Breakthrough Science of Functional Genetics - Kashif

Khan
welcome back to the conversation

1:19:05

today my special guest is kosi Khan hi kosf hey good to be here I'm so glad to
have you here let me introduce you to

1:19:11

our audience you're a functional genomics practitioner you're the author of the
DNA way you're a two-time

1:19:16

two-time tedex speaker you are a celebrity longevity coach founder of the DNA
company and in that company

1:19:24

personalizing medicine is really being pioneered through all these insights into
the human genome recently you

1:19:30

launched a community for practitioners and patients you take them on this
one-year healing Journey giving them

1:19:36

easy understanding of their complex biology and also right now you told me
you're developing an AI tool to increase

1:19:42

access to Functional Health Care I mean you're just up to big things and also
before we get started here I just want

1:19:47

our audience to know that kosf is my family's genome DNA functional

1:19:53

practitioner so Works directly with my parents with me with my siblings I mean

1:19:59

this guy is embedded in our family you also are uh you claim that we've
adopted

1:20:06
you which is amazing we love that and you said you know your

1:20:11

Pakistani Grandma you said some joke about your Pakistani grandma and my
mom it's so good so um anyhow we love you we

1:20:19

bring you into our community on a regular basis uh to teach to support to

1:20:25

clear up misunderstandings about DNA and so I'm thrilled to have this talk with
you today we really want to unpack how

1:20:32

DNA is really important uh with the aging process and all the factors that

1:20:39

go with that right so what we can see in somebody's functional DNA we can
really tell a lot about their um about their

1:20:46

sleep about their cognition about their hormones about their Digestive Health
about their cardiovascular health I mean

1:20:52

I just went through a 4H hour meeting with you and my parents digging deep
into their DNA as well so let's talk

1:20:59

about this first thing I would love to know from you well first off what was the
joke about your Pakistani Grandma I

1:21:05

can't remember it was so funny well I actually don't remember

1:21:10

either I just remember that your mom wanted to adopt me I just thought she
my grandma would be offended that's right that's right or no you said you
you're a

1:21:16

you said funny like you're a Pakistani living in French Canada with um with an
adopted American mom like something like

1:21:23
that it was really good so um anyhow let's talk about why this is relevant to this
conversation if

1:21:29

people are trying to live a long time and I know your goal is 120 years um

1:21:35

tell me why would we want to know our DNA well even that number 120 to
start

1:21:40

there it's not arbitrary and random when you actually study the physical
structure of DNA there's these caps on

1:21:47

the end that are called telr and they're meant to protect your DNA from
damage aging is literally the wear and tear

1:21:53

oxidation breakdown of DNA in the cells eventually start to unravel open up

loosen up and your skin sags hair turns

1:22:00

white right and that's the outward expression of that inward breakdown and so
these telr are meant to be like

1:22:05

literal bumpers protecting the DNA so that they don't get that wear and tear
and when you study a telome they are

1:22:12

physically designed to last 120 years so that tells me that our physical being

1:22:18

the 50 trillion cells that we walk around in are all designed to last 120 years so
in as much as we want to add

1:22:24

things and do things it's like what can you remove that's taking years away you
you already have that god-given gift of

1:22:30

like 120 is a number if you do everything and don't do everything wrong that's
the other thing well I would just
1:22:36

say speaking of the god-given gift if you read the Bible a lot of the characters in
The Bible lived to be 110

1:22:43

120 I mean it was common in the stories right it was very common and

1:22:49

there's actual passages in the Bible that say 120 is what you're supposed to
live to right and now if you look at so

1:22:55

you think okay then why do we all not get there well we have the wealthiest
Empire that's ever existed the United

1:23:02

States it's also the sickest and we have a $4.3 trillion Healthcare budget not
because we're healthy but because we're

1:23:08

masking disease literally 90% of that that's the actual number 90% is spent on
chronic disease management things we

1:23:14

don't need to have right so I say all this because if you go to other cultures and
other countries and sort of open up

1:23:21

the vision a little bit there are places like the blue zones for example where
people people do get to 990 95 100 110

1:23:27

100 is considered not good enough right 110 120 is the number and what
they're

1:23:33

doing differently they're not taking a 100 supplements a day like biohackers
you know they're not um listening to a

1:23:40

podcast every single night although all that stuff is great I do that stuff I'm not
saying don't right yeah me too I'm

1:23:46
just saying that that is after after your habits have been aligned to your

1:23:51

natural biology meaning we're not the same right somebody from okanawa has
the same habits of somebody 15 Generations

1:23:59

ago the same food the same environment the same culture which is exactly
what they're wired for and when they stick to

1:24:05

that and keep doing it they're at this homeostatic level where they're not
taking years away right they they get

1:24:12

there not because they did something special to get there but because they
didn't do anything wrong to take it away right now I want to talk a little

