{"id":"https://openalex.org/W1669342238","doi":"https://doi.org/10.1109/tbcas.2015.2446431","title":"A Cytomorphic Chip for Quantitative Modeling of Fundamental Bio-Molecular Circuits","display_name":"A Cytomorphic Chip for Quantitative Modeling of Fundamental Bio-Molecular Circuits","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W1669342238","doi":"https://doi.org/10.1109/tbcas.2015.2446431","mag":"1669342238","pmid":"https://pubmed.ncbi.nlm.nih.gov/26292344"},"language":"en","primary_location":{"id":"doi:10.1109/tbcas.2015.2446431","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbcas.2015.2446431","pdf_url":null,"source":{"id":"https://openalex.org/S80299757","display_name":"IEEE Transactions on Biomedical Circuits and Systems","issn_l":"1932-4545","issn":["1932-4545","1940-9990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Circuits and Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081901594","display_name":"Sung Sik Woo","orcid":"https://orcid.org/0000-0003-2863-7452"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sung Sik Woo","raw_affiliation_strings":["Massachusetts Institute of Technology, Research Laboratory of Electronics, Cambridge, MA, USA","Research Laboratory of Electronics , Massachusetts Institute of Technology , Cambridge , MA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Research Laboratory of Electronics, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Research Laboratory of Electronics , Massachusetts Institute of Technology , Cambridge , MA , USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100754676","display_name":"Jaewook Kim","orcid":"https://orcid.org/0000-0002-6152-7514"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaewook Kim","raw_affiliation_strings":["Massachusetts Institute of Technology, Research Laboratory of Electronics, Cambridge, MA, USA","Research Laboratory of Electronics , Massachusetts Institute of Technology , Cambridge , MA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Research Laboratory of Electronics, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Research Laboratory of Electronics , Massachusetts Institute of Technology , Cambridge , MA , USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009252030","display_name":"Rahul Sarpeshkar","orcid":"https://orcid.org/0000-0002-5975-0004"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rahul Sarpeshkar","raw_affiliation_strings":["Massachusetts Institute of Technology, Research Laboratory of Electronics, Cambridge, MA, USA","Research Laboratory of Electronics , Massachusetts Institute of Technology , Cambridge , MA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Research Laboratory of Electronics, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Research Laboratory of Electronics , Massachusetts Institute of Technology , Cambridge , MA , USA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":null,"apc_paid":null,"fwci":2.0692,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.86623243,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"9","issue":"4","first_page":"527","last_page":"542"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10323","display_name":"Analog and Mixed-Signal Circuit Design","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9782999753952026,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5944399833679199},{"id":"https://openalex.org/keywords/electronic-circuit","display_name":"Electronic circuit","score":0.5866357088088989},{"id":"https://openalex.org/keywords/transistor","display_name":"Transistor","score":0.5204694271087646},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.5109605193138123},{"id":"https://openalex.org/keywords/digital-electronics","display_name":"Digital electronics","score":0.5038477778434753},{"id":"https://openalex.org/keywords/chip","display_name":"Chip","score":0.502692699432373},{"id":"https://openalex.org/keywords/bicmos","display_name":"BiCMOS","score":0.45057398080825806},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.331376850605011},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.19472137093544006},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.16811221837997437}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5944399833679199},{"id":"https://openalex.org/C134146338","wikidata":"https://www.wikidata.org/wiki/Q1815901","display_name":"Electronic circuit","level":2,"score":0.5866357088088989},{"id":"https://openalex.org/C172385210","wikidata":"https://www.wikidata.org/wiki/Q5339","display_name":"Transistor","level":3,"score":0.5204694271087646},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.5109605193138123},{"id":"https://openalex.org/C81843906","wikidata":"https://www.wikidata.org/wiki/Q173156","display_name":"Digital electronics","level":3,"score":0.5038477778434753},{"id":"https://openalex.org/C165005293","wikidata":"https://www.wikidata.org/wiki/Q1074500","display_name":"Chip","level":2,"score":0.502692699432373},{"id":"https://openalex.org/C62427370","wikidata":"https://www.wikidata.org/wiki/Q173416","display_name":"BiCMOS","level":4,"score":0.45057398080825806},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.331376850605011},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.19472137093544006},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.16811221837997437},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001330","descriptor_name":"Electronic Data Processing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001330","descriptor_name":"Electronic