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Biosafety Hazards of Mycobacterium tuberculosis

This document provides information about characterizing biosafety hazards for the biological agent Mycobacterium tuberculosis. It includes filling out a hazard characterization sheet which identifies M. tuberculosis as a Risk Group 3 pathogen that is highly pathogenic, has a low infectious dose, can infect humans via respiratory transmission, and has a history of laboratory-acquired infections. The document then prompts identifying risks that could arise from the hazards, under what conditions risks may be manifested, and who would be at risk, such as lab workers being at risk of infection from inhalation of infectious aerosols generated during experiments.

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YUSNURDALILA DALI
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108 views3 pages

Biosafety Hazards of Mycobacterium tuberculosis

This document provides information about characterizing biosafety hazards for the biological agent Mycobacterium tuberculosis. It includes filling out a hazard characterization sheet which identifies M. tuberculosis as a Risk Group 3 pathogen that is highly pathogenic, has a low infectious dose, can infect humans via respiratory transmission, and has a history of laboratory-acquired infections. The document then prompts identifying risks that could arise from the hazards, under what conditions risks may be manifested, and who would be at risk, such as lab workers being at risk of infection from inhalation of infectious aerosols generated during experiments.

Uploaded by

YUSNURDALILA DALI
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd

Practical 1

My agent =
PART A Hazard characterisation

1. Identify what are the possible biosafety hazards for your agent.
2. Complete the Hazard Characterisation Sheet attached. You will need to search the
internet or other sources for scientific data. This will provide the information for the
risk assessment in the next section.
3. Use the template on the next page. Use extra paper if you need.

Hazard characterisation sheet (tick where applicable)


Name of biological agent (genus/species etc.): Mycobacterium tuberculosis

1. Type of agent:
/ Bacterium Virus Fungus Parasite
Cell Culture Prion Biological toxin Others:

2. Risk Group 1 2 / 3 4 Unknown

3. Pathogenicity
/ Highly pathogenic Pathogenic
Opportunistic pathogen Potential pathogen

4. Infectious dose Unknown / Known = low infectious dose of less


than 10 microorganisms

5. Host range
/ Human Animal Plants Others :
6. Communicability
/ Human to Animal to Human to Animal to
human human animal animal

7. Route of infection
/ Respiratory tract/ inhalation Mucosal membranes/ eyes, nose, mouth
Percutaneous / break in skin Gastrointestinal tract/ ingestion

8. Mode of transmission
Direct contact Indirect contact / Human-human Human-animal
Vector borne Inanimate Food, water Air, aerosols
objects

9. Individual highly at risk


Pregnant woman Immunocompromised
/ Aged person/ children / Others: homeless persons, injection drug
users, and persons with HIV infection.

10. History of Laboratory –Acquired Infection (LAI)


/ Yes Rare No reports

11. Vaccine / Yes No


available?

12. Cure available? / Yes No

For the procedures performed on this biological agent:


13. Will aerosols be produced in large / Yes No
amounts?

14. Will sharps be used? Yes / No


15. Are spills/ splashes likely to happen? / Yes No

Part B : Risk identification

1. Identify what risks can arise due to the hazard. One hazard can give risk to several
risks. The risk can be to the laboratory worker, people around the lab, or the
environment.
2. Identify under what conditions/ situations will the risk be manifested. Remember, just
by having a hazard doesn't mean that it will result in a risk.
3. Identify who will be at risk.

Table 1.1: (Give me a title)


Hazard Risk Under what conditions can Who is at risk
this happen
What can happen

1 Mycobacterium Infection via respiratory Generation of infectious Lab workers


tuberculosis route aerosols when vertexing
samples.

2 ……..

3 …….

4 Mycobacterium Unintentional release Contaminated waste was Lab workers/


tuberculosis not properly autoclaved support workers/
community

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