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Contents vii
11.14 Sources of Epidemiologic Data. . . . . . . . . . . . . 238 14.4 Example of an Ecological Study. . . . . . . . . . . . 292
11.15 Healthcare Marketing. . . . . . . . . . . . . . . . . . . . . . 239 14.5 Cohort Studies. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 293
Exercise 11.1. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 241 14.6 Example of a Prospective Cohort Study . . . . 300
Exercise 11.2. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 241 14.7 Example of a Retrospective Cohort Study. . . . 302
Case Study 11.1: Example of Regional 14.8 Case-Control Studies. . . . . . . . . . . . . . . . . . . . . . . 303
Market Analysis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 242 14.9 Example of a Case-Control Study. . . . . . . . . . . 307
Case Study 11.2: Planning for Mental 14.10 Risk Factor and Exposure in Cohort
Health Services . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 244 and Case-Control Studies����������������������������������� 309
11.16 Summary. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 246 14.11 Comparison of Cohort and Case-Control
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247 Study Design ����������������������������������������������������������� 310
14.12 Association and Causality����������������������������������� 310
Chapter 12 Prevention, Detection, 14.13 Bias. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 312
and Monitoring of Disease. . . . . . 249 14.14 Confounding. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 313
12.1 Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 250 Case Study 14.1: An Ecological Study. . . . . . . . . . . . . . 315
12.2 The Nature, Scope, and Levels Case Study 14.2: Prospective Cohort Study. . . . . . . . 316
of Prevention������������������������������������������������������������� 250 Case Study 14.3: Retrospective Cohort Study. . . . . . 317
12.3 Screening. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 255 Case Study 14.4: Case-Control Study. . . . . . . . . . . . . . 318
12.4 Surveillance. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 266 14. 15 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 321
Exercise 12.1. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 271 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 321
Exercise 12.2. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 271
Chapter 15 Experimental Studies. . . . . . . . . . 323
Case Study 12.1: Nosocomial Infection
Surveillance. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 271 15.1 Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 324
Case Study 12.2: Screening for Colorectal Cancer. . . . 272 15.2 Experimental or Interventional
12. 5 Summary. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 273 Study Design����������������������������������������������������������� 325
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 274 15.3 Categorization of Experimental Studies . . . . 327
15.4 Randomized Controlled Trials
or Clinical Trials ������������������������������������������������������� 328
Chapter 13 Basic Statistical Concepts 15.5 Example of a Randomized Clinical Trial. . . . . 330
and Tests . . . . . . . . . . . . . . . . . . . . 277 15.6 Community Trials. . . . . . . . . . . . . . . . . . . . . . . . . . 331
13.1 Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 278 15.7 Example of a Community Trial. . . . . . . . . . . . . . 331
13.2 Examples. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 278 15.8 Natural Experiments. . . . . . . . . . . . . . . . . . . . . . . 332
13.3 Basic Statistical Concepts . . . . . . . . . . . . . . . . . . 281 15.9 Factorial Trials. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 333
13.4 Statistical Tests for Comparison of Groups. . . . 286 Case Study 15.1: Randomized Control
Exercise 13.1. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 287 Trial – Chlorhexidine Bathing in ICUs
Exercise 13.2. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 287 to Prevent HAIs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 334
13.5 Summary. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 288 15.10 Summary. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 335
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 336
Chapter 14 Observational Studies . . . . . . . . . 289
14.1 Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 290 List of Acronyms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 337
14.2 Observational Studies. . . . . . . . . . . . . . . . . . . . . . 290 Glossary. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 341
14.3 Ecological Studies. . . . . . . . . . . . . . . . . . . . . . . . . . 291 Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 351
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viii
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Preface
M
any academic programs offering a degree in the reader for these discussions by introducing the
health administration include a course on underlying concepts of epidemiology, management,
managerial epidemiology in their curric- and evidence-based management.
ulum. The content of these courses, understandably, Chapters 2–5 focus on the determinants, assess-
differs from one program to another. The diversity in ment, and measurement of health in individuals and
the content of managerial epidemiology courses across populations and the characterization of health and
programs reflects the diversity of opinions about disease in terms of person, place, and time. Chapter
the scope and nature of the field called managerial 2 explains the holistic concept of health and the pop-
epidemiology. Increasingly, program directors and ulation model of health as opposed to the traditional
instructors favor content that combines elements of medical model. The chapter also provides a detailed
traditional introductory epidemiology courses with discussion of genetic, socioeconomic, and racial or
traditional population health courses. The desire to ethnic determinants of health. Chapter 3 deals with
combine concepts, methods, and skills from epide- the complex concepts of disease, death, and disabil-
miology and population health is not accidental but ity and various approaches to assess the health and
reflects two important realities. First, the whole idea of well-being of individuals and populations. Chapter 4
managerial epidemiology is to extend the boundaries discusses various measures of morbidity and mortal-
of epidemiology from an investigation of the deter- ity and different types of summary statistics reported
minants and distribution of disease and injury to the in literature as indicators of population health status.