1:24:19

bit just as we get into this to clear up some um myths so yeah you know
there's a

1:24:25

difference between functional DNA testing and the kind of DNA testing like

1:24:31

23 and me so maybe you could just talk about that real quick because people
listening right now may be thinking oh I

1:24:37

did 23 in me I can go back and I can figure out functionally what's happening in
my body and we'll get into that next

1:24:43

what we can actually see and it might be kind of fun to actually talk about um

1:24:48

you know some of some of the things you see in My DNA even because I've
done it and we talk about how my brain works and stuff and what you what
what I've

1:24:55

learned about myself to keep myself healthy I'd be a good study on that but
can you talk a little bit about why 23
1:25:02

and me doesn't doesn't make the so I can tell you a story about Thor Chris

1:25:07

Hemsworth and also you're going to be a character in the story I'm adding you
into it you'll find out soon where you

1:25:13

what you're I love Thor he's one of my favorite uh Marvel characters so one of

1:25:18

the things we do so there's you know what what the company does is one thing
what I talk about on online is one thing

1:25:24

but what my sort of day job is I support CEOs pro athletes celebrity type people

1:25:30

on these Functional Health Journeys using their DNA as a driving tool it helps us
make the right decisions so one

1:25:36

of the places where I work is with the Marvel movie sets right so we we've been
literally sitting on MAR Marvel mov popping pills into the star's mouths to

1:25:43

keep them at their best possible because we have their DNA we know what
their body needs and we also know what they what they need to remove so
there was a

1:25:50

show on Netflix called Limitless I think I don't know if you heard of it where
Chris did this mini docu series all

1:25:55

these challenges right yeah um and when that show first was created the
producer

1:26:02

came to us saying we want you to test this DNA and tell us what all we need to
know and tell us how to prevent you know

1:26:08

some Calamity in the future so we worked on it it was all set up and then Co hit
1:26:13

and the production shut down just like all Film Production Chris was in Australia
he said I'm going to shoot it

1:26:20

anyway right I'll get a local Australian crew and I'll start shooting and that's
what he did so they used a basic genetic

1:26:26

test like what you described right uh we weren't able to fly there because of
the lockdowns and the episode is somebody

1:26:34

telling Chris that you have a certain version of the apal eug Gene and you have
a high risk of

1:26:41

Alzheimer's good luck that was literally the prescription and the solution it's

1:26:46

like let's just see and the rest of the episode was Chris looking out like am I
going to see my grandchildren am I going

1:26:51

to recognize my wife like that was the whole show so that's genetics genetics is
apoe3 0% chance of Alzheimer's APO 34

1:27:01

8 to 10 times elevated risk APO 44 17 to 25 times elevated risk and the stress
of

1:27:07

that alone will probably give you Alzheimer's the anxiety right so why does it
cause Alzheimer's well it

1:27:14

doesn't that's where functional thinking comes in functional genetics functional

genetics is what does the APO Gene do it

1:27:22

instructs your body on how to trans support lipids the movement of cholesterol
and so then you start to

1:27:28
reverse engineer well why does that matter well if you have plaque in your
brain amid plaque starts to choke at the

1:27:33

brain cells cause death and eventually cognitive decline if I simplify it right so
why was there plaque in my brain

1:27:41

anywhere that you have inflammation in the body your body will use
cholesterol as a hormone as a tool to go fix the

1:27:48

inflammation it's like a Vaseline that Smooths things out right Y and so if you
have bad lipid transport

1:27:55

then some gets left behind and it's much easier to develop that plaque so the
apoy gene doesn't do the job of removal

1:28:03

which comes from studying people in the disease State Right medical research
is

1:28:08

studying illness not studying they don't study health healthy people and say
why did they not get sick so now the functional answer is why did you have

1:28:15

inflammation in the brain to begin with if I knew that it doesn't matter what
version of the a gene you have that's a

1:28:21

reaction right the cause is the inflammation in the brain well you Laura are
missing a very important Gene called

1:28:28

gstm1 you literally don't have it it's missing from your genetic code and that
Gene is a first line defense protector

1:28:35

for the gut so as you're eating whatever you're eating all that's coming along
with it is meant to be removed peed out

1:28:42
pooped out sweated out you don't do that so if you're not very very diligent at

1:28:47

what you're eating there's going to be gut inflammation leaky gut cross the
blood brain barrier because of those toxins coming out of the gut

1:28:54

causing dementia because of inflammation for some people it's their hormones
and this is why 80% of dementia cases are in

1:29:02

women because women make estrogen metabolites that can cause

inflammation to the brain Y and Men also do but a

1:29:09

tiny fraction in terms of volume and those are two out of five it's also your
stress cortisol the thing

1:29:14

that I actually said the anxiety can cause it that's true if you're in a constant
chronic stress State constant

1:29:20

trauma State fight or flight that alone could be the cause it could also be your
metabolic Health you know where I live

