Introduction

Background
Defining postpartum hemorrhage (PPH) is problematic and has been historically difficult. Waiting for a
patient to meet the postpartum hemorrhage criteria, particularly in resource-poor settings or with sudden
hemorrhage, may delay appropriate intervention. Postpartum hemorrhage is traditionally defined as blood
loss greater than 500 mL during a vaginal delivery or greater than 1,000 mL with a cesarean delivery.
However, significant blood loss can be well tolerated by most young healthy females, and an
uncomplicated delivery often results in blood loss of more than 500 mL without any compromise of the
mother's condition.

The addition of "a 10% drop in hemoglobin" to the definition provides an objective laboratory
measure. However, this is not helpful in acute situations since it can take hours for losses to create
laboratory changes in red blood cell measurements. Signs and symptoms of hypovolemia
(lightheadedness, tachycardia, syncope, fatigue and oliguria) are also of limited utility as they can be late
findings in a young and otherwise healthy female. As a result, any bleeding that has the potential to result
in hemodynamic instability, if left untreated, should be considered postpartum hemorrhage and managed
accordingly.

Postpartum hemorrhage can be divided into 2 types: early postpartum hemorrhage, which occurs within
24 hours of delivery, and late postpartum hemorrhage, which occurs 24 hours to 6 weeks after delivery.
Most cases of postpartum hemorrhage, greater than 99%, are early postpartum hemorrhage. Notably,
most women are still under the care of their delivering provider during this time. With many women
delivering outside of hospitals and early postpartum hospital discharge being a growing trend, postpartum
hemorrhage that presents to the emergency department may be either early or late.

Within this combined population, emergency medicine providers are likely to receive patients that fall into
1 of 3 categories:

 Those that are too close to delivery to be transferred to another location (the facility's labor and
delivery suite or to another facility)
 Women who delivered at home, at a nonhospital facility, or en route to the hospital and are too
hemodynamically unstable to be transferred to a labor and delivery floor within the facility or at
another location
 Patients who were discharged home after delivery in stable condition, but had concerning
bleeding that prompted an emergency department visit

Pathophysiology
At term, the uterus and placenta receive 500-800 mL of blood per minute through their low resistance
network of vessels. This high flow predisposes a gravid uterus to significant bleeding if not well
physiologically or medically controlled. By the third trimester, maternal blood volume increases by 50%,
which increases the body's tolerance of blood loss during delivery.

Following delivery of the fetus, the gravid uterus is able to contract down significantly given the reduction
in volume. This allows the placenta to separate from the uterine interface, exposing maternal blood
vessels that interface with the placental surface. After separation and delivery of the placenta, the uterus
initiates a process of contraction and retraction, shortening its fiber and kinking the supplying blood
vessels, like physiologic sutures or "living ligatures."

If the uterus fails to contract, or the placenta fails to separate or deliver, then significant hemorrhage may
ensue. Uterine atony, or diminished myometrial contractility, accounts for 80% of postpartum
hemorrhage. The other major causes include abnormal placental attachment or retained placental tissue,
laceration of tissues or blood vessels in the pelvis and genital tract, and maternal coagulopathies. An
additional, though uncommon, cause is inversion of the uterus during placental delivery. 

The traditional pneumonic "4Ts: tone, tissue, trauma, and thrombosis" can be used to remember the
potential causes. Here, a 5th is added; “T” for uterine inversion that will be called “traction.” 

Frequency
United States

The incidence of postpartum hemorrhage is about 1 in 5 pregnancies, but this figure varies widely due to
differential definitions for postpartum hemorrhage. 

Mortality/Morbidity
Mortality

Although accountable for only 8% of maternal deaths in developed countries, postpartum hemorrhage is
the second leading single cause of maternal mortality, ranking behind preeclampsia/eclampsia.1 Globally,
postpartum hemorrhage is the leading cause of maternal mortality. The condition is responsible for 25%
of delivery-associated deaths,2 and this figure is as high as 60% in some countries. International initiatives
to improve outcomes have invested in training birth attendants (traditional or otherwise) and nurse
midwives on the active management of the third stage of labor (the period immediately after delivering of
the infant). Most efforts focus on uterine atony, which is the primary cause of postpartum hemorrhage.
This has included education on manual techniques to increase uterine contraction-retraction and making
pharmacologic uterotonic agents (oxytocin and misoprostol) more available.3,4,5 

Morbidity 

Postpartum hemorrhage is a potentially life-threatening complication of both vaginal and cesarean

delivery. Associated morbidity is related to the direct consequences of blood loss as well as the potential
complications of hemostatic and resuscitative interventions.

Consequences of uncontrolled hemorrhage

 Hypovolemic shock and associated organ failure including renal failure, stroke, myocardial
infarction
 Postpartum hypopituitarism (Sheehan syndrome): Acute blood loss and/or hypovolemic shock
during and after childbirth can lead to hypoperfusion of the pituitary and subsequent necrosis.
Although often asymptomatic, it may present with an inability to breastfeed, fatigue,
hypogonadism, amenorrhea, and hypotension.
 Death secondary to hypovolemic shock

Consequences of fluid resuscitation

  Fluid overload can lead to extremity edema and pulmonary edema. The latter is less common in
young healthy women, but it should be suspected in the setting of large fluid and blood product
resuscitation.
 Dilutional coagulopathy occurs when crystalloids and/or serum-poor blood products are given in
large volume.