examination of the determinants and distribution of The chapter includes clear and concise definitions
health outcomes in populations. Second, because of for a number of epidemiologic concepts necessary to
the changes taking place in our thinking about health measure the health status and distribution of diseases
and healthcare delivery, there is a growing need for in populations. Chapter 5 discusses the demographic,
healthcare managers to acquire epidemiologic skills geographic, and temporal characterization and report-
on one hand and develop an understanding of the ing of health problems in terms of person, place, and
concepts and methods related to population health time. The chapter also includes a discussion of differ-
on the other. As such, managerial epidemiology must ent types of descriptive epidemiologic investigations
include the application of information regarding the in the way of case reports and cross-sectional studies.
determinants and distribution of disease and injury to Chapters 6–9 focus on the determinants of health
health promotion, disease prevention, and planning in relation to lifestyle and personal behavior, the dis-
of health services. This text presents a combination of tribution of infections and injuries in populations, and
materials from epidemiology and population health assessment of quality of care delivered by the health-
with the view that future healthcare managers need care system. The materials presented in these chapters
to have a good grasp of various aspects of population represent different dimensions of population health.
health as well as a foundational understanding of the Chapter 6 deals with health problems related to life-
epidemiologic principles and methods. The need for a styles and personal behavior, including sedentary
new text in managerial epidemiology is evident from lifestyle, substance abuse, and the impact of lifestyles
the dearth of existing textbooks on this subject. on the prevalence of cardiovascular disease and dia-
Chapter 1 in the text is foundational in nature betes in different populations. Chapter 7 engages in
and sets the stage for in-depth discussions in succeed- a detailed discussion of infectious disease epidemiol-
ing chapters on the determinants and distribution of ogy in the United States and worldwide, including the
health in individuals and populations, assessment of problem of emerging infectious diseases and antimi-
population health status, and methods for commu- crobial drug resistance in microorganisms. Chapter 8
nity health needs assessment. The chapter prepares discusses the epidemiology of various kinds of injuries
ix
x Preface
and provides national and international data on vio- technical aspect of designing and conducting various
lence, drownings, and burns. Chapter 9 explains the kinds of epidemiologic investigations. Chapter 13
relationship of the structure and processes of care serves as a convenient resource for brushing up on basic
with health outcomes and various methods of moni- quantitative and statistical concepts. Chapters 14 and
toring and reporting ambulatory and inpatient quality 15 provide comprehensive information on the design,
of care. The chapter also includes a discussion of the comparative suitability, and technical challenges of
impact of severity of disease and case mix on health observational and experimental epidemiologic inves-
outcomes and indicators of healthcare quality. tigations. Chapter 14 discusses the importance, intri-
Chapters 10 and 11 are designed to equip future cacies, and comparative advantages of prospective and
healthcare managers with the tools and skills nec- retrospective cohort and case-control studies. Chapter
essary for community health needs assessment and 15 provides a discussion of the frequency and rele-
planning for adequate delivery of services. The chap- vance of experimental epidemiologic investigations in
ters include various methods for estimating primary the form of randomized controlled trials and the prac-
and secondary service areas, determination of the size tical aspects of conducting experimental studies.
of a geographic market, level of competition in a geo- The content and case studies in various chapters
graphic market, and estimation of market share held are organized in a manner suitable to meet the needs
by various providers. Chapter 11 describes different of a diverse body of students and are drawn from a
approaches toward healthcare planning, setting prior- vast body of literature. The author hopes this text will
ities, determining levels of access, and designation of make a meaningful contribution to the field of man-
health professional shortage areas by the U.S. Health agerial epidemiology and serve as a valuable resource
Resources and Services Administration. worthy of the time and attention of students and
Chapters 12–15 deal with the concepts of preven- instructors in health administration programs.
tion, monitoring, surveillance, and reporting of dis-
eases that pose serious public health threats and the Amir A. Khaliq
© Monsitj/Getty Images
CHAPTER 1
Epidemiology for Evidence-
Based Management
LEARNING OBJECTIVES
Having mastered the materials in this chapter, the student will be able to:
1. Explain what the terms epidemiology and managerial epidemiology mean.
2. Explain what the terms management and evidence-based management mean.
3. Explain how epidemiologic data can be used in evidence-based management.
CHAPTER OUTLINE
1.1 Introduction 1.8 Scenario for Application of Managerial
1.2 Epidemiology Epidemiology
1.3 Management 1.9 Sources of Epidemiologic Data
1.4 Decision-Making Process Case Study 1.1 – Impact of Administrative Decisions
1.5 Evidence-Based Management on Patient Outcomes
1.6 Epidemiology and Evidence-Based Case Study 1.2 – Epidemiologic Patterns that Can
Management Guide Policy Decisions
1.7 Managerial Epidemiology 1.10 Summary
KEY TERMS
Epidemiology Evidence-based practice Managerial epidemiology
Evidence-based management (EBP) Nonprogrammed decisions
(EBM) Management Programmed decisions
1
2 Chapter 1 Epidemiology for Evidence-Based Management
G
ood management involves decisions that are and statistical techniques have been developed to
guided by both quantitative and qualitative evi- address issues resulting from the complexities of study
dence. By its very nature, effective healthcare design. Easy availability of vast amounts of clinical,
management requires the collection of appropriate data public health, demographic, and socioeconomic data
and application of decision-support tools from different from a variety of sources that can be integrated and ana-
disciplines. The purpose of managerial epidemiology is lyzed within minutes with the help of relatively inex-
to familiarize both aspiring and practicing healthcare pensive powerful computers has enormously increased
managers with the tools available from the fields of epi- the number of epidemiologic investigations being con-
demiology and management and give them the abil- ducted. Every year, thousands of research articles based
ity to make a concerted use of these tools for efficient on epidemiologic investigations are being published
and informed decision making. The combined use of in dozens if not hundreds of conventional and open-
techniques from epidemiology and management is the access journals from every corner of the world.
