code":"TR","type":"education","lineage":["https://openalex.org/I4405392"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Cesim Erten","raw_affiliation_strings":["1 Department of Computer Engineering, Kadir Has University, Cibali, Istanbul 34083 and 2Department of Computer Engineering, Bogazi\u00e7i University, Bebek, Istanbul 34342, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Computer Engineering, Kadir Has University, Cibali, Istanbul 34083 and 2Department of Computer Engineering, Bogazi\u00e7i University, Bebek, Istanbul 34342, Turkey","institution_ids":["https://openalex.org/I132286405","https://openalex.org/I4405392"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077606182","display_name":"Melih S\u00f6zdinler","orcid":"https://orcid.org/0000-0002-9698-4360"},"institutions":[{"id":"https://openalex.org/I132286405","display_name":"Kadir Has University","ror":"https://ror.org/03zzckc47","country_code":"TR","type":"education","lineage":["https://openalex.org/I132286405"]},{"id":"https://openalex.org/I4405392","display_name":"Bo\u011fazi\u00e7i University","ror":"https://ror.org/03z9tma90","country_code":"TR","type":"education","lineage":["https://openalex.org/I4405392"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Melih S\u00f6zdinler","raw_affiliation_strings":["1 Department of Computer Engineering, Kadir Has University, Cibali, Istanbul 34083 and 2Department of Computer Engineering, Bogazi\u00e7i University, Bebek, Istanbul 34342, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Computer Engineering, Kadir Has University, Cibali, Istanbul 34083 and 2Department of Computer Engineering, Bogazi\u00e7i University, Bebek, Istanbul 34342, Turkey","institution_ids":["https://openalex.org/I132286405","https://openalex.org/I4405392"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5066274617","https://openalex.org/A5077606182"],"corresponding_institution_ids":["https://openalex.org/I132286405","https://openalex.org/I4405392"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.537,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.66498489,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"26","issue":"20","first_page":"2594","last_page":"2600"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9638000130653381,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9638000130653381,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11612","display_name":"Stochastic Gradient Optimization Techniques","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biclustering","display_name":"Biclustering","score":0.908720076084137},{"id":"https://openalex.org/keywords/block-matrix","display_name":"Block matrix","score":0.6790425777435303},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.65443354845047},{"id":"https://openalex.org/keywords/row-and-column-spaces","display_name":"Row and column spaces","score":0.6102649569511414},{"id":"https://openalex.org/keywords/greedy-algorithm","display_name":"Greedy algorithm","score":0.5639563798904419},{"id":"https://openalex.org/keywords/heuristics","display_name":"Heuristics","score":0.5490565299987793},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.5241066217422485},{"id":"https://openalex.org/keywords/row","display_name":"Row","score":0.5032133460044861},{"id":"https://openalex.org/keywords/matrix-decomposition","display_name":"Matrix decomposition","score":0.49497169256210327},{"id":"https://openalex.org/keywords/block","display_name":"Block (permutation group theory)","score":0.4491989016532898},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.43390440940856934},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3377385139465332},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2685491442680359},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.22877463698387146},{"id":"https://openalex.org/keywords/correlation-clustering","display_name":"Correlation clustering","score":0.11026504635810852},{"id":"https://openalex.org/keywords/canopy-clustering-algorithm","display_name":"Canopy clustering algorithm","score":0.07733729481697083}],"concepts":[{"id":"https://openalex.org/C144817290","wikidata":"https://www.wikidata.org/wiki/Q2976575","display_name":"Biclustering","level":5,"score":0.908720076084137},{"id":"https://openalex.org/C85817219","wikidata":"https://www.wikidata.org/wiki/Q884772","display_name":"Block