{"id":"https://openalex.org/W1980723259","doi":"https://doi.org/10.1109/tbcas.2013.2288035","title":"Time-Varying Causal Inference From Phosphoproteomic Measurements in Macrophage Cells","display_name":"Time-Varying Causal Inference From Phosphoproteomic Measurements in Macrophage Cells","publication_year":2014,"publication_date":"2014-02-01","ids":{"openalex":"https://openalex.org/W1980723259","doi":"https://doi.org/10.1109/tbcas.2013.2288035","mag":"1980723259","pmid":"https://pubmed.ncbi.nlm.nih.gov/24681921"},"language":"en","primary_location":{"id":"doi:10.1109/tbcas.2013.2288035","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbcas.2013.2288035","pdf_url":null,"source":{"id":"https://openalex.org/S80299757","display_name":"IEEE Transactions on Biomedical Circuits and Systems","issn_l":"1932-4545","issn":["1932-4545","1940-9990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Circuits and Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025122130","display_name":"Maryam Masnadi-Shirazi","orcid":null},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryam Masnadi-Shirazi","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, USA","[Dept of Electr. & Comput. Eng., Univ. of California San Diego, La Jolla, CA, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"[Dept of Electr. & Comput. Eng., Univ. of California San Diego, La Jolla, CA, USA]","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062832709","display_name":"Mano R. Maurya","orcid":"https://orcid.org/0000-0003-4249-067X"},"institutions":[{"id":"https://openalex.org/I181653535","display_name":"San Diego Supercomputer Center","ror":"https://ror.org/04mg3nk07","country_code":"US","type":"facility","lineage":["https://openalex.org/I181653535","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mano Ram Maurya","raw_affiliation_strings":["San Diego Supercomputer Center and the Department of Bioengineering, University of California San Diego, La Jolla, CA, USA","Dept. of Bioeng., Univ. of California San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Diego Supercomputer Center and the Department of Bioengineering, University of California San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I181653535","https://openalex.org/I36258959"]},{"raw_affiliation_string":"Dept. of Bioeng., Univ. of California San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063396453","display_name":"Shankar Subramaniam","orcid":"https://orcid.org/0000-0002-8059-4659"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shankar Subramaniam","raw_affiliation_strings":["Department of Bioengineering, Departments of Chemistry and Biochemistry, Cellular and Molecular Medicine and the Graduate Program in Bioinformatics, University of California San Diego, La Jolla, CA, USA","Depts. of Bioeng., Chem. & Biochem., Cellular & Mol. Med. & the Grad. Program in Bioinf., Univ. of California San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Departments of Chemistry and Biochemistry, Cellular and Molecular Medicine and the Graduate Program in Bioinformatics, University of California San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Depts. of Bioeng., Chem. & Biochem., Cellular & Mol. Med. & the Grad. Program in Bioinf., Univ. of California San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6557,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.86944481,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"8","issue":"1","first_page":"74","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.5361781716346741},{"id":"https://openalex.org/keywords/macrophage","display_name":"Macrophage","score":0.5265054106712341},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4411733150482178},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.416897714138031},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4096916913986206},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3785497546195984},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.37241339683532715},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.35411542654037476},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.34865880012512207},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.19912394881248474},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.11885938048362732}],"concepts":[{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.5361781716346741},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5265054106712341},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4411733150482178},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.416897714138031},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4096916913986206},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3785497546195984},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.37241339683532715},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35411542654037476},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.34865880012512207},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.19912394881248474},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11885938048362732},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbcas.2013.2288035","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbcas.2013.2288035","pdf_url":null,"source":{"id":"https://openalex.org/S80299757","display_name":"IEEE Transactions on Biomedical Circuits and Systems","issn_l":"1932-4545","issn":["1932-4545","1940-9990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Circuits and Systems","raw_type":"journal-article"},{"id":"pmid:24681921","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24681921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on biomedical circuits and systems","raw_type":null},{"id":"pmh:oai:europepmc.org:3606840","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4631079","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4300000071525574,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G111177192","display_name":null,"funder_award_id":"R01 HL108735","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4674976940","display_name":null,"funder_award_id":"R33 HL087375","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5060433592","display_name":null,"funder_award_id":"R01HL087375-02","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5074362472","display_name":null,"funder_award_id":"R01 HL106579","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7799384533","display_name":null,"funder_award_id":"U54 