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Biopharmaceutical Technology Unit Test

This document contains information about two unit tests for a biopharmaceutical technology course. Unit Test I contains 5 short answer questions in Part A worth 10 marks total. Part B contains two long answer questions worth 16 marks each and one worth 8 marks for a total of 40 marks. The questions cover topics like defining a tablet, preservatives in oral solutions and parenterals, slugging, flocculated vs deflocculated suspensions, and tablet disintegration. Unit Test II also has 5 short answer questions in Part A worth 10 marks total. Part B has one question worth 16 marks about manufacturing bulk drugs or transdermal delivery systems. Another question is worth 16 marks about mechanisms of drug action or coating tablets

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Vigneshwaran Ravishankar
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220 views2 pages

Biopharmaceutical Technology Unit Test

This document contains information about two unit tests for a biopharmaceutical technology course. Unit Test I contains 5 short answer questions in Part A worth 10 marks total. Part B contains two long answer questions worth 16 marks each and one worth 8 marks for a total of 40 marks. The questions cover topics like defining a tablet, preservatives in oral solutions and parenterals, slugging, flocculated vs deflocculated suspensions, and tablet disintegration. Unit Test II also has 5 short answer questions in Part A worth 10 marks total. Part B has one question worth 16 marks about manufacturing bulk drugs or transdermal delivery systems. Another question is worth 16 marks about mechanisms of drug action or coating tablets

Uploaded by

Vigneshwaran Ravishankar
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOC, PDF, TXT or read online on Scribd

Roll.

NO

RAJALAKSHMI ENGINEERING COLLEGE, CHENNAI 602 105.

DEPARTMENT OF BIOTECHNOLOGY

UNIT TEST II Date : 25.08.2010


Sub. Code : BT 1010 Max. Marks : 50
Sub. Name : Biopharmaceutical
Technology Duration : 90 minutes
Year : IV “A”

Answer All Questions


PART A – (5 x 2 = 10 Marks)

1. Define a Tablet
2. Name two preservatives used in oral solution, two preservative in parentrals.
3. Write notes on slugging
4. What are the differences between flocculated and deflocculated suspension?
5. Write short notes on disintegration of tablet

Answer All Questions


PART – B [16+16+8=40 Marks]

6 (a). Write about tablet manufacture according to the following heads


i) Granulation and excipients (8)
ii) Tablet compression (8)
OR
(b) Write briefly about Transdermal drug delivery system and pharmaceutical
emulsion (16)

7. (a). Discuss briefly about different mechanism of drug action (16)

OR
(b) i) Describe the steps involved in sugar coating
ii)Write briefly about enteric coated tablet (16)

8. What is flocculated suspension? What will be the degree of flocculation of a


suspension given the following data Total volume of suspension is 100 ml,
volume of flocculated suspension is 75 and in deflocculated suspension is 15 (8)
Roll. NO
RAJALAKSHMI ENGINEERING COLLEGE, CHENNAI 602 105.
DEPARTMENT OF BIOTECHNOLOGY
UNIT TEST II Date : 25.08.2010
Sub. Code : BT 1010 Max. Marks : 50
Sub. Name : Biopharmaceutical
Technology Duration : 90 minutes
Year : IV “B”
Answer All Questions
PART A – (5 x 2 = 10 Marks)

1. What is a bulk drug? Give examples.


2. Define Clearance and total systemic clearance with expression.
3. What is a prodrug? Give examples.
4. Explain how radioactivity is used in pharmacokinetics.
5. Define Bioequivalence with examples and graphical representation.

Answer All Questions


PART – B [8+16+16=40 Marks]
6. (a). Describe the special requirements for manufacturing of bulk drugs. (16)
(OR)
(b). Discuss in detail about the processes and reactions involved in the
Manufacture of bulk drugs. (16)

7. a) Following a 650 mg i.v. bolus dose of a drug to a 65 Kg subject, the plasma drug concentration
was found to decline bioexponentially. The equation that best described the drug kinetics was :
C = 67 e-14t + 33 e-3t
Where t is in hours and C is in mcg/ml. Calculate the following.
a. The volume of the central compartment. (2)
b. The volume of the peripheral compartment. (2)
c. The apparent Vd at steady-state. (2)
d. Volume of distribution by area. (2)
e. Microconstants K12 and K21 (2)
f. The elimination rate constant for the disposal of drug from the central
compartment. (2)
g. The overall elimination half-life. (2)
h. The total systemic clearance of the drug. (2)

(OR)
b) Elaborate on the different mechanisms of drug action. (16)

8. (a). Define prodrug and its characteristics. What are the reasons for prodrug
Formulation? (8)

(OR)
(b). Give an account of renal excretion of drug metabolites. (8)

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