Biochemistyy Unih-3 P03
Cato.bo.liAm oHem
Dr. Parjanya Shukla
x Erythocyts (RBCs) hovu o
i
spon o 120 days Dr. M.P. Sinh Class
offar t beriod thy a7 imovd rom tiTuwahm.
xerymoyts degrad1d by macrophagus o
uialondothulial (RE) Systam in livr, spllun and
bonu mOYro w
Thu Kemoglo.bin i cleavad to (69/day brokun down, and
usynHusig0d)
rotuin part globin non protan Ktmc
uuklizad
Kamolobin
for 0maim o
or dagradi
807 oKma rom ryhrotytus
undro dgro dabo
to individua Amino Auidh
90 . Comu rom immatura
undrgo huT own mutabob'am RBC, myoglobin and
and uh qlabin &yn Kasis. cyto chroms
HemA xygenos www
Hums Oxyaanase, (micvo.omal
02 enzymu)
uHibzs NADPH and
chove mphenyl bridges b/w to pyroli ing A and B
om biliverdin. (a qrcenpiamunt).
fmaus on ( f ) i oxidizad to i c ion (fa3*)
and CObon monoxid Cco) ibau.
Brlivdin Reduckoss - Malheny bridgu o Bilivvdin's
w mmmw w
b/ byrolu sung "C and D
uduud to metkylonu grub to fon hiliubin (yloopigmunl)
This uacion ls cakalysad by an NADPH dipand1nt
olubl onzymi 'bilvardin uductase . Dr. Parjanya Shukla
&
Dr. M.P. 8ingh Clases
x 19 kmoglo.bin on digrodahom yiulds ahout 85 mg bi'lirabin
(2So -3So mg day).
Aqad Eryhrotytas
Hemoglobin N
H
Amino Biliubin (Untonugattd
Acids Macrophaga LoahT inAalaklu)
Globin BiliTubin- Albumin
OhLr Kem RaukliiphunBlood Cembux (wak1r Solubla)
rotins 07 dsgrod.d LivAY
M
Brlirubin
aUDP
glucuronaa Bilirubin
4
qlucuronyd
UDP
tronsros
M: Mehy(CH) Gluwnopiu
aue Gluuronic
P m V= Viny! H,=CH) auc.
Ham P-Propiony! cH
Oz, NADPH+H (CH,cM,cHaon) M CH (Hh M
Hama Oxygenast o
NADP f3+ co H N
Btlitubin diglucuronide (to bilu)
Tntshin MicTbbial
Kidnu enzymu (Intuin)
H H
Biliverdin UTobilinoqen- Microblal
NADPH+H Gilivrdin Kidnay Eh2ym
UTobili'n
NADP uductas Sturcobibin
To Urin
o Faus
Disovdas oHemu Motabobam-
Dr. Parjanya Shuhla
&
() Hyperbilivubine mio Dr. M. P. Stngh Clases
xhu novmal lasma comunhabon of bilirubin-
Tota Bilubin 0.2, to i.0 mg/dt
Unconjugated Bilirubin 0:2 to 06 mg/dl
Comiugatd Bilirubin 0. to 0.4
mg/d
locwasad Conunhahion Total bilirubin in plama
indicatas a clinical condihion callud typerbibrawbinumia.
Caurus-
Hemoly hc Anemio buakdown of evyhrocytus
Causes Imeraasad pro du ehon of bilirubin.
y Ham Metaboi'sm Abnormali Hes
OCcuYA duu to livir di'sodes or biliroy obshuchn.
Cmugatad bilraubin uentar blood.
cii) Dejackve Erylhropoiaais Improprly monuyoehurud RecA
kavs shorl b spon espaially in halau.amio, meqaloblaske
ongmia, and eryhrolukemia
Jaundiu Whan th pla^ma bilirubin xuds 3 mg/d
i dilus nto HusuuA giving a yellow distolaurahen
of Raskin ,sclurau and mucous mimbrant.
ymp toms 8y-Dr- Mahtndro Pralap Singh|
Ylow. skin
) Yallowing d lra o eya
Ciio Dork yallow or suddish urinu (du to t biliruin)
gv Anovxia ( Jom d opbehte) Dr. Parjaya Shukla
0) BiHY tast in mowh Dr.M.P. 8tngh ues
(vi Pal and o Amalling a tu.
(vIl) Dull ain in ivur ig/on. et
Claui icahan d Jaundiu1
a) Hemolyhe/ rnhupaic Jaundia :
Mawiv kamolyai , braoh down a kmoglobin
AXUAds sahs abliy of biur ulh
b) Habaocullulor Hepaht Jaundiu
Thu' th duu to domag in kapahc poranchymal ulls
bVT disunchon impar uptakr and conjugakon
obibvubin and susult in slh vatsd" Asrum
Comun rahon.
Post kubaki/Obshuchve Jaundiu -
Causad by obsiuchon biliony þanage by tumors
OT gallstonus
TuVEnbauog
l of emjugaked bilinabin from ivT
to intxHin
By-Dr. Mahundra Phalap Singh
