{"id":"https://openalex.org/W2344982137","doi":"https://doi.org/10.1109/tcbb.2015.2498552","title":"Calcium Ion Fluctuations Alter Channel Gating in a Stochastic Luminal Calcium Release Site Model","display_name":"Calcium Ion Fluctuations Alter Channel Gating in a Stochastic Luminal Calcium Release Site Model","publication_year":2015,"publication_date":"2015-11-06","ids":{"openalex":"https://openalex.org/W2344982137","doi":"https://doi.org/10.1109/tcbb.2015.2498552","mag":"2344982137","pmid":"https://pubmed.ncbi.nlm.nih.gov/26561478"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2015.2498552","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2015.2498552","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043","2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032700028","display_name":"Hao Ji","orcid":"https://orcid.org/0000-0001-8303-1491"},"institutions":[{"id":"https://openalex.org/I81365321","display_name":"Old Dominion University","ror":"https://ror.org/04zjtrb98","country_code":"US","type":"education","lineage":["https://openalex.org/I81365321"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Ji","raw_affiliation_strings":["Department of Computer Science, Old Dominion University, Norfolk, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Old Dominion University, Norfolk, VA","institution_ids":["https://openalex.org/I81365321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079316675","display_name":"Yaohang Li","orcid":"https://orcid.org/0000-0003-0178-1876"},"institutions":[{"id":"https://openalex.org/I81365321","display_name":"Old Dominion University","ror":"https://ror.org/04zjtrb98","country_code":"US","type":"education","lineage":["https://openalex.org/I81365321"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yaohang Li","raw_affiliation_strings":["Department of Computer Science, Old Dominion University, Norfolk, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Old Dominion University, Norfolk, VA","institution_ids":["https://openalex.org/I81365321"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064613832","display_name":"Seth H. Weinberg","orcid":"https://orcid.org/0000-0003-1170-0419"},"institutions":[{"id":"https://openalex.org/I81365321","display_name":"Old Dominion University","ror":"https://ror.org/04zjtrb98","country_code":"US","type":"education","lineage":["https://openalex.org/I81365321"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seth H. Weinberg","raw_affiliation_strings":["Virginia Modeling, Analysis, and Simulation Center, Old Dominion University, Suffolk, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia Modeling, Analysis, and Simulation Center, Old Dominion University, Suffolk, VA","institution_ids":["https://openalex.org/I81365321"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I81365321"],"apc_list":null,"apc_paid":null,"fwci":0.9647,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.7550645,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"14","issue":"3","first_page":"611","last_page":"619"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gating","display_name":"Gating","score":0.647603452205658},{"id":"https://openalex.org/keywords/calcium","display_name":"Calcium","score":0.5627015233039856},{"id":"https://openalex.org/keywords/calcium-channel","display_name":"Calcium channel","score":0.5205586552619934},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.49822092056274414},{"id":"https://openalex.org/keywords/master-equation","display_name":"Master equation","score":0.4932665228843689},{"id":"https://openalex.org/keywords/channel","display_name":"Channel (broadcasting)","score":0.4653374254703522},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.448275089263916},{"id":"https://openalex.org/keywords/steady-state","display_name":"Steady state (chemistry)","score":0.44350486993789673},{"id":"https://openalex.org/keywords/ion-channel","display_name":"Ion channel","score":0.4390278160572052},{"id":"https://openalex.org/keywords/joint-probability-distribution","display_name":"Joint probability distribution","score":0.43423473834991455},{"id":"https://openalex.org/keywords/ion","display_name":"Ion","score":0.4219823479652405},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4181336760520935},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.33798685669898987},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.32254767417907715},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.28670448064804077},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.24913296103477478},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.1550506055355072},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11666274070739746},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.09728619456291199},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.0869951844215393}],"concepts":[{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.647603452205658},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5627015233039856},{"id":"https://openalex.org/C85520022","wikidata":"https://www.wikidata.org/wiki/Q15322916","display_name":"Calcium channel","level":3,"score":0.5205586552619934},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.49822092056274414},{"id":"https://openalex.org/C128805008","wikidata":"https://www.wikidata.org/wiki/Q722878","display_name":"Master equation","level":3,"score":0.4932665228843689},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.4653374254703522},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.448275089263916},{"id":"https://openalex.org/C8171440","wikidata":"https://www.wikidata.org/wiki/Q903414","display_name":"Steady