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Date No.: Practical: 23

This document provides information on preparing and evaluating two topical semi-solid formulations: an ibuprofen gel and a barrier cream. It lists the ingredients, quantities, roles, preparation methods, characterization parameters, and references for each formulation. The characterization of both products involves evaluating appearance, texture, odor, spreadability, film formation, irritation potential, water washability, pH, particle size distribution, and emulsion type. Mean particle sizes are determined from frequency distribution curves of the number and size of particles.

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90 views9 pages

Date No.: Practical: 23

This document provides information on preparing and evaluating two topical semi-solid formulations: an ibuprofen gel and a barrier cream. It lists the ingredients, quantities, roles, preparation methods, characterization parameters, and references for each formulation. The characterization of both products involves evaluating appearance, texture, odor, spreadability, film formation, irritation potential, water washability, pH, particle size distribution, and emulsion type. Mean particle sizes are determined from frequency distribution curves of the number and size of particles.

Uploaded by

kjghlkdfjg
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd

Date

no.
PRACTICAL : 23

(A)
Aim: To prepare and evaluate Ibuprofen gel.
Formula: Each 30 g gel contains 1.5 g Ibuprofen
Excipients

q.s

Batch size: 50 g
Packaging: In metal or plastic collapsible tubes with screw caps.
Pack size: 30 g
Formulation:
Ingredients

Quantity given
(100 g)

Quantity
taken (50 g)

Role of
ingredients

Ibuprofen

5g

2.5 g

Alcohol
Propylene glycol
Carbopol
Isopropyl myristate

10 ml
10 ml
15 g
1 ml

5 ml
5 ml
7.5 g
0.5 ml

Preservatives
Water purified

q.s.
5g

q.s.
2.5 g

Active
pharmaceutical
ingredient
Vehicle
Vehicle
Gelling agent
To make the
gel less sticky
Preservative
Vehicle

Method of preparation:
Solution of Ibuprofen in alcohol and propylene glycol was made.
This solution was heated at 70-80 C.
Dissolve carbopol and isopropyl myristate in the above solution and
cool.
Dissolve preservatives in water and add in the above gel.

Date

no.

Observation:
Particle size distribution:
RANGE

MEAN(d)

NO.
OF f*d
PARTICLES(f)

frequency distribution curve


25
f
r 20
e
q 15
u 10
e
n 5
c
y 0

frequency
distribution curve

mean size

Date

no.

Method of characterization:
1. Appearance
2. Texture
3. Odour
4. Spreadability
5. Film formation
6. Irritation
7. Water washability
8. PH of the preparation
9. Particle size distribution
10.Type of emulsion

Comments:

Reference: Handbook of pharmaceutical manufacturing formulations; semisolid


products; volume -4; Sarfaraz K.Niazi; page no: 180.

Date

Observation parameters
Appearance
Texture
Odour
Spreadability
Film formation
Irritation
Water washability
PH of the preparation
Mean particle size
Type of emulsion

no.

Inference

Date

no.

Date

no.

(B)
Aim: To prepare and evaluate barrier cream.
Formula:
Batch size: 50 g
Packaging: In metal or plastic collapsible tubes with screw caps.
Pack size: 30 g
Formulation:
Ingredients

Quantity given
(100 g)

Quantity
Role of
taken (50 g) ingredients

Hard paraffin

25 g

12.5 g

Emulsifying wax

Soft paraffin

11.75 g

5.875 g

Emulsifying wax

Liquid paraffin

3.5 ml

1.75 ml

Emulsifying wax

Cetostearyl alcohol
Triethanolamine
Stearic acid
Chlorocresol

5 ml
0.7 ml
1.8 g
0.2 ml

2.5 ml
0.35 ml
0.9 g
0.1 ml

Emulsifying agent
Neutralizing agent
Emulsifying agent
Vehicle

Purified water

100 ml

50 ml

Vehicle

Method of preparation:
Cetostearyl alcohol, stearic acid and the three paraffins were melted
together.
Triethanolamine was dissolved in a solution of chlorocresol.

Date

no.

Observation:
Particle size distribution:

RANGE

MEAN(d)

NO.
OF f*d
PARTICLES(f)

frequency distribution curve


F 20
r
e 15
q
10
u
e 5
n
c
0
y
0

frequency
distribution curve

Mean size

Date

no.

Both solutions were maintained at about 70C.


Then oily constituents were added to the aqeous solution with constant
stirring until the emulsion was cold.

Method of characterization:
11.Appearance
12.Texture
13.Odour
14.Spreadability
15.Film formation
16.Irritation
17.Water washability
18.PH of the preparation
19.Particle size distribution
20.Type of emulsion

Comments:

Reference: Cooper and Gunns dispensing for pharmaceutical students; edited by


S.J.Carter; 12th edition; CBS publishers; page no: 157-158.

Date

Observation parameters
Appearance
Texture
Odour
Spreadability
Film formation
Irritation
Water washability
PH of the preparation
Mean particle size
Type of emulsion

no.

Inference

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