Anileridine
Clinical data
AHFS/[Link] Monograph
Routes of Tablets, injection
administration
ATC code N01AH05 (WHO)
Legal status
Legal status AU: S8 (Controlled)
CA: ℞-only
US: Schedule II
Pharmacokinetic data
Protein binding > 95%
Metabolism Hepatic
Identifiers
IUPAC name
CAS Number 144-14-9
PubChem CID 8944
DrugBank DB00913
ChemSpider 8600
UNII 71Q1A3O279
KEGG D02941
ChEBI CHEBI:61203
ChEMBL ChEMBL1201347
E number {{#property:P628}}
ECHA InfoCard {{#property:P2566}}Lua error in
Module:EditAtWikidata at line 36: attempt to
index field 'wikibase' (a nil value).
Chemical and physical data
Formula C22H28N2O2
Molar mass 352.47 g/mol
3D model (JSmol) Interactive image
Melting point 83 °C (181.4 °F)
SMILES
InChI
(what is this?) (verify)
As with other opiates, heroin is used both as a pain-killer and As with other opiates, heroin is used both as
a recreational drug. a pain-killer and a recreational drug.
One of the most common methods of heroin use is One of the most common methods of heroin u
via intravenous injection. When taken orally, heroin undergoes via intravenous injection. When taken orally,
extensive first-pass metabolism via deacetylation, making it heroin undergoes extensive first-pass
a prodrug for the systemic delivery of morphine.[1] When the metabolism via deacetylation, making it
drug is injected, however, it avoids this first-pass effect, very a prodrug for the systemic delivery of morphin
rapidly crossing the blood-brain barrier due to the presence of [1]
When the drug is injected, however, it avoid
the acetyl groups, which render it much more lipid-soluble than first-pass effect, very rapidly crossing the bloo
morphine itself.[2] Once in the brain, it is deacetylated into 3- and brain barrier due to the presence of the acety
6-monoacetylmorphineand morphine, which bind to μ-opioid groups, which render it much more lipid-solub
receptors resulting in intense euphoria with the feeling centered than morphine itself.[2] Once in the brain, it is
in the gut. deacetylated into 3- and 6-
monoacetylmorphineand morphine, which bin
to μ-opioid receptors resulting in intense euph
with the feeling centered in the gut.
As with other opiates, heroin is used both as a pain-killer and a recreational
WikiDoc
drug.
Resources for
One of the most common methods of heroin use is via intravenous injection.
Anileridine
When taken orally, heroin undergoes extensive first-pass metabolism via
deacetylation, making it a prodrug for the systemic delivery of morphine.[1] When
the drug is injected, however, it avoids this first-pass effect, very rapidly
crossing the blood-brain barrier due to the presence of the acetyl groups, which
render it much more lipid-soluble than morphine itself.[2] Once in the brain, it is
deacetylated into 3- and 6-monoacetylmorphineand morphine, which bind to μ-
opioid receptors resulting in intense euphoria with the feeling centered in the
gut.
Articles
Most recent articles
on Anileridine
Most cited articles on
Anileridine
Review articles on
Anileridine
Articles on
Anileridine in N Eng J
Med, Lancet, BMJ
Media
Powerpoint slides on
Anileridine
Images of Anileridine
Photos of Anileridine
Podcasts & MP3s on
Anileridine
Videos on Anileridine
Evidence Based
Medicine
Cochrane
Collaboration on
Anileridine
Bandolier on
Anileridine
TRIP on Anileridine
Clinical Trials
Ongoing Trials on
Anileridine at Clinical
[Link]
Trial results on
Anileridine
Clinical Trials on
Anileridine at Google
Guidelines /
Policies / Govt
US National
Guidelines
Clearinghouse on
Anileridine
NICE Guidance on
Anileridine
NHS PRODIGY
Guidance
FDA on Anileridine
CDC on Anileridine
Books
Books on Anileridine
News
Anileridine in the
news
Be alerted to news on
Anileridine
News trends on
Anileridine
Commentary
Blogs on Anileridine
Definitions
Definitions of
Anileridine
Yummy yummy
stuff this xxx
Patient Resources /
Community
Patient resources on
Anileridine
Discussion groups on
Anileridine
Patient Handouts on
Anileridine
Directions to
Hospitals Treating
Anileridine
Risk calculators and
risk factors for
Anileridine
Healthcare
Provider
Resources
Symptoms of
Anileridine
Causes & Risk
Factors for
Anileridine
Diagnostic studies for
Anileridine
Treatment of
Anileridine
Continuing
Medical Education
(CME)
CME Programs on
Anileridine
International
Anileridine en
Espanol
Anileridine en
Francais
Business
Anileridine in the
Marketplace
Patents on Anileridine
Experimental /
Informatics
List of terms related
to Anileridine
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Anileridine (trade name: Leritine) is a synthetic analgesic drug and is a member of
the piperidine class of analgesic agents developed by Merck & Co. in the 1950s. It differs
from pethidine (meperidine) in that the N-methyl group of meperidine is replaced by an N-
aminophenethyl group, which increases its analgesic activity.
Anileridine is no longer manufactured in the US or Canada.[1]
Administration
As tablets or injection.[2]
Pharmacokinetics
Anileridine usually takes effect within 15 minutes of either oral or intravenous
administration, and lasts 2–3 hours.[3] It is mostly metabolized by the liver.
