ANTIBIOTIC SENSITIVITY CHART

Created by James McCormack, BSc(Pharm), PharmD and Fawziah Lalji, BSc(Pharm), PharmD,
with assistance from Drs. Tim Lau, Cesilia Nishi, Solomon Chow
Faculty of Pharmaceutical Sciences, University of British Columbia, and Vancouver Hospital, Vancouver, BC

Gram Positive Cocci Gram Negative Bacilli Gram Negative Coccobacilli Anaerobes Atypicals
Streptococci Staphylococci
AmpC producing
Non-beta-lactamase producing (HECK YeS)
Bacteria Streptococcus Community Hospital Beta-lactamase producing ESBL-E
Staphylococcus Staphylococcus Escherichia coli , Hafnia alvei , CRE Below the Mycoplasma
(pneumoniae / acquired acquired Escherichia coli, (Extended spectrum beta- Pseudomonas Neisseria Neisseria Above the diaphragm Clostridioides Legionella Chlamydia
Enterococcus faecalis epidermidis aureus Klebsiella pneumoniae , Enterobacter cloacae , (Carbapenem-resistant diaphragm pneumoniae,
pyogenes / (Methicillin (Methicillin Klebsiella pneumoniae, lactamase producing) aeruginosa meningitidis gonorrhoeae (Peptostreptococcus ) difficile pneumophila trachomatis
(coagulase negative) (Methicillin sensitive) Haemophilus influenzae Citrobacter freundii, Enterobacterales ) (Bacteroide s spp) Chlamydophila spp
viridans group) resistant) resistant) Haemophilus influenzae Enterobacterales
Klebsiella aerogenes, Yersinia
enterocolitica
Pelvic Intraabdominal,
CNS, oral, respiratory tract, Intraabdominal, Central nervous Pelvic inflammatory
Site of infection Skin, prosthetics Oral, respiratory tract, heart, skin, bones/joint Respiratory, intraabdominal, urinary tract, and others inflammatory Oral, respiratory tract pelvic inflammatory Intraabdominal Respiratory tract
heart, skin urinary tract system disease/STI
disease/STI disease

Pencillin V/G Pencillin G-IV Pencillin V/G

Amoxicillin/Ampicillin Amoxicillin/Ampicillin Ampicillin-IV Amoxicillin/Ampicillin

Penicillins Cloxacillin

Amoxicillin-clavulanate Amoxicillin-clavulanate Amoxicillin-clavulanate Avoid in serious infections Amoxicillin-clavulanate

Piperacillin-
Piperacillin-tazobactam Piperacillin-tazobactam Piperacillin-tazobactam Avoid in serious infections Piperacillin-tazobactam
tazobactam
Cefazolin/Cephalexin Cefazolin/Cephalexin Cefazolin/Cephalexin Cefazolin/Cephalexin

Cefuroxime Cefuroxime Cefuroxime Cefuroxime

Cefoxitin Cefoxitin Cefoxitin Cefoxitin

Ceftriaxone/Cefotaxime Ceftriaxone/Cefotaxime Ceftriaxone/Cefotaxime Ceftriaxone/Cefotaxime

Cefixime Cefixime Cefixime

Ceftazidime Ceftazidime
Cephalosporins
Cefipime Cefipime Cefipime Unpredictable activity Cefipime Cefipime

Cefiderocol (SAP)
Ceftolozane-
Ceftolozane-tazobactam Ceftolozane-tazobactam
tazobactam
Ceftazidime-avibactam (SAP)

Ceftaroline (SAP) Ceftaroline (SAP) Ceftaroline (SAP)

Ceftobiprole Ceftobiprole Ceftobiprole

Only in Combination
Monobactams Aztreonam (SAP) Aztreonam (SAP)
with CFZ-AVI (SAP)
Meropenem/Imipenem Meropenem/Imipenem Meropenem/Imipenem Meropenem/Imipenem Meropenem/Imipenem

Carbapenems Ertapenem Ertapenem Ertapenem Ertapenem

Imipenem-relebactam (SAP) Imipenem-relebactam (SAP) Imipenem-relebactam (SAP) Imipenem-relebactam (SAP)

Erythromycin Erythromycin Erythromycin

Macrolides
Clarithromycin/Azithromycin
Clarithromycin/Azithromycin Clarithromycin/Azithromycin Azithromycin Clarithromycin/Azithromycin Azithromycin
(JUST [Link])
Tetracycline/Doxycycline/ Tetracycline/Doxycycline/Minocycline Tetracycline/Doxycycline/
Tetracycline/Doxycycline/Minocycline Tetracycline/Doxycycline
Minocycline (JUST [Link]) Minocycline
Tetracyclines
Tigecycline Tigecycline Tigecycline

Ciprofloxacin/Norfloxacin (Only bladder infections for Norfloxacin) Ciprofloxacin

Fluoroquinolones
Levofloxacin/Moxifloxacin Levofloxacin/Moxifloxacin Levofloxacin/Moxifloxacin Moxifloxacin Levofloxacin/Moxifloxacin

Aminoglycosides Gentamicin/Tobramycin/Amikacin Amikacin

Polymyxin Colistin/Polymyxin B

Lincosamides Clindamycin Clindamycin Clindamycin Chlamydia only

Glycopeptides/ Vancomycin/Daptomycin/
Vancomycin/Daptomycin/Dalbavancin Vancomycin (PO)
Lipoglycopeptides Dalbavancin
Oxazolidinones Linezolid Linezolid
Trimethoprim-
Trimethoprim-sulfamethoxazole Trimethoprim-sulfamethoxazole
Sulfamethoxazole
Chloramphenicol Chloramphenicol Chloramphenicol Chloramphenicol

Metronidazole Metronidazole

Nitrofurantoin/Fosfomycin Nitrofurantoin/Fosfomycin Nitrofurantoin/Fosfomycin Unpredictable activity Unpredictable activity

Rifampin Rifampin Rifampin

Fidaxomicin Fidaxomicin
Rifampin should not be used alone for Staphylococcal infections
Enterococci has two main species - Enterococcus faecalis and Enterococcus faecium; the antibiotics listed are active against [Link], but have limited activity for [Link]
Cephalosporins as well as beta-lactamase inhibitor combinations have in-vitro activity for HECK-YeS organisms but may induce production of beta-lactamases
Tigecycline is active against HECK-YeS organisms, but for Proteus spp it depends on local susceptibility data
SAP = Special Access Program (i.e., not marketed but available from Health Canada)

MAY 2024