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Probiotics
▪ Probiotics are defined as live micro-organisms used as dietary supplements to improve
the health of the host when given in adequate amounts;
▪ lactic-acid-producing organisms were first introduced as potential therapeutic agents
with the idea of acidifying the intestinal contents and thus preventing the growth of
putrefactive organisms;
▪ it is now thought that the gastrointestinal tract may play a wider part in host defences
and consequently there is increasing interest in the use of live non-pathogenic microbial
cultures to optimise the enteric microbiota, including in neonates.
WGO 2017; Martindale 2018
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Probiotics
▪ These are referred to as probiotics and are generally commensal lactic-acid producing
bacteria, although some yeasts are also used. Organisms currently being used in probiotic
preparations include Lactobacillus spp. and Bifidobacterium spp. Other organisms that
may be used are Enterococcus and Streptococcus spp., and the yeast Saccharomyces
boulardii;
▪ common criteria used for isolating and defining probiotic bacteria and specific strains include
the following:
▪ genera of human origin;
▪ stability against bile, acid, enzyme and oxygen;
▪ ability to adhere to intestinal mucosa;
▪ colonization potential in the human gastrointestinal tract;
▪ production of antimicrobial substances;
▪ demonstrable efficacy and safety.
WGO 2017; Martindale 2018
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Intestinal flora
Functions
1. Metabolic function:
• Absorption of calcium, magnesium and iron.
• Vitamin synthesis.
• Carbohydrate fermentation (sugars).
2. Trophic function (nutritive):
• Production of fatty acids that favour the physiological activity of the colon.
3. Immune function:
• Intra-information exchange between microorganisms and lymphatic tissue system (attacking system when
bacteria or harmful substances are involved).
4. Protective function:
• Competition action against pathogens for epithelial adhesion sites and available nutrients.
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Intestinal flora alterations
Intestinal infections
Enteritis
Colitis
Irritable colon syndrome
Antibiotic therapy
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Intestinal flora
A precious balance
Good Bacteria Pathogenic
Bacteria
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Intestinal flora
A precious balance
Good Bacteria Pathogenic Bacteria
Intestinal
inflammation
Climate Antibiotic
and Stress s Drugs
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Probiotics - Main Properties
Treatment and
prevention of
acute diarrhea
Prevention of
PROBIOTICS antibiotic-
associated
diarrhoea
Improving
Immune Response
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No elements of this document may be reproduced in any form without the written permission of Desma Group. All trademarks and registered trademarks are the property of their respective owners.
VIALS TABLETS
Good daily habit Colitis, diarrhea,
dismicrobism
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Infloran Bio Vials & Infloran Bio Kids
VIALS Vials
4 Billions of alive cells and
7vitamins
vials 10 ml INDICATIONS
Daily dose: 1-2 vials per
day ✓ Dietary supplement containing live
probiotics that promote the balance of
KIDS
VIALS intestinal flora.
2 Billions of alive cells and
vitamins
7 vials 10 ml
Daily dose: 1-2 vials per
day
GLUT LACTOS REFRIGERATION
EN E FREE STORAGE NOT
FREE NECESSARY
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InfloranBio Vials - Infloran Bio Kids
Vials
Lactobacillus acidophilus LA37
✓ It creates a protective barrier against pathogenic bacteria. Lactobacillus acidophilus and
Bifidobacterium bifidum are registered at
✓ It positively stimulates the immune system. “National Collection of Industrial, Food and
Marine Bacteria” and they result from
✓ It contributes to reduce the intestinal cells inflammation. Laboratorio Farmaceutico SIT researches
Bifidobacterium bifidum BB07
✓ It has an antibacterial activity against pathogenic bacteria
(such as Helicobacter pylori).
✓ It modulates the immune system.
✓ It reduces the inflammation.
Vitamins B 1, PP, B 6, Folic Acid and D 3:
✓ In synergy with probiotics they help to avoid deficiencies due
to intestinal flora disorders.
✓ Vitamin B 6 and Folic Acid contributes to the normal function of
the immune system.
✓ Vitamin D3 contributes to the normal absorption of calcium
and phosphorus.
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InfloranBio Plus
AN EXCLUSIVE MIXTURE BY 25 BILLIONS OF ALIVE CELLS AND 5 STRAINS IN ONE
SIT TABLET
Colitis?
A HELP TO
Diarrhea/gastroenteritis?
