Advice for hard-tech
and biotech founders
YC Startup School 2019
Outline
• What is a hard-tech company?
• Why should you start a hard-tech company?
• The 2 most common problems for hard-tech cos
• Fundraising for hard tech co's
What is a hard-tech
company?
1. It will take a lot of time and money to build
the first product
2. It may or may not be possible to build it
• Market Risk: Do people want it?
• Technical Risk: Can we make it?
Why start a hard-tech
company?
"In many ways, it's easier to start a
hard company than an easy company"
- Sam Altman
There's never been a better
time to start a "hard"
company
Hard-tech, Biotech and YC
• Funded over 250 bio companies
• YC is the largest bio seed investor in the world
• YC is the largest hard-tech seed investor in the world
• Biotech and hard-tech applications have 10X higher
acceptance rate
How much of YC's advice applies to
hard-tech founders?
Most of it.
How much of YC's advice applies to
hard-tech founders?
WEEK 1 WEEK 6
Startup School 2019 Orientation Building Culture
How to Talk to Users All About Pivoting
How to Evaluate Startup Ideas Pt. 1 WEEK 7
WEEK 2 How to Improve Conversion Rates
How to Plan an MVP Startup Pricing 101
How to Set KPIs and Goals WEEK 8
Analytics for Startups How to Prioritize Your Time
WEEK 3 How to Evaluate Startup Ideas Pt. 2
Nine Business Models & Metrics Investors Want WEEK 9
How Investors Measure Startups Q&A Advice for Hardtech and Biotech Startups
WEEK 4 Intro to Modern Startup Investments
How to Launch (Again and Again) WEEK 10
Growth for Startups How to Talk to Investors About Your Startup
WEEK 5 How to Become a $100B Company
Startup Finance Pitfalls & How to Avoid Them
How to Work Together
How do you make progress
when you have a "heavy MVP"?
Boom
Do things that don't cost money
• Assemble a team of top advisors
• Build computer simulations
• Build a plastic model
• Show customer demand
Solugen
Start small
2019: huge chemical plant
Solugen
Start small
2019: huge chemical plant 2016: a beaker
AirX
Launch a simplified version
Original plan:
Medical Device
3 years to get FDA approval
New plan:
Use existing medical device
Write software
Zero FDA approval
Notable Labs
Bootstrap with a service
Long-term vision: develop new
drugs for cancer
Hack to get started: provide tumor
screening services
Astranis
Start with a proof of
concept
Ginkgo Bioworks
Sell it before you make it
How do you prove people will
want your product, if you
haven't built it yet?
Pre-sales
Ideally, you sell your product before
you build it
LOI: Letter of Intent
"Non-binding contract to buy your
product when it's ready"
Good LOI's Include:
• How many units they will buy
• The price they will pay
• When they will buy
• What specs your product needs to achieve
Fundraising for Hard-Tech
and Biotech companies
50M Series A
Time
A better fundraising plan
Series B:
$30M
Series A:
$
$15M
Seed 2: $4M
Seed 1: $1M
YC: $150K
Time
Final Thought
The way to accomplish incredibly ambitious
things is to break them into very small steps