1:29:26

in Canada it's called type three diabetes Alzheimer's because if you're eating
the wrong foods that are not

1:29:32

align to your genetic ability to metabolize them that can cause it so explain
what happens to someone when

1:29:38

they're eating wrong for their genetics and when you talk about like you work
with a lot of actors CEOs you know

1:29:45

athletes if they're going to be on their best you know most productive game
then

1:29:51

eating for your DNA is important we just unpack this one little thing well the
1:29:57

average person who isn't the CEO of a multi-million dollar company or who isn't
you know on film in Hollywood we

1:30:04

want to feel good too we want to master our day we want to be productive we
want to be present for our families we want

1:30:11

to be able to have the energy to go on vacations and enjoy the life that we
work so hard to build so let's talk

1:30:17

about how this is relevant and this particular client of mine once she realized
that oh

1:30:24

I haven't been eating right for my DNA so let's just talk about that for one

1:30:29

second what if your DNA is made to eat a particular type of food and you're not

1:30:35

doing it what happens so in her case she actually didn't make the enzymes that

1:30:41

are required to break those Foods down right and so she might have felt clean

1:30:47

you know because she's eating plants but she would have had a severe uh gut
disbiosis over time and it also would

1:30:54

have affected her hormones so I can't tell you how many women in fact there's
a clinician who's probably on your

1:31:01

summit uh a well-known clinician who's a part of this circuit uh who was two

1:31:06

years into a vegan diet and didn't understand why they felt so horrible we kind
of revers engineered it did you

1:31:12
notice that the day you started feeling bad was about a month after you
started that diet right and for that person it

1:31:17

was more of a lifestyle Choice a moral choice like not wanting to eat animals
okay that's fine we just need to

1:31:23

consider what the reasons are and then build that ideal diet but the same thing
is true for other things like there's a

1:31:29

very famous person that pushes the keto diet which I've used and it helped me
but I don't do it all the time and this

1:31:36

person is probably one of the bigger pioneers of the keto high fat diet and
when I ran their DNA they don't process

1:31:43

fat there's a gene called apoa2 and it they had the worst possible version of

1:31:48

that Gene their insulin response wasn't so good and if your fat genetics aren't
good it will trigger an insulin C just

1:31:54

like sugar does and they felt horrible they were blaming it on mold because
they lived in a moldy home they moved

1:32:01

and they kept doing all these mold detoxes saying I still have no energy I still
feel horrible I still have brain fog I need to get the mold out I need to

1:32:07

get the mold out it was just their diet and they were solving this person is a
world famous author biohacker type

1:32:13

person but without the guidance of understanding your biology of course you
would just lean on what you see which is there's mold in my home absolutely
so

1:32:20
back to the woman that was in that is in my community so you nailed it like

1:32:25

without even knowing her her two biggest problems were she couldn't sleep
and her

1:32:31

hormones were disregulated and no I would say a third thing no matter how
many gut restoring protocols we did with

1:32:37

her and how aggressively we detoxed her everything she kept telling me Laura
I still don't feel better I still don't

1:32:42

feel better I still don't feel better yeah and so this was this was literally life-
changing for her um she you know is

1:32:50

now shifting she still eats plants of course if you don't have that enzyme to
digest the plants is there anything that

1:32:55

people can do can they take a particular digestive enzyme so that they can still
enjoy those Foods yeah this is the same

1:33:02

answer for anything genetic which is here's a job your body is supposed to do
here's a gene that instructs it the gene

1:33:09

isn't instructing it properly so you don't do this job in simple terms right now
you have two choices stop doing that

1:33:15

thing or add something to support the biology so we can handle it exactly or

maybe both right and so in her case we

1:33:22

had to talk to her about the proteins themselves the beans the lentils
chickpeas Etc that first of all

1:33:28
she needed to soak and Sprout them so that the nutrients were more
bioavailable she couldn't just pop a can or buy them raw you know she had to

1:33:34

literally Sprout them first and there's something to be said about what happens
there also adding the right digestive

1:33:40

enzymes to break specifically those types of foods down because her gut
doesn't make them and now she can

1:33:45

continue it's not the ideal scenario you know but again there's other factors
moral choices religious choices other

1:33:52

things people have to consider so there's always kind of a way but there's you
might get 95% of the result but

1:33:57

that's far better than the 10% that she was getting at her status quo right yes

1:34:02

yes absolutely well let's let's unpack some of these other factors that we can
find in DNA that may affect aging we've

1:34:08

just spent time talking about apoe and about Alzheimer's and about how we
can tell how you should eat um there's some

1:34:15

other fascinating information that we find from functional genomics I mean the
brain piece is critical I I love uh I

1:34:22

love every time I'm with you and your teaching about brain and the way that
you teach this is without you know