RESTORE
THE NATURAL BALANCE
OF THE INTESTINAL
FLORA
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InfloranBio Plus
TABLETS
25 Billions of
probiotics
20 tablets 250 mg
Daily dose: 1-2 tablets a day, with
water
GLUT
EN
FREE
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InfloranBio Plus
Bifidobacteria mix
• Bifidobacterium breve Bbr8.
Bifidobacterium animalis spp. 25 BILLIONS OF ALIVE CELLS
lactis Bi1, Bifidobacterium breve AND 5 STRAINS IN ONE TABLET
BL10
Lactobacillus rhamnosus IMC501
• With a potential antimicrobial
action against the major
pathogens responsible for
gastrointestinal infections.
• Useful in reducing the duration of
diarrhea and the frequency of the
discharges.
Lactobacillus paracasei IMC502
• Reduces intestinal inflammation.
• Improve the immune response.
• Rapid action on intestinal tract.
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INFLORAN BIO INFLORAN BIO KIDS INFLORAN BIO PLUS
Dosage form - 4 billions of live cells (Bifidobacterium - 2 billions of live cells (Bifidobacterium bifidum Infloran Bio Plus tablets contains:
bifidum BB07NCIMB 30 315, BB07, NCIMB 30315, Lactobacillus acidophilus - Bifidobacterium breve Bbr8
Lactobacillus acidiphilus LA37 LA37 NCIMB 30316) - Bifidobacterium animalis ssp. lactis Bi1
NCIMB 30316) - Vitamin B 1 0.55 mg - Bifidobacterium breve BL10
- Vitamin B 1 1.1 mg - Vitamin B 6 0.7 mg - Lactobacillus rhamnosus IMC501
- Vitamin B 6 1.4 mg - Folic acid 0.06 mg - Lactobacillus paracasei IMC502
- Folic acid 0.06 mg - Vitamin D 1.5 mcg
- Vitamin D 1.5 mcg - Niacin (vitamin PP) 8 mg 1 tablet (250 mg) contains 25 billion live cells.
- Vitamin PP 17.8 mg Max daily dose (2 cpr): 50 billion live cells.
Formulations Infloran Bio Infloran Bio Kids Infloran Bio Plus 20 tablets 250 mg.
Bifidobacterium breve Bbr8
7 vials – 10 ml 7 vials/10 ml Bifidobacterium animalis ssp. lactis Bi1
14 vials – 10 ml 14 vials/10 ml Bifidobacterium breve BL10
Lactobacillus rhamnosus IMC501
Lactobacillus paracasei IMC502
Indications Prevention of intestinal flora alterations. Prevention of intestinal flora alterations. Infloran Bio Plus is a dietary supplement containing live
Live probiotics favour the balance of Live probiotics favour the balance of intestinal flora. probiotics that promote the balance of intestinal flora.
intestinal flora. Vitamin D contributes to the normal absorption of calcium
Vitamin D contributes to the normal and phosphorus.
absorption of calcium and phosphorus. Vitamin B 6 and folic acid contribute to the normal function
Vitamin B 6 and folic acid contribute to the of the immune system.
normal function of the immune system.
Administration 1-2 vials per day 1-2 vials per day It is recommended 1-2 tablets per day, to be swallowed
with water.
Contraindications Dietary supplements are not intended to Dietary supplements are not intended to replace a varied Dietary supplements are not indicated to replace a varied
& Warnings replace a varied and balanced diet and a and balanced diet and a healthy life-style. Do not exceed balanced diet and a healthy life-style.
healthy life-style. Do not exceed the the recommended daily dose. Keep out of the reach of Keep out of reach of children under 3 years of age.
recommended daily dose. Keep out of the children aged under three years. Do not exceed the recommended daily dose.
reach of children aged under three years.
No elements of this document may/ be reproduced in any form without the written permission of Desma Group./All trademarks and registered trademarks are the property of their respective owners.
Special
Infloran Bio Plus - Key Points
- It is used for promoting the balance of intestinal flora (e.g. colitis, diarrhea, and
dismicrobism);
- Lactobacillus rhamnosus IMC501 has a potential antimicrobial action against
pathogens responsible for gastrointestinal infections;
- Lactobacillus rhamnosus IMC501 is useful in reducing the duration of diarrhea and the
frequency of discharges;
- Lactobacillus paracasei IMC502 reduces intestinal inflammation, and improves the
immune response.
No elements of this document may be reproduced in any form without the written permission of Desma Group. All trademarks and registered trademarks are the property of their respective owners.
No elements of this document may be reproduced in any form without the written permission of Desma Group. All trademarks and registered trademarks are the property of their respective owners.
Thanks a lot
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