Data Processing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001330","descriptor_name":"Electronic Data Processing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbcas.2015.2446431","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbcas.2015.2446431","pdf_url":null,"source":{"id":"https://openalex.org/S80299757","display_name":"IEEE Transactions on Biomedical Circuits and Systems","issn_l":"1932-4545","issn":["1932-4545","1940-9990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Circuits and Systems","raw_type":"journal-article"},{"id":"pmid:26292344","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26292344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on biomedical circuits and systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W48185882","https://openalex.org/W627140625","https://openalex.org/W1572063013","https://openalex.org/W1573813033","https://openalex.org/W1599969036","https://openalex.org/W1645305843","https://openalex.org/W1817736319","https://openalex.org/W1943884150","https://openalex.org/W1968156909","https://openalex.org/W1969101909","https://openalex.org/W1969423740","https://openalex.org/W1988931767","https://openalex.org/W1993546274","https://openalex.org/W1999777663","https://openalex.org/W2014617390","https://openalex.org/W2023403198","https://openalex.org/W2028263411","https://openalex.org/W2029967745","https://openalex.org/W2030848303","https://openalex.org/W2036573675","https://openalex.org/W2037200286","https://openalex.org/W2037913229","https://openalex.org/W2041985017","https://openalex.org/W2046857741","https://openalex.org/W2049060531","https://openalex.org/W2049986605","https://openalex.org/W2050492893","https://openalex.org/W2058221907","https://openalex.org/W2075735747","https://openalex.org/W2078734278","https://openalex.org/W2081781433","https://openalex.org/W2084118161","https://openalex.org/W2084924279","https://openalex.org/W2095888120","https://openalex.org/W2100995199","https://openalex.org/W2101531288","https://openalex.org/W2111510713","https://openalex.org/W2125010820","https://openalex.org/W2125135173","https://openalex.org/W2126586267","https://openalex.org/W2130912501","https://openalex.org/W2131763976","https://openalex.org/W2139016795","https://openalex.org/W2139042938","https://openalex.org/W2141877274","https://openalex.org/W2147539712","https://openalex.org/W2147757094","https://openalex.org/W2149799212","https://openalex.org/W2155418451","https://openalex.org/W2166499263","https://openalex.org/W2171280873","https://openalex.org/W4206315045","https://openalex.org/W4213353716","https://openalex.org/W6679951043","https://openalex.org/W6680419907"],"related_works":["https://openalex.org/W2538534558","https://openalex.org/W27766761","https://openalex.org/W2043562057","https://openalex.org/W1523515178","https://openalex.org/W2183033402","https://openalex.org/W2796521923","https://openalex.org/W606277608","https://openalex.org/W95651076","https://openalex.org/W2770163697","https://openalex.org/W2110521006"],"abstract_inverted_index":{"We":[0,136],"describe":[1],"a":[2],"0.35":[3],"\u03bcm":[4],"BiCMOS":[5],"silicon":[6],"chip":[7,183],"that":[8,138],"quantitatively":[9],"models":[10,144],"fundamental":[11],"molecular":[12,109,175],"circuits":[13,21,148,165],"via":[14,88,105],"efficient":[15],"log-domain":[16],"cytomorphic":[17],"transistor":[18,91,164],"equivalents.":[19],"These":[20],"include":[22],"those":[23,162],"for":[24,41,49,56,68,83],"biochemical":[25,117],"binding":[26],"with":[27,60,161],"automatic":[28],"representation":[29],"of":[30,63,73,95,122,145,174,192],"non-modular":[31],"and":[32,38,46,53,65,71,75,80,98,107,113,126,133,141,153,184],"loading":[33],"behavior,":[34],"e.g.,":[35],"in":[36,78,157,196],"cascade":[37],"fan-out":[39],"topologies;":[40],"representing":[42,50,85],"variable":[43],"Hill-coefficient":[44],"operation":[45],"cooperative":[47],"binding;":[48,55],"inducer,":[51],"transcription-factor,":[52],"DNA":[54],"probabilistic":[57],"gene":[58],"transcription":[59,79],"analogic":[61],"representations":[62],"log-linear":[64],"saturating":[66],"operation;":[67],"gain,":[69],"degradation,":[70],"dynamics":[72],"mRNA":[74],"protein":[76],"variables":[77],"translation;":[81],"and,":[82],"faithfully":[84],"biological":[86,147,197],"noise":[87],"tunable":[89],"stochastic":[90,171],"circuits.":[92],"The":[93,120],"use":[94,121],"on-chip":[96,127],"DACs":[97],"ADCs":[99],"enables":[100,130],"multiple":[101],"chips":[102],"to":[103],"interact":[104],"incoming":[106],"outgoing":[108],"digital":[110,124,128],"data":[111],"packets":[112],"thus":[114],"create":[115],"scalable":[116],"reaction":[118],"networks.":[119],"off-chip":[123],"processors":[125],"memory":[129],"programmable":[131],"connectivity":[132],"parameter":[134],"storage.":[135],"show":[137],"published":[139],"static":[140],"dynamic":[142],"MATLAB":[143],"synthetic":[146],"including":[149],"repressilators,":[150],"feed-forward":[151],"loops,":[152],"feedback":[154],"oscillators":[155],"are":[156,177],"excellent":[158],"quantitative":[159],"agreement":[160],"from":[163],"on":[166],"the":[167,182,190],"chip.":[168],"Computationally":[169],"intensive":[170],"Gillespie":[172],"simulations":[173],"production":[176],"also":[178],"rapidly":[179],"reproduced":[180],"by":[181],"can":[185],"be":[186],"reliably":[187],"tuned":[188],"over":[189],"range":[191],"signal-to-noise":[193],"ratios":[194],"observed":[195],"cells.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2016-06-24T00:00:00"}