Risks from exposure to blood products

 Allergic or febrile reactions have an incidence of about 1 case per 333 population.6
 Anaphylactic reactions occur in 1 in 20,000 to 1 in 47,000 blood products transfused.7
 Transfusion-related acute lung injury (TRALI) occurs in 1 out of every 5,000 transfusions, but
more often with high plasma containing products like fresh frozen plasma (FFP) and platelets. It
often starts within 1-2 hours of the transfusion, but it can happen anytime up to 6 hours after a
transfusion. The symptom complex includes severe bilateral pulmonary edema, severe
hypoxemia, tachycardia, cyanosis, hypotension, and fever.8
 Acute immune hemolytic reaction, though rare, is the most serious type of transfusion reaction.
Symptoms are associated with red blood cell hemolysis. Patients may have fevers, chills, chest
and lower back pain, nausea, renal failure, and death if the transfusion is not stopped.
 Delayed hemolytic reaction: This type of reaction happens when the body slowly attacks antigens
(other than ABO antigens) on the transfused blood cells. Symptoms occur days to weeks after a
transfusion. Affected patients are either asymptomatic or have mild symptoms, which may include
jaundice, low-grade fever, and a low hemoglobin or hematocrit.9
 Infection: Hepatitis is the most common disease transmitted by blood transfusions. According to
the American Red Cross, about 1 blood transfusion in 205,000 transmits a hepatitis B infection,
and 1 blood transfusion in about 2 million transmits hepatitis C. Other rare but potential infections
include HIV (risk of 1 in 2.5 million), Lyme disease, babesiosis, and malaria. Donors are screened
for potential exposure so transmission is very rare. Rarely, blood may be contaminated with tiny
amounts of skin bacteria during donation. Platelets are the most likely blood product to be
affected by contamination from skin flora.
 Metabolic reactions: With large volume and rapid transfusions, patients are at risk of encountering
3 metabolic reactions: hypothermia, hyperkalemia, and citrate toxicity. Hypothermia results from
the transfusion of unwarmed crystalloid or colloid that drops the body temperature. Hypothermia
inhibits coagulation and can worsen postpartum hemorrhage. Citrate is a blood product additive
that binds serum calcium and can cause hypocalcemia with large-volume transfusions. Hemolysis
occurs with red blood cell storage releasing increasing amounts of intracellular potassium with
time. Transfusions of older red blood cells increase the risk of hyperkalemia.

Risks associated with surgical intervention

 Intubation and anesthesia complications: Pregnant women have an increased risk for aspiration,
failed intubation, and death from failed ventilation when compared with nonpregnant patients.
Respiratory injury or infection, myocardial infarction, myocardial arrhythmia, stroke, or allergic
reactions to anesthetic medications may also rarely occur.
 Bleeding: Continued bleeding from the genital tract or a bleeding complication from the surgery
may occur.
 Infection: Sepsis, wound infection, or pneumonia is possible.
  Deep venous thrombosis and/or pulmonary embolism: Risk is increased due to postpartum and
postoperative associated hypercoagulability as well as from relative immobility in the operative
and postoperative period.

Need for permanent sterilization to control bleeding

If the bleeding cannot be controlled conservatively (removal of products of conception, suturing disrupted
tissues, application of pressure) then surgical intervention may be necessary. In severe cases, the
following may occur:

 Hysterectomy
 Asherman syndrome, which is secondary (non-hormone mediated) amenorrhea due to uterine
scarring that develops after infection and/or curettage performed to remove placental fragments

Clinical

History
The clinical history should be taken as a primary survey (ABCs) of the patient. This should include
collecting an initial set of vital signs to guide the patient’s management, as the patient is positioned to
begin the physical examination. Keep in mind, that if the bleeding is very brisk, the patient’s mental status
may wane. As a result, this first set of questions should include queries about signs and symptoms that
are most crucial in managing potential circulatory collapse, identifying the cause of postpartum
hemorrhage (PPH), and selecting appropriate therapies.10 

