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The document outlines the history and advancements of bacterial therapies in cancer treatment, starting from early observations in the 1860s to the development of Coley's Toxin in 1893. It highlights significant milestones such as the use of the BCG vaccine and the emergence of oncolytic bacteria in the late 20th century. Recent research focuses on combining bacterial therapies with other treatments to enhance their effectiveness.

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thaophuong030409
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3 views2 pages

Today

The document outlines the history and advancements of bacterial therapies in cancer treatment, starting from early observations in the 1860s to the development of Coley's Toxin in 1893. It highlights significant milestones such as the use of the BCG vaccine and the emergence of oncolytic bacteria in the late 20th century. Recent research focuses on combining bacterial therapies with other treatments to enhance their effectiveness.

Uploaded by

thaophuong030409
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd

Today, I’m excited to take you on a journey through the fascinating history and

advancements of bacterial therapies in cancer treatment. I will divide this journey


into three stages to make it easier for everyone to follow.
The exploration of bacteria in cancer treatment began over
150 years ago. In 1868, Dr Busch- who made early observations in cancer
treatmentsaw that two patients with serious tumors got better for a short
time after getting erysipelas infections - a type of skin infection caused by bacteria. It
usually causes red on the skin, often with pain and fever. It can sometimes lead to better health
However, it wasn't until 1891 that William Coley, a
in some cancer patients.
physician in New York City, began to try using bacteria for treatment. He
noticed that one patient’s tumor got smaller after they had a streptococcal
infection.

In 1893, Coley created "Coley's Toxin," - a mix of heat-killed bacteria,


including Streptococcus pyogenes and Serratia marcescens. He
discovered that introducing this toxin into cancer tissues could stop tumor
growth and promote healing in some patients.

Later, scientists found other types of bacteria, like Clostridium, that could
live without oxygen. These bacteria could reduce oxygen levels in tumors,
which helped kill cancer cells.

In the mid-20th century ,the (BCG) vaccine was used for cancer treatment,
especially bladder cancer. BCG helps the immune system attack cancer
cells and is now a common treatment for bladder cancer.

Advances in Immunotherapy

From the 1980s to the early 2000s, They looked at different types of
bacteria to see which ones could target tumors while causing less harm to
healthy cells. This research led to new methods in genetic engineering,
where scientists changed bacteria to make them better at finding and
attacking tumors.

One important development was oncolytic bacteria - that can infect and kill
cancer cells but no effect on normal cells. Medical trials showed positive
results, using these bacteria to help reduce tumor size.
Recent Research (2010s–Present) Combination Therapies:
Researchers are also studying how to use bacteria together with other
treatments, to make them more effective.

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