Title: The Challenges of Crafting an Antidiabetic Plants Thesis
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Jovanovski E, Smircic-Duvnjak L, Komishon A, Au-Yeung FR, Sievenpiper JL, Zurbau A, et al.
Again, cinnamaldehyde can ameliorate the uptake of glucose by upraising the amount of AKT2 and
aortic nitric oxide synthase 3 (eNOS), insulin receptor substrate1 (IRS1) and p-85 regulatory subunit
of PI3K (PI3K-P85) while concurrently abating the expression of NADPH oxidase 4 (NOX4) which
eventually balance the increased glucose concentration ( 56, 59 ). It was suggested that cryptolepine
works directly at the cellular level to enhance the glucose transport in 3T3-L1 cells and thus causes a
reduction in blood glucose level ( 78 ). Acute Effect of Ceylon Cinnamon Extract on Postprandial
Glycemia: Alpha-Amylase Inhibition, Starch Tolerance Test in Rats, and Randomized Crossover
Clinical Trial in Healthy Volunteers. Kobayashi M, Akaki J, Ninomiya K, Yoshikawa M, Muraoka O,
Morikawa T, Odawara M, et al. These cookies ensure basic functionalities and security features of
the website, anonymously. Despite the availability of insulin preparations and several synthetic oral
antidiabetic drugs, there is a crucial need for the discovery and development of novel antidiabetic
drugs because of the development of resistance and side effects of those drugs in long-term use.
Anti-Diabetic Activity of Methanol Leaf Extract of Costus Pictus D. Antihyperglycemic Effects of
Stevioside in Type 2 Diabetic Subjects. Not much has been done to validate the effect of the plant in
animal model studies. Rashid 5 Nusrat Islam Chaity 1 Chao Zhao 6 Jianbo Xiao 7 Elsayed E. Root
extract B. aristata regulates glucose homeostasis by reducing gluconeogenesis and oxidative stress
and exhibits a strong anti-hyperglycemic activity ( 30, 31 ). In order to be human-readable, please
install an RSS reader. There are several medicines available in the market to treat diabetes mellitus but
no drug is found to be fully effective and safe. Lupinus perennis L. Lupinus perennis L. (family:
Fabaceae) is a perennial herb which is abundantly found in Canada and USA ( 105 ). The Role of
Microbial Amino Acid Metabolism in Host Metabolism. This review is expected to identify the
existing knowledge gaps and serves as an important baseline for future research on scientifically
underexploited plant species. 2. Methods A comprehensive literature survey was thoroughly
conducted from January 2021 to August 2022. Evaluation of Antidiabetic and Antioxidant Activity
of Moringa Oleifera in Experimental Diabetes. Next Article in Journal Durability of Repair
Metakaolin Geopolymeric Cement under Different Factors. Guarino G, Strollo F, Carbone L, Della
Corte T, Letizia M, Marino G, et al. Plant-derived medicaments have also been mentioned in various
ethnic and traditional practices including the Indian, Koran, Chinese and Mexican cultures as well as
in Western and Ayurvedic herbalism approaches which accredits their tremendous antidiabetic
potential ( 7, 295 ). Besides, it has also been reported that the active ingredients of 5-
hydroxymethylfural and acacetin in L. Pushparaj PN, Low HK, Manikandan J, Tan BKH, Tan CH. It
occurs throughout India, and mainly found in tidal forests of India. Anti-Glycation Effect of Mixed
Herbal Extract in Individuals With Pre-Diabetes Mellitus. Hypoxis colchicifolia (Hypoxidaceae
family) is the second most vital Hypoxis medicinal species with marketable value in South Africa.
Protein ( introduction, classification, properties, structure, importance and. Potential Activity of
Moringa Oleifera Leaf Extract and Some Active Ingredients Against Diabetes in Rats. Revilla-
Monsalve M, Andrade-Cetto A, Palomino-Garibay MA, Wiedenfeld H, Islas-Andrade S. Publisher’s
Note All claims expressed in this article are solely those of the authors and do not necessarily
represent those of their affiliated organizations, or those of the publisher, the editors and the
reviewers.
