USP Dissolution Apparatuses

By Dr. Luke Lee

USP Apparatus 1,2,5,6,
USP Apparatus 1,2,5,6,

UDT-812GS
Universal Dissolution tester
With Gas Spring Lift
USP Apparatus 1,2,5,6,

UDT-812A
Universal Dissolution tester
With Power Lift
USP Apparatus 1,2,5,6,

UDT-814
Universal Dissolution tester
With Power Lift

Year 2014 model

with color touch
screen display
UDT-804-12+2 Universal Dissolution Tester
UDT-804-2L Universal Dissolution Tester
(2L Dissolution tester)
UDT-804-4L Universal Dissolution Tester
(2L Dissolution tester)
 Physical Calibration tool set

Wobble gauge & Stand

Centering Shaft

Speed tachometer

Thermometer Timer
USP Apparatus 3,7,

Water Bath System

USP Dissolution Method 7

Dry Heat System

SYSTEM 800S with SHIMADZU UV 1600 /1650/1700

Automated Dissolution UV System

SYSTEM U800S with SHIMADZU UV 1600/1650/1700

Automated Dissolution UV System

Method

Product

Sample
SYSTEM 850BDL For HPLC off line analysis
Automated Dissolution Syringe Pump Sampling System
SYSTEM 850KS-12
Automated Dissolution Syringe Pump Sampling System
SYSTEM 850K-2S For HPLC off line analysis
Automated Dissolution Syringe Pump Sampling System

One system controller to control 2 dissolution sampling systems

 LOGAN/pION
Fiber Optic Dissolution System

Logan UDT-804 Dissolution Tester pION Fiber Optic System

 LOGAN/pION
Fiber Optic Dissolution System

Moving Plate

Fiber Optic Probes

LOGAN Bubble Kicker manifold design
(patented)
 LOGAN/pION
Fiber Optic Dissolution System
MDS 600
Media Delivery System

* Mobile unit brings media to

dissolution tester
* Six Vessels filled to the same
volume simultaneously
* Volume delivered to better than
+/-1%
* Deaerated by filtration,
circulation, vacuum and heat.
MDS 600
Media Delivery System
MDS-600 Delivery
Manifold

UDT-804
Dissolution Tester
MDS 600T
Media Delivery System

* Table top unit fills

media into 6
dissolution vessels
* Six Vessels filled to
the same volume
simultaneously
* Volume delivered to
better than +/-1%
* Deaerated by
filtration, circulation,
vacuum and heat.
MDS 600T
Media Delivery System

Vessel tray for carry 6

dissolution vessels to
dissolution tester
 MDS 600T
Media Delivery System
Media
reservoir

Heater /
Delivery
manifold Degassing
system
MDS 600T
Media Delivery System

Media reservoir &

Temperature controlling
system for degassing
Total of 4 types media
reservoir / degassing
system can be link up
with the MDS-600T
AVC-100 HTP
Automated Vessel Cleaner

• For Validation
• Color Touch Screen
Display
• Mobile unit brings
cleaner to bath
• Selectable Methods for
different products,
* High pressure turbo
wash and vacuum
* Media neutralization in
waste tank
• Automatic waste
discharge
AVC-100
Automated Vessel Cleaner

Wash Head

UDT-804
Dissolution Tester
AVC-100 HTB Automated Vessel Cleaner
Wash Head Design

Wash head with

built-in brush
 LOGAN SYSTEM 1000
Fully Automated Dissolution System
Schematic
System 1000 total control
software package
Cleaning Logan UDT-804AB Air bath Sampling Analysis
with vessel filling nozzles & wash / Fiber optic
rinse station & sampling manifolds
AVC-1000 Transfer probes
USP I : 8 Tests USP II : 12 Tests
A. Vessel face up design pumps for
B. Vessel face down design sampling On line UV
Waste Filling
MDS-600
Sample HPLC
Media Supply Tank collector injection

Rinse Water Media A Media B Media C Media D Media E

Tank Tank Tank Tank Tank Tank
 LOGAN SYSTEM 1000
Fully Automated Dissolution System
UDT-804AB (Air Bath)
Heater in the shaft Air chamber for temperature
isolation

Temp read-out for

each vessel

Temperature sensor under the vessel

 LOGAN SYSTEM 1000
Fully Automated Dissolution System
Media Filling
Dissolution Media Filling by MDS-600
Media Delivery Module

* Automatically fills pre-heated degassed media

into 6 test vessels
* 6 Vessels filled to the same volume
simultaneously
* Volume delivered to better than +/-1%

NOTE: 5 types of media can be select by

program, selected media transferred into
MDS-600 reservoir for pre-heat
 LOGAN SYSTEM 1000
Fully Automated Dissolution System
USP I Basket Test
For USP I Basket Test:
Preload baskets in the
carousal
Max: 8 tablets
The basket carousal is
stationed between each
drive head and vessel. The
shaft engages basket before
it gets into the vessel
 LOGAN SYSTEM 1000
Fully Automated Dissolution System
USP II Paddles Test

