February 2009
[KU 740] Sub. Code: 4231
SECOND [Link]. DEGREE EXAMINATION
(Regulation 2004)
Candidates Admitted from 2004-05
Paper II – PHARM ANALYSIS AND PHYSICAL CHEMISTRY
Q.P. Code : 564231
Time : Three hours Maximum : 90 marks
Answer Part I and Part II Separately
PART – I
(PHARMACEUTICAL ANALYSIS)
I. Essay Questions : Answer any ONE question (1 x 20 = 20)
1. a) Explain the theory of redox titration.
b) Write notes on standard oxidation potential.
2. a) Explain the basic concept of acid base titration.
b) Write notes on common ion effect.
c) Write the importance of acids and bases in pharmacy.
II. Write Short Notes : Answer any FOUR questions (4 x 5 = 20)
1. Masking and demasking agent.
2. Explain the kjeldahl method of nitrogen estimation.
3. How will you assay of oxygen.
4. What is redox potential? Write the application of parameter in
pharmacy.
5. Write notes on Fajan’s method?
III. Short Answers: Answer any TWO questions (2 x 2.5 = 5)
1. Define buffer solution.
2. Mohrs method.
3. Define Iodometry.
PART – II
(PHYSICAL CHEMISTRY)
I. Essay Questions : Answer any ONE question (1 x 20 = 20)
1. a) State phase rule. Explain the various terms involved in it. Write its
applications.
b) Explain Hess’s law of constant heat of summation.
2. a) State first law of Thermodynamics.
b) Define the order of reaction. Explain various methods for
determining the order of reaction.
II. Write Short Notes : Answer any FOUR questions (4 x 5 = 20)
1. Discuss briefly Langmuir’s theory of adsorbtion and its application.
2. Write in detail about the bomb calorimeter used for the measurement
of heat of reaction.
3. Write the factor affecting the rate of chemical reaction.
4. Explain the partition coeffeicient.
5. Write the relation between ¨H and ¨E.
III. Short Answers: Answer any TWO questions (2 x 2.5 = 5)
1. Define Enthalpy.
2. Rate of reaction.
3. Vant hoff equation.
******
2 [KU 740]
August 2009
[KV 740] Sub. Code: 4231
SECOND [Link]. DEGREE EXAMINATION
(Regulation 2004)
Candidates Admitted from 2004-05
Paper II – PHARM ANALYSIS AND PHYSICAL CHEMISTRY
Q.P. Code : 564231
Time : Three hours Maximum : 90 marks
Answer Part I and Part II Separately
PART – I
(PHARMACEUTICAL ANALYSIS)
I. Essay Questions : Answer any ONE question (1 x 20 = 20)
1. a) Write note on the Gaussian distribution (Normal distribution curve).
b) Describe in detail about i) Henderson-Hasselbalch ii) Volhard’s
method
2. a) Define buffer. What are the applications of buffer solution in
pharmacy?
b) Masking and demasking agents in complexometric titrations.
II. Write Short Notes : Answer any FOUR questions (4 x 5 = 20)
1. Define Gasometry. Give the procedure for the assay of oxygen.
2. Theories of indicators in Neutralization titrations.
3. Explain the preparation and standardization of acetous perchloric acid
including the precautions to be taken.
4. Write the importance of quality control of drugs.
5. Give note on factors affecting solubility of precipitates.
III. Short Answers: Answer any TWO questions (2 x 2.5 = 5)
1. pH of the solution.
2. Define Acid value and Saponification value.
3. Stoichiometric end point.
PART – II
(PHYSICAL CHEMISTRY)
I. Essay Questions : Answer any ONE question (1 x 20 = 20)
1. a) What is adsorption? Explain the various factors influencing the
adsorption.
b) Write note on i) Molar heat capacity ii) Elevation of boiling point.
2. a) What are the colligative properties? Explain the methods of
determination for any two.
b) Give a note on Nernst’s distribution law.
II. Write Short Notes : Answer any FOUR questions (4 x 5 = 20)
1. Explain about Debye – Huckle theory.
2. Discuss briefly about second law of thermodynamics.
3. Write in detail about the Bomb calorimeter used for the measurement
of heat of reaction.
4. What is adsorption isotherm? Explain freundlisch adsorption isotherm.
5. Hess law of heat of summation.
III. Short Answers: Answer any TWO questions (2 x 2.5 = 5)
1. Define exothermic and endothermic reactions.
2. Parachor and Rheochor.
3. Raoult’s law.
******
2 [KV 740]
February 2010
[KW 740] Sub. Code: 4231
SECOND [Link]. DEGREE EXAMINATION
(Regulation 2004)
Candidates Admitted from 2004-05
Paper II – PHARM ANALYSIS AND PHYSICAL CHEMISTRY
Q.P. Code : 564231
Time : Three hours Maximum : 90 marks
Answer Part I and Part II Separately
PART – I
(PHARMACEUTICAL ANALYSIS)
I. Essay Questions : Answer any ONE question. (1 x 20 = 20)
1. a) Describe the determination of errors and methods to minimize the
errors.
b) Explain the various concepts of Acid-base titrations.
2. a) Explain the different types of complexometric titrations by using
various titratants with suitable examples.
b) Explain in detail about the following:
i) Diazotisation
ii) Kjeldhal’s method of nitrogen determination.
II. Write Short Notes : Answer any FOUR questions (4 x 5 = 20)
1. Enumerate various types of indicators used in precipitation titrations.
2. Define co-precipitation and post precipitation. Give notes on various
step involved in gravimetric analysis.
3. Write about the preparation and standardization of 0.1 M potassium
permanganate with principle and reaction.
