Cardiac Markers
•hs-cTnT •Myoglobin •CK-MB •NT-proBNP
•ST2 •Lp-PLA2 •D-Dimer
南BIOTECH
REALMIND 京 仁 迈CO.,LTD
生 物 科 技 [Link]
有 限公司
NANJING REALMIND BIOTECH CO.,LTD.
RealMind cardiac tests are employed in diagnosis, risk stratification, monitoring
disease course, prognosis as well as guiding treatments for cardiovascular
diseases (CVDs). The comprehensive test menu includes the following 4 panels.
All biomarkers support whole blood/serum/plasma test, and are available on
the Realmind MCL60 which is a compact, bench-top, and easy to use fully-auto
chemiluminescence analyzer.
Myocardial Infarction Chest pain
hs-cTnT hs-cTnT
CK-MB D-Dimer
NT
Myoglobin
proBNP
Heart failure Atherosclerosis
NT
ST2 Lp-PLA2
proBNP
Advantage of Assays
Comprehensive menu
Full cardiac test options of screening for myocardial infarction,
chest pain, heart failure and atherosclerosis
510mm
Reliable results
Direct chemiluminescence immunoassay (acridinium ester label)
1 pg/mL hypersensitized test
Repeatability CV≤3%
Easy operation 645mm
Direct loading of original sample tubes 590mm
8 sample positions, 20 reagents positions
Throughput 144T/H, with a footprint <0.35m2
hs-cTnT
High-sensitivity Cardiac Troponin T
There are three main types of cardiac troponin proteins: I, T, and C. Blood test for tropnin T has been
developed to measure the levels of tropnin proteins. The high-sensitivity cardiac troponin test (hs-cTnT)
is more refined and allows for detection of very low levels of troponin T, helping to diagnose heart
attacks more rapidly and accurately.
Myoglobin
Myoglobin
Myoglobin is a sensitive marker of acute myocardial infarction (AMI), as it presents in both skeletal and
cardiac muscle. Any damages to these muscle types result in its release into blood. The levels of myo-
globin is often used in combination with the troponins (hs-cTnT) or CK-MB for diagnosis.
CK-MB
Creatine Kinase MB Isoenzyme
Creatine Phosphokinase enzyme consists of two subunits with greatest activity in muscle in brain
(CK-BB), muscle (CK-MM), and heart (CK-MB). Isoenzyme CK-MB is an important indicator for the
diagnosis of AMI. It is released within 12 hours after symptom onset of acute myocardial infarction
(AMI), peaks in serum at 24–36 hours, and returns to normal in 48–72 hours. The peak time of CK-MB is
usually used as an indicator to assess the severity of AMI.
510mm
NT-proBNP
N-terminal pro-B-type Natriuretic Peptide
It is a hormone secreted primarily by the ventricular myocardium in response to increased wall stress
due to volume expansion and/or pressure overload in heart failure (HF) patients. NT-proBNP levels
correlate with the severity of HF and can be used for HF diagnosis and prognosis. It can also be consid-
ered as an indicator for risk assessment of HF and MI.
ST2
Soluble Growth Stimulation Expressed Gene 2
ST2 is a strong predictor of cardiovascular outcomes in both chronic and acute heart failure (HF). ST2
level is associated with the severity of HF. It can be used to estimate the increased risk of cardiac death,
cardiovascular events and hospitalization. It adds information to other cardiac biomarkers for risk
stratification, therapy guide and prognosis.
Lp-PLA2
Lipoprotein-associated Phospholipase A2
Lp-PLA2 is produced by inflammatory cells and is a highly specific biomarker to predict the presence of
the atherosclerotic plaque and vascular dysfunction. Increased Lp-PLA2 levels have been found in these
plaques and rupture [Link] contributes to improve stratification of patients at the risk and guide
treatment based on risk level.
D-Dimer
D-Dimer
D-Dimer has high negative-predict value for thrombogenesis, offering etiological evidence to rule out
thromboembolic disease. The combined application of hs-cTnT, NT-proBNP and D-dimer is recom-
mended not only for the diagnosis of patients with acute chest pain or breathing difficulties, but can
also be used for risk assessment of critical patients and for treatment decisions.
510mm
Performance of Assay
Performance:
RealMind hs-cTnT vs. Roche Diagnostics hs-cTnT RealMind Whole Blood hs-cTnT vs. RealMind Serum hs-cTnT
Sample: Serum Correlation R²=0.999
Correlation R²=0.995
RealMind ST2 vs. PresageTM ST2
Sample: Serum
Correlation R²=0.989
Assay Specification
hs-cTnT ST2 Myoglobin CK-MB NT-proBNP D-Dimer Lp-PLA2
Principle direct chemiluminescence immunoassay (acridinium ester label)
Sample
serum, plasma, whole blood
type
Sample
50 µL 20 µL 10 µL 10 µL 20 µL 8 µL 10 µL
volume
3.00 0.500 21.00 0.300 5.00 0.030 1.00
Reference ｜ ｜ ｜ ｜ ｜ ｜ ｜
range 10000 400.0 3000 300.0 35000 50.00 1000
ng/L ng/mL ng/mL ng/mL pg/mL mg/L FEU ng/mL
Repeatability CV≤3%
Suzhou
Reference Roche Roche Roche Roche Siemens
PresageTM Evermed
brand Diagnostics Diagnostics Diagnostics Diagnostics Healthineers
Biomedical
Correlation R2 0.995 0.989 0.992 0.997 0.993 0.992 0.971
Nanjing RealMind Biotech Co., Ltd.
3rd floor, Bldg. A6, Maple Science Park, Nanjing Economic and Technological Development Zone,
Nanjing, Jiangsu, 210033 CHINA
Tel: +86-15013529715
Email: sales@[Link]
Web: [Link]
