GSE21138 GO_Biological_Process_2023 (side-by-side, top100)

ML
Manual
Insulin-Like Growth Factor Receptor Signaling Pathway (GO:0048009)
tRNA Threonylcarbamoyladenosine Metabolic Process (GO:0070525)
Inositol Phosphate Biosynthetic Process (GO:0032958)
Positive Regulation Of Synaptic Transmission (GO:0050806)
Regulation Of BMP Signaling Pathway (GO:0030510)
Positive Regulation Of Sodium Ion Transmembrane Transport (GO:1902307)
Lung Epithelium Development (GO:0060428)
Postsynapse Assembly (GO:0099068)
Iron Ion Transmembrane Transport (GO:0034755)
Ectoderm Development (GO:0007398)
Presynaptic Membrane Organization (GO:0097090)
Positive Regulation Of Smooth Muscle Contraction (GO:0045987)
Peptidyl-Cysteine Modification (GO:0018198)
Regulation Of Hair Cycle (GO:0042634)
Second-Messenger-Mediated Signaling (GO:0019932)
Plasma Membrane Organization (GO:0007009)
Negative Regulation Of Cellular Response To Growth Factor Stimulus (GO:0090288)
Synapse Assembly (GO:0007416)
Bundle Of His Cell To Purkinje Myocyte Communication (GO:0086069)
Presynaptic Membrane Assembly (GO:0097105)
Synapse Pruning (GO:0098883)
Negative Regulation Of Glycoprotein Biosynthetic Process (GO:0010561)
RNA Secondary Structure Unwinding (GO:0010501)
Regulation Of Heme Biosynthetic Process (GO:0070453)
RISC Complex Assembly (GO:0070922)
Tricarboxylic Acid Metabolic Process (GO:0072350)
Regulation Of Fibroblast Apoptotic Process (GO:2000269)
Golgi Ribbon Formation (GO:0090161)
Cellular Response To Muramyl Dipeptide (GO:0071225)
Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing (GO:0060054)
Regulation Of Monoatomic Ion Transmembrane Transporter Activity (GO:0032412)
Regulation Of Heart Contraction (GO:0008016)
Nitrogen Compound Transport (GO:0071705)
Inhibitory Postsynaptic Potential (GO:0060080)
Hair Cell Differentiation (GO:0035315)
Amino-Acid Betaine Transport (GO:0015838)
Termination Of RNA Polymerase II Transcription (GO:0006369)
Taurine Metabolic Process (GO:0019530)
Negative Regulation Of Fatty Acid Oxidation (GO:0046322)
L-alanine Transport (GO:0015808)
Regulation Of Dopamine Metabolic Process (GO:0042053)
Positive Regulation Of Isomerase Activity (GO:0010912)
Peptidyl-Lysine Deacetylation (GO:0034983)
Sulfur Amino Acid Transport (GO:0000101)
Postsynaptic Membrane Assembly (GO:0097104)
Arginine Catabolic Process (GO:0006527)
Positive Regulation Of Cell Junction Assembly (GO:1901890)
Chemical Synaptic Transmission (GO:0007268)
Positive Regulation Of Multicellular Organism Growth (GO:0040018)
Positive Regulation Of Fibroblast Apoptotic Process (GO:2000271)
Regulation Of Saliva Secretion (GO:0046877)
Serine Transport (GO:0032329)
Regulation Of Digestive System Process (GO:0044058)
Inner Ear Receptor Cell Differentiation (GO:0060113)
Membrane Biogenesis (GO:0044091)
Positive Regulation Of Trophoblast Cell Migration (GO:1901165)
Regulation Of Pyruvate Dehydrogenase Activity (GO:1904182)
Cardiac Muscle Cell-Cardiac Muscle Cell Adhesion (GO:0086042)
Regulation Of Respiratory System Process (GO:0044065)
Regulation Of Calcium Ion Transport (GO:0051924)
Regulation Of Cation Channel Activity (GO:2001257)
Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process (GO:0042985)
Epithelial Tube Branching Involved In Lung Morphogenesis (GO:0060441)
Regulation Of Focal Adhesion Disassembly (GO:0120182)
Bundle Of His cell-Purkinje Myocyte Adhesion Involved In Cell Communication (GO:0086073)
Positive Regulation Of Focal Adhesion Disassembly (GO:0120183)
Basic Amino Acid Transport (GO:0015802)
Inner Ear Auditory Receptor Cell Differentiation (GO:0042491)
Regulation Of Guanylate Cyclase Activity (GO:0031282)
L-aspartate Transmembrane Transport (GO:0070778)
L-aspartate Import Across Plasma Membrane (GO:0140009)
Carboxylic Acid Transport (GO:0046942)
Positive Regulation Of Ras Protein Signal Transduction (GO:0046579)
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol (GO:0051279)
Intracellular Iron Ion Homeostasis (GO:0006879)
Amino Acid Transport (GO:0006865)
Cardiac Conduction (GO:0061337)
Positive Regulation Of Biosynthetic Process (GO:0009891)
Modulation Of Chemical Synaptic Transmission (GO:0050804)
Negative Regulation Of BMP Signaling Pathway (GO:0030514)
Regulation Of Heart Rate By Cardiac Conduction (GO:0086091)
Membrane Assembly (GO:0071709)
Regulation Of Postsynaptic Membrane Potential (GO:0060078)
Regulation Of Cardiac Muscle Contraction (GO:0055117)
Regulation Of Sodium Ion Transport (GO:0002028)
Macrophage Activation (GO:0042116)
Regulation Of Metal Ion Transport (GO:0010959)
Glial Cell Differentiation (GO:0010001)
Positive Regulation Of Ion Transmembrane Transporter Activity (GO:0032414)
Regulation Of Calcium Ion Transmembrane Transporter Activity (GO:1901019)
Regulation Of Potassium Ion Transport (GO:0043266)
Limb Development (GO:0060173)
Regulation Of Cardiac Muscle Cell Action Potential (GO:0098901)
Protein Localization To Cell Surface (GO:0034394)
Regulation Of Cardiac Muscle Cell Contraction (GO:0086004)
Regulation Of AMPA Receptor Activity (GO:2000311)
Positive Regulation Of Cation Transmembrane Transport (GO:1904064)
Regulation Of Secretion (GO:0051046)
Regulation Of Keratinocyte Migration (GO:0051547)
Positive Regulation Of Keratinocyte Migration (GO:0051549)

0.0 0.5 1.0 1.5 2.0 2.5 3.0

-log10(adjusted p-value)

GSE21138 GO_Biological_Process_2023 divergence scatter (top100)

Low divergence
3.5 Moderate divergence
High divergence

Positive Regulation Of Keratinocyte Migration (GO:0051549)

Regulation Of Keratinocyte Migration (GO:0051547)

3.0

Regulation Of Secretion (GO:0051046)

Positive Regulation Of Cation Transmembrane Transport (GO:1904064)

2.5
Regulation Of AMPA Receptor Activity (GO:2000311)
Regulation Protein
Of Cardiac
Localization
Muscle Cell
To Cell
Contraction
Surface (GO:0086004)
(GO:0034394)
Regulation Of Cardiac Muscle Cell
LimbAction
Development
Potential (GO:0060173)
(GO:0098901)
Regulation Of Potassium Ion Transport (GO:0043266)