1:34:28

fixing the brain health first and understanding that first you can't really fix all
the other things so let's

1:34:35
talk a little bit about brain we can use some examples we can use my brain I
mean my DNA explains why I am the way I

1:34:42

am it's it's when I did my moms and dads with you um oh my gosh like every
like I

1:34:49

understand my mother now I understand the way she operates and the way
she

1:34:55

reacts to any scenario and this has helped me as a

1:35:00

daughter have more grace for the way that her brain processes information
and

1:35:06

the way she responds it all makes so much sense now so I mean and for myself

1:35:11

too like oh that's why I do that and then knowing that it makes me a better

1:35:16

wife a better mother a better sister a better uh employer a better provider if

1:35:22

I understand how brain works and I can see the deficits I can shift faster and

1:35:28

I can do something about it so there there's two ends to this everything you
said which is now that I know who I

1:35:35

actually am perception completely changes what you to be what's wrong with

1:35:40

that person is like oh sorry I'm actually going to tone things down right but the
other end of it is you can't

1:35:47

heal anything if your brain is stuck in a fight or flight in a trauma stage if your
nervous system is highly engage and
1:35:54

activated and if you're on Red Alert all the time pop the supplements do the
treatments they're not going to get you to the Finish Line because your body's

1:36:00

not even trying to heal it's in it's in fight or flight and you really can't do fight or
flight and rest and recovery at

1:36:06

the same time you're one and you're on one of the buckets so you got to turn
this off first so you know using you as

1:36:12

an example there's a pathway for serotonin 5httlpr is a pathway and it

1:36:17

determines how efficiently you bind serotonin and what's going on in your
wonderful brain if we talk about your

1:36:22

brain that can fill the entire show by the way because there's a lot going on up
there so with your serotonin

1:36:28

pathway you have less ability to bind enough serotonin to be able to react

1:36:34

appropriately for whatever stimulus is coming in now is that good or bad

depends what you're doing with it in the

1:36:40

context of everything is irritating annoying me it could be bad in the context of

I'm a practitioner and I

1:36:47

don't miss a bead like every little thing get I get I catch right so why you're
because you don't have enough

1:36:53

serotonin in your brain because you're not binding it properly you can't filter
stimulus you can't prioritize so you're

1:37:01
seeing and hearing everything that's true for you as a giver and provider but
it's also true

1:37:07

for somebody who is a patient that something is lingering something can't

1:37:13

get fixed there's stacking of like first I had this pain now my hair is falling out
now I have a bunion on my left foot

1:37:18

and I don't know what's going on with my body because the the brain actually
doesn't know what's happening it's relying on your thoughts and if your

1:37:24

serotonin is driving you to think about far too much at a much higher level of
detail than you need to you're going to manifest those things that don't need to

1:37:30

be manifested or you'll take a two out of 10 problem and turn it into an eight
out of 10 right incredible superpower

1:37:37

when you're getting to work and have the leadership and drive a bit of a
burden if you don't understand that what you

1:37:43

think is happening is an exaggerated version of the truth right yes I mean the
first time

1:37:50

that you explained this to me so much made sense I'm a highly analytical
person I've done so much

1:37:56

self-development and you know transformational leadership work and when

you divide people into personality

1:38:01

Styles I'm always the analyzer perfectionist bit of a controller like all of that and
um and it's served me

1:38:09
very well in my career because you know somebody who does that you can
really

1:38:14

count on them to pay close attention and also it makes it hard when I'm doing
like a fun project or something and and

1:38:21

it has to be perfect like that's when it doesn't works so well so it was really
fascinating to learn so what do I do about it now let's talk about that so

1:38:28

once you find out that you don't that you don't that you don't have enough of
this serotonin or you don't process it

1:38:34

well there's a solution yeah so first we look at an additional pathway that

1:38:39

drives your tryptophane tryptophane is a precursor to serotonin so question

one how much do I bind not so much for you

1:38:47

question two is how much do I make I think you were okay there so when we
find people that don't make enough tryptophane it exaggerates what I just

1:38:54

described and it creates a bit of a negative filter which I think your mom had if
you remember exactly exactly so

1:39:00

you were explaining that my mom has an emotional experience uh again and
again and again that's height that's

1:39:07

heightened when something when she goes through something uncomfortable

or she has a memory of something bad when it

1:39:14

comes up again it's it's like it's happening all over again yeah so she binds
trauma more aggressively than the

1:39:21
body needs to yeah and that's different pathway adrenaline but it ties into what
we're talking about so adrenaline drives

1:39:28

in that adrenal deed moment the wow factor God forbid a car accident or
something like that adrenaline is

1:39:34

pumping there's a rush right so do you remember the information or do you

remember the feeling or both and some

1:39:39

people do like your mom imprint the feeling so the next time something like
that is happening again she's

1:39:45

experiencing trauma which is the feeling came back and she thinks it's a
continuation like Laura why are you

