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Medication adherence BOOK
Book · December 2023
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2 authors:
Andrew Boris Zimenkovsky Myroslava Sekh
Danylo Halytsky Lviv National Medical University Danylo Halytsky Lviv National Medical University
86 PUBLICATIONS 158 CITATIONS 31 PUBLICATIONS 8 CITATIONS
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CONTENT
Abbreviations ……………………………………………. 7
Glossary ……………………………….………………..... 9
Introduction ……………………………………………... 19
References ………………………………………………... 22
CHAPTER 1 PATIENTS DRUG BEHAVIOR MODELS ………….. 24
1.1. Compliance and non-compliance …….…………………... 24
1.2. Adherence and non-adherence …………………………… 26
1.3. Persistence and non-persistence …………………………. 31
1.4. Mixed models of drug behavior ………………………..... 34
1.5. Sciences that study drug-related behavior………………… 38
Questions for self-control ………………………………… 40
References …………………………………...................... 41
CHAPTER 2 THE CONCEPT OF DRUG PSYCHOLOGY ………... 44
Questions for self-control ………………………………… 50
References ………………………………………………... 50
CHAPTER 3 TAXONOMY OF MEDICATION ADHERENCE …… 52
3.1. Phases of medication adherence ………………………….. 52
3.2. Management of medication adherence …………………… 57
Questions for self-control ………………………………… 60
References ………………………………………………... 61
CHAPTER 4 EPIDEMIOLOGY AND CONSEQUENCES OF NON-
ADHERENCE …………………………………………... 62
4.1. Non-adherence statistics in the world ……………………. 62
4.2. Non-adherence economic and clinical consequences ……. 66
Questions for self-control ………………………………. 74
References ……………………………………………… 74
CHAPTER 5 MEDICATION ADHERENCE BARRIERS ………….. 77
5.1. Types of non-adherence ………………………………….. 77
5.2. Classification of factors affecting medication adherence ... 79
5.3. Potential non-adherence indicators ………………………. 88
Questions for self-control ………………………………… 91
References …………………………………....................... 92
CHAPTER 6 METHODS OF MEASURING MEDICATION
ADHERENCE ……………............................................... 96
6.1. Measuring medication adherence ………………………… 96
6.2. Direct methods …………………………………………… 101
6.2.1. Directly observed therapy ………………………………... 101
6.2.2. Biochemical monitoring & biological markers…………… 103
6.2.3. Digital tablet ……………………………………………… 105
6.3. Indirect objective methods ……………….......................... 107
6.3.1. Medication Possession Ratio and the Proportion of days
covered …………………………………………………… 107
6.3.2. Electronic adherence monitoring ………………………… 114
6.4. Indirect subjective methods ………………………………. 116
6.4.1. Questionnaire and self-report questionnaires …………….. 117
6.4.2. Adherence diaries ……………………………………….... 126
Questions for self-control ………………………………… 131
References …………………………………....................... 132
CHAPTER 7 INSTRUMENTS OF INFLUENCE ON
MEDICATION ADHERENCE ………………………... 136
7.1. Classification of interventions to increase medication
adherence …………………………………………………. 136
7.2. Behavioral interventions …………………………………. 139
7.3. Cognitive and educational interventions …………………. 143
7.4. Technical interventions …………………………………... 151
7.5. Reward-based interventions ……………………………… 153
7.6. Complex interventions …………………………………… 154
Questions for self-control ………………………………… 163
References …………………………………....................... 163
CHAPTER 8 INNOVATIVE DRUG DELIVERY SYSTEMS &
MEDICATION ADHERENCE ………………………... 168
8.1. Evolution of drug delivery systems ………………………. 169
8.2. Characteristics of drug delivery systems ………………..... 174
8.3. Ways to improve medication adherence using drug
delivery systems ……………………….............................. 177
8.4. The influence of drug delivery systems on medication
adherence in various diseases …………………...………... 183
Questions for self-control …………………………...……. 192
References …………………………………………….….. 193
CHAPTER 9 DIGITAL MEDICINE ROLE IN PATIENT
MEDICATION ADHERENCE 198
Questions for self-control ……………………………….. 213
References ……………………………………………….. 213
APPENDIX 1 Questionnaires & self-report questionnaires …………….. 217
APPENDIX 2 Tools to assess self-administer medication ability……….. 222
APPENDIX 3 Medication adherence: algorithm for practicing doctors … 234
APPENDIX 4 Medication adherence: Strategies for Health Care
Managers …………………………………………………. 236
APPENDIX 5 Comparison of traditional dosage forms & drug delivery
systems with the same active pharmaceutical ingredient…. 238
APPENDIX 6 Review of digital technologies for monitoring medication
adherence ……………………………................................. 247
USEFUL RESOURCES
Video resources for patient medication adherence
improving ………………………………………………… 270
Educational resources for patient medication adherence
improving ………………………………………………… 272
Educational resources for supporting clinical decision 275
making
Digital medicine & medication adherence (mobile health –
mHealth) ……… 277
NOTES 279
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