{"id":"https://openalex.org/W4200086601","doi":"https://doi.org/10.1115/1.4053273","title":"Smart Vaccine Manufacturing Using Novel Biotechnology Platforms: A Study During COVID-19","display_name":"Smart Vaccine Manufacturing Using Novel Biotechnology Platforms: A Study During COVID-19","publication_year":2021,"publication_date":"2021-12-15","ids":{"openalex":"https://openalex.org/W4200086601","doi":"https://doi.org/10.1115/1.4053273"},"language":"en","primary_location":{"id":"doi:10.1115/1.4053273","is_oa":false,"landing_page_url":"https://doi.org/10.1115/1.4053273","pdf_url":null,"source":{"id":"https://openalex.org/S173178594","display_name":"Journal of Computing and Information Science in Engineering","issn_l":"1530-9827","issn":["1530-9827","1944-7078"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310316053","host_organization_name":"ASM International","host_organization_lineage":["https://openalex.org/P4310316053"],"host_organization_lineage_names":["ASM International"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computing and Information Science in Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101959819","display_name":"Vishnu Kumar","orcid":"https://orcid.org/0000-0002-9487-159X"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vishnu Kumar","raw_affiliation_strings":["The Harold and Inge Marcus Department of Industrial and Manufacturing Engineering, The Pennsylvania State University, 310 Leonhard Building, University Park, PA 16802"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Harold and Inge Marcus Department of Industrial and Manufacturing Engineering, The Pennsylvania State University, 310 Leonhard Building, University Park, PA 16802","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101718449","display_name":"Vijay Srinivasan","orcid":"https://orcid.org/0000-0002-4653-8821"},"institutions":[{"id":"https://openalex.org/I1321296531","display_name":"National Institute of Standards and Technology","ror":"https://ror.org/05xpvk416","country_code":"US","type":"funder","lineage":["https://openalex.org/I1321296531","https://openalex.org/I1343035065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijay Srinivasan","raw_affiliation_strings":["Engineering Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engineering Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899","institution_ids":["https://openalex.org/I1321296531"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042211113","display_name":"Soundar Kumara","orcid":"https://orcid.org/0000-0002-7941-8818"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soundar Kumara","raw_affiliation_strings":["The Harold and Inge Marcus Department of Industrial and Manufacturing Engineering, The Pennsylvania State University, 310 Leonhard Building, University Park, PA 16802"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Harold and Inge Marcus Department of Industrial and Manufacturing Engineering, The Pennsylvania State University, 310 Leonhard Building, University Park, PA 16802","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3221,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.61489107,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"22","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9000999927520752,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biopharmaceutical","display_name":"Biopharmaceutical","score":0.8487939834594727},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.5486746430397034},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45564374327659607},{"id":"https://openalex.org/keywords/product","display_name":"Product (mathematics)","score":0.4366607666015625},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.43563586473464966},{"id":"https://openalex.org/keywords/business","display_name":"Business","score":0.3900952637195587},{"id":"https://openalex.org/keywords/manufacturing-engineering","display_name":"Manufacturing engineering","score":0.37878262996673584},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.37548571825027466},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.3735620081424713},{"id":"https://openalex.org/keywords/biotechnology","display_name":"Biotechnology","score":0.3670903444290161},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1388527750968933},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.09187278151512146}],"concepts":[{"id":"https://openalex.org/C2781047461","wikidata":"https://www.wikidata.org/wiki/Q679692","display_name":"Biopharmaceutical","level":2,"score":0.8487939834594727},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5486746430397034},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45564374327659607},{"id":"https://openalex.org/C90673727","wikidata":"https://www.wikidata.org/wiki/Q901718","display_name":"Product (mathematics)","level":2,"score":0.4366607666015625},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.43563586473464966},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.3900952637195587},{"id":"https://openalex.org/C117671659","wikidata":"https://www.wikidata.org/wiki/Q11049265","display_name":"Manufacturing engineering","level":1,"score":0.37878262996673584},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.37548571825027466},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.3735620081424713},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.3670903444290161},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1388527750968933},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09187278151512146},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1115/1.4053273","is_oa":false,"landing_page_url":"https://doi.org/10.1115/1.4053273","pdf_url":null,"source":{"id":"https://openalex.org/S173178594","display_name":"Journal of Computing and Information Science in Engineering","issn_l":"1530-9827","issn":["1530-9827","1944-7078"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310316053","host_organization_name":"ASM International","host_organization_lineage":["https://openalex.org/P4310316053"],"host_organization_lineage_names":["ASM International"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computing and Information Science in Engineering","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1562578637","https://openalex.org/W1763790326","https://openalex.org/W2148416884","https://openalex.org/W2336042548","https://openalex.org/W2603780899","https://openalex.org/W2623083822","https://openalex.org/W2765808006","https://openalex.org/W2992417916","https://openalex.org/W3013660050","https://openalex.org/W3044336785","https://openalex.org/W3081126574","https://openalex.org/W3093367571","https://openalex.org/W3093841828","https://openalex.org/W3106666734","https://openalex.org/W3165247118","https://openalex.org/W3216089782","https://openalex.org/W4210753583"],"related_works":["https://openalex.org/W2016389161","https://openalex.org/W2597027489","https://openalex.org/W2294527235","https://openalex.org/W3186279510","https://openalex.org/W2413138590","https://openalex.org/W4250104310","https://openalex.org/W2375119646","https://openalex.org/W2286298226","https://openalex.org/W2099579303","https://openalex.org/W3044525780"],"abstract_inverted_index":{"Abstract":[0],"Healthcare":[1],"experts":[2],"have":[3],"come":[4],"to":[5,15,38,49,55,76,93,133,187,195],"a":[6,66,142,150],"consensus":[7],"that":[8,175],"effective":[9,136],"and":[10,33,52,60,85,105,113,132,193],"safe":[11],"vaccines":[12,64],"are":[13],"necessary":[14],"control":[16],"the":[17,21,26,29,40,57,98,103,106,115,122,126,139,153,158,167,184,197],"rapid":[18],"spread":[19],"of":[20,62,97,125,161],"ongoing":[22],"COVID-19":[23,43,63,116,129],"pandemic":[24],"across":[25],"globe.":[27],"Since":[28],"traditional":[30,104,140],"vaccine":[31,44,78,110,117,130,199],"development":[32],"manufacturing":[34,79,111,118,164,170],"approaches":[35,80],"were":[36],"unable":[37],"meet":[39,196],"rapidly":[41],"growing":[42],"demand,":[45],"biopharmaceutical":[46,99,185],"firms":[47,186],"had":[48],"devise":[50],"novel":[51,82,107,127,168],"smart":[53,77,163],"techniques":[54,112],"boost":[56],"development,":[58],"production,":[59],"distribution":[61],"in":[65],"large":[67],"scale":[68],"with":[69,138,166],"lightning":[70],"speed.":[71],"This":[72,90],"triggered":[73],"their":[74,190],"transition":[75],"using":[81],"viral":[83],"vector":[84],"nucleic":[86],"acid":[87],"biotechnology":[88,108],"platforms.":[89],"paper":[91],"tries":[92],"explore":[94],"this":[95,176],"rationality":[96],"industry":[100],"by":[101,156],"comparing":[102],"platform-based":[109,128,169],"reviewing":[114],"scenarios.":[119],"To":[120],"highlight":[121],"\u201csmart\u201d":[123],"characteristics":[124],"products":[131],"make":[134],"an":[135,181],"comparison":[137],"products,":[141],"well-established":[143],"product":[144],"classification":[145],"framework":[146],"is":[147,173],"used":[148],"as":[149,180],"reference.":[151],"Finally,":[152],"study":[154,177],"concludes":[155],"presenting":[157],"future":[159],"possibility":[160],"incorporating":[162],"paradigms":[165],"process.":[171],"It":[172],"hoped":[174],"would":[178],"serve":[179],"asset":[182],"for":[183],"appropriately":[188],"streamline":[189],"strategies,":[191],"resources,":[192],"goals":[194],"global":[198],"requirements.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}