1:39:50

doing this again and Laura's this has nothing to do with that what are you
talking about I don't know why you keep bringing this stuff up and the friction

1:39:57

that that could potentially create right yeah and her tryptophane pathway
because it's so extremely

1:40:02

disregulated whatever is new she's coming at it looking for problems she is

1:40:08

always and this is why she was so incredible in her career emergency room
nurse because she would walk into the room quickly assess and just find what

1:40:14

was wrong and know exactly what to tell the doctor go do this yes right so now

1:40:20

in a different context helicopter mom that kid get frustrated by right because
always looking for problems always

1:40:26

protecting overprotecting she was very overprotective yes it was a lot of

conflict when I was you know 16 to 18
1:40:34

for sure yeah and then you with your serotonin getting irritated and annoyed
by her over protection and just like

1:40:39

Clash of the Titans type of thing going on right so you know so now knowing
this stuff what she thought was misbehavior

1:40:47

and what you thought was Mom's overdoing it again is just how you're wired
and now if you know it you harness it and

1:40:54

use it as a tool when you want to need to and then you slow it down by
acknowledging and this is honestly half

1:41:00

the story when people go through this and they find out who they are half of
that friction goes away because they now

1:41:06

see it differently they're like oh I get why this person speaks like this or how
why I'm reacting like this it's not

1:41:11

actually as bad as I think right right so I mean it's it's amazing to have that

1:41:17

knowledge I want to make sure we have enough time to talk about so obviously
brain is critical if you're in constant fight or flight and your brain is

1:41:23

thinking that it's constantly putting out a fire you can't heal so you got to work
on your brain and and understand

1:41:29

your genetics your functional genomics to actually um to actually solve that so

1:41:34

for me just to wrap this up really quick it's tryp toan what else yeah so for you
tryptophane

1:41:40
5htp and I think it's actually working on the nervous system so not everything
is a supplement there's some things you

1:41:45

need to do that are work and so literally releasing an unwinding trauma so your
brain when it comes to trauma

1:41:54

uh anxiety those negative feelings the part of your brain that processes that

1:41:59

is the exact part of your brain that processes gratitude and forgiveness so if
you can take that thing that feels

1:42:05

like trauma and in your mind speak to it forgive it release it have gr find the
value in it and start to see it as

1:42:12

gratitude you can't literally do trauma or anxiety at the same time and so
there's work to be done through breath

1:42:18

work etc then there's devices like stimulating your Vagas nerve there's things
you can do with fre

1:42:23

so there's a lot of answers uh and the the amazing news here is like on this
event people are going to hear so many

1:42:30

incredible things they can do all I'm saying is take them all they're all great
yeah but which one is for you

1:42:36

what's what's your actual problem and what's the actual tool you need to solve
it as opposed to all the trial and error

1:42:41

exactly exactly and by the way I do own a Vegas stimulator I own frequency
devices all the things to help me get

1:42:48
into parasympathetic because I know that that's a thing for me um okay I want
to make sure we cover another couple more

1:42:54

really important topics I want to talk about hormones um and what we learn
about hormones and also uh sleep so a

1:43:01

lot of people have tried everything to sleep including hormones which is not
you know a lot of times we know that

1:43:07

well maybe it's low progesterone right let's get your progesterone you know
replaced and then you can sleep but that

1:43:12

doesn't work sometimes for people um so for

1:43:17

me um there was some really interesting information in my genetics and one of

1:43:23

the things that I did after talking to you was I started sleeping under a 25
pound blanket even in the middle of

1:43:30

summer and when I was in Europe I was living and working in Europe um few
months ago and I didn't have it with me

1:43:37

so I'm here like in airbnbs and hotels you know what I do I take all the pillows in
the house or the hotel and I

1:43:43

and I pile them on top of me so I have some weight yeah so sleep I mean you
we can

1:43:49

see some reasons why you can't sleep we can also see some pretty important
things about hormones so let's talk about those yeah so it's it's very easy

1:43:56

to get into the root cause as opposed to I can't sleep that's too general of an
answer and again you get stuck in trial
1:44:02

and error so let's figure out what the actual problem is so with you uh your
problem isn't I can't fall asleep it's I

1:44:08

can't stay asleep so somewhere 2 3:00 a.m. in the night it's like I wake up
brain's active what's going on here so

1:44:15

single genes don't have single meanings and purposes and this is why the
research we did I think is exactly what

1:44:21

the world needed because we didn't research d in a lab I spent 3 years with
7,000 people actually helping them to

1:44:27

figure out how we apply it so we took what was already academically and
scientifically known and then actually

1:44:33

got people to the finish line so we learn those subtle nuances for example this
serotonin Gene that we just talked

1:44:38

about is only spoken of as a neurochemical for the brain but it also affects your
sleep but it's not