 Severity of bleeding
o Is the placenta delivered?
o What has been the duration of the third stage of labor?
o How long has the bleeding been heavy?
o Was initial postdelivery bleeding light, medium, or heavy?
o Are symptoms of hypovolemia present such as dizziness/lightheadedness, changes in
vision, palpitations, fatigue, orthostasis, syncope or presyncope?
o If evaluating a patient with delayed postpartum hemorrhage, what has been the bleeding
pattern since delivery?
 Intervention guides
o Is there a history of transfusion? What was the reason for transfusion? Is there a history
of a transfusion reaction?
o Past medical history (particularly cardiovascular, pulmonary, or hematologic conditions)
o Allergies
 Predisposing factors and potential etiology
o History of postpartum hemorrhage
o Gravity, parity, length of most recent pregnancy, history of multiple gestations
o Number of fetuses for the most recent pregnancy
o Pregnancy complications (polyhydramnios, infection, vaginal bleeding, placental
abnormalities)
o If the placental was delivered, was it spontaneous, or was manual delivery required?
o Current and past history of vaginal delivery versus cesarean delivery
 o If cesarean delivery, was it planned in advance, decided upon after a failed vaginal
delivery attempt, or performed emergently?
o Other uterine surgeries such as myomectomy (transvaginal vs transabdominal), uterine
septum removal
o Personal or family history of bleeding disorder
o Medications such as prescribed, over the counter, diet supplements, or vitamins (with
particular attention to anticoagulants, platelet inhibitors, uterine relaxants, and
antihypertensives)
o Vaginal penetration since delivery (tampons, finger, other foreign object, vaginal
intercourse)
o Signs or symptoms of infection such as uterine pain or tenderness, fever, tachycardia, or
foul vaginal discharge
o Information helpful for continued management
o When and where was the delivery?
o Who assisted the delivery?
o Where and with whom was prenatal care?
o Healthy infant(s) delivered (any complications or concerns before, during, or after
delivery)?
o Past surgical history

Physical
As mentioned earlier, patients with postpartum hemorrhage (PPH) should be managed like all emergency
department resuscitation situations, with the history and physical examination occurring simultaneously
while following acute life support algorithms.

The physical examination should focus on determining the cause of the bleeding. The patient may not
have the typical hemodynamic changes of shock early in the course of the hemorrhage due to physiologic
maternal hypervolemia. 

Important organ systems to assess include the pulmonary system (evidence of pulmonary edema), the
cardiovascular (heart murmur, tachycardia, strength of peripheral pulses), and neurological systems
(mental status changes from hypovolemia).The skin should also be checked for petechiae or oozing from
skin puncture sites, which could indicate a coagulopathy, or a mottled appearance, which can
be indicative of severe hypovolemia.

Looking for occult postpartum hemorrhage—in the form of a pelvic, vaginal, uterine, or abdominal
wall hematoma, or intra-abdominal or perihepatic bleeding—is always an important consideration when
unstable hemodynamic findings are present without evidence of excessive vaginal blood loss. 

Having a gynecologic examination bed is helpful but not necessary. The patient's pelvis can always be
elevated on an inverted bedpan (thick-side toward the patient's feet) cushioned with towels and a sheet
for comfort. Ensure that good lighting and suction are available before beginning.

 Abdominal examination: Pain and tenderness (concerning for retained placenta tissue, rupture, or
endometritis), distension, boggy or grossly palpable uterus (at or above the umbilicus) is
suggestive of atony. Palpation of an overdistended bladder may indicate a barrier to adequate
uterine contraction.
  Perineal examination: A brisk bleed should be visible at the introitus; identify any perineal
lacerations.
 Speculum examination: Gently suction blood, clots, and tissue fragments as needed to maintain
the view of the vagina and cervix. Careful inspection of the cervix and vagina under good light
may reveal the presence and extent of lacerations.
 Bimanual examination: Bimanual palpation of the uterus may reveal bogginess, atony, uterine
enlargement, or a large amount of accumulated blood. Palpation may also reveal hematomas in
the vagina or pelvis. Assess if the cervical os is open or closed. 
 Placental examination: Examine the placenta for missing portions, which suggest the possibility of
retained placental tissue.

Causes
The 4Ts of postpartum hemorrhage (PPH) +1: tone, trauma, tissue, thrombosis, and traction. More than
one of these can cause postpartum hemorrhage in any given patient.