matrix","level":3,"score":0.6790425777435303},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.65443354845047},{"id":"https://openalex.org/C104140500","wikidata":"https://www.wikidata.org/wiki/Q2088159","display_name":"Row and column spaces","level":3,"score":0.6102649569511414},{"id":"https://openalex.org/C51823790","wikidata":"https://www.wikidata.org/wiki/Q504353","display_name":"Greedy algorithm","level":2,"score":0.5639563798904419},{"id":"https://openalex.org/C127705205","wikidata":"https://www.wikidata.org/wiki/Q5748245","display_name":"Heuristics","level":2,"score":0.5490565299987793},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.5241066217422485},{"id":"https://openalex.org/C135598885","wikidata":"https://www.wikidata.org/wiki/Q1366302","display_name":"Row","level":2,"score":0.5032133460044861},{"id":"https://openalex.org/C42355184","wikidata":"https://www.wikidata.org/wiki/Q1361088","display_name":"Matrix decomposition","level":3,"score":0.49497169256210327},{"id":"https://openalex.org/C2777210771","wikidata":"https://www.wikidata.org/wiki/Q4927124","display_name":"Block (permutation group theory)","level":2,"score":0.4491989016532898},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.43390440940856934},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3377385139465332},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2685491442680359},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.22877463698387146},{"id":"https://openalex.org/C94641424","wikidata":"https://www.wikidata.org/wiki/Q5172845","display_name":"Correlation clustering","level":3,"score":0.11026504635810852},{"id":"https://openalex.org/C104047586","wikidata":"https://www.wikidata.org/wiki/Q5033439","display_name":"Canopy clustering algorithm","level":4,"score":0.07733729481697083},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C158693339","wikidata":"https://www.wikidata.org/wiki/Q190524","display_name":"Eigenvalues and eigenvectors","level":2,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btq473","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq473","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/20/2594/48852883/bioinformatics_26_20_2594.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20733064","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20733064","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btq473","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq473","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/20/2594/48852883/bioinformatics_26_20_2594.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2106418887.pdf"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1493217831","https://openalex.org/W1608091105","https://openalex.org/W1836100053","https://openalex.org/W1979053278","https://openalex.org/W1980503920","https://openalex.org/W1984238247","https://openalex.org/W2005143737","https://openalex.org/W2018593731","https://openalex.org/W2022637272","https://openalex.org/W2035359116","https://openalex.org/W2036328877","https://openalex.org/W2044427170","https://openalex.org/W2054966761","https://openalex.org/W2057682468","https://openalex.org/W2058849889","https://openalex.org/W2059398218","https://openalex.org/W2059413897","https://openalex.org/W2061439657","https://openalex.org/W2064787891","https://openalex.org/W2071529189","https://openalex.org/W2079966248","https://openalex.org/W2080278541","https://openalex.org/W2085349009","https://openalex.org/W2099862356","https://openalex.org/W2105883975","https://openalex.org/W2106336008","https://openalex.org/W2109174028","https://openalex.org/W2113654464","https://openalex.org/W2123765724","https://openalex.org/W2130095365","https://openalex.org/W2130158951","https://openalex.org/W2136107412","https://openalex.org/W2137683543","https://openalex.org/W2144544802","https://openalex.org/W2144792853","https://openalex.org/W2151763757","https://openalex.org/W2152320972","https://openalex.org/W2156153879","https://openalex.org/W2161920970","https://openalex.org/W2166195983","https://openalex.org/W3100951886","https://openalex.org/W4210777595","https://openalex.org/W4235419234","https://openalex.org/W6629329278","https://openalex.org/W6664918