1:44:43

considered a sleep Gene it isn't what it's doing is there's kind of two halves to
sleep the first half which is

1:44:49

recovery so detox lymphatic drainage getting rid of everything that happened

the day before then there's the second

1:44:55

half which is more prep which is preparing for the next day making your
hormones making your neurochemicals that all happens here and the first half
is

1:45:01

usually a lot deeper the second half is more REM and a lighter sleep now in this
second half your brain knows that it's
1:45:08

supposed to wake up at some point and it knows in that first half it isn't right so
in between the two you wake up then

1:45:14

you go back to sleep and at some point sunlight is supposed to pierce through
your eyelid and it creates a peachy

1:45:20

color and that's actually the signal for your brain to start binding serotonin and
then serotonin wakes you

1:45:27

up you start responding to stimulus and then eventually make cortisol and
you're on your feet and you're gone because you

1:45:33

can't prioritize incoming stimulus your brain which is supposed to be waiting for
sunlight is responding to everything

1:45:40

which is it's too hot it's too cold the blanket is on my neck the Blanket's now

1:45:45

up on my ear I don't like it there's a noise three blocks down the street right all
these things that other people can

1:45:51

sleep through your brain is constant checking in is it time to wake up no is it

time to wake up no dreaming awake

1:45:56

dreaming awake right so your nervous system needs to be told that it's okay

1:46:02

to sleep and that's why the weighted blanket gives you that sensation because
now if you have you have to one thing

1:46:09

contextually our DNA hasn't changed for 250,000 years same wiring same
genetics

1:46:15
just different versions that keep getting passed on but there's been no
Evolution or change and what that tells you is the vast majority of our wiring

1:46:23

is assuming that it's supposed to support us in the caveman context right it's
not meant to support

1:46:30

us in this context this current context so why does that matter because you
were

1:46:35

wired to sit at the front of the cave and listen for the bear stepping on a twig
and protect the tribe yep sometimes

1:46:41

you were allowed to sleep which meant you were in the back of the cave in the
pitch black with a weighted fur on you and the nervous system is still waiting

1:46:48

for that signal so and there's there's more like we can go deep into sleep for a
W but

1:46:53

there's so many things you can do that are solving the actual problem as
opposed to trying to mask sleep with a

1:46:58

pill y I mean it's helped immensely can you explain why a weighted blanket
works why why does that help because now

1:47:05

you've got blanket all over you yeah so the nervous system is literally feeling

1:47:10

The Sensation that it would have felt when you were a cave woman on the
nights where you were allowed to sleep which was a heavy weight of fur and
you're not

1:47:16

using a fur anymore using a blanket so it's that coddling that tells your nervous
system that things are safe

1:47:22
right um then you know Cooling and making sure you're cool it's zero light
leakage zero noise but also there are

1:47:29

things you can do to supplement so that the tryptophane and the 5hdp you
talked about earlier if you were to add those

1:47:34

prior to sleep you're going to have a higher level of those chemicals to be able
to ignore the stimulus also exactly

1:47:41

exactly okay let's talk about hormones because I also found out that I don't
clear uh estrogen very well and um and

1:47:50

when we think about you know risk of t too much estrogen in the body we think
of breast cancer for example so let's

1:47:57

talk about these hormones and Pathways I mean this is just one hormone right
but um yeah that was that was relevant for

1:48:03

me so when it comes to hormones this is the one area where I think genetics is

1:48:08

underserved everybody because if you go by that Gene by Gene interpretation

I was like when we were talking about

1:48:14

Alzheimer's and a e it doesn't work because if you don't map the whole
Cascade step one till whatever you don't

1:48:21

have a real n answer and this is also why Health Care fails women because

1:48:27

health care is all researched on men who don't have a menstrual cycle and so
the the context is different where you have

1:48:33

several stages from the folicular to the Leal phases the different things are
happening with your hormones so some
1:48:39

women and if we have the DNA we can predict if you're too estrogen dominant
you're making too much if you're more

1:48:45

Androgen dominant you're not making enough uh and more importantly if a

woman like you for

1:48:51

example was deciding whether or not to go on hormone replacement therapy

right

1:48:57

now when you go to a clinician to add bhrt which so many women listening
here probably are considering or already

1:49:03

potentially doing your body takes the estral which is the majority of what

1:49:08

clinicians prescribe for good reason it's very potent and it does a good job there
is a gene called sip

1:49:14

1b1 that is responsible to take estr and convert it into something called for

1:49:20

hydroxy estrogen for hydroxy estrogen is inflammatory in nature and it loves to

1:49:27

live in breast tissue that's where it goes right that's where vacation so if

1:49:32

you take a woman who is estrogen dominant the zp 19 A1 Gene takes

testosterone and aromatizes it into

1:49:38

estrogen she may have a rapid version of that Gene making too much and that
same woman might have a fast sip 1b1 Gene

