WikiJournalClub:List of landmark papers/Cardiology
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< WikiJournalClub:List of landmark papers
Contents
1 Hypertension
2 Stable CAD
2.1 PCI/CABG
2.2 RAAS inhibition
3 Acute Coronary Syndrome
3.1 Antiplatelets
3.2 Anticoagulation
3.3 -blockers
3.4 GPIIb/IIIa Inhibitors
3.5 PCI/CABG
3.6 Lytics
3.7 RAAS inhibitors
3.8 Statins
3.9 ICD/CRT
3.10 Risk Assessment
4 Atrial Fibrillation
4.1 Epidemiology
4.2 Management
4.3 Antiarrhythmics
4.4 Anticoagulation
5 CHF
5.1 Hydralazine & nitrates
5.2 -blockers
5.3 Ace-inhibitors
5.4 ARBs
5.5 Aldosterone antagonists
5.6 Digoxin
5.7 ICD
5.8 Volume management
5.9 Nesiritide
5.10 LVAD
5.11 Fish oil
5.12 Telemonitoring
6 Cardiac Risk Assessment
7 Endocarditis
Hypertension
1967 VA Cooperative Study htn control reduces morbidity [1] ([Link]
2001 DASH DASH diet with differen sodium levels and bp results [2]
([Link]
1992 TOHP I lifestyle interventions in prehypertension [3] ([Link]
1997 TOHP II sodium interventions in prehypertension [4] ([Link]
2008 HYVET BP treatment in elderly [5] ([Link]
Stable CAD
PCI/CABG
2007 COURAGE PCI vs. OMT in stable CAD [6] ([Link]
2009 BARI 2D PCI or CABG vs. OMT in T2DM and stable CAD [7] ([Link]
2009 FAME FFR in PCI [8] ([Link]
2009 SYNTAX PCI vs. CABG in LM/3VD [9] ([Link]
2011 STICH CABG vs. OMT in LV dysfunction [10] ([Link]
2012 FREEDOM CABG vs. PCI in DM [11] ([Link]
RAAS inhibition
2000 HOPE Ramipril in high-risk patients [12] ([Link]
2003 EUROPA Perindopril in stable CAD [13] ([Link]
2004 PEACE Trandolapril in stable CAD [14] ([Link]
Acute Coronary Syndrome
Antiplatelets
1988 Aspirin, heparin, or both in UA [15] ([Link]
1988 ISIS-2: Aspirin and streptokinase in ACS [16] ([Link]
2001 CURE Clopidogrel in UA/NSTEMI [17] ([Link]
2005 CLARITY-TIMI 28 Clopidogrel in STEMI [18] ([Link]
2007 TRITON-TIMI 38 Prasurgrel vs. clopidogrel in ACS [19] ([Link]
2009 PLATO Ticagrelor vs. clopidogrel in ACS [20] ([Link]
2010 CURRENT-OASIS 7 Dosing of clopidogrel and aspirin in ACS [21]
([Link]
Anticoagulation
1988 Aspirin, heparin, or both in UA [22] ([Link]
1996 Heparin in UA: meta-analysis [23] ([Link]
2004 SYNERGY Enoxaparin vs. UFH in UA/NSTEMI [24] ([Link]
2006 ACUITY Bivalirudin + GPIIb/IIIa vs. UFH + GPIIb/IIIa in ACS [25] ([Link]
2006 ExTRACT-TIMI 25 Enoxaparin vs. UFH with fibrinolysis in STEMI [26]
([Link]
2006 OASIS-5 Fondaparinux vs. enoxaparin in ACS [27] ([Link]
2008 ISAR-REACT 3 Bivalirudin vs. UFH in stable angina/UA [28] ([Link]
2012 ATLAS ACS-2, TIMI 51 Rivaroxaban in ACS [29] ([Link]
-blockers
2005 COMMIT Metoprolol in STEMI [30] ([Link]
GPIIb/IIIa Inhibitors
2001 ADMIRAL Abciximab plus stenting in ACS [31] ([Link]
2006 ACUITY Bivalirudin + GPIIb/IIIa vs. UFH + GPIIb/IIIa in ACS [32] ([Link]
2008 ISAR-REACT 3 Bivalirudin vs. UFH in stable angina/UA [33] ([Link]
2008 HORIZONS-AMI Bivalirudin vs. heparin+GPIIb/IIIa in STEMI [34]
([Link]
PCI/CABG
1999 SHOCK Early PCI/CABG in ACS complicated by cardiogenic shock [35]
([Link]
2003 DANAMI-2 Lytics vs. transfer for PCI in STEMI [36] ([Link]
2006 BASKET-LATE DES vs. BMS [37] ([Link]
2009 TIMACS Early (<24h) vs. delayed (>36h) intervention in ACS [38] ([Link]
2010 BASKET-PROVE DES vs. BMS [39] ([Link]
Early invasive vs conservative approach 32% decreased rehosp for ACS, nonsignificant 16% decrease in MI, no change in mortality
compared with conservative strategy.