2.0
Manual -log10(adj. p)

1.5

1.0

0.5

0.0
0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5
ML -log10(adj. p)
 GSE21138 GO_Molecular_Function_2023 (side-by-side, top100)
ML
Manual
Kinase Binding (GO:0019900)
Protein Homodimerization Activity (GO:0042803)
Amyloid-Beta Binding (GO:0001540)
Phosphotransferase Activity, Alcohol Group As Acceptor (GO:0016773)
Cytokine Receptor Activity (GO:0004896)
ATPase Binding (GO:0051117)
RNA Nuclease Activity (GO:0004540)
Calcium Ion Transmembrane Transporter Activity (GO:0015085)
GTPase Binding (GO:0051020)
Transcription Regulatory Region Nucleic Acid Binding (GO:0001067)
Acyltransferase Activity, Transferring Groups Other Than Amino-Acyl Groups (GO:0016747)
PDZ Domain Binding (GO:0030165)
Endonuclease Activity (GO:0004519)
Hydrolase Activity, Acting On Carbon-Nitrogen (But Not Peptide) Bonds, In Linear Amides (GO:0016811)
Protein Serine/Threonine Phosphatase Activity (GO:0004722)
Flavin Adenine Dinucleotide Binding (GO:0050660)
Chloride Transmembrane Transporter Activity (GO:0015108)
Monoatomic Anion Channel Activity (GO:0005253)
Phosphoric Ester Hydrolase Activity (GO:0042578)
Calcium-Dependent Phospholipid Binding (GO:0005544)
Hydro-Lyase Activity (GO:0016836)
Actin Binding (GO:0003779)
Protein Phosphorylated Amino Acid Binding (GO:0045309)
Single-Stranded RNA Binding (GO:0003727)
Regulatory RNA Binding (GO:0061980)
RNA Endonuclease Activity (GO:0004521)
Neutral L-amino Acid Transmembrane Transporter Activity (GO:0015175)
Protein Kinase Binding (GO:0019901)
Transmitter-Gated Monoatomic Ion Channel Activity (GO:0022824)
Pentosyltransferase Activity (GO:0016763)
Phosphotyrosine Residue Binding (GO:0001784)
Transmembrane Receptor Protein Kinase Activity (GO:0019199)
Amino Acid Binding (GO:0016597)
Basal RNA Polymerase II Transcription Machinery Binding (GO:0001099)
Chemoattractant Activity (GO:0042056)
NADP Binding (GO:0050661)
Core Promoter Sequence-Specific DNA Binding (GO:0001046)
Adenyl Ribonucleotide Binding (GO:0032559)
Sodium Channel Regulator Activity (GO:0017080)
Transcription Coactivator Binding (GO:0001223)
Ubiquitin-Like Protein Conjugating Enzyme Binding (GO:0044390)
RNA Polymerase Core Enzyme Binding (GO:0043175)
Monocarboxylic Acid Transmembrane Transporter Activity (GO:0008028)
Adenyl Nucleotide Binding (GO:0030554)
RNA Polymerase II Complex Binding (GO:0000993)
Protein Tyrosine Kinase Activator Activity (GO:0030296)
miRNA Binding (GO:0035198)
Ubiquitin Conjugating Enzyme Binding (GO:0031624)
Dicarboxylic Acid Transmembrane Transporter Activity (GO:0005310)
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen (GO:0016709)
ADP Binding (GO:0043531)
NAD Binding (GO:0051287)
NAD+ ADP-ribosyltransferase Activity (GO:0003950)
Mitogen-Activated Protein Kinase Binding (GO:0051019)
Fibroblast Growth Factor Receptor Binding (GO:0005104)
GABA Receptor Activity (GO:0016917)
Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor (GO:0016620)
Ligand-Gated Monoatomic Anion Channel Activity (GO:0099095)
Histone Deacetylase Activity (GO:0004407)
Ankyrin Binding (GO:0030506)
GABA-A Receptor Activity (GO:0004890)
Kinase Activity (GO:0016301)
Neuropeptide Receptor Binding (GO:0071855)
Basic Amino Acid Transmembrane Transporter Activity (GO:0015174)
Quaternary Ammonium Group Transmembrane Transporter Activity (GO:0015651)
Acidic Amino Acid Transmembrane Transporter Activity (GO:0015172)
BMP Binding (GO:0036122)
G Protein-Coupled Photoreceptor Activity (GO:0008020)
Aldehyde Dehydrogenase (NAD+) Activity (GO:0004029)
C4-dicarboxylate Transmembrane Transporter Activity (GO:0015556)
Aldehyde Dehydrogenase [NAD(P)+] Activity (GO:0004030)
Alanine Transmembrane Transporter Activity (GO:0022858)
Acetylgalactosaminyltransferase Activity (GO:0008376)
Inhibitory Extracellular Ligand-Gated Monoatomic Ion Channel Activity (GO:0005237)
Carbonate Dehydratase Activity (GO:0004089)
GABA-gated Chloride Ion Channel Activity (GO:0022851)
Neurexin Family Protein Binding (GO:0042043)
Complement Component C3b Binding (GO:0001851)
Extracellular Ligand-Gated Monoatomic Ion Channel Activity (GO:0005230)
FMN Binding (GO:0010181)
Benzodiazepine Receptor Activity (GO:0008503)
Prostaglandin Receptor Activity (GO:0004955)
cAMP Response Element Binding (GO:0035497)
Hydrolase Activity, Acting On Carbon-Nitrogen (But Not Peptide) Bonds, In Linear Amidines (GO:0016813)
Protein Binding Involved In Heterotypic Cell-Cell Adhesion (GO:0086080)
L-aspartate Transmembrane Transporter Activity (GO:0015183)
Serine Transmembrane Transporter Activity (GO:0022889)
L-alanine Transmembrane Transporter Activity (GO:0015180)
Double-Stranded RNA Binding (GO:0003725)
Arginine Binding (GO:0034618)
Chloride Channel Activity (GO:0005254)
L-amino Acid Transmembrane Transporter Activity (GO:0015179)
RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity (GO:0008420)
L-serine Transmembrane Transporter Activity (GO:0015194)
NAD-dependent Protein Deacetylase Activity (GO:0034979)
Carboxylic Acid Transmembrane Transporter Activity (GO:0046943)
Amino Acid Transmembrane Transporter Activity (GO:0015171)
Keratin Filament Binding (GO:1990254)
Myosin Light Chain Binding (GO:0032027)
Sulfur Amino Acid Transmembrane Transporter Activity (GO:0000099)

0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5

-log10(adjusted p-value)

GSE21138 GO_Molecular_Function_2023 divergence scatter (top100)

Low divergence
Moderate divergence
High divergence
4.0

Sulfur Amino Acid Transmembrane Transporter Activity (GO:0000099)

3.5

3.0

2.5
Manual -log10(adj. p)

2.0

Myosin
Keratin
Light
Filament
Chain Binding (GO:1990254)
(GO:0032027)
Amino Acid Transmembrane Transporter Activity (GO:0015171)
Carboxylic
RNA Polymerase Acid Transmembrane
II CTDL-serine
NAD-dependent
Heptapeptide Repeat
Protein Phosphatase
Deacetylase (GO:0046943)
Transporter Activity (GO:0034979)
(GO:0015194)
(GO:0008420)
L-amino Acid Transmembrane Transporter Activity (GO:0015179)
Chloride Channel Activity (GO:0005254)
1.5