1:49:44

making too much for hydroxy estrogen which is now the net result and then
you add at the top of the funnel more estral
1:49:51

the net result isn't more estrad it's a gene taking that estr and turning it into
the inflammatory insult and you

1:49:57

wonder why you know in February I did this breast cancer group with a whole
bunch of women that had reoccurring

1:50:03

second third bels and an oncologist asked me to work with them to figure out
why what what was the cause and so many

1:50:09

of them it was the hormones they were taking which were meant to be
protective now I'm not saying don't take hormones

1:50:15

I'm just saying shooting in the dark you can hurt yourself personalization
there's no risk if you do it the way

1:50:20

your genes want you to do it often you don't even need to add something you
just need to slow down the leakage like

1:50:27

for example that you have as opposed to adding more stop the gene that's
taking it and turning it into something else

1:50:32

and just have more free flowing hormone that you want right so there's easier
cleaner simpler ways to intervene

1:50:38

absolutely so now I use various herbs to help clear hormones from my body
and I

1:50:45

do take bioidentical hormones mostly estriol there's a little bit of estradiol and I
um I work towards

1:50:52

clearing that out of my body every single day yeah and that's the so there are
there is a solution it goes back to
1:50:58

what you asked me earlier it's remove the thing you can't handle or add
something to help you handle it ideally

1:51:04

a little bit of both and that's exactly what you did now you can benefit from the
hormones without hurting yourself

1:51:10

yeah uh now there's obviously so much we haven't had time to touch on I

mean I

1:51:15

found out that I have the what I call the trifecta of aful for vitamin D

1:51:20

there's three Pathways I basically suck at all three so I found out how I need to
take vitamin D and I need to take it

1:51:27

differently than most practitioners recommend so now I'm Shifting the way I do
that I found out that in my

1:51:33

cardiovascular health my endothelium the genetics for my endothelium is

terrible

1:51:39

and so now I take support supplements to keep my endothelium the lining of

my

1:51:44

vessels healthy because I'm one of those people that would be high- risk for
cardiovascular event based on my

1:51:50

genetics I mean it was it was it's literally life-changing to know this

1:51:56

information in terms of prevention right so here I am 51 years old looking

1:52:01

towards the rest of my life thinking I want to stop aging right here I don't want
to go any further right I mean
1:52:08

obviously I'm going to get older but but I don't want to feel any different than I
do now in fact I want to feel even

1:52:14

better than I do now um so let's let's wrap this up with with aging so we

1:52:21

started this with the human body is engineered to live to

1:52:26

120 yeah so what would you say to our audience about achieving that goal no

1:52:33

matter where they're at in their current um health status right A lot of people

1:52:39

who are watching this right now are probably thinking gosh you know I've got
I've collected some health problems I've

1:52:45

got some issues and I don't know if I can you know reverse this mhm so what

1:52:52

would you say if it's a chronic issue that you weren't born with there's no

1:52:57

reason to have it that's lifestyle environment nutrition that caused it no

1:53:02

fault of your own because what we are told is go do whatever you want and
when you break something it's a doctor's problem they're supposed to fix you

1:53:09

right as opposed to why do you need a doctor something got caused so unless
you broke an arm you shouldn't need to

1:53:15

call a clinician what you should do is understand that everything you eat

1:53:21

everything you breathe everywhere you talk to is a choice between advancing

your age or slowing your aging down and
1:53:28

I know this because I've done it when I was 38 um my biological age was tested
as

1:53:34

43 so I was 5 years older than myself and this is when I started my journey of
even learning what Functional Health was

1:53:41

right I'm now 44 and my biological age is 33 so I not only stopped that rapid

1:53:48

progression I not only got those 5 years back I added and additional 10 years
and

1:53:54

so that's the potential and you know and guys like Mark Heyman and Dave
aspe are saying they're they're pushing harder

1:54:00

they're trying to get into their 20s biologically right so having said that you
don't need to have aggressive goals I'm not trying to live forever I'm just

1:54:06

trying to make sure my habits are always the right choice I'm I have to choose

1:54:12

every day what to eat who to talk to why don't I just always make the right
choice and if I tell you what those things

1:54:17

are the biggest ones and the sort of the order to go in it's usually nervous

1:54:22

system first irrespective of what you're dealing with because if you're dealing
with something you know your nervous system is engaged and in today's
reality

1:54:30

going through years of uncertainty with the mega virus and then inflation and
then economy and then politics and we

1:54:37
are all overburdened with tension and potentially trauma depending on your
DNA

1:54:42

so nervous system first get the terrain ready to do what you even want to do
next it's typically the gut you know

1:54:49

again given the reality of how we eat and what we're surrounded by and what's
on our food if you haven't been super

1:54:54

super careful all your life which most of us haven't until recently when we
started trying your gut probably need