 Uterine atony - "Tone": Atony is by far the most common cause of postpartum
hemorrhage. Uterine contraction is essential for appropriate hemostasis, and disruption of this
process can lead to significant bleeding. Uterine atony is the typical cause of postpartum
hemorrhage that occurs in the first 4 hours after delivery. Risk factors for atony include the
following:
o Overdistended uterus (eg, multiple gestation, fetal macrosomia, polyhydramnios)
o Fatigued uterus (eg, augmented or prolonged labor, amnionitis, use of uterine tocolytics
such as magnesium or calcium channel blockers)
o Obstructed uterus (eg, retained placenta or fetal parts, placenta accreta, or an overly
distended bladder)
 Laceration or hematoma - "Trauma": Trauma to the uterus, cervix, and/or vagina is the second
most frequent cause of postpartum hemorrhage. Injury to these tissues during or after delivery
can cause significant bleeding because of their increased vascularity during pregnancy. Vaginal
trauma is most common with surgical or assisted vaginal deliveries. It also occurs more
frequently with deliveries that involve a large fetus, manual exploration, instrumentation, a
fetal hand presenting with the head, or spontaneously from friction between mucosal tissue and
the fetus during delivery. Cervical lacerations are rarer now that forceps-assisted deliveries are
less common. They are more likely to occur when delivery assistance is provided before the
cervix is fully dilated. Risk factors for trauma include the following:
o Delivery of a large infant
o Any instrumentation or intrauterine manipulation (eg, forceps, vacuum, manual removal
of retained placental fragments)
o Vaginal birth after cesarean section (VBAC)
o Episiotomy
 Retained placenta - "Tissue": Retained placental tissue is most likely to occur with a placenta that
has an accessory lobe, deliveries that are extremely preterm, or variants of placenta
accreta. Retained or adherent placental tissue prevents adequate contraction of the uterus
allowing for increased blood loss. Risk factors for retained products of conception include the
following:
o Prior uterine surgery or procedures
o Premature delivery
o Difficult or prolonged placental delivery
 o Multilobed placenta
o Signs of placental accreta by antepartum ultrasonography or MRI
 Clotting disorder - "Thrombosis": During the third stage of labor (after delivery of the fetus),
hemostasis is most dependent on contraction and retraction of the myometrium. During this
period, coagulation disorders are not often a contributing factor. However, hours to days after
delivery, the deposition of fibrin (within the vessels in the area where the placenta adhered to the
uterine wall and/or at cesarean delivery incision sites) plays a more prominent role. In this
delayed period, coagulation abnormalities can cause postpartum hemorrhage alone or contribute
to bleeding from other causes, most notably trauma. These abnormalities may be preexistent or
acquired during pregnancy, delivery, or the postpartum period. Potential causes include the
following:
o Platelet dysfunction: Thrombocytopenia may be related to preexisting disease, such
as idiopathic thrombocytopenic purpura (ITP) or, less commonly, functional platelet
abnormalities. Platelet dysfunction can also be acquired secondary to HELLP syndrome
(hemolysis, elevated liver enzymes, and low platelet count).
o Inherited coagulopathy: Preexisting abnormalities of the clotting system, as factor X
deficiency or familial hypofibrinogenemia
o Use of anticoagulants: This is an iatrogenic coagulopathy from the use of heparin,
enoxaparin, aspirin, or postpartum warfarin.
o Disseminated intravascular coagulation (DIC): This can occur, such as from
sepsis, placental abruption, amniotic fluid embolism, HELLP syndrome, or intrauterine
fetal demise. 
o Dilutional coagulopathy: Large blood loss, or large volume resuscitation with crystalloid
and/or packed red blood cells (PRBCs), can cause a dilutional coagulopathy and worsen
hemorrhage from other causes.
o Physiologic factors: These factors may develop during the hemorrhage such as
hypocalcemia, hypothermia, and acidemia.
 Uterine inversion - "Traction": The traditional teaching is that uterine inversion occurs with an
atonic uterus that has not separated well from the placenta as it is being delivered, or from
excessive traction on the umbilical cord while placental delivery is being assisted. Studies have
yet to demonstrate the typical mechanism for uterine inversion. However, clinical vigilance for
inversion, secondary to these potential causes, is generally practiced. Inversion prevents the
myometrium from contracting and retracting, and it is associated with life-threatening blood losses
as well as profound hypotension from vagal activation.

Differential Diagnoses

Endometritis

Other Problems to Be Considered

Endometritis: Consider uterine infection, or endometritis, particularly with late postpartum
hemorrhage. Signs and symptoms that should peak the clinical suspicion for this diagnosis include fever,
chills, foul discharge, tender abdomen/uterus, and elevated WBC count with a differential favoring
bacterial infection (neutrophilia with or without bands). Start early broad-spectrum antibiotic coverage and
consider sepsis.

Wound breakdown: Internal wound breakdown from repaired genital tract lacerations or previously closed
cesarean delivery incisions should be considered as a potential cause of vaginal bleeding, internal
bleeding, or hematoma.

Genital tract manipulation: Genital tract lacerations may be induced by intercourse, finger penetration, or
foreign object insertion (including tampons) into the genital tract.

Nongenital sources of bleeding: Birth trauma may lead to retroperitoneal hematomas, which may be
initially difficulty to identify. Women who have undergone cesarean delivery may have an abdominal wall
or subfacial hematoma. Rarely, HELLP syndrome can produce life-threatening bleeding into and rupture
of the liver capsule, and this should be suspected in the setting of severe epigastric or right upper
quadrant pain. Ruptured splenic artery aneurysms have been reported in pregnancy as well. 

Workup

Laboratory Studies

 Complete blood count (CBC)

o The hemoglobin and hematocrit are helpful in estimating blood losses. However, in a
patient with acute hemorrhage, several hours may pass before these levels change to
reflect the blood loss and platelet count.
o If the white blood cell count is elevated, suspect endometritis or toxic shock syndrome.
o Look for thrombocytopenia.
 Coagulation laboratory studies: Elevations of the prothrombin time (PT), activated partial
thromboplastin time (aPTT), and international normalized ratio (INR) can indicate a present or
developing coagulopathy.
 Electrolytes: Check for complicating electrolyte derangements such as a hypocalcemia,
hypokalemia, and hypomagnesemia. Use this first set as a baseline for comparison during and
after fluid and/or blood resuscitation.
 BUN/creatinine: These measurements can be helpful in identifying renal failure as a complication
of shock. If the BUN level rises during or after resuscitation with blood products, consider red
blood cell hemolysis as a complication.
 Type and crossmatch: Begin the process of finding appropriately matched blood for resuscitation
in the event that it is needed.
 Fibrinogen level: Levels are normally elevated to 300-600 mg/dL in pregnancy. Normal or low
values raise concerns for a consumptive coagulopathy.
 Liver function tests (LFTs), amylase, lipase: These studies can be helpful in considering other
abdominal pathology, such as HELLP syndrome, if there is abdominal pain in addition to, or
instead of, uterine tenderness.
 Lactate: Consider ordering this if the initial electrolyte study shows an anion gap or septic or
hypovolemic shock is suspected as a concomitant diagnosis.