1.0

0.5

0.0
0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0
ML -log10(adj. p)
 GSE21138 GO_Cellular_Component_2023 (side-by-side, top100)
ML
Manual
Mitochondrial Membrane (GO:0031966)
Lysosome (GO:0005764)
Intracellular Organelle Lumen (GO:0070013)
Endoplasmic Reticulum Membrane (GO:0005789)
Intracellular Membrane-Bounded Organelle (GO:0043231)
Lysosomal Membrane (GO:0005765)
Cell-Cell Junction (GO:0005911)
Lytic Vacuole Membrane (GO:0098852)
Secretory Granule Membrane (GO:0030667)
Nucleus (GO:0005634)
Bounding Membrane Of Organelle (GO:0098588)
Nuclear Lumen (GO:0031981)
Vesicle (GO:0031982)
Nucleolus (GO:0005730)
Nuclear Membrane (GO:0031965)
Axon (GO:0030424)
Golgi Membrane (GO:0000139)
Basolateral Plasma Membrane (GO:0016323)
Tertiary Granule (GO:0070820)
Cell-Substrate Junction (GO:0030055)
Specific Granule (GO:0042581)
Focal Adhesion (GO:0005925)
Postsynaptic Density (GO:0014069)
Mitochondrial Matrix (GO:0005759)
Peroxisome (GO:0005777)
Actin Cytoskeleton (GO:0015629)
Intracellular Non-Membrane-Bounded Organelle (GO:0043232)
U2-type Spliceosomal Complex (GO:0005684)
Specific Granule Membrane (GO:0035579)
Dendrite (GO:0030425)
Clathrin-Coated Endocytic Vesicle (GO:0045334)
Plasma Membrane Raft (GO:0044853)
Glutamatergic Synapse (GO:0098978)
Clathrin-Coated Vesicle (GO:0030136)
COPII-coated ER To Golgi Transport Vesicle (GO:0030134)
Tertiary Granule Membrane (GO:0070821)
Actin Filament (GO:0005884)
Vesicle Membrane (GO:0012506)
Cortical Cytoskeleton (GO:0030863)
Transport Vesicle Membrane (GO:0030658)
Spliceosomal snRNP Complex (GO:0097525)
Coated Vesicle Membrane (GO:0030662)
ER To Golgi Transport Vesicle Membrane (GO:0012507)
Synaptic Vesicle Membrane (GO:0030672)
Exocytic Vesicle Membrane (GO:0099501)
Collagen-Containing Extracellular Matrix (GO:0062023)
Endoplasmic reticulum-Golgi Intermediate Compartment Membrane (GO:0033116)
Neuron Projection (GO:0043005)
Endocytic Vesicle (GO:0030139)
Sarcoplasmic Reticulum (GO:0016529)
Cortical Actin Cytoskeleton (GO:0030864)
Cornified Envelope (GO:0001533)
Membrane Raft (GO:0045121)
Recycling Endosome (GO:0055037)
Dendrite Membrane (GO:0032590)
Asymmetric Synapse (GO:0032279)
Cytoskeleton (GO:0005856)
Excitatory Synapse (GO:0060076)
Polymeric Cytoskeletal Fiber (GO:0099513)
Core Mediator Complex (GO:0070847)
GABA-ergic Synapse (GO:0098982)
U1 snRNP (GO:0005685)
GABA-A Receptor Complex (GO:1902711)
Cell Projection Membrane (GO:0031253)
Desmosome (GO:0030057)
Endoribonuclease Complex (GO:1902555)
Prespliceosome (GO:0071010)
U2-type Prespliceosome (GO:0071004)
mRNA Cleavage And Polyadenylation Specificity Factor Complex (GO:0005847)
RISC Complex (GO:0016442)
Intermediate Filament Cytoskeleton (GO:0045111)
Perisynaptic Extracellular Matrix (GO:0098966)
Inhibitory Synapse (GO:0060077)
Perineuronal Net (GO:0072534)
Intermediate Filament (GO:0005882)
RISC-loading Complex (GO:0070578)
Spectrin-Associated Cytoskeleton (GO:0014731)
Symmetric Synapse (GO:0032280)
Asymmetric, Glutamatergic, Excitatory Synapse (GO:0098985)
Sarcolemma (GO:0042383)
Cell-Cell Contact Zone (GO:0044291)
Brush Border Membrane (GO:0031526)
Ionotropic Glutamate Receptor Complex (GO:0008328)
Intercalated Disc (GO:0014704)
AMPA Glutamate Receptor Complex (GO:0032281)

0.0 0.5 1.0 1.5 2.0 2.5

-log10(adjusted p-value)

GSE21138 GO_Cellular_Component_2023 divergence scatter (top100)

Low divergence
Moderate divergence
High divergence

AMPA Glutamate Receptor Complex (GO:0032281)

2.5

Intercalated Disc (GO:0014704)

Ionotropic Glutamate Receptor Complex (GO:0008328)

2.0
Brush Border Membrane (GO:0031526)

Cell-Cell Contact Zone (GO:0044291)

Sarcolemma (GO:0042383)
Asymmetric, Glutamatergic,Symmetric
Excitatory Synapse (GO:0032280)
(GO:0098985)
Manual -log10(adj. p)

Spectrin-Associated
RISC-loading
Cytoskeleton
Complex (GO:0014731)
(GO:0070578)
1.5

1.0

0.5

0.0
0.0 0.5 1.0 1.5 2.0 2.5
ML -log10(adj. p)
 GSE21138 KEGG_2021_Human (side-by-side, top100)
ML
Manual
Pathways of neurodegeneration
Alzheimer disease
Amyotrophic lateral sclerosis
MicroRNAs in cancer
Cytokine-cytokine receptor interaction
Salmonella infection
Chemical carcinogenesis
Ras signaling pathway
Herpes simplex virus 1 infection
Proteoglycans in cancer
Epstein-Barr virus infection
Pathogenic Escherichia coli infection
Transcriptional misregulation in cancer
Neutrophil extracellular trap formation
Tuberculosis
Hepatocellular carcinoma
Wnt signaling pathway
Hippo signaling pathway
JAK-STAT signaling pathway
Spliceosome
Gastric cancer
Retrograde endocannabinoid signaling
Breast cancer
Apelin signaling pathway
PI3K-Akt signaling pathway
Relaxin signaling pathway
Growth hormone synthesis, secretion and action
Leukocyte transendothelial migration
Pathways in cancer
Parathyroid hormone synthesis, secretion and action
T cell receptor signaling pathway
Protein digestion and absorption
Amoebiasis
MAPK signaling pathway
Hematopoietic cell lineage
Choline metabolism in cancer
Inflammatory mediator regulation of TRP channels
mRNA surveillance pathway
Phosphatidylinositol signaling system
Circadian entrainment
Staphylococcus aureus infection
Salivary secretion
Morphine addiction
GABAergic synapse
PD-L1 expression and PD-1 checkpoint pathway in cancer
Taste transduction
Complement and coagulation cascades
Arrhythmogenic right ventricular cardiomyopathy
Leishmaniasis
Pertussis
Inositol phosphate metabolism
Non-small cell lung cancer
Melanoma
Glycolysis / Gluconeogenesis
Acute myeloid leukemia
Lysine degradation
Glycerolipid metabolism
Mineral absorption
Long-term depression
Rap1 signaling pathway
Legionellosis
Valine, leucine and isoleucine degradation
Pyruvate metabolism
Glycosphingolipid biosynthesis
ABC transporters
Fatty acid degradation
Tryptophan metabolism
Nicotine addiction
Nicotinate and nicotinamide metabolism
Pentose and glucuronate interconversions
Phagosome
Cell adhesion molecules
Ascorbate and aldarate metabolism
beta-Alanine metabolism
Arginine biosynthesis
Calcium signaling pathway
Selenocompound metabolism
Nitrogen metabolism
Regulation of actin cytoskeleton
Vitamin B6 metabolism
Arginine and proline metabolism
Neuroactive ligand-receptor interaction
Histidine metabolism