1:55:00

some repair and you know Dr gundry is famous for saying that he is one of the

1:55:05

few cardiologists I would think even the only cardiologist that has done a gut
test for every single one of his

1:55:11

patients Cardiology Alzheimer's diabetes and he said not a single one not even

1:55:16

one did not have a broken gut which tells you how tight it is to chronic disease
after these two things are done

1:55:23

then it's everything else why you here what what do you need right what's
broken what what hurts then you start

1:55:28

working on that stuff and this stuff doesn't start with what are the 120
supplements I take like a biohacker it

1:55:35

starts with putting the fire out let's calm it down right it starts with opening up
Pathways what you're so good

1:55:40

at right and then that progression of it took you 50 years to get here let's
spend a year reversing it right that's
1:55:47

true Functional Health like any good functional medicine practitioner will tell
you it's a two-year Journey I guess

1:55:52

all I'm saying is if we know exactly what to prioritize and focus on two years
can become 8 months to a year

1:55:59

because now we're not fixing the wrong problems uh now one more thought in
terms of what are the threats EMF is one

1:56:06

that we don't think about you know constant trickle of inflammatory insult
ubiquitous no matter where you are is

1:56:11

hitting you even if you turn your Wi-Fi off your neighbor's Wi-Fi is still on so
protecting yourself from that the other

1:56:17

thing think people don't think about is inhalation based toxins so depending
where you live

1:56:22

there was a study that came out of a Dutch University about a month ago
saying that indoor air quality in North

1:56:30

American Homes is now four to five times worse outdoor air quality so we used
to go outside or we used to come inside

1:56:37

sorry to escape the pollution depending where you live now it's worse because
of all the fragrances chemicals dry cleaning trapped in this drywall box

1:56:43

that doesn't Breathe Right third hormone disruption again you go out into a

1:56:49

hormone disrupting soup every day not knowing how many things that you're
touching

1:56:54
breathing amongst are causing your estrogen receptors to be blocked too much
estrogen causing inflammation now

1:57:01

because they can't achieve uh docking into a station so these are three big
ones I could go on and on and on and on

1:57:07

but even if you focus on these three for now and focus on the sequence I talked
about uh life can change absolutely this

1:57:14

is a message of Hope um and you know I think our audience right now who's
still

1:57:20

listening is sitting on the edge of their seat wanting to know more learn more
we could go for hours right yeah we

1:57:26

could s we could seriously just dig into my own personal DNA for for four hours
but um let's let's uh let our audience

1:57:34

know where they can find you kosif where are you at how can people get a hold
of you how can people learn more from you

1:57:41

sure so I actually don't run my company anymore very intentionally you know
my intention is to do this teach educate

1:57:48

speak let the world know that there's more they need to know and partner with
with people that are on the same Mission

1:57:53

like yourself and put the science together right as opposed to this is mine I
want to keep it it's like how do

1:58:00

we put it all together and make it better for everybody that's my mission right
now so uh my personal website is

1:58:06
the same as my Instagram cashon official so k a KH ha an official um and I
would

1:58:13

also say you know if you're subscribe to my email newsletter you'll learn the
types of things that we're talking about

1:58:20

here right and we can share all that stuff with you but if you want to find me
Instagram my website um and I and as

1:58:28

much as all the insights we've been talking about today people are like how do
I get this it's hard for me to work with everybody but depending on what the

1:58:35

need is I probably know who can solve the problem absolutely there and and
also

1:58:40

you're training practitioners to be able to do the work that you do because

clearly there's not enough you to go around in the

1:58:46

world so thank you for you know I I just can't acknowledge you enough for your
contribution to humanity

1:58:52

really I mean I know you on a personal level you are the most humble person
you work with all these really high levels

1:59:00

you know people celebrities athletes CEOs I mean I wouldn't be surprised if

1:59:05

you've got an in to the President right so so so I just want to thank you

1:59:12

because you're just you just have a heart to heal and help and love people I've
never seen you you know I don't see

1:59:20

that you that this is going to your head is what I'm saying I'm saying like you're
really important in the world and
1:59:25

you just act like a normal guy and that is something and so I want to
acknowledge you and for just the work

1:59:31

that you're doing you're constantly trying to create something else to help
people it's almost like you're this like

1:59:39

Bor scientist like okay I I I did that I I solved that problem I got to go solve

1:59:44

another one now so that comes from my broken brain DNA can't St yeah so you

1:59:50

know why you do that it's because of your DNA like you'll never be satisfied
you know you're going to be inventing and creating for the rest of your life

1:59:56

so thank goodness so thank you this has been wonderful as always I appreciate
all the

2:00:02

wisdom that you're pouring into our audience and giving people hope to really
create ageless energy right to

2:00:10

create this this longevity and to feel good so thank you so much Ki and you

2:00:16

enjoy the rest of your day bye now pleasure thank you this was awesome