Imaging Studies
Studies to be considered with vaginal bleeding and decreasing red blood cell counts in the postpartum
patient include ultrasonography (U/S), computed tomography (CT), or magnetic resonance imaging
(MRI).

Ultrasonography is a fast and helpful modality for imaging pelvic structures and should be the first-line
study for pelvic pathology.

Ultrasonography 

In a hemodynamically unstable patient, a bedside ultrasonography can be performed by an experienced

emergency medicine provider as an extension of the physical examination. In general, a dedicated pelvic
ultrasonography (transabdominal and/or transvaginal) is helpful in identifying large retained placental
fragments, hematomas, or other intrauterine abnormalities. Retained placenta and hematoma can look
ultrasonographically identical. Using a Doppler ultrasound to look for vascularity can help to differential
between the two, with clots being avascular and retained placenta often receiving persistent blood flow
from the uterus.

The abdominal views of the focused assessment with sonography in trauma (FAST) examination are
helpful in identifying fluid within the peritoneum that may be the result of hemorrhage. This study is
designed to identify intra-abdominal and pericardial fluid that requires early operative intervention in
trauma patients. However, the abdominal views are useful in any patient with suspected intra-abdominal
free fluid. These include views of the right upper quadrant (RUQ)/Morison's pouch area (the most
dependent area of a supine patient's peritoneal cavity), the left upper quadrant (LUQ) spleno-renal
recess, and views of the pelvis (sagittal and coronal views of the uterus and pouch of Douglas). This
study can detect 250-500 mL of fluid in the peritoneum, but it is a poor study for identifying retroperitoneal
or paravaginal hemorrhage (extra-peritoneal bleeding).

Ultrasonography cannot reliably differentiate between blood, urine, or ascites; however, in the setting of
suspected hemorrhage, any fluid in the abdomen should prompt further investigation.

More stable patients can have their abdominal and/or pelvic ultrasonography confirmed with an official
study performed by a radiologist.

Computed tomography

In the event that ultrasonography is not diagnostic, CT is a helpful follow-up study. This may also be the
first-line study when a pelvic hematoma or abscess is suspected, which may be missed with a sonogram.
The traditional teaching is that pelvic CT is a less than ideal study for pelvic structures, due to artifact from
the surrounding pelvic bones that reduces the image quality. However, this is generally not the case with
modern multidetector CT studies. When enhanced with intravenous (I+) and intra-intestinal (O/R+...either
oral or rectal contrast), CT can detail pelvic hematomas, cesarean delivery wound dehiscence, and
retained placental tissue.

Magnetic resonance imaging

MRI is a time consuming study that is rarely performed from the ED in these patients. It can be helpful in
delineating tissue planes to determine if a fluid collection (hematoma or abscess) is intrauterine or
extrauterine when this is not clear from ultrasonography or CT. It can also help to distinguish a placenta
accreta from simple retained products of conception.

Limited literature is available on abdominopelvic imaging in postpartum hemorrhage since the

presentation of significant bleeding prompts rapid resuscitation and immediate intervention based on the
clinical picture rather than documented imaging. Nonetheless, all 3 imaging modalities can assist in the
evaluation of a bleeding source, but ultrasonography is usually sufficient for emergent situations.

Treatment

Prehospital Care
For any obstetric emergency medical services (EMS) field call, emergency medical technicians (EMTs)
should be vigilant and prepared for postpartum hemorrhage (PPH) as a potential complication. After
delivery, there are two patients to assess: the mother and the baby. Their intervention needs should be
prioritized according to the airway, breathing, and circulation (ABCs) of acute life support.

 A primary survey of the mother should be performed by obtaining vital signs and doing a brief
physical examination focused on the ABCs: If she is able to speak her A irway is intact. Consider
providing supplemental oxygen to augment her B reathing and oxygen delivery; in addition to
evaluating heart rate and blood pressure, include a perineal examination for sources of bleeding
as part of the assessment of C irculation.
 Once the primary survey is completed, immediate interventions include the following:
 Gentle massage of the uterine fundus to encourage bleeding control and delivery of the
placenta (which normally takes up to 15-30 min)
 Fluid resuscitation with crystalloids, particularly if bleeding continues: This situation
should be managed like that of any patient at risk of hemorrhagic shock.  
 Visible perineal lacerations may be packed with sterile gauze to tamponade bleeding
during transport.
 Some EMS systems are equipped with oxytocin in the prehospital setting. An infusion of
oxytocin may be started in accordance with standing orders or with the agreement of the
online medical control physician. (For dosing information, see the Medication section).
 Do only what is needed at the scene to stabilize the mother and the baby for transport and further
care in a more resourced setting. Transport should be to the nearest appropriate hospital with
preference for those with obstetric services. In rural areas, the patient may need to be stabilized
in a smaller community hospital ED, followed by transport to a second facility with higher-level
obstetric care capabilities.