foundation of the emerging field of evidence-based There is a mutually supportive and symbiotic rela-
management (EBM). Before discussing the application tionship between the practice of medicine and epi-
of epidemiologic methods in healthcare management, demiology. Epidemiology is population medicine in
it is important to remind ourselves of the nature of the that it deals with the identification, investigation, and
two disciplines called epidemiology and management. control of diseases in populations. The same is done at
In the following sections, we introduce the terminology the individual level by those who practice medicine—
and basic principles of epidemiology and management namely physicians.2 Clinical medicine benefits from
and then explain how EBM can use the quantitative the knowledge of the frequency of a disease in a given
evidence generated by epidemiologic investigations. population obtained through epidemiologic investi-
Two case studies at the end of the chapter demonstrate gations. Conversely, epidemiologic investigations rely
how epidemiologic evidence can be used for effective on accurate identification of diseases in individuals by
healthcare management and policy formulation. physicians. Although epidemiologic information is
essential for better practice of medicine and formula-
tion of control strategies, assessment of the incidence
▸▸ 1.2 Epidemiology and prevalence of disease in a population is entirely
dependent on accurate diagnosis and reporting of
Porta1 defines epidemiology as “The study of the disease by clinicians.2 For example, community-level
occurrence and distribution of health-related events, strategies for the prevention and control of AIDS or
states, and processes in specified populations, includ- delivery of medical and social services to Alzheimer’s
ing the study of the determinants influencing such pro- disease patients require data regarding the frequency
cesses, and the application of this knowledge to control and distribution of these diseases in the population.
relevant health problems.” A less-comprehensive older Such data can only become available through accurate
definition states that epidemiology is “the study of the diagnosis and reporting by physicians.
distribution and determinants of diseases and inju-
ries in human populations.” 2 The implication of both
definitions is that diseases and their causes are distrib-
uted neither randomly nor evenly across populations.
▸▸ 1.3 Management
Understanding the distribution of diseases across Management can be defined as “The act, manner,
populations, time, and space can give us valuable or practice of managing, supervising, or controlling.” 3
information about their causes, and this information Another way to describe management is that it
can be used to develop prevention and control strat- involves “getting results through the work of others for
egies. Recognizing that diseases differentially afflict the benefit of the client.” 4 In either case, management
dwellers of different regions or people of different col- involves the use of organizational resources and han-
ors, creeds, and sexes has been an important element dling of processes, situations, and relations. A number
in our quest to live a healthier and longer life. of theoretical models have been developed to explain
The field of epidemiology has experienced tre- what managers do and how they do it.4-6 Management
mendous growth and methodologic sophistication of healthcare organizations such as hospitals, clinics,
in the last few decades. The scope of epidemiologic and nursing homes poses challenges that are different
investigations now spans from genetics to social sci- from those of other organizations. Healthcare man-
ences, from forensic medicine to veterinary medicine, agement requires knowledge of healthcare policy,
1.4 Decision-Making Process 3
r egulatory environment, and insurance. Additionally, functions of managers. The interpersonal role involves
it requires an understanding of issues related to access, leadership through motivation and mentoring. The
utilization, and biomedical ethics, as well as analytic informational role involves collection and dissemina-
skills to use epidemiologic data for decision making. tion of information and serving as a spokesperson for
Researchers explore how healthcare managers carry a department or the organization. As entrepreneurs,
out their responsibilities and make decisions, and what mangers set goals and objectives for their departments
factors explain different styles of management. For or organizations, and as “disturbance handlers,” they
practitioners, management means attaining efficiency, resolve conflicts and solve problems.
improving quality, motivating staff, and achieving In the “art” and “science” of management, the sci-
organizational goals. As practitioners, healthcare man- entific component relies on systematic analysis of data
agers have to learn the principles of leadership, motiva- and use of evidence, whereas the art of management
tion, financial management, and quality improvement. requires creative thinking and innovation to solve a
They have to employ “soft power” and diplomatic given problem.5 The unique blend of art and science
skills, as well as “hard” analytic skills.7 employed by a person creates his or her management
The purpose of management is to specify, com- style. Clearly, the management style of a person is also
municate, and achieve the goals and objectives of the a function of individual characteristics, values, experi-
organization in a consistent manner while provid- ence, analytic skills, and the level of authority enjoyed
ing a harmonious work environment for employees. in the organization. Strong quantitative skills are essen-
Researchers have identified three main goals of health- tial for problem solving and finding the best solutions.