0.0 0.5 1.0 1.5 2.0 2.5

-log10(adjusted p-value)

GSE21138 KEGG_2021_Human divergence scatter (top100)

Low divergence
Moderate divergence
High divergence

2.5
Histidine metabolism

2.0
Neuroactive ligand-receptor interaction

Arginine and proline metabolism

Vitamin B6 metabolism

1.5
Manual -log10(adj. p)

Regulation of actin cytoskeleton

Selenocompound
Nitrogen metabolism
Calcium signaling pathway
Arginine biosynthesis

1.0
Ascorbate and aldarate metabolism

0.5

0.0
0.0 0.5 1.0 1.5 2.0 2.5
ML -log10(adj. p)
 GSE21138 BioCarta_2016 (side-by-side, top100)
MAPKinase Signaling Pathway Homo sapiens h mapkPathway
Keratinocyte Differentiation Homo sapiens h keratinocytePathway
ML
Trefoil Factors Initiate Mucosal Healing Homo sapiens h tffPathway Manual
Signal transduction through IL1R Homo sapiens h il1rPathway
Ceramide Signaling Pathway Homo sapiens h ceramidePathway
NFkB activation by Nontypeable Hemophilus influenzae Homo sapiens h nthiPathway
Regulation of eIF4e and p70 S6 Kinase Homo sapiens h eif4Pathway
mTOR Signaling Pathway Homo sapiens h mTORPathway
TNF/Stress Related Signaling Homo sapiens h stressPathway
Growth Hormone Signaling Pathway Homo sapiens h ghPathway
NF-kB Signaling Pathway Homo sapiens h nfkbPathway
Nitric Oxide Signaling Pathway Homo sapiens h nos1Pathway
AKT Signaling Pathway Homo sapiens h aktPathway
Gamma-aminobutyric Acid Receptor Life Cycle Homo sapiens h gabaPathway
Double Stranded RNA Induced Gene Expression Homo sapiens h rnaPathway
Cardiac Protection Against ROS Homo sapiens h flumazenilPathway
CD40L Signaling Pathway Homo sapiens h cd40Pathway
SUMOylation as a mechanism to modulate CtBP-dependent gene responses Homo sapiens h ctbp1Pathway
0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4
-log10(adjusted p-value)
GSE21138 BioCarta_2016 divergence scatter (top100)
1.6 SUMOylation as a mechanism to modulate CtBP-dependent gene responses Homo sapiens Low divergence
h ctbp1Pathway
CD40L Signaling Pathway Homo sapiens h cd40Pathway
1.4 Cardiac Protection Against ROS Homo sapiens h flumazenilPathway Moderate divergence
Double Stranded RNA High divergence
Gamma-aminobutyric AcidInduced Gene
Receptor LifeExpression
Cycle HomoHomo sapiens
sapiens h rnaPathway
h gabaPathway

Manual -log10(adj. p)
1.2 Nitric
NF-kBOxide AKT Signaling
Signaling
Signaling
Pathway
Pathway
Pathway HomoHomo sapiens
sapiens h aktPathway
h nos1Pathway
Growth Hormone
TNF/Stress Related Signaling HomoHomo sapiens
sapiens h ghPathway
nfkbPathway
h stressPathway
1.0
0.8
0.6
0.4
0.2
0.0
0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6
ML -log10(adj. p)
 GSE38485 GO_Biological_Process_2023 (side-by-side, top100)
ML
Manual

Polyadenylation-Dependent snoRNA 3'-End Processing (GO:0071051)