Emergency Department Care

The patient with suspected or obvious postpartum hemorrhage should be managed like any other
hemorrhaging patient. Resuscitation measure should be started with the history and physical examination
according to acute life support algorithms. Have someone call a consultant obstetrician/gynecologist
(OB/GYN) immediately as care for the patient is initiated in order to make the patient's transition from
resuscitative care to definitive care with the OB/GYN team smooth and early.

 Primary survey (ABCs): Perform the A irway assessment evaluating it for patency.

Assess B reathing adequacy and provide supplementation with 100% oxygen as needed. Assess
the C irculatory status (including peripheral pulses, heart rate, blood pressure, and a perineal
examination). Support circulation to vital organs by putting the patient into the Trendelenburg
position, placing at least 2 large-bore IVs, starting a rapid crystalloid infusions through both IVs,
and establishing continuous vital sign monitoring to guide continued management.
 Laboratory studies: Obtain samples for laboratory testing. Consider blood cultures if the patient is
febrile or the vaginal blood/discharge is malodorous, as endometritis may be a complicating
factor. See Laboratory Studies for more detail.
 Secondary survey: Perform a focused physical examination (see Physical Examination). Also,
consider a bedside ultrasonography (a FAST examination to look for intra-abdominal fluid and/or
a pelvic ultrasound) as an adjunct to the physical examination. See Imaging Studies for more
detail.
 Interventions: Address the "4Ts plus 1" starting with "tone" since it is the most common cause of
postpartum hemorrhage:
o Tone
 Uterine atony should always be treated empirically in the early postpartum
period. Uterine massage will stimulate uterine contractions and frequently stops
uterine hemorrhage. The examiner's gloved hand can be placed into the lower
uterus, extracting any large clots or tissue that prevent adequate contractions.
 Do not apply excessive pressure on the fundus of the uterus as this may
increase the risk of inversion. Note that massaging a hard, contracted uterus can
actually impede detachment of the placenta and increase bleeding.
 With a boggy uterus, continue to massage and administer uterotonics to increase
uterine contraction. Give oxytocin, an analogue of the identically named
endogenous hormone, 20-40 units in 1 L lactated Ringer (LR) at 600 mL/h to
maintain uterine contraction and to control hemorrhage. Ergotamines (eg,
ergonovine, methylergonovine [Methergine]) can be used instead of, or with the
failure of oxytocin, to facilitate uterine contraction.11 Other alternatives include 15-
methyl-prostaglandin, also known as carboprost (Hemabate) (0.25 mg IM), and
misoprostol (1 mg PR), which is an inexpensive prostaglandin E1 analogue that
has been used in several trials with good success in controlling postpartum
hemorrhage in cases refractory to oxytocin. In settings in which oxytocin use is
not feasible, misoprostol might be a suitable treatment alternative for postpartum
hemorrhage.12 See the Medication section for more details.
o Uterine rupture: If uterine rupture is suspected, consider performing a FAST examination
to look for intra-abdominal fluid, a bedside pelvic ultrasonography to evaluate the
myometrial tissue for continuity and an upright kidneys, ureters, bladder (KUB) to look for
peritoneal free air. Consider giving broad-spectrum antibiotics and plan for an emergent
laparotomy with an OB/GYN or a general surgeon for repair.
o Trauma
 If lacerations or hematomas are found, direct pressure may help control bleeding.
Actively bleeding perineal, vaginal, and cervical lacerations should be repaired. If
brisk bleeding comes from the uterus, it may be urgently slowed by packing the
uterine cavity. This may be accomplished by introducing a long vaginal pack into
the cavity with dressing forceps. Alternatively (and usually more easily), a Bakri
or Blakemore balloon may be introduced into the uterus and inflated. The balloon
should be filled with as much saline as possible to produce adequate tamponade.
It is important that the pack is placed into the uterus itself rather than into the
vagina. If these devices are not available, a Foley catheter with a large balloon
(30 mL or more) may be introduced into the lower uterine segment.
 Hematomas should not be disrupted if they are unruptured. However, steady
pressure may be applied to prevent expansion. If there is no other cause of blood
 loss, resuscitate the patient and admit her to the hospital with a plan to monitor
the hematoma for expansion and follow her hemoglobin and hematocrit levels.
o Tissue: If retained placental tissue is identified, plan for manual extraction. This may be
performed by wrapping gauze around one hand, then inserting it through the vagina to
the uterus in order to gently sweep the inner wall and very carefully remove adherent
placental tissue fragments. This is often a difficult procedure to perform and very painful
for the patient. Before starting, provided analgesia to assist with the patient's tolerance. If
the bleeding is severe or accreta is suspected, it is more prudent to pack the bleeding
uterus and transfer the patient to an operating room. In the operating room, the surgeon
can use suction evacuation or, if needed, laparotomy, to manage the bleeding in a more
controlled environment.
o Traction: If uterine inversion occurs, gently push the uterus back into position. Do this by
pressing the fingers of the dominant hand together to form a tear drop shape. Enter the
vagina with the tips of the fingers. Once contact is made with the fundus, use an outward
to inward motion of the fingers along with gentle upward pressure to move the uterus
through the cervix. If the uterus has contracted down in an inverted position, the patient
may be treated with nitroglycerin (50-100 mcg IV) to relax the myometrium and allow
uterine replacement. Emergency surgical intervention is indicated if initial replacement
attempts fail.
o Thrombosis: Evaluate the CBC and coagulation study results for evidence of clotting
disorders. Providing blood products will be necessary if the bleeding is profuse or initial
laboratory results show hemoglobin drop >10% from the patient's prior value or from the
midpoint of the normal range with continued bleeding.
 For anemia, transfuse type-specific blood (or O- blood if unable to wait). Using
blood warmers that permit rapid infusion is highly recommended as long as this
does not delay transfusion.
 For thrombocytopenia, particularly if platelets are less than 50,000, consider
transfusing a pack of platelets.
 Fresh frozen plasma (FFP) may also be necessary in the setting of a
coagulopathy (prolonged PT or PTT or INR >1.3). In the event of massive
hemorrhage, plasma transfusion should be initiated with the replacement of red
blood cells to avoid a dilutional coagulopathy by adding back a proportional
amount of clotting factors.13
 If transfusing more than 6 units of pRBCs occurs or is anticipated, give 4 units of
FFP, 1 unit of platelets, and 1 unit of cryoprecipitate to avoid a transfusion-
related dilutional coagulopathy.
 The effects of any anticoagulant medications that the patient may have on board
should be reversed (aspirin with platelets, low molecular weight heparin [LMWH]
or heparin with protamine, warfarin with vitamin K or FFP).