432","https://openalex.org/W6665669757","https://openalex.org/W6667016274","https://openalex.org/W6668408644","https://openalex.org/W6684449836"],"related_works":["https://openalex.org/W2152668278","https://openalex.org/W2611629964","https://openalex.org/W2020537032","https://openalex.org/W2884830791","https://openalex.org/W1608091105","https://openalex.org/W4289751370","https://openalex.org/W1967570720","https://openalex.org/W2146625169","https://openalex.org/W4229011705","https://openalex.org/W2106418887"],"abstract_inverted_index":{"MOTIVATION:":[0],"Biclustering":[1],"gene":[2],"expression":[3,30],"data":[4,27,80,179,328],"is":[5],"the":[6,20,23,33,37,44,73,78,96,126,129,145,176,189,199,226,241,244,259,268,275,286,296,299,316],"problem":[7,38],"of":[8,11,25,29,36,43,77,108,120,128,243,261,298],"extracting":[9],"submatrices":[10,174],"genes":[12],"and":[13,22,65,75,187,215,264,315],"conditions":[14],"exhibiting":[15,114],"significant":[16],"correlation":[17],"across":[18],"both":[19],"rows":[21,74],"columns":[24,76],"a":[26,55,63,84,115,162],"matrix":[28,81,208,229],"values.":[31],"Even":[32],"simplest":[34],"versions":[35],"are":[39,318,329],"computationally":[40,227],"hard.":[41],"Most":[42],"proposed":[45,99,200],"solutions":[46],"therefore":[47],"employ":[48],"greedy":[49,138,247,288],"iterative":[50,139,248],"heuristics":[51],"that":[52,71,119,171,212,240,274],"locally":[53],"optimize":[54],"suitably":[56],"assigned":[57],"scoring":[58],"function.":[59],"METHODS:":[60],"We":[61,142,197,210,237],"provide":[62],"fast":[64,214],"simple":[66,163,216],"pre-processing":[67,131,147,202,205,231,254,301],"algorithm":[68,101,154],"called":[69],"localization":[70,100,130,146,177,201,217,253,281],"reorders":[72],"input":[79],"in":[82,91,258,309],"such":[83],"way":[85],"as":[86,191],"to":[87,112,118,124,155,234],"group":[88],"correlated":[89,192],"entries":[90],"small":[92],"local":[93],"neighborhoods":[94],"within":[95],"matrix.":[97],"The":[98,272],"takes":[102],"its":[103],"roots":[104],"from":[105,175],"effective":[106],"use":[107],"graph-theoretical":[109],"methods":[110,250,290],"applied":[111],"problems":[113],"similar":[116,220],"structure":[117],"biclustering.":[121],"In":[122],"order":[123],"evaluate":[125],"effectivenesss":[127],"algorithm,":[132,165],"we":[133,160],"focus":[134],"on":[135,280],"three":[136,245],"representative":[137,153,246,287],"heuristic":[140,249,289],"methods.":[141],"show":[143,211],"how":[144],"can":[148],"be":[149],"incorporated":[150],"into":[151],"each":[152],"improve":[156,251],"biclustering":[157,164],"performance.":[158],"Furthermore,":[159],"propose":[161],"Random":[166],"Extraction":[167],"After":[168],"Localization":[169],"(REAL)":[170],"randomly":[172],"extracts":[173],"pre-processed":[178],"matrix,":[180],"eliminates":[181],"those":[182],"with":[183,203,232,252],"low":[184],"similarity":[185],"scores,":[186],"provides":[188,219],"rest":[190],"structures":[193],"representing":[194],"biclusters.":[195],"RESULTS:":[196],"compare":[198],"another":[204],"alternative,":[206],"non-negative":[207],"factorization.":[209],"our":[213],"procedure":[218],"or":[221],"even":[222],"better":[223,284],"results":[224,317],"than":[225,285],"heavy":[228],"factorization":[230],"regards":[233],"H-value":[235],"tests.":[236],"next":[238],"demonstrate":[239],"performances":[242],"when":[255],"biological":[256],"correlations":[257],"form":[260],"functional":[262],"enrichment":[263],"PPI":[265],"verification":[266],"constitute":[267],"main":[269],"performance":[270],"criteria.":[271],"fact":[273],"random":[276],"extraction":[277],"method":[278],"based":[279],"REAL":[282],"performs":[283],"under":[291],"same":[292],"criteria":[293],"also":[294],"confirms":[295],"effectiveness":[297],"suggested":[300],"method.":[302],"AVAILABILITY:":[303],"Supplementary":[304,327],"material":[305],"including":[306],"code":[307],"implementations":[308],"LEDA":[310],"C++":[311],"library,":[312],"experimental":[313],"data,":[314],"available":[319,330],"at":[320,331],"http://code.google.com/p/biclustering/":[321],"CONTACTS:":[322],"cesim@khas.edu.tr;":[323],"melihsozdinler@boun.edu.tr":[324],"SUPPLEMENTARY":[325],"INFORMATION:":[326],"Bioinformatics":[332],"online.":[333]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}