Acid-Base Disorders Worksheet
Step #1: Gather the necessary data (a P1 and an ABG).
Preferably, these values are all obtained from the same blood sample. At
WRAMC, ordering an ABG and a P1 (Chem 7) will give you all of the
information you need.
pH
pCO2
pO2
HCO3
Step #2: Look at the pH. If it is > 7.4, then pt has primary alkalosis, proceed to
Step 3a. If pH < 7.4, then pt has primary acidosis, proceed to step 3b.
Patient has primary:
acidosis
| alkalosis
Step #3: Look at the PCO2.
3a: If PCO2 is > 40, then pts alkalosis is metabolic; if < 40 then respiratory.
3b: If PCO2 is > 40, then pts acidosis is respiratory; if < 40, then metabolic.
Process is:
respiratory | metabolic
Step #4: Check if patient has a significant anion gap (> 12-18). (Formula for
this is: Na Cl HCO3.) If they do, then they have a metabolic acidosis in
addition to (or confirmatory of) whatever Steps #1 and #2 yielded. If no
significant gap, then skip to Step #6.
Patient has | does not have
metabolic acidosis.
Step #5: Calculate the excess anion gap. (Pts gap 12 + pts serum bicarb)
If gap excess > 30, then pt has an underlying metabolic alkalosis in addition to
whatever disorders Steps #1 through #4 yielded.
If gap excess < 23, then pt has an underlying metabolic acidosis in addition to
whatever disorders Steps #1 through #4 yielded.
Patient has underlying
metabolic:
acidosis
| alkalosis
Step #6: Figure out whats causing the problem(s), using the differentials below.
Anion Gap
Metabolic Acidosis
Non-Gap
Metabolic Acidosis
Acute Respiratory
Acidosis
Metabolic
Alkalosis
Respiratory
Alkalosis
MUDPILERS
HARDUPS
anything that causes
hypoventilation, i.e.:
CLEVER PD
CHAMPS
Methanol
Uremia
DKA/Alcoholic KA
Paraldehyde
Isoniazid
Lactic Acidosis
Etoh/Ethylene Glycol
Rhabdo/Renal Failure
Salicylates
Hyperalimentation
Acetazolamide
Renal Tubular Acidosis
Diarrhea
Uretero-Pelvic Shunt
Post-Hypocapnia
Spironolactone
Contraction
Licorice*
Endo: (Conns/
anything that causes
hyperventilation, i.e.:
Cushings/Bartters)*
CNS disease
Hypoxia
Anxiety
Mech Ventilators
Progesterone
Salicylates/Sepsis
CNS Depression
(drugs/CVA)
Airway Obstruction
Pneumonia
Pulmonary Edema
Hemo/Pneumothorax
Myopathy
(Chronic respiratory
acidosis is caused by
COPD and restrictive
lung disease)
Vomiting
Excess Alkali*
Refeeding Alkalosis*
Post-hypercapnia
Diuretics*
*assoc with high urine CL levels
Step #7: Fix it!
Used with permission of Dr. Erik Rupard. Ref: Haber, A practical approach to acid-base disorders. West J Med 1991. Aug; 155:146-151. Last revised June 10, 2009.