The STOP-HCC-HCV program to screen and treat hepatitis C, vaccinate for hepatitis B, and prevent hepatocellular carcinoma (HCC) is implementing a novel approach that includes a novel cloud-based privacy-preserving platform, TripleBlind, to overcome electronic health record (EHR) native reporting limitations without removing data at four Federally Qualified Health Centers (FQHC) in South Texas, USA. The program serves a primarily low-income, medically underserved Latino population, in which HCC occurs at higher rates than nationally. At the first two FQHCs, the approach yielded improved accuracy, showing that 28% and 308% more patients, respectively, were screened than was previously reported, with quarterly reporting time decreased from many hours over multiple days to under four minutes.