Also see the American College of Obstetricians and Gynecologist for guidelines on the treatment of
postpartum hemorrhage.14

Consultations
For all cases, do the following:
  Obstetrics and gynecology: Immediate consultation with an OB/GYN is vital for the appropriate
care of a patient with postpartum hemorrhage. As mentioned above, an OB/GYN should be
consulted as the assessment of the patient is initiated or upon arrival of the patient in the ED. If
no OB/GYN is available, consult a general surgeon.
 Blood bank: Direct contact with the blood bank is essential in assuring timely arrival of any blood
products ordered.

For cases of extreme hemorrhage or when it is not possible to identify the source of the bleeding after the
secondary survey, consider an urgent transfer of the patient to an operating room with the OB/GYN or
general surgery consulting team.

 Obstetric and gynecology: Recontact the OB/GYN consultant to notify him or her of the situation
and discuss the appropriateness of the location change. Solicit advice from the OB/GYN
consultant on how best to temporize the patient in the interim.
 Operating room: Notify the appropriate OR of the urgent arrival.
 Anesthesiology: Make the anesthesia service aware so that they can evaluate the patient and
prepare their staff for the case.
 Blood bank: Notify the blood bank when the patient is being moved so that products are sent to
the appropriate location.
 Interventional radiology: In centers where rapid arterial embolization can be achieved,
consultation with interventional radiology should be obtained. Studies report over a 90% success
rate in stopping bleeding, which can prevent hysterectomy. The decision to embolize should be
made in conjunction with the OB/GYN consultant. 

Medication

Medications used to control postpartum hemorrhage (PPH) are in the category of uterotonic drugs. These
drugs stimulate contraction of the uterine muscle, helping to control PPH.

Uterotonics
These agents are useful in the treatment and prophylaxis of PPH. The information below
applies only following delivery of the fetus (the dosing, indications, and contraindications will vary prior to
delivery).

Oxytocin (Pitocin)

Produces rhythmic uterine contractions, can stimulate the gravid uterus, and has vasopressive and
antidiuretic effects. Can be used to control postpartum bleeding or hemorrhage. Some suggest its
prophylactic use in the third stage of labor; one study of 1000 deliveries revealed a 32% reduction in the
rate of PPH.15

 Dosing
 Interactions
 Contraindications
 Precautions
 Adult

Add 20 units of oxytocin to 1 L of crystalloid

Administer fluid at rate high enough to control uterine atony
If 20 units are added to 1 L, infuse at rate of 200-600 mL/h
Add 20 units of oxytocin to 1 L of crystalloid
Administer fluid at rate high enough to control uterine atony
It may also be given as 10-20 units in a single IM injection
If 20 units are added to 1 L, infuse at rate of 200-600 mL/h

Pediatric

<12 years: Not established

>12 years: Administer as in adults

Methylergonovine (Methergine)

Acts directly on uterine smooth muscle, causing a sustained tetanic uterotonic effect that reduces uterine
bleeding and shortens the third stage of labor. Administer IM or intramyometrially during puerperium,
during delivery of placenta, or after delivering anterior shoulder.

 Dosing
 Interactions
 Contraindications
 Precautions
Adult

0.2 mg IM/IV repeat q2-4h if required

Pediatric

<12 years: Not established

>12 years: Administer as in adults

Carboprost (Hemabate)

Prostaglandin similar to F2-alpha, but it has a longer duration and produces myometrial contractions that
induce hemostasis at the placentation site, which reduces postpartum bleeding.