Polyamine Biosynthetic Process (GO:0006596)
Cellular Response To Bacterial Lipopeptide (GO:0071221)
Regulation Of Inositol Phosphate Biosynthetic Process (GO:0010919)
Negative Regulation Of Plasminogen Activation (GO:0010757)
Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis (GO:1903588)
Regulation Of Natural Killer Cell Cytokine Production (GO:0002727)
Regulation Of Myosin-Light-Chain-Phosphatase Activity (GO:0035507)
Adherens Junction Maintenance (GO:0034334)
Regulation Of Cellular Response To Hypoxia (GO:1900037)
Proton Motive Force-Driven Mitochondrial ATP Synthesis (GO:0042776)
Positive Regulation Of Telomere Maintenance (GO:0032206)
Rho Protein Signal Transduction (GO:0007266)
Regulation Of Proteolysis (GO:0030162)
Apoptotic Process (GO:0006915)
Regulation Of Substrate Adhesion-Dependent Cell Spreading (GO:1900024)
Regulation Of Telomere Maintenance Via Telomerase (GO:0032210)
Ribosome Assembly (GO:0042255)
Regulation Of Interleukin-12 Production (GO:0032655)
Cytosolic Transport (GO:0016482)
Regulation Of Tumor Necrosis Factor Production (GO:0032680)
Regulation Of Response To External Stimulus (GO:0032101)
Positive Regulation Of Cell Motility (GO:2000147)
Regulation Of Nitric Oxide Mediated Signal Transduction (GO:0010749)
Kidney Morphogenesis (GO:0060993)
Peptidyl-Diphthamide Biosynthetic Process From Peptidyl-Histidine (GO:0017183)
Protein Repair (GO:0030091)
Interleukin-5-Mediated Signaling Pathway (GO:0038043)
Axo-Dendritic Transport (GO:0008088)
Negative Regulation Of Arp2/3 Complex-Mediated Actin Nucleation (GO:0034316)
Regulation Of cGMP-mediated Signaling (GO:0010752)
Peptidyl-Diphthamide Metabolic Process (GO:0017182)
Positive Regulation Of NK T Cell Proliferation (GO:0051142)
Regulation Of System Process (GO:0044057)
Response To Testosterone (GO:0033574)
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors (GO:1902043)
Short-Chain Fatty Acid Catabolic Process (GO:0019626)
Regulation Of Growth Hormone Receptor Signaling Pathway (GO:0060398)
Nephron Tubule Development (GO:0072080)
Regulation Of Long-Chain Fatty Acid Import Across Plasma Membrane (GO:0010746)
Response To Angiotensin (GO:1990776)
Glomerular Epithelial Cell Differentiation (GO:0072311)
Gamma-Aminobutyric Acid Metabolic Process (GO:0009448)
Regulation Of Stress Granule Assembly (GO:0062028)
Renal Filtration Cell Differentiation (GO:0061318)
Response To Peptidoglycan (GO:0032494)
Determination Of Liver Left/Right Asymmetry (GO:0071910)
Cholesterol Import (GO:0070508)
acetyl-CoA Biosynthetic Process From Pyruvate (GO:0006086)
Positive Regulation Of Reactive Oxygen Species Metabolic Process (GO:2000379)
Regulation Of T Cell Differentiation (GO:0045580)
Mitotic G2/M Transition Checkpoint (GO:0044818)
Regulation Of Cell Migration (GO:0030334)
Regulation Of Stem Cell Differentiation (GO:2000736)
Regulation Of Telomerase Activity (GO:0051972)
I-kappaB kinase/NF-kappaB Signaling (GO:0007249)
Positive Regulation Of mRNA Catabolic Process (GO:0061014)
Protein Transport (GO:0015031)
Positive Regulation Of Nucleocytoplasmic Transport (GO:0046824)
Positive Regulation Of MAPK Cascade (GO:0043410)
mRNA Destabilization (GO:0061157)
Energy Derivation By Oxidation Of Organic Compounds (GO:0015980)
Regulation Of Endothelial Cell Apoptotic Process (GO:2000351)
Regulation Of MAP Kinase Activity (GO:0043405)
Response To Lipid (GO:0033993)
Cellular Response To Salt (GO:1902075)
Regulation Of Microtubule Polymerization (GO:0031113)
Regulation Of Cytokine-Mediated Signaling Pathway (GO:0001959)
Cellular Response To Heat (GO:0034605)
Protein Deacetylation (GO:0006476)
Response To Tumor Necrosis Factor (GO:0034612)
Positive Regulation Of Metabolic Process (GO:0009893)
Positive Regulation Of T Cell Activation (GO:0050870)
Negative Regulation Of Cell-Substrate Adhesion (GO:0010812)
Regulation Of Mitotic Spindle Organization (GO:0060236)
Nuclear-Transcribed mRNA Catabolic Process, Deadenylation-Dependent Decay (GO:0000288)
Regulation Of Cell Differentiation (GO:0045595)
Regulation Of Signal Transduction (GO:0009966)
Tumor Necrosis Factor-Mediated Signaling Pathway (GO:0033209)
Mitochondrial Gene Expression (GO:0140053)
RNA Stabilization (GO:0043489)
Regulation Of Cellular Component Biogenesis (GO:0044087)
Positive Regulation Of Telomere Maintenance Via Telomere Lengthening (GO:1904358)
Positive Regulation Of Cold-Induced Thermogenesis (GO:0120162)
Mitochondrial Translation (GO:0032543)
Endosomal Transport (GO:0016197)
Negative Regulation Of Mitotic Cell Cycle (GO:0045930)
Positive Regulation Of Supramolecular Fiber Organization (GO:1902905)
Positive Regulation Of Transmembrane Receptor Protein Serine/Threonine Kinase Signaling Pathway (GO:0090100)
Positive Regulation Of Telomerase Activity (GO:0051973)
Regulation Of Potassium Ion Transmembrane Transport (GO:1901379)
Sphingolipid Metabolic Process (GO:0006665)
Retrograde Transport, Endosome To Golgi (GO:0042147)
Glycosphingolipid Metabolic Process (GO:0006687)
Positive Regulation Of Telomere Maintenance Via Telomerase (GO:0032212)
Regulation Of Response To Biotic Stimulus (GO:0002831)
Leukocyte Cell-Cell Adhesion (GO:0007159)
Phagocytosis, Engulfment (GO:0006911)
Regulation Of Platelet Activation (GO:0010543)
Cortical Cytoskeleton Organization (GO:0030865)
Peptide Cross-Linking (GO:0018149)
Regulation Of Keratinocyte Differentiation (GO:0045616)
Positive Regulation Of Microtubule Polymerization Or Depolymerization (GO:0031112)
Regulation Of Cellular Component Organization (GO:0051128)
Negative Regulation Of Cell Junction Assembly (GO:1901889)
Positive Regulation Of Epithelial Cell Apoptotic Process (GO:1904037)
Negative Regulation Of G Protein-Coupled Receptor Signaling Pathway (GO:0045744)
Response To Molecule Of Bacterial Origin (GO:0002237)
Aerobic Electron Transport Chain (GO:0019646)
Nuclear-Transcribed mRNA poly(A) Tail Shortening (GO:0000289)
Regulation Of Spindle Organization (GO:0090224)
Cell Projection Organization (GO:0030030)
Regulation Of Cell-Matrix Adhesion (GO:0001952)
RNA Destabilization (GO:0050779)
Receptor Clustering (GO:0043113)
Cortical Actin Cytoskeleton Organization (GO:0030866)
Oxidative Phosphorylation (GO:0006119)
Regulation Of MAPK Cascade (GO:0043408)
Positive Regulation Of Natural Killer Cell Activation (GO:0032816)
Aerobic Respiration (GO:0009060)
Positive Regulation Of Protein Metabolic Process (GO:0051247)
Cellular Response To Tumor Necrosis Factor (GO:0071356)
Negative Regulation Of Cytokine Production Involved In Immune Response (GO:0002719)
Positive Regulation Of Cell Activation (GO:0050867)
Positive Regulation Of Endothelial Cell Apoptotic Process (GO:2000353)
Positive Regulation Of Actin Filament Bundle Assembly (GO:0032233)
Response To Calcium Ion (GO:0051592)
Negative Regulation Of Interleukin-12 Production (GO:0032695)
Protein Monoubiquitination (GO:0006513)
Translation (GO:0006412)
Regulation Of Microtubule Nucleation (GO:0010968)
Regulation Of Nitric Oxide Biosynthetic Process (GO:0045428)
Cellular Respiration (GO:0045333)
Positive Regulation Of Platelet Activation (GO:0010572)
Establishment Of Spindle Orientation (GO:0051294)
Regulation Of Pattern Recognition Receptor Signaling Pathway (GO:0062207)
Establishment Of Mitotic Spindle Localization (GO:0040001)
Glycolipid Metabolic Process (GO:0006664)
Positive Regulation Of Microtubule Nucleation (GO:0090063)
Regulation Of G Protein-Coupled Receptor Signaling Pathway (GO:0008277)
Mitochondrial ATP Synthesis Coupled Electron Transport (GO:0042775)
Establishment Of Mitotic Spindle Orientation (GO:0000132)
Positive Regulation Of Microtubule Polymerization (GO:0031116)
Regulation Of Actin Filament Bundle Assembly (GO:0032231)
Regulation Of Toll-Like Receptor Signaling Pathway (GO:0034121)

0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0

-log10(adjusted p-value)

GSE38485 GO_Biological_Process_2023 divergence scatter (top100)

4.0

Regulation Of Toll-Like Receptor Signaling Pathway (GO:0034121)

3.5

Regulation Of Pattern Recognition Receptor Signaling Pathway (GO:0062207)

Positive Regulation Of Platelet Activation (GO:0010572)

3.0

Protein Monoubiquitination (GO:0006513)

Negative Regulation Of Interleukin-12 Production (GO:0032695)

2.5
Manual -log10(adj. p)

2.0

1.5

1.0

0.5

0.0 Positive Regulation Of EndothelialRegulation

CellPositive
Apoptotic
OfRegulation
Microtubule
Process Of
(GO:2000353)
Translation
Nucleation
Microtubule(GO:0006412)
(GO:0010968)
Polymerization
Nucleation (GO:0090063)
(GO:0031116)
0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0
ML -log10(adj. p)
 GSE38485 GO_Molecular_Function_2023 (side-by-side, top100)
ML
Manual

RNA Polymerase II-specific DNA-binding Transcription Factor Binding (GO:0061629)