Bhat M, Kothiwale SK, Tirmale AR, Bhargava SY, Joshi BN. Rashid 5 Nusrat Islam Chaity 1 Chao
Zhao 6 Jianbo Xiao 7 Elsayed E. The main trait element of diabetes is hyperglycemia, which reflects
the drop in the use of glucose due to a poor reaction to insulin discharge. These cookies will be
stored in your browser only with your consent. Diabetes mellitus is characterized by hyperglycemic
condition along with impaired metabolic functions. It has also been reported to significantly reduce
the plasma levels of IL-6 with increased insulin sensitivity. Journal of Manufacturing and Materials
Processing (JMMP). The alpha-glucosidase inhibitor class of oral antidiabetic drugs is occasionally
called “starch blockers”. However, further research is necessary to disclose the absolute and exact
mechanism of action of these compounds which would facilitate their outset as drugs or chemical
leads. Note that from the first issue of 2016, this journal uses article numbers instead of page
numbers. Some plants with antidiabetic effects from South Africa are available in the form of herbal
supplements, possessing the NAPPI code, a unique coding identifier for medicine, surgical products
and medical procedures. OF DRUG) introduction to pharmacology ( PK, PD, ROUTE OF ADM.
Ritu M, Nandini J. Nutritional Composition of Stevia Rebaudiana, a Sweet Herb, and its
Hypoglycaemic and Hypolipidaemic Effect on Patients With Non-Insulin Dependent Diabetes
Mellitus. It naturally grows from north of Minas Gerias to Piaui ( 41 ). Lupinus perennis L. Lupinus
perennis L. (family: Fabaceae) is a perennial herb which is abundantly found in Canada and USA (
105 ). Understanding and Controlling the Cell Cycle With Natural Products. Potent Hypoglycaemic
Activity of the Aqueous Extract of Chamaemelum Nobile in Normal and Streptozotocin-Induced
Diabetic Rats. Natural Products and Combinatorial Chemistry: Back to the Future. Momordica
charantia L. (family: Cucurbitaceae) is a flowering vine cultivated in Asia including Bangladesh,
India and in other regions like East Africa and South America as well. These three antidiabetic
compounds extracted from fenugreek showed prominent efficacy in alloxan induced severe and
moderate diabetic rabbit models ( 178 ). These cookies help provide information on metrics the
number of visitors, bounce rate, traffic source, etc. Kim HJ, Park KS, Lee SK, Min KW, Han KA,
Kim YK, et al. Cinnamon extract was also co-administered with other herbals to evaluate the
synergistic activity on diabetic complications. Nigella sativa L. Nigella sativa L. (family:
Ranunculaceae) is a herbaceous plant which occurs in several southern Mediterranean and Middle
Eastern countries. It is distributed in the Eastern Cape province, mostly from the mist belt, moving
inland. In skeletal muscle and adipose tissue, glucose uptake is enhanced via the activation of a
series of events which take place following an increase in insulin levels. The same study also reported
a significant reduction in oxidative stress related to hyperglycemia ( 108 ). Current Anti-Diabetes
Mechanisms and Clinical Trials Using Morus Alba L. Tiong SH, Looi CY, Hazni H, Arya A, Paydar
M, Wong WF, et al. Bioactive Compounds in Anti-Diabetic Plants: From Herbal Medicine to Modern
Drug Discovery.
Thus, turmeric rhizomes exert inhibitory action against enzymes related to type 2 diabetes ( 71 ).
