"LipidTrend" is an R package that implements a permutation-based statistical test to identify significant differences in lipidomic features between groups. The test incorporates Gaussian kernel smoothing of region statistics to improve stability and accuracy, particularly when dealing with small sample sizes. This package also includes two plotting functions for visualizing significant tendencies in one-dimensional and two-dimensional feature data, respectively.

To install LipidTrend, ensure that you have R 4.5.0 or later installed (see the R Project at http://www.r-project.org) and are familiar with its usage.

LipidTrend package is available on Bioconductor repository http://www.bioconductor.org. Before installing LipidTrend, you must first install the core Bioconductor packages. If you have already installed them, you can skip this step.

if (!requireNamespace("BiocManager", quietly=TRUE))
    install.packages("BiocManager")
BiocManager::install()

Once the core Bioconductor packages are installed, you can proceed with installing LipidTrend.

if (!requireNamespace("BiocManager", quietly=TRUE))
    install.packages("BiocManager")
BiocManager::install("LipidTrend")

After the installation is complete, you’re ready to start using LipidTrend.