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T.E.S.T Toxicity: Presented By: Nahal Aya Presented By: Zineb Hafdallah Directed By: DR - Yahyaoui

The document presents the Toxicity Estimation Software Tool (T.E.S.T), a computational model designed to predict the toxicity of chemicals based on their properties. It outlines the methodology for using the software, including inputting chemical structures and selecting toxicity models, and highlights its applications in regulatory risk assessment, drug development, and environmental monitoring. T.E.S.T aims to reduce animal testing and enhance safety assessments across various industries.

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zinebhfd26
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16 views10 pages

T.E.S.T Toxicity: Presented By: Nahal Aya Presented By: Zineb Hafdallah Directed By: DR - Yahyaoui

The document presents the Toxicity Estimation Software Tool (T.E.S.T), a computational model designed to predict the toxicity of chemicals based on their properties. It outlines the methodology for using the software, including inputting chemical structures and selecting toxicity models, and highlights its applications in regulatory risk assessment, drug development, and environmental monitoring. T.E.S.T aims to reduce animal testing and enhance safety assessments across various industries.

Uploaded by

zinebhfd26
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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République Algérienne Démocratique Et Populaire

Ministère de l'enseignement Supérieure et de La Recherche Scientifique


Université Cheikh Larbi Tebessi -Tébessa
Faculté des sciences exactes de la nature et de la vie
Département des sciences de la nature et de la vie
M2 Pharmaco-toxicologie
Module: bioinformatic

Presented by:
Presented by: Zineb Hafdallah
Directed by:
Nahal Aya
Dr.yahyaoui

T.E.S.T
TOXICITY
WORK PLAN

T.E.S.T
3
METHODOLOGY
INTRODUCTION 1

T.E.S.T

DEFINITION 2

4 APPLICATION
5

CONCLUSION
2
INTRODUCTION

Hazardous chemicals present in the


environment create a need for
understanding the risk of exposure to
living things. EPA’s Office of Research
and Development is creating tools that
make toxicity estimation accessible.
TEST uses New Approach Methods for
toxicity estimation.
3 3
DEFINITION

T.E.S.T. stands for Toxicity Estimation Software Tool.


It's a computational model designed to predict the
potential toxicity of chemicals based on their
physicochemical properties. By inputting data
about a chemical's structure and properties

Download Site
https://clowder.edap-
4
cluster.com/datasets/61147fefe4b0856fdc65639b#folderId=6352a8a6e4b04f6bb13cec84
T.E.S.T METHODOLOGY
Step 2: Input Chemical Step 3: Select the Toxicity
Step 1: Launch the Software
Structure Models
Open TEST on your computer. Option 1: Draw the Structure: •Choose the desired endpoints
The main interface will display Use the built-in chemical to estimate toxicity (LD50,
options for entering chemical structure editor to manually mutagenicity, carcinogenicity,
information and selecting draw the chemical. etc.).
toxicity models. Option 2: Import a structure •TEST provides several models:
file (e.g., SDF, MOL format). QSAR, Hierarchical, FDA, etc.
Choose one based on your
needs.

5
T.E.S.T METHODOLOGY
Step 4: Run the Prediction Step 5: View the Results

•Click on the “calculate" or •Once the computation is done, TEST will display the
"Predict" button to estimate predicted toxicity values.
the toxicity of the compound. •You can export these results or save them in different
•TEST will process the chemical formats
structure using the selected
model(s).

6
APPLICATION

Regulatory Risk Assessment: Predicts chemical


toxicity for regulatory compliance and environmental
safety.

Drug Development: Estimates toxicity of drug


candidates, aiding in early safety assessments.

Chemical Manufacturing: Helps ensure product


safety and compliance by predicting potential toxic
effects.

7
APPLICATION

Academic Research: Used in predictive toxicology


and environmental chemistry studies.

Environmental Monitoring: Screens pollutants and


assesses environmental impact.

Cosmetic & Personal Care: Evaluates the safety of


cosmetic ingredients

8
CONCLUSION

TEST is a valuable tool for predicting the toxicity of chemicals


across various industries. It helps reduce reliance on animal
testing, speeds up safety assessments, and aids in regulatory
compliance. By applying computational models, TEST enables
users to estimate the potential health and environmental risks
associated with chemicals, facilitating safer product
development and environmental protection. Its broad
applications from pharmaceuticals to environmental science
make it a key resource in modern toxicology.

9
THANK YOU

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