Scribd
Upload
379 views2 pages

Microcytic Anemia and Iron Disorders

The document discusses microcytic anemia and various iron-related disorders including iron deficiency anemia, anemia of chronic inflammation, and hereditary and acquired sideroblastic anemias. It provides details on iron, noting that 70% is in hemoglobin, 25% is stored, and the rest is in enzymes and cytochromes. Iron metabolism depends on intake, bioavailability, and need, with heme iron from meat being more readily absorbed than non-heme iron from plants.

Uploaded by

clower112
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
379 views2 pages

Microcytic Anemia and Iron Disorders

The document discusses microcytic anemia and various iron-related disorders including iron deficiency anemia, anemia of chronic inflammation, and hereditary and acquired sideroblastic anemias. It provides details on iron, noting that 70% is in hemoglobin, 25% is stored, and the rest is in enzymes and cytochromes. Iron metabolism depends on intake, bioavailability, and need, with heme iron from meat being more readily absorbed than non-heme iron from plants.

Uploaded by

clower112
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
You are on page 1/ 2

Lecture 1

Microcytic Anemia o < 80 MCV Sideroblastic anemia Iron deficiency Anemia chronic inflammation Iron-related Disorders o Iron deficiency anemia (IDA) o Anemia of chronic inflammatory disease (ACD) o Sideroblastic anemias Hereditary sideroblastic anemia Acquired sideroblastic anemia Lead poisoning (porphyrias) o Hemochromatosis o Acute blood loss Iron o 70% is in hemoglobin o 25% is in storage as ferritin and hemosiderin o Rest is in cytochromes, enzymes o Iron Function Interacts reversibly with oxygen and functions in electrontransfer reactions (as ferrous) o The body is very efficient at recycling iron, daily need is only about 1 mg per day from loss through shedding of epithelial cells. o Menstruating women lose 2x as much o Too much iron in the body is toxic

Iron Metabolism o Depends on: Iron intake & bioavailability Ingestion - 90% iron salts, 10% heme iron from meat (but iron is more readily used from meat) Absorption heme iron (Hb & myoglobin in meat) is readily absorbed, iron in vegetables is mostly ferric, which is only absorbed if it is converted to ferrous (Fe++) Need (iron losses) Decreased iron stores and increased erythropoiesis increases absorption. o

You might also like