Lytics
2006 ExTRACT-TIMI 25 Enoxaparin vs. UFH with fibrinolysis in STEMI [40]
([Link]
2006 OASIS-6 Fondaparinux vs. UFH in STEMI [41] ([Link]
2001 GUSTO-V Combined reteplase + abciximab vs. reteplase in STEMI [42]
([Link]
2003 DANAMI-2 Lytics vs. transfer for PCI in STEMI [43] ([Link]
RAAS inhibitors
1994 GISSI-3 Lisinipril in ACS [44] ([Link]
1995 ISIS-4 Captopril in ACS [45] ([Link]
2003 EPHESUS Eplerenone in post-MI LV dysfunction [46] ([Link]
2003 VALIANT ARBS vs. ACE inhibitors post-MI and LV dysfunction [47]
([Link]
Statins
2001 MIRACL Atorvastatin statins in post-MI [48] ([Link]
2004 PROVE IT-TIMI 22 Intensive atorvastatin vs. moderate pravastatin post-MI [49]
([Link]
ICD/CRT
2003 DINAMIT Prophylactic ICD in post-MI LV dysfunction [50] ([Link]
2003 IRIS Prophylactic ICD early-post-MI [51] ([Link]
2009 MADIT-CRT ICD-CRT in LV dysfunction and prolonged QRS [52]
([Link]
Risk Assessment
2000 TIMI Risk stratification in UA/NSTEMI [53] ([Link]
2012 ROMICAT-II ([Link]
action=edit&preload=WikiJournalClub%3ADefault+journal+article+page+%28for+beginners%29&editintro=&summary=&nosummary=&prefi
II&create=Create+article): CT coronary angiography in acute chest pain [54]
([Link]
Atrial Fibrillation
Epidemiology
ATRIA Risk factors in AF
Management
2001 ACUTE TEE in AF [55] ([Link] *363*
2002 AFFIRM Rate vs. rhythm control in chronic AF [56] ([Link] *1993 cites*
2002 RACE Rate vs. rhythm control in chronic AF
2008 AF-CHF Rate vs. rhythm control in AF and HF [57] ([Link] *421*
2010 RACE II Lenient vs. strict rate control in permanent AF [58] ([Link]
Antiarrhythmics
2000 CTAF Amiodarone vs. sotalol or propafenone in AF [59] ([Link]
2005 SAFE-T Amiodarone vs. sotalol in AF
2007 ADONIS Dronedarone for maintenance of SR in AF [60] ([Link] *341*
2009 ATHENA Dronedarone in AF [61] ([Link] *479*
Anticoagulation
1989 AFASAK Warfarin vs. aspirin in chronic AF [62] ([Link]
*1030*
1990 BAATAF Warfarin in chronic AF [63] ([Link] *911 cites*
1991 SPAF I Warfarin vs. aspirin in chronic AF
1992 SPINAF Warfarin in chronic AF [64] ([Link] *827*
1994 SPAF II Warfarin vs. aspirin in AF [65] ([Link] *809*
1996 SPAF III Adjusted-dose warfarin vs. low-dose warfarin plus aspirin in AF [66]
([Link] *858*
2000 HAEST LMWH vs. aspirin in AF [67] ([Link]
2003 SPORTIF III Ximelagatran vs. warfarin in AF [68] ([Link]
*662*
2006 ACTIVE W Warfarin vs. aspirin plus clopidogrel in AF [69]
([Link] *1996*
2007 BAFTA Warfarin vs. aspirin for AF in elderly [70] ([Link]
*508*
2009 ACTIVE Plavix and aspirin in AF [71] ([Link] *427*
2009 RE-LY Dabigatran vs. coumadin in AF [72] ([Link] *1577*
2011 ROCKET AF Rivaroxaban vs. warfarin in AF [73] ([Link] *444*
2011 ARISTOTLE Apixaban vs. warfarin in AF [74] ([Link] *388*
2011 AVERROES Apixaban vs. aspirin in AF [75] ([Link] *321*
CHF
Hydralazine & nitrates
1986 V-HeFT ISDN/hydralazine in CHF [76] ([Link]