Journal of Manufacturing and Materials Processing (JMMP). Adverse side effects of DPP-IV
inhibitors include headache, runny nose, diarrhea, nausea, stomach pain, and sore throat. Evaluation
of the Medicinal Potentials of Bulbine abyssinica A. It has been found that upon the administration
of aqueous extract of C. The blood sugar-lowering potential of the leaf extract was equivalent to that
of the commercially available drug Tolbutamide in the animal models ( 45, 46 ). Despite the
enormous use of these plants in the treatment of life-threatening diseases such as diabetes, there are
still several plants that remain to be recorded. In order to explore and validate proper mechanistic
pathways of pharmacological activities demonstrated by the reported antidiabetic phytochemicals,
further investigations are warranted. Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D,
et al. MAR, NIC, CZ, JX, EH, SAK, and INM critically revised the manuscript. The Effect of
Chamomile (Matricaria Recutita L.) Infusion on Blood Glucose, Lipid Profile and Kidney Function
in Type 2 Diabetic Patients: A Randomized Clinical Trial. The bitterness becomes more intensified
when it ripens. Thus, an effort needs to be devoted to the isolation and purification of these
antidiabetic molecules and the determination of their mechanism of action, both in in vitro and in
vivo experimental animal models. It is required to isolate, purify and characterize the specific
compounds with the efficacy to control by reducing blood glucose level and by means of
regenerating the damaged. Google Scholar 111. Kato A, Minoshima Y, Yamamoto J, Adachi I,
Watson AA, Nash RJ. Other Promising Plants and Phytocompounds Researchers suggested that there
are almost 800 dietary and non-dietary plants with antidiabetic properties ( 77 ). Cookie Settings
Accept All Reject All Privacy Policy Manage consent. The beneficial potential of each plant matrix is
given by the combined and concerted action of their profile of biologically active compounds.
Altered Gut Microbiota in Type 2 Diabetes: Just a Coincidence. Abas F, Khatib A, Perumal V,
Suppaiah V, Ismail A, Hamid M, et al. Hypoglycemic Effects of Morus Alba Leaf Extract on
Postprandial Glucose and Insulin Levels in Patients With Type 2 Diabetes Treated With Sulfonylurea
Hypoglycemic Agents. Effectiveness of Chamomile Tea on Glycemic Control and Serum Lipid
Profile in Patients With Type 2 Diabetes. Effect of Mulberry (Morus Indica L.) Therapy on Plasma
and Erythrocyte Membrane Lipids in Patients With Type 2 Diabetes. Andallu B, Suryakantham V,
Lakshmi B Srikanthi, Reddy GK. If a meal is skipped the medication is also skipped. Presl-A
Versatile Spice Used in Food and Nutrition. Jafarnejad S, Keshavarz SA, Mahbubi S, Saremi S, Arab
A, Abbasi S, et al. Hypoglycemic and anti-hyperglycemic actions have been saved with abundant
plants, a lot of which are worn as an established herbal treatment of diabetes. Two New Pyrrolidine
Alkaloids, Radicamines A and B, as Inhibitors of Alpha-Glucosidase From Lobelia Chinensis Lour.
ALL the evidence webinar: Appraising and using evidence about community conte.
When catalases (CAT) are deficient, pancreatic islet-cells are more susceptible to excessive formation
of reactive oxygen species (ROS) and oxidative stress, which leads to pancreatic islet dysfunction
and overt type 2 diabetes mellitus ( 15 ). These gut hormones (GIP and GLP-1) are highly sensitive
to degradation by DPP-IV, a serine protease that cleaves polypeptides containing proline and alanine
residues at the penultimate N-terminal position and thus decreases the effectiveness of the hormones.
An Extract of Black, Green, and Mulberry Teas Causes Malabsorption of Carbohydrate But Not of
Triacylglycerol in Healthy Volunteers. Diabetes mellitus is becoming a severe hazard to human health
in all regions of the world due to its fast growing occurrence. There are several medicines available in
the market to treat diabetes mellitus but no drug is found to be fully effective and safe. Evaluation of
the Hypoglycemic and Hypolipidemic Effects of an Ethylacetate Fraction of Artocarpus
Heterophyllus (Jak) Leaves in Streptozotocin-Induced Diabetic Rats. Effects of Population Size and
Density on Pollinator Visitation, Pollinator Behavior, and Pollen Tube Abundance in Lupinus
Perennis. These cookies track visitors across websites and collect information to provide customized
ads. Hypoglycemic Activity of a New Carbohydrate Isolated From the Roots of Psacalium Peltatum.
