{"id":"https://openalex.org/W3126880407","doi":"https://doi.org/10.1109/bibm49941.2020.9313215","title":"Predicting circRNA-disease associations using meta path-based representation learning on heterogenous network","display_name":"Predicting circRNA-disease associations using meta path-based representation learning on heterogenous network","publication_year":2020,"publication_date":"2020-12-16","ids":{"openalex":"https://openalex.org/W3126880407","doi":"https://doi.org/10.1109/bibm49941.2020.9313215","mag":"3126880407"},"language":"en","primary_location":{"id":"doi:10.1109/bibm49941.2020.9313215","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm49941.2020.9313215","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085608332","display_name":"Lei Deng","orcid":"https://orcid.org/0000-0003-2869-1619"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Deng","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101581104","display_name":"Jing Yang","orcid":"https://orcid.org/0000-0002-9530-196X"},"institutions":[{"id":"https://openalex.org/I4210153482","display_name":"Changzhou University","ror":"https://ror.org/04ymgwq66","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210153482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Yang","raw_affiliation_strings":["Aliyun School of Big Data, Changzhou University, Changzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aliyun School of Big Data, Changzhou University, Changzhou, China","institution_ids":["https://openalex.org/I4210153482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100387512","display_name":"Hui Liu","orcid":"https://orcid.org/0000-0001-7158-913X"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Liu","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"5","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9850000143051147,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6900318264961243},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.6714339256286621},{"id":"https://openalex.org/keywords/path","display_name":"Path (computing)","score":0.6411775350570679},{"id":"https://openalex.org/keywords/meta-learning","display_name":"Meta learning (computer science)","score":0.5339573621749878},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.49959444999694824},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.49025800824165344},{"id":"https://openalex.org/keywords/feature-learning","display_name":"Feature learning","score":0.4211437702178955},{"id":"https://openalex.org/keywords/meta-analysis","display_name":"Meta-analysis","score":0.41693946719169617},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4037209153175354},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16278019547462463},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.15011820197105408},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.08511069416999817},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.05732432007789612}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6900318264961243},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.6714339256286621},{"id":"https://openalex.org/C2777735758","wikidata":"https://www.wikidata.org/wiki/Q817765","display_name":"Path (computing)","level":2,"score":0.6411775350570679},{"id":"https://openalex.org/C2781002164","wikidata":"https://www.wikidata.org/wiki/Q6822311","display_name":"Meta learning (computer science)","level":3,"score":0.5339573621749878},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.49959444999694824},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.49025800824165344},{"id":"https://openalex.org/C59404180","wikidata":"https://www.wikidata.org/wiki/Q17013334","display_name":"Feature learning","level":2,"score":0.4211437702178955},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.41693946719169617},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4037209153175354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16278019547462463},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.15011820197105408},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08511069416999817},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.05732432007789612},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.0},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm49941.2020.9313215","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm49941.2020.9313215","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5799999833106995,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1521279639","https://openalex.org/W1874402154","https://openalex.org/W2054891772","https://openalex.org/W2115171906","https://openalex.org/W2119412782","https://openalex.org/W2147806662","https://openalex.org/W2266356262","https://openalex.org/W2285247593","https://openalex.org/W2557141539","https://openalex.org/W2611747160","https://openalex.org/W2617715606","https://openalex.org/W2737722001","https://openalex.org/W2740948561","https://openalex.org/W2757711868","https://openalex.org/W2759279048","https://openalex.org/W2767774008","https://openalex.org/W2768086794","https://openalex.org/W2909637325","https://openalex.org/W2996158690","https://openalex.org/W3033631147"],"related_works":["https://openalex.org/W3210678099","https://openalex.org/W4200025911","https://openalex.org/W3088977003","https://openalex.org/W4226264679","https://openalex.org/W4360943417","https://openalex.org/W4246615163","https://openalex.org/W4206095708","https://openalex.org/W2611523470","https://openalex.org/W4386361997","https://openalex.org/W1594018981"],"abstract_inverted_index":{"Circular":[0],"RNA":[1,21],"(circRNA)":[2],"is":[3,62],"a":[4,17,63,85,109,146],"new":[5,86],"class":[6],"of":[7,31,45,57,92],"regulatory":[8],"non-coding":[9],"RNAs":[10],"modulating":[11],"gene":[12],"expression":[13],"by":[14,179],"acting":[15],"as":[16],"microRNA":[18],"(miRNA)":[19],"sponge,":[20],"binding":[22],"protein":[23,125],"sponge":[24],"and":[25,47,55,78,132,145],"translational":[26],"regulator.":[27],"A":[28,135],"increasing":[29],"number":[30],"experimental":[32,169],"studies":[33],"have":[34],"shown":[35],"that":[36,114,172],"circRNA":[37,48,119],"plays":[38],"an":[39,68],"important":[40],"role":[41],"in":[42],"the":[43,53,74,90,93,165],"development":[44],"diseases,":[46],"biomarkers":[49],"are":[50],"helpful":[51],"for":[52,89,104],"diagnosis":[54],"treatment":[56],"various":[58],"human":[59],"diseases.":[60,79],"There":[61],"pressing":[64],"demand":[65],"to":[66,72,141,152],"establish":[67],"effective":[69],"computational":[70,87],"method":[71,174],"identify":[73],"associations":[75,131],"between":[76],"circRNAs":[77],"In":[80,96],"this":[81],"paper,":[82],"we":[83,98],"propose":[84],"framework":[88],"prediction":[91],"circRNA-disease":[94,128,154],"associations.":[95,134,155],"particular,":[97],"calculated":[99],"meta":[100],"path-based":[101],"feature":[102],"vectors":[103],"each":[105],"circRNAdisease":[106],"pair":[107],"on":[108,164,183],"heterogeneous":[110],"information":[111],"network":[112],"(HIN)":[113],"integrated":[115],"multiple":[116],"subnetworks,":[117],"including":[118],"similarity":[120,123,126],"network,":[121,124,127],"disease":[122],"associations,":[129],"circRNA-protein":[130],"protein-disease":[133],"positive-unlabeled":[136],"learning":[137],"algorithm":[138],"was":[139,150],"adopted":[140],"generate":[142],"negative":[143],"samples,":[144],"random":[147],"forest":[148],"classifier":[149],"trained":[151],"predicted":[153],"We":[156],"conducted":[157],"performance":[158],"comparison":[159],"with":[160],"three":[161],"popular":[162],"methods":[163,178],"CircR2Disease":[166],"dataset.":[167],"The":[168],"results":[170],"show":[171],"our":[173],"outperform":[175],"other":[176],"existing":[177],"achieving":[180],"AUC":[181],"0.983":[182],"5-fold":[184],"cross-validation.":[185]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