Protein Phosphatase Regulator Activity (GO:0019888)
Receptor Tyrosine Kinase Binding (GO:0030971)
Protein Heterodimerization Activity (GO:0046982)
Protein Serine/Threonine Kinase Activator Activity (GO:0043539)
Protein-Lysine N-methyltransferase Activity (GO:0016279)
Syntaxin Binding (GO:0019905)
Actin Binding (GO:0003779)
S-adenosylmethionine-dependent Methyltransferase Activity (GO:0008757)
Protein Kinase Inhibitor Activity (GO:0004860)
Proton Transmembrane Transporter Activity (GO:0015078)
Adenyl Ribonucleotide Binding (GO:0032559)
Transcription Corepressor Binding (GO:0001222)
Endopeptidase Regulator Activity (GO:0061135)
2-Oxoglutarate-Dependent Dioxygenase Activity (GO:0016706)
Transmitter-Gated Monoatomic Ion Channel Activity (GO:0022824)
Monoatomic Ion Gated Channel Activity (GO:0022839)
Catalytic Activity, Acting On A tRNA (GO:0140101)
Phosphotyrosine Residue Binding (GO:0001784)
Calcium Channel Regulator Activity (GO:0005246)
Peptidase Inhibitor Activity (GO:0030414)
Protein Kinase C Binding (GO:0005080)
Non-Membrane Spanning Protein Tyrosine Kinase Activity (GO:0004715)
Histone H3 Methyltransferase Activity (GO:0140938)
ATP Binding (GO:0005524)
GTPase Regulator Activity (GO:0030695)
NADP Binding (GO:0050661)
Inorganic Cation Transmembrane Transporter Activity (GO:0022890)
Transmitter-Gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential (GO:1904315)
Kinase Inhibitor Activity (GO:0019210)
3'-5'-RNA Exonuclease Activity (GO:0000175)
Nuclear Estrogen Receptor Binding (GO:0030331)
NADH Dehydrogenase (Quinone) Activity (GO:0050136)
Ribonucleoside Triphosphate Phosphatase Activity (GO:0017111)
NADH Dehydrogenase (Ubiquinone) Activity (GO:0008137)
GTPase Activity (GO:0003924)
SH2 Domain Binding (GO:0042169)
Adenyl Nucleotide Binding (GO:0030554)
Gamma-Tubulin Binding (GO:0043015)
Hydrolase Activity, Hydrolyzing O-glycosyl Compounds (GO:0004553)
Protease Binding (GO:0002020)
Tumor Necrosis Factor Receptor Superfamily Binding (GO:0032813)
Histone Acetyltransferase Activity (GO:0004402)
Nuclear Thyroid Hormone Receptor Binding (GO:0046966)
Voltage-Gated Monoatomic Ion Channel Activity (GO:0005244)
Protein Serine/Threonine/Tyrosine Kinase Activity (GO:0004712)
MHC Class II Protein Complex Binding (GO:0023026)
Epidermal Growth Factor Receptor Binding (GO:0005154)
Phosphatidylinositol-3,4-Bisphosphate Binding (GO:0043325)
Protein Homodimerization Activity (GO:0042803)
Active Monoatomic Ion Transmembrane Transporter Activity (GO:0022853)
Protein Kinase Binding (GO:0019901)
Phospholipid Transfer Activity (GO:0120014)
Disordered Domain Specific Binding (GO:0097718)
Actin Monomer Binding (GO:0003785)
Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential (GO:0099529)
Telomerase RNA Binding (GO:0070034)
Tau-Protein Kinase Activity (GO:0050321)
Ubiquitin-Specific Protease Binding (GO:1990381)
Protein Serine/Threonine Kinase Activity (GO:0004674)
Cysteine-Type Endopeptidase Inhibitor Activity Involved In Apoptotic Process (GO:0043027)
Microtubule Plus-End Binding (GO:0051010)
RNA Cap Binding (GO:0000339)
Chemokine Receptor Activity (GO:0004950)
Purine Ribonucleoside Triphosphate Binding (GO:0035639)
GTPase Activator Activity (GO:0005096)
Amino Acid:Sodium Symporter Activity (GO:0005283)
Ligand-Gated Calcium Channel Activity (GO:0099604)
Hormone Receptor Binding (GO:0051427)
Growth Factor Receptor Binding (GO:0070851)
Chemokine Binding (GO:0019956)
Protein Phosphatase 1 Binding (GO:0008157)
Kinase Binding (GO:0019900)
Ionotropic Glutamate Receptor Activity (GO:0004970)
Low-Density Lipoprotein Particle Binding (GO:0030169)
Ubiquitin-Like Protein Ligase Activity (GO:0061659)
Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor (GO:0016655)
Ubiquitin Protein Ligase Activity (GO:0061630)
Heme Binding (GO:0020037)
Alanine Transmembrane Transporter Activity (GO:0022858)
3'-5' DNA Helicase Activity (GO:0043138)
MAP Kinase Kinase Activity (GO:0004708)
G Protein-Coupled Chemoattractant Receptor Activity (GO:0001637)
Nuclear Vitamin D Receptor Binding (GO:0042809)
Histone H3K4 Methyltransferase Activity (GO:0042800)
4 Iron, 4 Sulfur Cluster Binding (GO:0051539)
Ubiquitin-Ubiquitin Ligase Activity (GO:0034450)
RNA 7-Methylguanosine Cap Binding (GO:0000340)
poly(A)-specific Ribonuclease Activity (GO:0004535)
Microtubule Minus-End Binding (GO:0051011)
2 Iron, 2 Sulfur Cluster Binding (GO:0051537)
Organic Acid:Sodium Symporter Activity (GO:0005343)
3'-5'-DNA Exonuclease Activity (GO:0008296)
DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity (GO:0003906)
Histone Methyltransferase Binding (GO:1990226)
Metal Ion Binding (GO:0046872)
Glycine Transmembrane Transporter Activity (GO:0015187)
Cytidylyltransferase Activity (GO:0070567)
Inhibitory MHC Class I Receptor Activity (GO:0032396)
Amino Acid:Monoatomic Cation Symporter Activity (GO:0005416)
Intramolecular Transferase Activity, Phosphotransferases (GO:0016868)
Histone H3 Kinase Activity (GO:0140996)
Magnesium Ion Binding (GO:0000287)
Phosphoserine Residue Binding (GO:0050815)
Growth Hormone Receptor Binding (GO:0005131)
L-glutamine Transmembrane Transporter Activity (GO:0015186)
Nucleosome Binding (GO:0031491)
NMDA Glutamate Receptor Activity (GO:0004972)
Histone Ubiquitin Ligase Activity (GO:0140852)
Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor (GO:0016624)
Nuclease Activity (GO:0004518)
Iron Ion Binding (GO:0005506)
Oxidoreduction-Driven Active Transmembrane Transporter Activity (GO:0015453)
Ceramide Transfer Activity (GO:0120017)
Guanyl Ribonucleotide Binding (GO:0032561)
GTPase Binding (GO:0051020)
Nuclear Receptor Coactivator Activity (GO:0030374)
Protein Carboxyl O-methyltransferase Activity (GO:0051998)
Cobalamin Binding (GO:0031419)
Four-Way Junction Helicase Activity (GO:0009378)
Ceramide 1-Phosphate Binding (GO:1902387)
Ceramide 1-Phosphate Transfer Activity (GO:1902388)
Annealing Activity (GO:0140666)
Tubulin Binding (GO:0015631)
Cadherin Binding (GO:0045296)
Potassium Channel Regulator Activity (GO:0015459)
Protein Phosphorylated Amino Acid Binding (GO:0045309)
GTP Binding (GO:0005525)
Small GTPase Binding (GO:0031267)
Tau Protein Binding (GO:0048156)
Nucleosomal DNA Binding (GO:0031492)
Protein Kinase Activator Activity (GO:0030295)
Protein Tyrosine Kinase Activator Activity (GO:0030296)
Chromatin DNA Binding (GO:0031490)
Amyloid-Beta Binding (GO:0001540)
Ferrous Iron Binding (GO:0008198)
Lipoprotein Particle Binding (GO:0071813)
Transforming Growth Factor Beta Binding (GO:0050431)
Ubiquitin-Protein Transferase Activity (GO:0004842)
Fibroblast Growth Factor Binding (GO:0017134)
Calcium-Dependent Phospholipid Binding (GO:0005544)
Ubiquitin-Like Protein Transferase Activity (GO:0019787)
RNA Binding (GO:0003723)