state (chemistry)","level":2,"score":0.44350486993789673},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.4390278160572052},{"id":"https://openalex.org/C18653775","wikidata":"https://www.wikidata.org/wiki/Q1333358","display_name":"Joint probability distribution","level":2,"score":0.43423473834991455},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.4219823479652405},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4181336760520935},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33798685669898987},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.32254767417907715},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.28670448064804077},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.24913296103477478},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.1550506055355072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11666274070739746},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09728619456291199},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0869951844215393},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C84114770","wikidata":"https://www.wikidata.org/wiki/Q46344","display_name":"Quantum","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2015.2498552","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2015.2498552","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043","2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26561478","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26561478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3327866426","display_name":"CAREER: Novel Sampling Approaches for Protein Modeling Applications","funder_award_id":"1066471","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320311672","display_name":"Old Dominion University","ror":"https://ror.org/04zjtrb98"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W571141297","https://openalex.org/W1514324734","https://openalex.org/W1595525782","https://openalex.org/W1973011350","https://openalex.org/W1974631391","https://openalex.org/W1983131160","https://openalex.org/W1989639886","https://openalex.org/W1995854415","https://openalex.org/W1998689980","https://openalex.org/W2011619431","https://openalex.org/W2013272733","https://openalex.org/W2027337291","https://openalex.org/W2032918887","https://openalex.org/W2036631404","https://openalex.org/W2039600625","https://openalex.org/W2039881921","https://openalex.org/W2048188187","https://openalex.org/W2059424963","https://openalex.org/W2062202483","https://openalex.org/W2069182935","https://openalex.org/W2098512872","https://openalex.org/W2098898173","https://openalex.org/W2102787760","https://openalex.org/W2102807963","https://openalex.org/W2150103532","https://openalex.org/W2171052391","https://openalex.org/W2171437709","https://openalex.org/W2335428857","https://openalex.org/W2344982137","https://openalex.org/W2798909945","https://openalex.org/W2888753267","https://openalex.org/W3022136271","https://openalex.org/W3104859924","https://openalex.org/W3161820760","https://openalex.org/W4241461965","https://openalex.org/W6796239517"],"related_works":["https://openalex.org/W2031449089","https://openalex.org/W2073801793","https://openalex.org/W1986260494","https://openalex.org/W2112596406","https://openalex.org/W2125499229","https://openalex.org/W4385304246","https://openalex.org/W4387096018","https://openalex.org/W4387096269","https://openalex.org/W2111360083","https://openalex.org/W2232251872"],"abstract_inverted_index":{"Stochasticity":[0],"and":[1,15,81,90,99,116,126,157],"small":[2,86,152,159,177],"system":[3,17,29,87,178],"size":[4,88,179],"effects":[5,89],"in":[6,169],"complex":[7],"biochemical":[8,66],"reaction":[9,24,67],"networks":[10],"can":[11],"greatly":[12],"alter":[13,101],"transient":[14],"steady-state":[16,102],"properties.":[18],"A":[19],"common":[20],"approach":[21],"to":[22,59,83,135,143],"modeling":[23],"networks,":[25],"which":[26],"accounts":[27],"for":[28,45],"size,":[30],"is":[31,55,133],"the":[32,38,41,52,60,120,137,145,172],"chemical":[33],"master":[34],"equation":[35],"that":[36,150,167,175],"governs":[37],"dynamics":[39],"of":[40,51,118,161],"joint":[42],"probability":[43],"distribution":[44,54],"molecular":[46],"copy":[47],"number.":[48],"However,":[49],"calculation":[50],"stationary":[53,146],"often":[56],"prohibitive,":[57],"due":[58],"large":[61],"state-space":[62,121],"associated":[63,138],"with":[64],"most":[65],"networks.":[68],"Here,":[69],"we":[70],"analyze":[71],"a":[72,75,110,127,158],"network":[73],"representing":[74],"luminal":[76],"calcium":[77,91,165],"release":[78],"site":[79],"model":[80,115,174],"investigate":[82],"what":[84],"extent":[85],"fluctuations,":[92],"driven":[93],"by":[94],"ion":[95,103,112,162],"channel":[96,104,113],"gating,":[97],"influx":[98],"diffusion,":[100],"properties":[105],"including":[106],"open":[107],"probability.":[108],"For":[109],"physiological":[111],"gating":[114],"number":[117,160],"channels,":[119],"may":[122],"be":[123],"between":[124],"approximately$10^6-10^8$elements,":[125],"novel":[128],"modified":[129],"block":[130],"power":[131],"method":[132],"used":[134],"solve":[136],"dominant":[139],"eigenvector":[140],"problem":[141],"required":[142],"calculate":[144],"distribution.":[147],"We":[148],"demonstrate":[149],"both":[151],"local":[153],"cytosolic":[154],"domain":[155],"volume":[156],"channels":[163],"drive":[164],"fluctuations":[166],"result":[168],"deviation":[170],"from":[171],"corresponding":[173],"neglects":[176],"effects.":[180]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1}],"updated_date":"2026-07-30T17:31:21.811387","created_date":"2025-10-10T00:00:00"}