care management:8 first, manage the financial affairs of Analytical tools are especially useful for solving prob-
the organization to ensure financial stability; second, lems that are discrete in nature and lend themselves to
provide highest quality services through efficient use of quantitative analysis. Although managers frequently
resources; and third, maintain high moral and ethical encounter problems that are ambiguous or multi-
standards while serving competing or divergent inter- dimensional, off-the-cuff decision making without
ests of stakeholders. The success of an organization in quantitative analysis and empirical evidence can be
achieving these goals is a direct measure of the suc- very detrimental to the goals of an organization. The
cess of its managers. Given the challenging economic, element of art in decision making is meant only to sup-
political, and social environment in which healthcare plement the scientific approach toward decision mak-
organizations operate, some of these goals can be in ing rather than replace it. Based on quantitative data, a
conflict with one another. For example, the necessity good understanding of the demographic characteris-
of attaining monetary success can compel managers to tics of the community, demand for services, and evolv-
forego desirable social objectives, such as delivery of ing patterns of morbidity and mortality are critically
discounted care to socially marginalized populations. important for excellence in healthcare management.
While specific duties of managers inevitably vary
from one organization to another or from one depart-
ment to another, these duties are conventionally
categorized into planning, coordination, directing,
▸▸ 1.4 Decision-Making Process
and control functions. Such a categorization is help- According to management theory, managerial deci-
ful in developing a framework in which appropriate sions vary in complexity and can be divided into two
empirical data or evidence can be used to understand main categories: programmed and nonprogrammed
managerial functions and to make a case for rational decisions.10 Programmed decisions address prob-
decision making. In practice, these roles merge and lems that are encountered frequently and are repet-
mix during the daily process of decision making and itive in nature. In dealing with these problems,
problem solving. Managers transition back and forth managers do not need to find new solutions. Because
into these roles without compartmentalizing their of the familiarity of managers with such problems,
work into these conceptual domains. In carrying out rules and procedures usually exist to resolve them.
all these managerial functions, the use of data and The level of risk associated with such decisions is
empirical evidence can make the difference between minimal because of successful past application of
an effective and ineffective manger. similar decisions. Nonprogrammed decisions,
Mintzberg9 challenges the “planning, organiz- on the other hand, are unprecedented and demand
ing, coordinating, and controlling” model of man- innovative solutions. In both programmed and non-
agerial functions developed in the earlier part of the programmed situations, managers are expected to
20th century and offers “interpersonal, informational, adopt a rational and systematic approach to problem
entrepreneurial, and decisional” activities as the main solving and decision making.
4 Chapter 1 Epidemiology for Evidence-Based Management
Researchers have also identified four different of medicine and, (2) focus on the whole person rather
approaches toward decision making.10 The underly- than episodic treatment of “cases” of diseases. The
ing premise in all these approaches is that import- demand for evidence-based decisions in the practice
ant decisions are complex, and individuals are of medicine stems from studies showing that, in the
constrained in their ability to make sound decisions past, only about 15% of physicians’ decisions were
because of their inability to simultaneously process based on evidence.13 Following these developments
multiple dimensions of a complex problem.11 The in the practice of medicine, two similar developments
first of these approaches focuses on the application occurred in health services management: (1) a grow-
of operations research or management science meth- ing emphasis on EBM and (2) a focus on population
ods such as linear programming, Bayesian probabili- health. EBM simply means using data or statistical
ties, and simulation modeling. The second approach evidence to guide managerial decisions. Statistical
emphasizes that decisions are not made individually evidence allows managers to make better decisions
by top managers such as the chief executive officer, by rank-ordering priorities based on empirical evi-
but through an alliance and coalition-building pro- dence and following a systematic process in which
cess involving multiple participants. A collective or steps are taken sequentially to arrive at the final deci-
participatory process is primarily needed for clar- sion. EBP is often used as an umbrella term instead of
ifying the nature and importance of the problem discipline-specific terms such as evidence-based medi-
and for negotiations among internal stakeholders cine, evidence-based nursing, and evidence-based man-
to determine organizational priorities. The third agement. EBP is defined as “making decisions through
model posits that decisions are made in multiple conscientious, explicit and judicious use of the best
steps through an incremental process in which a available evidence from multiple sources.”14
series of smaller decisions finally lead to the culmi- A variety of approaches, ranging from role mod-
nating decision. According to this model, the process eling to teachable moments of the lived experiences
of arriving at a decision evolves over time and goes of mentors, are recommended for teaching EBM.
through the stages of identification, development, and McAlearney and Kovner15 have suggested the follow-
selection. The fourth model, known as the “garbage ing six steps for EBM: first, framing a question for
can” model, characterizes the decision-making pro- which an answer can be found; second, finding the
cess to be highly chaotic, nonlinear, and fluid.12 This data or evidence to answer the question; third, assess-
model applies to organizational environments char- ing the validity of the evidence; fourth, aligning the
acterized by a high level of uncertainty in which par- evidence to the specific circumstances of the orga-
ticipants come and go, and the emergence of ideas, nization; fifth, determining whether the evidence is
problems, and solutions is independent or even a adequate to guide the decision; and sixth, determin-
random event. As a result, in the garbage can model, ing whether the organization can take action on the
solutions may be offered or implemented when a basis of the available evidence.
problem does not even exist, choices may be made In contrast to clinical decisions, which are usually
that do not solve a problem, or people may stop try- made by individuals in a relatively short timeframe,
ing to solve the problem, either because they become important managerial decisions are made by teams or
used to it or no suitable solutions exist. groups of individuals through a consultative process
The use of any of these decision making models over weeks and months.16 The results of these deci-
depends on the characteristics of the organization sions can take years to become clear. As such, there
as well as the specific situation or problem that calls is enough time to collect data from various sources
for a decision. Therefore, approaches toward decision to guide important managerial decisions. Electronic
making vary across different organizations as well as resources and decision-support technologies can
within the same organization at different occasions. be used to identify, assess, and evaluate quantitative
and/or qualitative evidence in the pursuit of EBM.