0.0 0.5 1.0 1.5 2.0 2.5 3.0

-log10(adjusted p-value)

GSE38485 GO_Molecular_Function_2023 divergence scatter (top100)

3.5

3.0

2.5

Amyloid-Beta Binding (GO:0001540)

Protein Tyrosine Kinase Activator Activity (GO:0030296)

Protein Kinase Activator Activity (GO:0030295)
2.0
Manual -log10(adj. p)

1.5

RNA Binding (GO:0003723)

1.0

Calcium-Dependent Phospholipid Binding (GO:0005544)

0.5

0.0 Potassium ChannelGTPase

Small
Cadherin
Regulator
Binding
GTPase
GTP
Binding
Activity
Binding
Binding
(GO:0051020)
(GO:0045296)
(GO:0015459)
(GO:0005525)
(GO:0031267)
0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5
ML -log10(adj. p)
 GSE38485 GO_Cellular_Component_2023 (side-by-side, top100)
ML
Manual

trans-Golgi Network Membrane (GO:0032588)

Bounding Membrane Of Organelle (GO:0098588)
Late Endosome Membrane (GO:0031902)
P-body (GO:0000932)
trans-Golgi Network (GO:0005802)
Vesicle (GO:0031982)
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane (GO:0031234)
Cytoplasmic Vesicle Membrane (GO:0030659)
Small-Subunit Processome (GO:0032040)
Lytic Vacuole (GO:0000323)
Recycling Endosome Membrane (GO:0055038)
Intermediate Filament (GO:0005882)
Spindle Microtubule (GO:0005876)
Cortical Cytoskeleton (GO:0030863)
Specific Granule Lumen (GO:0035580)
Ribosome (GO:0005840)
Lysosomal Membrane (GO:0005765)
Extracellular Vesicle (GO:1903561)
Transport Vesicle Membrane (GO:0030658)
Ficolin-1-Rich Granule Membrane (GO:0101003)
Azurophil Granule Membrane (GO:0035577)
Extracellular Membrane-Bounded Organelle (GO:0065010)
Lysosome (GO:0005764)
Coated Vesicle Membrane (GO:0030662)
ER To Golgi Transport Vesicle Membrane (GO:0012507)
Microtubule (GO:0005874)
Cytosolic Large Ribosomal Subunit (GO:0022625)
Large Ribosomal Subunit (GO:0015934)
Golgi Cisterna (GO:0031985)
Actin Cytoskeleton (GO:0015629)
Heterochromatin (GO:0000792)
Peroxisomal Matrix (GO:0005782)
Microbody Lumen (GO:0031907)
Sarcoplasmic Reticulum (GO:0016529)
Phagocytic Vesicle Membrane (GO:0030670)
Cortical Actin Cytoskeleton (GO:0030864)
Chromosome (GO:0005694)
Nuclear Lumen (GO:0031981)
Small Ribosomal Subunit (GO:0015935)
Endocytic Vesicle Membrane (GO:0030666)
Nucleolus (GO:0005730)
Cytosolic Small Ribosomal Subunit (GO:0022627)
Mitochondrial Respiratory Chain Complex I (GO:0005747)
Respiratory Chain Complex I (GO:0045271)
Cornified Envelope (GO:0001533)
Brush Border Membrane (GO:0031526)
Keratin Filament (GO:0045095)
Postsynaptic Specialization Membrane (GO:0099634)
Cul4-RING E3 Ubiquitin Ligase Complex (GO:0080008)
Cul3-RING Ubiquitin Ligase Complex (GO:0031463)
Mitotic Spindle (GO:0072686)
Postsynaptic Density Membrane (GO:0098839)
Ionotropic Glutamate Receptor Complex (GO:0008328)
Golgi Stack (GO:0005795)
SWI/SNF Complex (GO:0016514)
NuA4 Histone Acetyltransferase Complex (GO:0035267)
U2-type Catalytic Step 2 Spliceosome (GO:0071007)
Protein Serine/Threonine Phosphatase Complex (GO:0008287)
H4/H2A Histone Acetyltransferase Complex (GO:0043189)
Polysomal Ribosome (GO:0042788)
Lumenal Side Of Endoplasmic Reticulum Membrane (GO:0098553)
Endoplasmic Reticulum Tubular Network (GO:0071782)
Endosome Lumen (GO:0031904)
Collagen-Containing Extracellular Matrix (GO:0062023)
Vacuolar Proton-Transporting V-type ATPase Complex (GO:0016471)
Nuclear Membrane (GO:0031965)
Mitochondrial Ribosome (GO:0005761)
Mitochondrial Matrix (GO:0005759)
Proton-Transporting V-type ATPase Complex (GO:0033176)
Pericentric Heterochromatin (GO:0005721)
Sin3-type Complex (GO:0070822)
MHC Protein Complex (GO:0042611)
Sin3 Complex (GO:0016580)
Respiratory Chain Complex IV (GO:0045277)
Spindle (GO:0005819)
Mitochondrial Respiratory Chain Complex IV (GO:0005751)
Protein Phosphatase Type 2A Complex (GO:0000159)
Platelet Alpha Granule Membrane (GO:0031092)
Nucleus (GO:0005634)
Endocytic Vesicle (GO:0030139)
Azurophil Granule Lumen (GO:0035578)
TIM23 Mitochondrial Import Inner Membrane Translocase Complex (GO:0005744)
Secretory Vesicle (GO:0099503)
Lysosomal Lumen (GO:0043202)
RSC-type Complex (GO:0016586)
Plasma Membrane Raft (GO:0044853)
Cytoplasmic Side Of Endoplasmic Reticulum Membrane (GO:0098554)
GBAF Complex (GO:0140288)
Brahma Complex (GO:0035060)
Set1C/COMPASS Complex (GO:0048188)
Cul4A-RING E3 Ubiquitin Ligase Complex (GO:0031464)
npBAF Complex (GO:0071564)
Mitochondrial Respiratory Chain Complex III (GO:0005750)
Respiratory Chain Complex III (GO:0045275)
Membrane Raft (GO:0045121)
Tertiary Granule Membrane (GO:0070821)
Proton-Transporting V-type ATPase, V1 Domain (GO:0033180)
Vacuolar Proton-Transporting V-type ATPase, V1 Domain (GO:0000221)
Vacuolar Lumen (GO:0005775)
Intracellular Membrane-Bounded Organelle (GO:0043231)
Platelet Alpha Granule Lumen (GO:0031093)
Pseudopodium (GO:0031143)
Caveola (GO:0005901)
NMDA Selective Glutamate Receptor Complex (GO:0017146)
Astral Microtubule (GO:0000235)
Tertiary Granule Lumen (GO:1904724)
Microtubule Cytoskeleton (GO:0015630)
External Side Of Apical Plasma Membrane (GO:0098591)
Rough Endoplasmic Reticulum Membrane (GO:0030867)
Intracellular Non-Membrane-Bounded Organelle (GO:0043232)
Phagocytic Vesicle (GO:0045335)
Cytoskeleton (GO:0005856)
Platelet Alpha Granule (GO:0031091)
Azurophil Granule (GO:0042582)
Mitochondrial Membrane (GO:0031966)
Cytoplasmic Dynein Complex (GO:0005868)
Intracellular Organelle Lumen (GO:0070013)
Cytoplasmic Vesicle Lumen (GO:0060205)
Tertiary Granule (GO:0070820)
Organelle Inner Membrane (GO:0019866)
Cell-Substrate Junction (GO:0030055)
Focal Adhesion (GO:0005925)
Mitochondrial Inner Membrane (GO:0005743)
Ficolin-1-Rich Granule Lumen (GO:1904813)
Ficolin-1-Rich Granule (GO:0101002)
Specific Granule Membrane (GO:0035579)
Secretory Granule Membrane (GO:0030667)
Secretory Granule Lumen (GO:0034774)
Specific Granule (GO:0042581)