 Dosing
 Interactions
 Contraindications
 Precautions
Adult

250 mcg IM or intramyometrial q15-90min; not to exceed 2 mg

 Pediatric

<12 years: Not established

>12 years: Administer as in adults

Misoprostol (Cytotec)

Synthetic prostaglandin E 1 analog.

 Dosing
 Interactions
 Contraindications
 Precautions
Adult
600-1000 mcg PR for 1 dose

Pediatric

<12 years: Not established

>12 years: Administer as in adults

Ergonovine (Ergotrate Maleate)

Used to prevent and treat PPH due to uterine atony by producing firm contraction of the uterus within
minutes. Although it is intended primarily for IM administration, a faster response can be achieved with IV
use. Compared with IM route, IV route has a higher incidence of adverse effects; IV use should be
reserved for emergencies (eg, excessive uterine bleeding). Severe uterine bleeding may require repeated
doses, but it seldom requires more than one injection q2-4h.

 Dosing
 Interactions
 Contraindications
 Precautions
Adult

0.2 mg IM/IV; repeat q2-4h prn

Pediatric

<12 years: Not established

>12 years: Administer as in adults

Recombinant factor VIIa (NovoSeven)

Man-made activated protein that promotes thrombosis.

 Dosing
 Interactions
 Contraindications
 Precautions
Adult

40-90 mcg/kg IV

Pediatric

<12 years: Not established

>12 years: Administer as in adults

Follow-up

Transfer
If a patient is brought to a hospital without obstetric services, the EM providers should initiate
resuscitation and transfer the patient as quickly as possible to a hospital with obstetric services for
definitive care. Discuss an en route resuscitation plan with the EMS transport team, and make the
receiving hospital aware of what the patient's status was upon departure from the ED so that the
appropriate resources are mobilized before her arrival. Be sure to adhere to patient transfer laws set by
the transferring facility, city, EMS transport organization, and state.

Deterrence/Prevention
The active management of the third stage of labor has been shown to decrease the incidence and
severity of postpartum hemorrhage (PPH). This includes the administration of oxytocin or misoprostol,
uterine massage, gentle traction on the umbilical cord, and prompt placental delivery. Women with a
known uterine scar or suspected placental abnormalities should be delivered and managed in a hospital
setting, and instrumentation should be avoided, when possible, during vaginal delivery.

For further information, see the World Health Organizations recommendations on the prevention of
postpartum hemorrhage.16

Complications
Consequences include the sequelae of hemorrhage; aggressive fluid resuscitation; blood-product
exposure; and procedures done to control uterine, cervical, vaginal, or peritoneal
hemorrhage. See Mortality/Morbidity for more detail.

Prognosis
The prognosis depends on the cause of the PPH, its duration, the amount of blood loss, comorbid
conditions, and the effectiveness of treatment. Prompt diagnosis and treatment are essential to achieving
the best outcome for any given patient. Most reproductive-age women will do well if managed promptly in
a setting with operative and blood-product resources available.

Patient Education
Postpartum hemorrhage can be a frightening experience for patients. It is important to provide
reassurance and communicate through each step of emergency care. Make patients aware of what
to anticipate through their clinical course including expected procedures; transport; and the indication,
risks, and benefits of interventions. 
Miscellaneous

Medicolegal Pitfalls
To avoid common medicolegal pitfalls consider the following:

 Active management of the third stage of labor is key to reducing the incidence and severity of
postpartum hemorrhage (PPH). Be sure to perform early uterine massage and
administer oxytocic agents.
 Contact an OB/GYN consultant before or upon initiating the evaluation of the patient.
 Some typical vaginal deliveries are associated with blood loss of more than 500 mL. However,
emergency department personnel should assume that any patient with blood loss greater than
500 mL and ongoing bleeding has postpartum hemorrhage. Resuscitation should be started while
evaluating the patient for the cause of postpartum hemorrhage.
 Always suspect occult hemorrhage (eg, hematoma, intra-abdominal) in postpartum patients who
have unstable vital signs with little or no external bleeding. Consider atypical signs of
hemorrhage, such as restlessness, dyspnea, and back and abdominal pain, which may be the
first signs of hemorrhage in a hemodynamically stable patient. 
 Early recognition of a coagulopathy and prompt administration of coagulation factors may be life
saving. This may entail immediate transfusion based on clinical suspicion, rather than waiting for
laboratory results to return.
 When a patient is delivered to a facility without obstetrical services, adequate resuscitation should
be achieved before the patient is transferred. An en route resuscitation plan should be
communicated to the transporting EMS team, and the patient's condition upon departure should
be reported to the receiving providers. All institutional, state, and national regulations for patient
transfer should be followed.

Special Concerns

 With early postpartum hemorrhage occurring right after delivery, remember that 2 patients—the
mother and the newborn—require evaluation and intervention.
 Because of the hemodynamic changes in pregnancy (increased blood volume and physiologic
anemia), the signs and symptoms of hypovolemia may not be apparent until the hemorrhage is
severe.

 
Acknowledgments
Special thanks to Dr. Donnie Bell for his assistance with the "Imaging" section for this topic.

The authors and editors of eMedicine gratefully acknowledge the contributions of previous author, Michael P Wainscott, MD,
to the development and writing of this article.