Article Dans Une Revue Journal of Neuroscience Methods Année : 2025

Detecting fast-ripples on both micro- and macro-electrodes in epilepsy: A wavelet-based CNN detector

Résumé

Background: Fast-ripples (FR) are short (∼10 ms) high-frequency oscillations (HFO) between 200 and 600 Hz that are helpful in epilepsy to identify the epileptogenic zone. Our aim is to propose a new method to detect FR that had to be efficient for intracerebral EEG (iEEG) recorded from both usual clinical macro-contacts (millimeter scale) and microwires (micrometer scale). New method: Step 1 of the detection method is based on a convolutional neural network (CNN) trained using a large database of > 11,000 FR recorded from the iEEG of 38 patients with epilepsy from both macro-contacts and microwires. The FR and non-FR events were fed to the CNN as normalized time-frequency maps. Step 2 is based on feature-based control techniques in order to reject false positives. In step 3, the human is reinstated in the decision-making process for final validation using a graphical user interface. Results: WALFRID achieved high performance on the realistically simulated data with sensitivity up to 99.95 % and precision up to 96.51 %. The detector was able to adapt to both macro and micro-EEG recordings. The real data was used without any pre-processing step such as artefact rejection. The precision of the automatic detection was of 57.5. Step 3 helped eliminating remaining false positives in a few minutes per subject. Comparison with existing methods: WALFRID performed as well or better than 6 other existing methods. Conclusion: Since WALFRID was created to mimic the work-up of the neurologist, clinicians can easily use, understand, interpret and, if necessary, correct the output.

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hal-05409976 , version 1 (19-01-2026)

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Ludovic Gardy, Jonathan Curot, Luc Valton, Louis Berthier, Emmanuel J. Barbeau, et al.. Detecting fast-ripples on both micro- and macro-electrodes in epilepsy: A wavelet-based CNN detector. Journal of Neuroscience Methods, 2025, 415, pp.110350. ⟨10.1016/j.jneumeth.2024.110350⟩. ⟨hal-05409976⟩
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