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Aulton's Pharmaceutics Overview

This document provides a summary of the contents of the book "Aulton's Pharmaceutics: The Design and Manufacture of Medicines". The book is divided into 6 parts that cover scientific principles of dosage form design, particle science and powder technology, pharmaceutical microbiology and sterilization, biopharmaceutical principles of drug delivery, dosage form design and manufacture, and pharmaceutical plant design. The contents include chapters on topics such as dissolution, rheology, disperse systems, kinetics of product stability, solid-state properties, particle size analysis, granulation, drying, compaction, solutions, suspensions and emulsions, powders and granules, modified-release dosage forms, coating, capsules, and sterilization techniques

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Leyla Majunda
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586 views3 pages

Aulton's Pharmaceutics Overview

This document provides a summary of the contents of the book "Aulton's Pharmaceutics: The Design and Manufacture of Medicines". The book is divided into 6 parts that cover scientific principles of dosage form design, particle science and powder technology, pharmaceutical microbiology and sterilization, biopharmaceutical principles of drug delivery, dosage form design and manufacture, and pharmaceutical plant design. The contents include chapters on topics such as dissolution, rheology, disperse systems, kinetics of product stability, solid-state properties, particle size analysis, granulation, drying, compaction, solutions, suspensions and emulsions, powders and granules, modified-release dosage forms, coating, capsules, and sterilization techniques

Uploaded by

Leyla Majunda
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

Aulton's Pharmaceutics

The Design and Manufacture of Medicines


Edited by

M i c h a e l E . AultOriBPharmPhDFAAPSFRPharmS

THIRD EDITION

CHURCHILL LIVINGSTONE

11 si \ 1 1
EDINBURGH LONDON NEW YORK OXFORD PHILADELPHIA ST LOUIS SYDNEY TORONTO 2007

Contents

What is "pharmaceutics'? 1 Design of dosage forms 4

12 13

Mixing 152
\ \ t I n It, l u l l

Powder flow 168


./ \ Sldiutuitli M I Aultmi

PART1 Scientific principles of dosage form design 15 2 3 4 5 6 7 Dissolution and solubility 16


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PART 3 Pharmaceutical microbiology and sterilization 181 14 15 Fundamentals of microbiology 182


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Properties of solutions 33
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Rheology 42
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Pharmaceutical applications of microbiological techniques 205


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Surface and interracial phenomena 59 ./. / I'll Disperse systems 70


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16

Action of physical and chemical agents on microorganisms 225


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17 18

Principles of sterilization 242 V A. Wuhh. ./>: Maillanl Sterilization in practice 251


./>. MailUinl. S. I, Wdhh

Kinetics of product stability 99

PART 2 Particle science and powder technology 109 8 9 10 Solid-state properties 1 0 1


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PART 4 Biopharmaceutical principles of drug delivery 265 19 20 Introduction to biopharmaceutics 266


M. Ashlunl

Particle size analysis 121


./. ,V Stdiiitorth. M. /.. Altitun

Particle size reduction 137


./. ,V. Stdiiifurth, M. E. Altitun

Gastrointestinal tract - physiology and drug absorption 270 M. Ashfoni Bioavailability - physicochemical and dosage form factors 286 M. Ashfoni

21

11 Particle size separation 145 ./. N. Staniforth. M. E. Aulton

CONTENTS

22

Assessment of biopharmaceutical properties 304

34

Hard gelatin capsules II /.'. Junes

515

M. Ashtonl 35 23 Dosage regimens ./. //. (ulleti 324 36 Soft gelatin capsules 527 K. (i. Hutchison, J. lerdiiidinlu Pulmonary drug delivery A. M (i. Taylor Nasal drug delivery /' M Idxlur 555 539

PART 5 Dosage form design and manufacture 335


24 Pharmaceutical preformulation
./. /. Wells. M /;. Altitun

37

38 336 39 25 26 27 Solutions 361 M. K. Billanv 40 Clarification 374 A. M. Iw it, hell 41 Suspensions and emulsions M. R HilldiiY Powders and granules M I' Summers 406 43 29 Granulation 410 M. I' Summers, M. E. Aiilton Drying 425 M. /.. Aultnn Tablets and compaction (/'. Alderhuni 441 44 383 42 28

Transdermal drug delivery B. W. Barrx Wound dressings (7. M. Ea lestun 598

565

Rectal and vaginal drug delivery ./. ./. Tukker

606

Delivery of pharmaceutical proteins 616 I). ./. A. Cruinmelln, E. van Wiiuicn. A. Mckkinti Packs and packaging /' M. Taylor 626

Microbial contamination, spoilage and preservation of medicines 640 A'. A. HudKe\ Product stability and stability testing
A. R. Barnes

30 31 32

650

45

Pharmaceutical plant design M. /;. Aulton, A. M. Twitehell

666

Modified-release peroral dosage forms 483 ./. H. Collclt. R. ('. Moreton Coating of tablets and multiparticulates 500 S. C. Porter

46

H e a t transfer and the properties and use

of steam 679 /\. M. Twitehell Index 691

33

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