Barends et al.14 argue that the nature of “evidence” in
▸▸ 1.5 Evidence-Based EBP does not strictly translate into quantitative data,
Management but rather should be interpreted as information that
may be quantitative, qualitative, or descriptive in
In conjunction with the development of electronic nature and that may come from a variety of sources.
health records, two other developments that have altered They argue that six misconceptions exist regarding the
the practice of medicine in the last couple of decades nature of evidence in EBM: (1) it “ignores the prac-
are (1) emphasis on evidence-based practice (EBP) titioner’s professional experience”; (2) it “is all about
1.7 Managerial Epidemiology 5
numbers and statistics”; (3) “managers need to make on the frequency and duration of disease in various age
decisions quickly and don’t have the time for EBM”; groups. In EBM, priority problems are identified and
(4) “each organization is unique, so the usefulness of rank-ordered by combining data on disease frequency,
scientific evidence is limited”; (5) “if you do not have severity, lethality, and responsiveness to treatment in
high-quality evidence, you cannot do anything”; and mathematical algorithms and developing an index or
(6) “good-quality evidence gives you the answers to a composite score for each disease. Recent efforts in
the problem.” In their opinion, these myths are com- using epidemiologic data for healthcare planning and
pletely unfounded and should not be allowed to get in setting priorities have relied on the estimation of years
the way of EBM. of potential life lost (YPLL) due to a disease. Calcu-
According to McVey et al.,17 “Evidence Based Man- lation of YPLL in a population takes into account life
agement (EBM) is about removing emotion, opinion, expectancy at various ages and premature deaths due to
bias, and personal experience from decision-making.” one disease or another in a population. The disease or
Similarly, Pfeffer and Sutton13 argue that “gut feeling” condition responsible for the most number of YPLL is
and obsolete “best practices” have no place in decision usually ranked as the number one priority.
making. They contend that instead of using empiri- Epidemiologic data are also valuable in evaluating
cal evidence generated by research studies, typically the comparative impact of various services, strategies,
managers use the following six substitutes for best and technologies. Such an assessment involves com-
evidence: (1) obsolete knowledge, (2) personal expe- parison of population health statistics, such as infant
rience, (3) specialist skills, (4) hype, (5) dogma, and mortality or teen pregnancy rates, before and after the
(6) mindless mimicry of top performers.13 Rather implementation of new strategies and services. The
than using obsolete knowledge, hype, or dogma, Pfef- outcome of interest or the measure of impact in such
fer and Sutton have developed the following guiding studies can be the reduction in disease-specific disabil-
principles for the practice of EBM (http://evidence ity, mortality, or YPLL that can be directly attributed
-basedmanagement.com/): to the new strategy or intervention.
1. Face the facts and build a culture in which
people are encouraged to tell the truth, even
if it is unpleasant. ▸▸ 1.7 Managerial Epidemiology
2. Be committed to “fact-based” decision mak-
ing, which means being committed to get- Managerial epidemiology is defined in various
ting the best evidence and using it to guide ways. Fos and Fine18 defined it as “the study of the
actions. distribution and determinant of health and diseases,
3. Treat your organization as an unfinished including injuries and accidents, in specified pop-
prototype—encourage experimentation and ulations and the application of the study to the pro-
“learning by doing.” motion of health, prevention, and control of disease,
4. Look for the risks and drawbacks in what the design of healthcare services to meet population
people recommend—even the best medi- needs, and the elaboration of health policy.” Fleming
cine has side effects. et al.19,20 defined it as “the application of the tools and
5. Avoid basing decisions on untested but principles of epidemiology to the decision-making
strongly held beliefs, what you have done process within healthcare settings.” Accordingly, man-
in the past, or uncritical “benchmarking” of agerial epidemiology entails the use of epidemiologic
what winners do. tools in designing health services and formulating
health policy to meet the needs of target populations.
Because epidemiologic investigations provide criti-
cal information to managers and planners regarding
▸▸ 1.6 Epidemiology and the burden of disease in populations and potential
Evidence-Based Management demand for health services, it is “virtually impossi-
ble to develop a comprehensive strategic plan with-
The origins of various approaches to incorporating out incorporating estimates of the prevalence of dis-
epidemiologic data into the healthcare management ease.”20 Rohrer21 posited that managerial epidemiology
and decision-making process can be traced back to involves planning for populations rather than individ-
the techniques developed at the Central University of uals, planning for prevention rather than treatment,
Venezuela in the early 1960s. These techniques were later and planning for health rather than disease. He argued
refined by the U.S. Institute of Medicine by using data that managers are primarily concerned with issues
6 Chapter 1 Epidemiology for Evidence-Based Management
r elated to cost, quality, and access; therefore, mana- of investigations would be necessary to
gerial epidemiology needs to draw from clinical epi- c ollect data regarding the demographic and
demiology, the study of the determinants and impact socioeconomic characteristics of the target
of clinical decisions. Managerial epidemiology can population?