GM069338","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7864170123","display_name":null,"funder_award_id":"U19 AI090023","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8532500507","display_name":null,"funder_award_id":"U54GM69338","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G984289028","display_name":null,"funder_award_id":"R38 AI140299","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":86,"referenced_works":["https://openalex.org/W65155625","https://openalex.org/W67061917","https://openalex.org/W97523097","https://openalex.org/W161395021","https://openalex.org/W1518972222","https://openalex.org/W1663371441","https://openalex.org/W1701092691","https://openalex.org/W1756428283","https://openalex.org/W1758789982","https://openalex.org/W1913785883","https://openalex.org/W1964504843","https://openalex.org/W1964887620","https://openalex.org/W1973217014","https://openalex.org/W1973251504","https://openalex.org/W1976286904","https://openalex.org/W1981053728","https://openalex.org/W1981446514","https://openalex.org/W1986040959","https://openalex.org/W1986275598","https://openalex.org/W1998682097","https://openalex.org/W1999982643","https://openalex.org/W2006668556","https://openalex.org/W2014222652","https://openalex.org/W2017292900","https://openalex.org/W2017592134","https://openalex.org/W2018365867","https://openalex.org/W2022255691","https://openalex.org/W2022371765","https://openalex.org/W2035868461","https://openalex.org/W2039629489","https://openalex.org/W2042746242","https://openalex.org/W2042832398","https://openalex.org/W2056907950","https://openalex.org/W2058138221","https://openalex.org/W2059608747","https://openalex.org/W2060630008","https://openalex.org/W2064532472","https://openalex.org/W2064811541","https://openalex.org/W2066580949","https://openalex.org/W2070363338","https://openalex.org/W2073307618","https://openalex.org/W2076238420","https://openalex.org/W2076892771","https://openalex.org/W2082141855","https://openalex.org/W2084103591","https://openalex.org/W2093621392","https://openalex.org/W2093954984","https://openalex.org/W2094348357","https://openalex.org/W2094558888","https://openalex.org/W2094863064","https://openalex.org/W2095860222","https://openalex.org/W2098118861","https://openalex.org/W2098595332","https://openalex.org/W2099235429","https://openalex.org/W2099442582","https://openalex.org/W2100212868","https://openalex.org/W2102010992","https://openalex.org/W2103031848","https://openalex.org/W2106177160","https://openalex.org/W2107725425","https://openalex.org/W2110065044","https://openalex.org/W2110625090","https://openalex.org/W2112964135","https://openalex.org/W2117372074","https://openalex.org/W2117524604","https://openalex.org/W2118467699","https://openalex.org/W2121443434","https://openalex.org/W2122807946","https://openalex.org/W2125904354","https://openalex.org/W2130589939","https://openalex.org/W2133801172","https://openalex.org/W2138838677","https://openalex.org/W2146288972","https://openalex.org/W2146811846","https://openalex.org/W2147821795","https://openalex.org/W2148460690","https://openalex.org/W2158395929","https://openalex.org/W2160824210","https://openalex.org/W2169294680","https://openalex.org/W2178225550","https://openalex.org/W2611370172","https://openalex.org/W4205651771","https://openalex.org/W4233838756","https://openalex.org/W4237822095","https://openalex.org/W4245169559","https://openalex.org/W6681606010"],"related_works":["https://openalex.org/W2055243143","https://openalex.org/W4321636575","https://openalex.org/W2357796999","https://openalex.org/W2045526782","https://openalex.org/W2741131631","https://openalex.org/W1986418932","https://openalex.org/W2156919374","https://openalex.org/W35446969","https://openalex.org/W1984019423","https://openalex.org/W4280588203"],"abstract_inverted_index":{"Cellular":[0],"signaling":[1,87,115,130,226,247],"circuitry":[2],"in":[3,64,97,118,135,157,177,231,244],"eukaryotes":[4],"can":[5,68,144],"be":[6],"studied":[7],"by":[8],"analyzing":[9],"the":[10,61,70,85,93,119,139,162,183,186,194,197,213,224,238,241,245],"regulation":[11],"of":[12,28,84,114,121,150,164,185,199,212,215,240],"protein":[13,42,49],"phosphorylation":[14,29,50],"and":[15,73,99,167,196,219],"its":[16],"impact":[17],"on":[18],"downstream":[19],"mechanisms":[20],"leading":[21,124],"to":[22,31,36,76,125,173,192,222],"a":[23,34,41,45,52,108,146,169,216,232],"phenotype.":[24],"A":[25],"primary":[26],"role":[27],"is":[30,51,89],"act":[32],"as":[33,79],"switch":[35],"turn":[37],"\"on\"":[38],"or":[39,44],"\"off\"":[40],"activity":[43],"cellular":[46,66],"pathway.":[47],"Specifically,":[48],"major":[53],"leit":[54],"motif":[55],"for":[56,91,111],"transducing":[57],"molecular":[58,94],"signals":[59],"inside":[60],"cell.":[62],"Errors":[63],"transferring":[65],"information":[67,200],"alter":[69],"normal":[71,98],"function":[72],"may":[74],"lead":[75],"diseases":[77],"such":[78],"cancer;":[80],"an":[81,126],"accurate":[82],"reconstruction":[83,113,184],"\"true\"":[86],"network":[88,235],"essential":[90],"understanding":[92],"machinery":[95],"involved":[96,117],"pathological":[100],"function.":[101],"In":[102],"this":[103],"study,":[104],"we":[105,160,189],"have":[106,132],"developed":[107],"novel":[109],"framework":[110],"time-dependent":[112],"networks":[116],"activation":[120],"macrophage":[122,136,180],"cells":[123],"inflammatory":[127],"response.":[128],"Several":[129],"pathways":[131],"been":[133,155],"identified":[134],"cells,":[137],"but":[138],"time-varying":[140],"causal":[141,242],"relationship":[142],"that":[143,236],"produce":[145],"dynamic":[147],"directed":[148],"graph":[149],"these":[151],"molecules":[152],"has":[153],"not":[154],"explored":[156],"detail.":[158],"Here,":[159],"use":[161],"notion":[163],"Granger":[165],"causality,":[166],"apply":[168],"vector":[170],"autoregressive":[171],"model":[172,218],"phosphoprotein":[174,187,225,234],"time-course":[175],"data":[176],"RAW":[178],"264.7":[179],"cells.":[181],"Through":[182],"network,":[188],"were":[190,204,220],"able":[191],"estimate":[193],"directionality":[195],"dynamics":[198],"flow.":[201],"Significant":[202],"interactions":[203,243],"selected":[205],"through":[206],"statistical":[207],"hypothesis":[208],"testing":[209],"(":[210],"t-test)":[211],"coefficients":[214],"linear":[217],"used":[221],"reconstruct":[223],"network.":[227],"Our":[228],"approach":[229],"results":[230],"three-stage":[233],"represents":[237],"evolution":[239],"intracellular":[246],"pathways.":[248]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}