For USP II Paddle Test:

Preload tablets in the
carousal
Max: 12 tablets
The tablet carousal is
mounted on top of the driver
head
LOGAN CUSTOM MADE
SYSTEMS
LOGAN SYSTEM 7000-24
Automated USP 7
Hip Stem Test System
LOGAN SYSTEM 7000-24
Automated Hip Stem Test System
LOGAN SYSTEM 7000-24
Automated Hip Stem Test System

SYSTEM CONTROLLER
•LCD Display
•Touch Screen
LOGAN SYSTEM 7000-24
Automated Hip Stem Test System
LOGAN SYSTEM 7000-24
Automated USP 7
Heart Stents Test System
LOGAN Fully Automated USP 7
System
LOGAN  “E  Trans”  SYSTEM
The drug delivery system thru eyes into the brain
LOGAN  “E  Trans”  SYSTEM
The drug delivery system thru eyes into the brain

Apply drugs from eyes

LOGAN SYSTEM 64
Robotic Transdermal System
LOGAN Tablets Physical Testing
Products

• Disintegration Tester
• Friability Tester
• Hardness Tester
• Tap Density Tester
DST-3/6
Disintegration Tester

•Easy-To-Use input keypad

•Audible end of run signal
•Modular design for 1 to 6
simultaneous tests
• 2 Single in-line layout for
ease of viewing all basket
assembles
•Meets or exceeds all USP
requirements and
specifications
FAB-2S
Friability Tester

•As per USP specification

•Adjustable speed at 20-70 rpm
•Test with one or two drums
•Select of counter or timer
•Easy input key pad
•Microprocessor control & LCD
display
FAB-2SP
Friability Tester

•As per USP specification

•Adjustable speed at 20-70 rpm
•Test with one or two drums
•Select of counter or timer
•Easy input key pad
•Microprocessor control & LCD
display
•Printer / report center
LOGAN HDT-400L
Automated Hardness Tester
For: Hardness / Thickness / Diameter / Weight measurements
LOGAN TAP-2S
Automated Tap Density Tester

Meets all current USP, BP, JP

guidelines.
LED Display for TIME or
COUNTER.
Microprocessor Technology
Control System.
Easy - To - Use Input Keypad.
Modular Design for One or
Two Platforms.
Simultaneous tapping and
rotary motion
LOGAN TAP-2SP
Automated Tap Density Tester w/ Printer

Meets all current USP, BP, JP

guidelines.
LED Display for TIME or
COUNTER.
Microprocessor Technology
Control System.
Easy - To - Use Input Keypad.
Modular Design for One or
Two Platforms.
Simultaneous tapping and
rotary motion
 Report printer
Transdermal Diffusion Cell
Systems

Manual Systems
 LOGAN FDC-6
Transdermal diffusion cell drive console
Temperature Controller

Water Tank

Franz
cells FDC-6 Drive Console
 LOGAN SDC-6
Transdermal Diffusion Cell Drive Console
( 6 Side By Side Cells)
 LOGAN SFDC-6
Transdermal Diffusion Cell Drive Console
( 3 Verital Cells & 3 Side By Side Cells)
 LOGAN DHC-6T
Dry Heat Transdermal System
 LOGAN DHC-6T
Dry Heat Transdermal System

For sampling, the cell support plate lays flat

 LOGAN DHC-6T
Dry Heat Transdermal System

For media replacement, the cell support plate tilts to purge the bubbles
Transdermal Diffusion Cell
Systems

Semi- Automated Systems

LOGAN FDC-6T
(patents)

A. Bubble Free Cell

B. Tilting Divice

C. Manifold system
LOGAN FDC-6T
Semi- Automated System
LOGAN FDC-6T
Semi-Automated Systems
Automated Transdermal
Systems
 LOGAN SYSTEM 912-6 Automated Transdermal Diffusion
Cell System
FDC-6 T
Syringe Pump

SCT-160V Sample Collector

System Controller
 LOGAN SYSTEM 912-12 Automated Transdermal Diffusion
Cell System
SYRINGE
PUMP

SYSTEM CONTROLLER SCT-240V SAMPLE

COLLECTOR
FDC-6 DIFFUSION CELL DRIVE CONSOLE
 LOGAN SYSTEM 912-24 Automated
Transdermal Systems
Syringe Pump

System Controller
FDC-6T Diffusion Cell Drive Console SCT-480 Sample Collector
 LOGAN INSTRUMENTS CORP.
19-C Schoolhouse Rd, Somerset New Jersey 08873 USA

Prepared by Dr. Luke Lee THANK YOU!