do so by assessing the value of therapeutic and pre- 3. What evidence exists regarding the success
ventive interventions in relation to their costs, qual- of treatment procedures such as artificial
ity, and impact on access to health services. Inclusion insemination and in-vitro fertilization,
of clinical variables in studies related to the cost and where did that evidence come from, and
quality of care can be useful in addressing managerial how good is that evidence?
concerns. The most direct application of clinical epi- 4. What are the size, boundaries, and socio-
demiology to address a managerial concern is in the economic characteristics of the geographic
improvement of healthcare quality through reduction market that would be served by the pro-
of healthcare-associated complications, morbidity, posed center?
and mortality.20 5. What is the projected volume of assisted
reproductive services that Blue Sky can
expect to provide every year?
▸▸ 1.8 Scenario for Application 6. Who are the competitors for infertility
of Managerial Epidemiology treatment services in this geographic mar-
ket, and what is the current distribution of
The management of Blue Sky Health, a hypothetical market shares among those providers?
healthcare system that operates several urban and 7. What is the projected number of deliver-
rural inpatient facilities and community-based out- ies resulting from infertility treatment ser-
patient clinics in St. Louis, Missouri, is interested in vices and the volume of obstetric services
adding a full-service infertility treatment center to its that Blue Sky can expect to provide at its
portfolio. Blue Sky wishes to have this center go into facilities?
operation by early 2020 in the Doctor’s Plaza building 8. What volume of patients and fee structure
adjacent to its main hospital in South St. Louis. for various procedures would be necessary
For planning and marketing the proposed infer- to make the proposed center financially
tility treatment center, Blue Sky would like to con- viable?
duct a feasibility study in the fall of 2018. Mark Plato, Through a cursory examination of available liter-
the vice president for planning and marketing, has ature, Mark Plato has collected the following epidemi-
developed a list of epidemiologic questions he would ologic information.
like the feasibility study to address. These questions Currently 7.5 million American women aged
must be addressed before developing amortized pro- 15–44 years—that is, 12.3% of women in this age
jections of fixed and variable costs and determina- group—have impaired ability to get pregnant or carry
tion of a fee structure to achieve a reasonable return a baby to term. Nearly 6.9 million of them—that is,
on investment and a steady revenue stream. He 11.3% of women aged 15–44—have used some form of
believes the study proposal must also identify meth- infertility services.22 Since 2003, there has been a 65%
ods for primary data collection and a list of second- increase in in-vitro fertilization (IVF) in the United
ary data sources. Plato, who had taken a course in States. Every year, approximately 50,000 babies—
managerial epidemiology at Lyceum University, real- about 1.6% of all babies born in the country—are
izes that many of the questions in the feasibility study born through IVF. In 2013, about 175,000 cycles of
can be answered with the help of concepts, methods, IVF were completed in the United States.23 In a survey,
and techniques described in the chapters of a good 55% of those who had experienced infertility reported
managerial epidemiology textbook. The following is it to be more stressful than unemployment, and 61%
a partial list of questions Mark Plato thinks he needs reported it to be more stressful than divorce. Approx-
to have answered by the feasibility study. imately 58% of respondents indicated that because of
1. How common is infertility, and what are the cost and lack of coverage by insurance companies as
geographic, demographic, and socioeconomic an essential health benefit, they would forgo infertility
characteristics of the affected population (i.e., treatment.24 Without assisted reproductive technol-
what is the epidemiology of infertility)? ogy, fertile 30-year-old American women each month
2. If epidemiologic data were not available only have a 20% chance of conceiving.25,26 About 61%
to answer the above question, what kinds of single-embryo transfers and 65% of two-embryo
Case Study 1.1: Impact of Administrative Decisions on Patient Outcomes 7
transfers result in a live birth. Nearly 30% of all IVF source to another or from one agency to the next.
