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Properties and Mechanisms of Skeletal Muscle

The document outlines various topics related to muscle physiology, including the neuromuscular junction, excitation-contraction coupling, and differences between muscle types. It also covers pathophysiological conditions like myasthenia gravis, the components of the sarcotubular system, and the roles of ATP and calcium in muscle contraction. Additionally, it discusses muscle contraction mechanisms, the significance of motor units, and the importance of regulatory proteins.

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manojj2022
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67 views1 page

Properties and Mechanisms of Skeletal Muscle

The document outlines various topics related to muscle physiology, including the neuromuscular junction, excitation-contraction coupling, and differences between muscle types. It also covers pathophysiological conditions like myasthenia gravis, the components of the sarcotubular system, and the roles of ATP and calcium in muscle contraction. Additionally, it discusses muscle contraction mechanisms, the significance of motor units, and the importance of regulatory proteins.

Uploaded by

manojj2022
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd

1

MUSCLE PHYSIOLOGY
10 marks

1. Draw a labeled diagram of the neuromuscular junction and explain how an impulse is
transmitted across it. Add a note on the drugs that influence the transmission
2. Explain with suitable diagram the mechanism of excitation- contraction coupling in skeletal
muscle. Explain the molecular basis of skeletal muscle contraction or describe the mechanism
of sliding theory of muscle contraction.

5 marks

1. List out the differences between smooth & skeletal muscle


2. With suitable diagram, explain the effect of muscle length on force of contraction Or on the
basis of sliding filament hypothesis, explain the length tension relationship in skeletal muscle
Or draw a labeled length-tension curve and explain the importance of initial length in skeletal
muscle contraction
3. What is ‘myasthenia gravis’ and ‘Lambert Eaton syndrome’. Explain the pathophysiology of
‘myasthenia gravis’ along with its treatment.
4. Explain the components of sarcotubular system in skeletal muscle. How is it different in
cardiac and smooth muscle?
5. What are the functions of ATP in muscle contraction and relaxation
6. What are the different types of smooth muscle? Give two examples for each. Mention three
important properties of the smooth muscle.
7. Explain the mechanism of smooth muscle contraction

3 marks

1. What is sarcomere? Draw an illustrative diagram of sarcomere


2 Draw the electron microscopic structure of a skeletal muscle fiber
3. What is latch mechanism? W hat is the importance of this mechanism in smooth muscle
contraction?
4. What is plasticity of smooth muscle?
5. Describe the role of calcium in smooth muscle contraction
6. Explain the mechanism of Treppe or staircase phenomenon in the skeletal muscle
7. Explain the Heat production of the skeletal muscles
8. Explain why calcium is necessary for muscle contraction
9. Explain the role of Troponin & Tropomyosin in modulating muscle contraction
10. Define motor unit. Explain briefly the significance of motor unit size Or compare the
motor unit of muscles of skilled & gross movements
11. What is the function of calmodulin? Why is this function important? Or describe the role of
Ca++ in smooth muscle contraction
12. How do you differentiate isometric & isotonic muscle contraction with one example for each?
13. What is the importance of destruction of the released acetylcholine by aetylcholinestrase?
14. Name the regulatory and contractile proteins and their functions in skeletal muscle.
15. Define oxygen debt mechanism and give its functions

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