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Medicinal Chemistry Exam Questions

This document contains 6 questions about medicinal chemistry: 1. It asks for the structure, classification, 3 uses, and mechanism of action of Phenoxybenzamine, which is described as a "chemical sympathectomy" due to its selective blockade of smooth muscle and heart muscle responses. 2. It asks for the structure, classification, and an explanation of why Prazosin Hydrochloride has added advantages compared to other antagonists in the management of hypertension. 3. It asks for the structure and an explanation of the mixed α/β adrenergic blocking action of Carvediol.

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79 views2 pages

Medicinal Chemistry Exam Questions

This document contains 6 questions about medicinal chemistry: 1. It asks for the structure, classification, 3 uses, and mechanism of action of Phenoxybenzamine, which is described as a "chemical sympathectomy" due to its selective blockade of smooth muscle and heart muscle responses. 2. It asks for the structure, classification, and an explanation of why Prazosin Hydrochloride has added advantages compared to other antagonists in the management of hypertension. 3. It asks for the structure and an explanation of the mixed α/β adrenergic blocking action of Carvediol.

Uploaded by

ambroce
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

CATHOLIC UNIVERSITY OF HEALTH AND

ALLIED Email: vc@[Link] Call


Us: +255 (0)­ 28­ 250 0881 SCIENCE

MEDICINAL CHEMISTRY QUESTIONS

1. Phenoxybenzamine is described as representing a “chemical sympathectomy

because of its selective blockade of the excitatory responses of smooth muscle and of

the heart muscle

a. Give structure and classification of the drug

b. Mention 3 uses

c. And give detailed mechanism of action The α -adrenoreceptor blocking

agents.

2. Prazosin Hydrochloride U.S.P is A quinazoline derivative with value in the

management of hypertension

a. Give structure and classification of the drug

b. Explain why its Is an antagonist with added advantages comparable to

others.

c.

3. CARVEDIOL is Mixed α/β adrenergic blockers give structure and explain SARS

for mixed action


4. isosorbide which is basically a bicyclic form of sorbitol and is used orally to reduce

intraocular pressure in glaucoma [Link] structure of both compound and explain

how they work to reduce pressure.

5. Timolol is Non selective β-blocker approved in 1978 for with no significant

membrane- stabilizing (local nesthetic) action or intrinsic

[Link] aromatic side is different from other -antagonists but

the side chain is structurally identical Give structure of the drug and uses 3

6. Explain why aryloxypropanolamine β-Blockers binds on the same receptors with

aryloxypropanolamineβ-Blockers

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