pregnancies and 46% of two-embryo transfers result However, cross-sectional and longitudinal data from
in a twin delivery. Births through assisted reproductive these and other sources can be successfully integrated
technology (ART) pose greater risk for both mother and analyzed to guide managerial decisions. In the
and child than a normal pregnancy. For example, United States, some of the most common and use-
women who deliver through ART are much more likely ful sources of epidemiologic and demographic data
to have multiple births than women who conceive nat- include the following:
urally. In 2013, more than 160,000 ART procedures 1. U.S. Census Bureau – Census Data (http://
were performed at 467 infertility clinics in the United www.census.gov/2010census/data/)
States, with a use rate of approximately 2,520 proce- 2. National Center for Health Statistics –
dures per million women aged 15–44 years. These pro- National Vital Statistics System (https://
cedures involved more than 135,000 embryo transfers www.cdc.gov/nchs/nvss/index.htm)
and resulted in more than 65,000 pregnancies, with 3. National Health Interview Survey (NHIS)
about 66,700 live-born infants.27 The total cost for one (http://www.cdc.gov/nchs/nhis/index.htm)
embryo transfer was estimated to be approximately 4. National Survey of Children’s Health
$48,500, and $90,500 for two-embryo transfers.24 (NSCH) (http://www.nschdata.org/)
With the help of tools and methods described 5. Health Resources and Services
in the following chapters and infertility-related epi- Administration – Maternal and Child
demiologic information provided in the preceding Health Bureau (http://mchb.hrsa.gov/)
paragraphs, the student can find answers to Mark 6. Centers for Disease Control and Prevention –
Plato’s questions. Naturally, some assumptions about Behavioral Risk Factor Surveillance System
the size of the geographic market and the number of (BRFSS) (http://www.cdc.gov/brfss/)
competitors in the service area of Blue Sky will have 7. U.S. Census Bureau – American Com-
to be made. At the completion of the course for which munity Survey (https://www.census.gov
this text is being used, the student is encouraged to /programs-surveys/acs/)
undertake this task and create multiple estimates by 8. Harvard University’s Maternal and Child
changing assumptions regarding population density, Health (MCH) Data Connect – A cat-
socioeconomic characteristics of the population, cost alog of more than 150 sources of data
and coverage of fertility services by insurance compa- (https://d ataverse.harvard.edu/dataverse
nies, and the size of the service area. /dataconnect)
9. Cornell University’s National Data Archive
on Child Abuse and Neglect (http://www
▸▸ 1.9 Sources of Epidemiologic .ndacan.cornell.edu/)
Data 10. U.S. Bureau of Labor Statistics – Injuries,
Illnesses, and Fatalities (http://www.bls
A wide variety of demographic, epidemiologic, and .gov/iif/)
socioeconomic data are available on the Internet. As 11. Centers for Disease Control and Prevention –
is often the case with the sources of secondary data, National Center for Injury Prevention and
the type and quality of available data varies from one Control (https://www.cdc.gov/injury/)
The physician call schedule is an important determinant of the quality of care at a hospital. However, it also presents a
paradox between two conflicting variables: (1) physician sustainability (i.e., a physician cannot be available at all times)
and (2) continuity of care (i.e., patients prefer to interact with the same physician throughout their hospital stay). In a
(continues)
8 Chapter 1 Epidemiology for Evidence-Based Management
recent study, Yarnell et al. examined the impact of changes in the physician call schedule at an academic tertiary care
hospital by comparing patient readmission rates before and after a change in the call system.
On January 1, 2009, Sunnybrook Health Sciences Center in Toronto, Canada, transitioned from the old
“concentrated” (or “bolus”) call schedule system for all general medicine inpatient physician teams to a new “distributed”
(or “drip”) system. The main feature of the old system was that one team was on call every fourth day and managed all
admissions in that 24-hour period. The main feature of the new system was that admissions were distributed over all
teams every day. The new system entailed a host of additional changes. For example, a different member from each
team was on call each day, and one member from each team was absent postcall each day. The schedule of rotating
attending faculty remained unchanged. The change from the concentrated to the distributed call system was intended
to improve quality and continuity of care by having at least one team member from a given team be present each day.
The general internal medicine service at Sunnybrook comprised four teams—each with an attending physician, a senior
resident, two or three first-year residents, and two or three medical students. Each team was responsible for 15–25
patients.
The researchers identified all consecutive adult patients who were originally admitted through the Emergency
Department at Sunnybrook hospital and were later discharged from internal medicine teams during the 10-year period
(January 2004 through December 2013) and examined whether each patient was readmitted for any reason within 28
days following discharge. Patients discharged for a surgical, obstetric, or psychiatric diagnosis were excluded from the
study.
The study reported that during the 10-year period, 89,697 patients were discharged from the general internal
medicine service, of whom 10,001 (11%) were readmitted within 28 days following discharge, and 4,280 died. The
risk of readmission increased by 26% after the change in the physician call system (from 9.7% readmission rate before
the change in call system to 12.2% after the change; P < .001). Using a computer algorithm (LACE score), the risk of
readmission was adjusted for patient characteristics such as predischarge length of stay in the hospital, total number of
Emergency Department visits in the preceding 6 months, and the Charlson comorbidity index—a composite measure
of the overall effect of all other coexisting medical conditions or diseases a patient might have. To assess whether
increased readmission rates at Sunnybrook were related to the change in the physician call system, Sunnybrook’s
readmission rates were compared with readmission rates at a similar nearby hospital (North York General Hospital)
during the same interval. North York General Hospital is similar to Sunnybrook in all other respects, except it did not
experience a change in the physician call system.
Before the call system change, a total of 37,982 patients were discharged, of whom 1,643 died and 3,675 were
readmitted within 28 days after discharge. After the call system change, a total of 51,715 patients were discharged
of whom 2,386, died and 6,326 were readmitted within 28 days after discharge. The results showed that, even after
adjusting for extraneous factors, increased risk of readmission after the change in the physician call system persisted
across all patient age groups and medical diagnoses. The overall negative impact of change in the physician call system
was estimated to be about 7,240 additional patient days in the hospital. However, no increased risk of patient deaths
was found to be associated with increased hospital readmissions and change in physician call schedule. TABLE 1.1
provides data and assessment of the relative risk of readmission or death within 28 days of discharge before and after
the call system change.
Questions
Question 1. What was the purpose of this study?
Question 2. How does the study relate to managerial decisions?