The literature survey showed no report on the antidiabetic activity of isolated compounds. The
involvement of resveratrol can also promote glucose uptake in diabetic rat models ( 190 ). The plant
produced notable antidiabetic and hypoglycemic actions which ascertain the adjuvant use of the
plant along with conventional commercialized drugs ( 115 ). Deutschlander MS. Isolation and
Identification of a Novel Anti-Diabetic Compound From Euclea Undulata Thunb. Rab proteins
(Rab8 and Rab14) lead to GLUT-4 translocation into the cell membrane from intracellular GLUT4
storage vesicle (GSV) which increases glucose internalization up to 10-20 times ( 280, 281 ). Again,
cinnamaldehyde can ameliorate the uptake of glucose by upraising the amount of AKT2 and aortic
nitric oxide synthase 3 (eNOS), insulin receptor substrate1 (IRS1) and p-85 regulatory subunit of
PI3K (PI3K-P85) while concurrently abating the expression of NADPH oxidase 4 (NOX4) which
eventually balance the increased glucose concentration ( 56, 59 ). The chronic hyperglycemic
condition leads to long term damage and failure of target organs. Traditional herbal medicines and
functional foods are believed to ameliorate diabetic syndromes via six notable mechanism of actions
including enhanced insulin secretion and sensitivity, glucose uptake by muscle cells and adipose
tissues and inhibition of glucose absorption from intestine and glucose production from hepatocytes
along with demonstrating anti-inflammatory properties ( 7 ). In the Eastern Cape province of South
Africa, the number of people using medicinal plants for the management of diabetes has been
climbing steadily over the past two decades due to their cultural acceptability, accessibility,
affordability, efficacy, and safety claims. In this study, a review of antidiabetic medicinal plants used
in the Eastern Cape province of South Africa was conducted. Antidiabetic Medicinal Plants Used in
the Eastern Cape Province of South Africa: An Updated Review. Another compound, ?-amyrin-3O-
?-(5-hydroxy) ferulic acid isolated from E. The Effect of Chamomile (Matricaria Recutita L.)
Infusion on Blood Glucose, Lipid Profile and Kidney Function in Type 2 Diabetic Patients: A
Randomized Clinical Trial. Alongside these phytochemicals, concerned researchers should also
evaluate other aforementioned phytochemicals in this review work to establish absolute safety and
toxicity profile as well as the mechanism of antidiabetic actions. TABLE 2. Nigella sativa L. Nigella
sativa L. (family: Ranunculaceae) is a herbaceous plant which occurs in several southern
Mediterranean and Middle Eastern countries. In addition, in six clinical trials, treating type 2 diabetic
patients with curcuminoids ranging from 0.25 g to 1 g per day also ameliorated glycemic control by
decreasing fasting blood glucose, HbA1c, HOMA-IR (insulin resistance) levels and increasing
adiponectin level without causing any major side effects. Protein tyrosine phosphatase 1B (PTP1B)
was also inhibited by valoneic acid dilactone which can also ameliorate the level of blood glucose in
alloxan induced diabetic rat models. The chronic hyperglycaemic status in diabetics yields an
increased risk of complications due to the long-term damage and dysfunction of several organs such
as the eyes, kidneys, heart, and nerves. Available online: (accessed on 16 August 2022). CJM
Grower. Available online: (accessed on 16 August 2022). CABI. Available online: (accessed on 16
August 2022). Plants with reported antidiabetic phytochemicals along with mechanism of actions
have been considered only for the review work. Another clinical trial also showed the efficacy of
berberine as adjuvant therapy in poorly controlled type 2 diabetic patients ( 32 ). These cookies track
visitors across websites and collect information to provide customized ads.