4. Scope and limitations of various titrants used in non-aqueous titrations.
5. Give the detail note on calibration of analytical equipments.
III. Short Answers: Answer any TWO questions (2 x 2.5 = 5)
1. Define common ion and common ion effect.
2. Redox potential.
3. Define iodimetry and iodometry.
PART – II
(PHYSICAL CHEMISTRY)
I. Essay Questions : Answer any ONE question. (1 x 20 = 20)
1. a) Define rate of reaction. Clarify with examples and derive the
equation for first order reaction.
b) Explain Hess’s law of constant heat of summation.
2. a) Describe briefly about first law of thermodynamics.
b) Explain about i) Partition co-efficient ii) Activation energy
II. Write Short Notes : Answer any FOUR questions (4 x 5 = 20)
1. Describe carnots cycle.
2. Give note on Joule-Thomson effect.
3. Determine the molecular mass from elevation of boiling point.
4. Give note on Langmuir’s isotherms.
5. Write note on Henry’s law for solubility of gas in liquid.
III. Short Answers: Answer any TWO questions (2 x 2.5 = 5)
1. Degree of freedom.
2. Raoult’s low.
3. Define chemisorptions.
******
2 [KW 740]
September 2010
[KX 740] Sub. Code: 4231
SECOND [Link]. DEGREE EXAMINATION
(Regulation 2004)Candidates Admitted from 2004-05
and 2009-2010 Lateral Entry Batch)
Paper II – PHARM ANALYSIS AND PHYSICAL CHEMISTRY
Q.P. Code : 564231
Time : Three hours Maximum : 90 marks
Answer Part I and Part II Separately
PART I
(PHARMACEUTICAL ANALYSIS)
I. Essay Questions : Answer any ONE question. (1 X 20 = 20)
1. a) Explain the theory of complexometric titration. What are the different types of
complexometric titration.
b) Discuss the importance of buffer in complexometric titration.
2. a) Write a methodology of different steps involved in Gravimetric analysis.
b) Explain co-precipitation and post precipitation.
II. Write Short Notes : Answer any FOUR questions. (4X 5 = 20)
1. Write a note on oxygen flask method.
2. Explain the laws of mass action.
3. Write the mechanism involved in diazotization reaction.
4. Give an account on Neutralization curve.
5. Write notes on Non-aqueous titration.
III. Short Answers: Answer any TWO questions. (2X2.5 = 5)
1. Define Iodimetry
2. Redox potential.
3. Chelating agents.
PART II
(PHYSICAL CHEMISTRY)
I. Essay Questions : Answer any ONE question. (1 X 20 = 20)
1. a) State phase rule. Explain the various terms involved in it and write its
application.
b) Explain in detail about Joule – Thomson effect.
2. a) State and explain second law of Thermodynamics.
b) Describe the Carnot cycle in detail.
II. Write Short Notes : Answer any FOUR questions. (4X 5 = 20)
1. Explain Hess’s law of constant heat summation and explain some of its
application.
2. Write a note on Freundlich adsorption isotherm.
3. Explain the theory of partition coefficient with limitation.
4. Write notes on ideal solution.
5. What is adsorption? Discuss the factors influencing adsorption.
III. Short Answers: Answer any TWO questions. (2X2.5 = 5)
1. Define heat of combustion.
2. Vant-hoff equation.
3. Enthalpy of a reaction.
******
FEBRUARY 2011
[KY 740] Sub. Code : 4231
SECOND [Link]. DEGREE EXAMINATION.
(Regulation 2004)
(Candidates admitted from 2004-2005 and 2009-2010 Lateral Entry Batch)
Paper II — PHARM ANALYSIS AND PHYSICAL CHEMISTRY
Q.P. Code : 564231
Time : Three hours Maximum : 90 marks
Answer Part I and Part II Separately.
PART I
(PHARMACEUTICAL ANALYSIS)
I. Essay Questions :
Answer any ONE questions. (1 x 20 = 20)
1. (a) Write the principles involved in the Law of Mass action and Henderson
Hasselbalch equation and give suitable examples.
(b) Explain Buffer solutions and theories of indicators.
2. (a) Discuss about the Diasotization titration reactions and indicators used for this
titrations.
(b) Write a methodology of different steps involved in Gravimetric analysis.
II. Write short notes :
Answer any FOUR questions. (4 x 5 = 20)
1. Write a note on Standardization of perchloric acid.
2. Explain complexometric titrations.
3. Explain the mechanism involved in the oxidation reduction titrations.
4. Give an account on ionic product of water.
5. Write a now on Volhards and Mohrs Methods.
III. Short Answers :
Answer any TWO questions. (2 x 2.5 = 5)
1. Define the term common ion effect.
2. Chelating agent.
3. PM indicators.
(PTO)
PART II
(PHYSICAL CHEMISTRY)
I. Essay questions :
Answer any ONE questions. (1 x 20 = 20)
1. (a) Define and explain the various types of colligative properties and the methods
used for determining the elevation of boiling point.
(b) Define Osmotic pressure. Write the Methods of determinations and its
applications.
2. (a) Define the term adsorption and write the uses of adsorption in analysis.
(b) Explain the methods used to measure the adsorption capacity adsorbents and
factors influencing adsorption.
II. Write short notes :
Answer any FOUR questions. (4 x 5 = 20)
1. Write briefly about liquid solutions.
2. Explain the uses of gas solid solutions.
3. Discuss about Phase rule.
4. Define and explain Hess Law of constant Heat of summation.
5. Briefly describe the second law of Thermodynamics.
III. Short Answers :
Answer any TWO questions. (2 x 2.5 = 5)
1. Partition coefficient.
2. Ideal solution.
3. Joule Thomson Effect.
******
2 [KY 740]