Question 3. What were the overall findings of the study?
Question 4. What impact, if any, did the management’s decision to change the physician call system have on the
quality of care?
Question 5. How did the investigators ensure that their findings regarding the impact of the physician call system were
not tainted by extraneous factors, such as the characteristics of the hospital?
Question 6. Based on the data presented in Table 1.1, after the change in the call system, how much higher or lower
was the overall risk of readmission or death within 28 days following discharge? Explain your answer with the help of
data shown in Table 1.1.
Question 7. Based on the data presented in Table 1.1, after the change in the call system, how much higher or lower
was the risk of readmission or death within 28 days following discharge for men and for those with congestive heart
failure? Explain your answer with the help of data shown in Table 1.1.
Case Study 1.1: Impact of Administrative Decisions on Patient Outcomes 9
Age in Years
Sex
Medical Diagnosis*
* Selected list, not comprehensive. 1 patient may have had more than 1 diagnosis.
Reprinted from: Yarnell CJ, Shadowitz S, Redelmeier DA. Hospital readmissions following physician call system change: a comparison of concentrated and distributed schedules.
Am J Med. 2016;129(7):706–714. Copyright © 2016 with permission from Elsevier.
10 Chapter 1 Epidemiology for Evidence-Based Management
Suicide rates have increased globally in the last half-century, and suicide now ranks as one of the leading causes of
death among those between the ages of 15 and 44 years. In the U.S. military, the suicide rate nearly doubled between
2001 and 2011.
In a recent study, Anglemyer et al. calculated suicide rates per 100,000 active duty enlisted (nonofficer) U.S. military
personnel from 2005 to 2011. The purpose of the study was to examine suicide rates in different years across different
branches of the military and identify personnel at the highest risk. For mortality statistics and demographics, the
researchers used data from the Suicide Data Repository, which combines data from the U.S. Centers for Disease Control
and Prevention and the Military Mortality Database. To obtain the count of enlisted personnel in each branch of the
military in each of the study years, researchers used data from the military. The study did not include suicides committed
outside the United States. Altogether, 1,455 active duty enlisted personnel in the U.S. Army, Air Force, Marine Corps,
and Navy committed suicide during the study period. With 29.44 and 29.15 suicides per 100,000 individuals in 2009
and 2010, respectively, the rates were highest among Army personnel (see FIGURE 1.1). The rates were lowest in the Air
Force and Navy in 2005 (9.95 and 9.79, respectively). More than 95% of suicides were committed by men. Only 1 female
Marine and 9 female Navy personnel committed suicide. Of the 1,455 total suicides, 1,416 were among nontrainees
(TABLE 1.2). As shown in Table 1.2, about 60% of nontrainee suicides occurred in the lower ranks of enlisted personnel
(E1 to E4). In the Navy and Air Force, less than 50% of suicides were in lower ranks, but in the Army, about 66.9% were in
lower enlisted ranks. More than 75% of suicides in all branches were among white enlisted personnel.
Questions
Question 1. What percentage of suicides in the Marine Corps was among lower rank (E1 to E4) enlisted personnel?
Question 2. What percentage of suicides occurred in white Marines?
Question 3. Across various branches, was there much difference in the percentage of suicide by marital status?
Question 4. Across various branches, was there much difference in the percentage of suicides among those who
were never married?
Question 5. What percentage of all suicides occurred in service members who only had a high school diploma?
Question 6. What was the overall number and percentage of female suicides across all branches of the military?
Question 7. Across all branches, what was the overall number and percentage of suicides among those who had
education higher than a high school diploma?
Question 8. Based on the data presented in Table 1.2, what, if any, effect do education and rank have on the overall risk
of suicide in the military and across various branches?
Drawdown in Iraq
30
20
10
FIGURE 1.1 Suicide rates per 100,000 persons (2005 to 2011), by branch of service.
Reproduced from: Anglemyer A, Miller ML, Buttrey S, Whitaker L. Suicide rates and methods in active duty military personnel, 2005 to 2011: a cohort study. Ann Intern Med. 2015;165(3):167–174. Copyright © 2016 American College of Physicians.
All Rights Reserved. Reprinted with permission of American College of Physicians, Inc.
Case Study 1.2: Epidemiologic Patterns That Can Guide Policy Decisions 11
TABLE 1.2 Characteristics of Suicides Among Active Duty Military Personnel, 2005–2011*
Characteristic Navy (n = 226) Army (n = 744) Air Force (n = 236) Marines (n = 210)
Sex
Rank
Race
Marital Status
(continues)
12 Chapter 1 Epidemiology for Evidence-Based Management
TABLE 1.2 Characteristics of Suicides Among Active Duty Military Personnel, 2005–2011* (continued)
High school diploma 181 (80.1) 482 (64.8) 197 (83.5) 179 (85.2)
Religion
* Values are numbers (percentages) unless otherwise indicated. Percentages may not sum to 100 due to rounding.
Modified from: Anglemyer A, Miller ML, Buttrey S, Whitaker L. Rates and predictors of violent suicide within military. Ann Intern Med. 2016;165(3):167–174. Copyright © 2016 American
College of Physicians. All Rights Reserved. Reprinted with permission of American College of Physicians, Inc.
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