Association Between Microbiota-Dependent Metabolite Trimethylamine-N-Oxide and Type 2
Diabetes. Besides, chicoric acid can exert both insulin-secreting and sensitizing activities ( 53 ). The
reduction of fasting glucose level and improved glucose tolerance referred that it might act following
more than one mechanism ( 49 ). Despite the availability of insulin preparations and several synthetic
oral antidiabetic drugs, there is a crucial need for the discovery and development of novel
antidiabetic drugs because of the development of resistance and side effects of those drugs in long-
term use. Upon oral administration, this moiety upraised serum insulin and liver glycogen level in
normal rat models ( 149 ). Novel compounds with antihyperglycemic potential have to be isolated
from the plant sources. According to 163, 1,5,8-trihydroxy-3- methoxyxanthone extracted from the
aerial parts and roots of the S. Protein tyrosine phosphatase 1B (PTP1B) was also inhibited by
valoneic acid dilactone which can also ameliorate the level of blood glucose in alloxan induced
diabetic rat models. Phytochemical and Pharmacological Properties of Gymnema Sylvestre: An
Important Medicinal Plant. There are many bioactive phytocompounds isolated from M. When
silymarin was supplemented with glibenclamide in type 2 diabetes patients, a reduction in
postprandial hyperglycemia was also observed ( 33 ). Isolation of Antidiabetic Principle From
Bougainvillea Spectabilis Willd (Nyctaginaceae) Stem Bark. Download Free PDF View PDF See
Full PDF Download PDF Loading Preview Sorry, preview is currently unavailable. Chemical Class
Wise Few Most Prominent Antidiabetic Phytochemicals Along With the Reported Mechanism of
Actions Based on previous research studies, few phytochemicals have been already recognized as the
most prominent antidiabetic lead compounds. In traditional medicine, the fresh corms of the plant
are milled, boiled in water and then taken orally to treat diabetes. Polysaccharides From Laminaria
Japonica Show Hypoglycemic and Hypolipidemic Activities in Mice With Experimentally Induced
Diabetes. Note that from the first issue of 2016, this journal uses article numbers instead of page
numbers. The blood sugar-lowering potential of the leaf extract was equivalent to that of the
commercially available drug Tolbutamide in the animal models ( 45, 46 ). So it is not possible to
describe every plant and its isolated bioactive phytochemicals in a single study. In addition, in a
randomized control design trial, promising inhibition in the increment of serum glucose after 2h of
75g oral glucose intake was observed after taking capsules processed with M. Edited by: Alessandro
Leone, University of Milan, Italy Reviewed by: Mohammad H. These MAM contacts are known to
contain several insulin signaling proteins such as AKT kinase, mTORC2, PP2A, and PTEN and thus
participate in insulin signaling. Fruits Aqueous Extract on the Alloxan-Diabetic Wistar Rats. The
chronic hyperglycaemic status in diabetics yields an increased risk of complications due to the long-
term damage and dysfunction of several organs such as the eyes, kidneys, heart, and nerves. Rab
proteins (Rab8 and Rab14) lead to GLUT-4 translocation into the cell membrane from intracellular
GLUT4 storage vesicle (GSV) which increases glucose internalization up to 10-20 times ( 280, 281 ).
Moreover, bassic acid was found to significantly increase the glucose uptake and glycogen synthesis
process in isolated rat diaphragm. Leone A, Bertoli S, Di Lello S, Bassoli A, Ravasenghi S,
Borgonovo G, et al. Nigella Sativa Improves Glycemic Control and Ameliorates Oxidative Stress in
Patients With Type 2 Diabetes Mellitus: Placebo Controlled Participant Blinded Clinical Trial.
SANBI (South African National Biodiversity Institute). We also use third-party cookies that help us
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