Scribd
Upload
77 views1 page

Acute vs Chronic Pancreatitis Overview

1. Acute pancreatitis has several main causes including gallstones, alcohol use, and genetic mutations. Grossly, the pancreas appears hemorrhagic with yellow-white areas of fat necrosis. Microscopically there is interstitial edema, fat necrosis, and acute inflammation. 2. Chronic pancreatitis is mainly caused by long term alcohol abuse which activates stellate cells. The pancreas appears hard with dilated ducts and visible calcifications. Microscopic findings include parenchymal fibrosis, fewer and smaller acini, and dilated ducts filled with protein plugs. 3. Diagnosis is based on characteristic clinical symptoms, elevated pancreatic enzyme levels, and imaging showing pancreatic inflammation.

Uploaded by

Maryam Fadah
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
77 views1 page

Acute vs Chronic Pancreatitis Overview

1. Acute pancreatitis has several main causes including gallstones, alcohol use, and genetic mutations. Grossly, the pancreas appears hemorrhagic with yellow-white areas of fat necrosis. Microscopically there is interstitial edema, fat necrosis, and acute inflammation. 2. Chronic pancreatitis is mainly caused by long term alcohol abuse which activates stellate cells. The pancreas appears hard with dilated ducts and visible calcifications. Microscopic findings include parenchymal fibrosis, fewer and smaller acini, and dilated ducts filled with protein plugs. 3. Diagnosis is based on characteristic clinical symptoms, elevated pancreatic enzyme levels, and imaging showing pancreatic inflammation.

Uploaded by

Maryam Fadah
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd

Main player in

Pancreatitis Etiology Gross morphology Microscopic morphology Dx


pathogenesis
1) Typical
clinical
symptom

- Hemorrhagic 2) High se
parenchyma & amylase a
scattered yellow- [Link] edema. lipase leve
st white chalky areas of [Link] necrosis. greater th
1 : Gallstones. Trypsinogen
Acute fat necrosis. [Link] inflammation. three tim
2nd: Alcohol. activation.
- Peritoneal serous [Link] parenchymal destruction. upper lim
slightly turbid or [Link] vessels destruction normal
brownish fluid
contains fat globules. 3) Imagin
showing
pancreati
inflamma
CT is the b
Clinical
symptom
1. Pancrea
1. Parenchymal fibrosis. calcificatio
2. ↓number/size of acini with relative
sparing of islets of Langerhans. 2. Ductal
Stellate cells Hard, dilated ducts,
Chronic* Alcohol Abuse. 3. Pancreatic ducts dilatation with dilatation
activation. Visible calcifications.
luminal protein plugs.
4. Chronic inflammation around lobules 3. Parench
& ducts atrophy a
focal
inflamma
masses.
*PRSS1 or SPINK1 gene mutation

You might also like