1991 V-HeFTII Hydralazine & nitrates vs. Ace-inhibitors in CHF [77]
([Link]
2004 A-HeFT ISDN/hydralazine in blacks with NYHA class III-IV CHF [78]
([Link]
-blockers
2000 MERIT-HF Metoprolol XL in CHF [79] ([Link]
([Link]
2002 COPERNICUS Carvedilol in severe CHF [81] ([Link]
2003 COMET Carvedilol vs. metoprolol tartrate in CHF (Lancet 2003;362:7)
Ace-inhibitors
1987 CONSENSUS Enalapril in NYHAIV CHF [82] ([Link]
1991 SOLVD Enalapril in CHF with EF <35% [83] ([Link]
1992 SAVE Captopril in post-MI CHF with EF 40%[84] ([Link]
1992 SOLVD-PEnalapril in aSx CHF with EF 35%[85] ([Link]
ARBs
2001 Val-HeFT Valsartan in CHF [86] ([Link]
2003 CHARM-Added Candesartan added to ACE inhibitors in CHF [87]
([Link]
2003 CHARM-Preserved Candesartan added to ACE inhibitors in CHF [88]
([Link]
2003 CHARM-Alternative Candesartan alone in CHF [89] ([Link]
2008 I-PRESERVE Irbesartan in HFPEF [90] ([Link]
2009 HEAL Higher doses of Losartan in CHF [91] ([Link]
Aldosterone antagonists
1999 RALES Spironolactone in NYHA III/IV CHF & EF <= 35% [92]
([Link]
2003 EPHESUS Eplerenone in post-MI patients with LV dysfunction EF40% [93]
([Link]
2011 EMPHASIS-HF Eplerenone in NYHA II CHF with LVEF <30% [94]
([Link]
Digoxin
1997 DIG Digoxin in CHF with LVEF 45%[95] ([Link]
ICD
2002 MADIT-II ICD in post-MI CHF with LVEF 30 [96] ([Link]
2004 DEFINITE ICD in severe, nonischemic dilated cardiomyopathy [97] ([Link]
2004 DINAMIT Prophylactic ICD post-MI [98] ([Link]
2005 SCD-HeFT Amiodarone vs. ICD in CHF [99] ([Link]
2005 CARE-HF CRT in NYHA III-IV CHF [100] ([Link]
2009 IRIS Prophylactic ICD post-MI [101] ([Link]
2009 MADIT-CRT ICD-CRT in NYHA I-II CHF with EF < 30%, prolonged QRS [102]
([Link]
2009 TIME-HF BNP- vs. Symptom-guided therapy in CHF [103] ([Link]
Volume management
2007 UNLOAD Ultrafiltration in CHF (JACC 2007;49:675)
2010 DOSE Continuous vs. intermittent lasix
2012 CARRESS-HF Ultrafiltration in decompensated HF [104] ([Link]
Nesiritide
2002 ASCEND-HF Nesiritide in CHF [105] ([Link]
LVAD
2001 REMATCH LVAD in HF [106] ([Link]
2006 LVAD in CHF [107] ([Link]
2009 HEARTMATE II LVAD in advanced CHF [108] ([Link]
Fish oil
2008 GISSI-HF FIsh oil in CHF [109] ([Link]
Telemonitoring
2011 CHAMPION Wireless PA monitoring in CHF [110] ([Link]
Cardiac Risk Assessment
2004 CARP Revascularization before elective vascular surgery [111] ([Link]
2008 POISE Perioperative metoprolol succinate [112] ([Link]
2009 DECREASE Preoperative fluvastatin [113] ([Link]
2009 DECREASE-V Revascularization in high-risk patients before major vascular surgery [114]
([Link]
2012 VISION ([Link]
action=edit&preload=WikiJournalClub%3ADefault+journal+article+page+%28for+beginners%29&editintro=&summary=&nosummary=&prefi
Post-op troponin for predicting mortality [115] ([Link]
Endocarditis
2012 EASE Early surgery for endocarditis [116] ([Link]
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