0 1 2 3 4 5
-log10(adjusted p-value)

GSE38485 GO_Cellular_Component_2023 divergence scatter (top100)

Specific Granule (GO:0042581)

Secretory Granule Membrane (GO:0030667)

Specific Granule Membrane (GO:0035579)
4

3
Manual -log10(adj. p)

2
Phagocytic Vesicle (GO:0045335)

Focal Adhesion (GO:0005925)

Cell-Substrate Junction (GO:0030055)

1 Cytoplasmic Dynein Complex (GO:0005868)

NMDA Selective
External
0 Glutamate
Side Of Apical
Receptor
Astral
Plasma
Microtubule
Complex
Membrane
(GO:0017146)
(GO:0000235)
(GO:0098591)
0 1 2 3 4 5
ML -log10(adj. p)
 GSE38485 KEGG_2021_Human (side-by-side, top100)
ML
Manual

AGE-RAGE signaling pathway in diabetic complications

Circadian entrainment
GnRH signaling pathway
Small cell lung cancer
Th1 and Th2 cell differentiation
GABAergic synapse
PD-L1 expression and PD-1 checkpoint pathway in cancer
Endocytosis
ErbB signaling pathway
Peroxisome
Synaptic vesicle cycle
Leishmaniasis
Human cytomegalovirus infection
p53 signaling pathway
Adherens junction
Human T-cell leukemia virus 1 infection
Prolactin signaling pathway
Epithelial cell signaling in Helicobacter pylori infection
cAMP signaling pathway
Amphetamine addiction
Mitophagy
Fc epsilon RI signaling pathway
Long-term potentiation
Rap1 signaling pathway
Lysine degradation
Viral carcinogenesis
Long-term depression
Pathogenic Escherichia coli infection
Hedgehog signaling pathway
Herpes simplex virus 1 infection
Autoimmune thyroid disease
Human papillomavirus infection
Cysteine and methionine metabolism
Vibrio cholerae infection
Arginine and proline metabolism
Cocaine addiction
Sphingolipid metabolism
Intestinal immune network for IgA production
Valine, leucine and isoleucine degradation
Pyruvate metabolism
Carbohydrate digestion and absorption
Proteasome
ABC transporters
Vasopressin-regulated water reabsorption
Hippo signaling pathway
Hepatitis B
Type I diabetes mellitus
Necroptosis
Bladder cancer
Hepatitis C
Nicotine addiction
Primary immunodeficiency
Allograft rejection
Spinocerebellar ataxia
Signaling pathways regulating pluripotency of stem cells
Propanoate metabolism
SNARE interactions in vesicular transport
Base excision repair
Yersinia infection
Systemic lupus erythematosus
Asthma
Glyoxylate and dicarboxylate metabolism
Pentose phosphate pathway
Oocyte meiosis
Lysosome
Collecting duct acid secretion
Shigellosis
AMPK signaling pathway
Neurotrophin signaling pathway
Sphingolipid signaling pathway
Glutamatergic synapse
Toxoplasmosis
Insulin resistance
Glucagon signaling pathway
NF-kappa B signaling pathway
T cell receptor signaling pathway
Hematopoietic cell lineage
Other glycan degradation
Proteoglycans in cancer
Staphylococcus aureus infection
Epstein-Barr virus infection
TGF-beta signaling pathway
Kaposi sarcoma-associated herpesvirus infection
ECM-receptor interaction
Chemokine signaling pathway
Cardiac muscle contraction
RNA degradation
PPAR signaling pathway
Central carbon metabolism in cancer
Ribosome
Viral myocarditis
Ubiquitin mediated proteolysis
Glutathione metabolism
PI3K-Akt signaling pathway
Natural killer cell mediated cytotoxicity
Cholesterol metabolism
Amino sugar and nucleotide sugar metabolism
Regulation of actin cytoskeleton
Fat digestion and absorption
Leukocyte transendothelial migration
Graft-versus-host disease
Focal adhesion
Starch and sucrose metabolism
Rheumatoid arthritis
Galactose metabolism
Tight junction
Non-alcoholic fatty liver disease
Phagosome
Antigen processing and presentation
Cell adhesion molecules
Thermogenesis
Adipocytokine signaling pathway
Glycolysis / Gluconeogenesis
Lipid and atherosclerosis
Pathways of neurodegeneration
Alzheimer disease
Prion disease
Malaria
Salmonella infection
Parkinson disease
Huntington disease
Diabetic cardiomyopathy
Oxidative phosphorylation
Amyotrophic lateral sclerosis
Citrate cycle (TCA cycle)

0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5

-log10(adjusted p-value)

GSE38485 KEGG_2021_Human divergence scatter (top100)

3.5

3.0

2.5

Antigen processing and presentation

Phagosome

2.0
Manual -log10(adj. p)

Rheumatoid arthritis

Graft-versus-host disease

Amino sugar and nucleotide sugar metabolism

Natural killer cell mediated cytotoxicity

1.5
Ubiquitin mediated proteolysis
Alzheimer disease

PPAR signaling pathway

1.0

Tight junction

0.5

0.0
0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5
ML -log10(adj. p)
 GSE38485 BioCarta_2016 (side-by-side, top100)
ML
MAPKinase Signaling Pathway Homo sapiens h mapkPathway Manual
T Cell Receptor Signaling Pathway Homo sapiens h tcrPathway
Keratinocyte Differentiation Homo sapiens h keratinocytePathway
Rac 1 cell motility signaling pathway Homo sapiens h rac1Pathway
Signal transduction through IL1R Homo sapiens h il1rPathway
Ceramide Signaling Pathway Homo sapiens h ceramidePathway
Integrin Signaling Pathway Homo sapiens h integrinPathway
Bioactive Peptide Induced Signaling Pathway Homo sapiens h biopeptidesPathway
Rho cell motility signaling pathway Homo sapiens h rhoPathway
Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia Homo sapiens h ecmPathway
Fc Epsilon Receptor I Signaling in Mast Cells Homo sapiens h fcer1Pathway
ADP-Ribosylation Factor Homo sapiens h arapPathway
Role of ERBB2 in Signal Transduction and Oncology Homo sapiens h her2Pathway
Control of Gene Expression by Vitamin D Receptor Homo sapiens h vdrPathway
TPO Signaling Pathway Homo sapiens h TPOPathway
CCR3 signaling in Eosinophils Homo sapiens h CCR3Pathway
Caspase Cascade in Apoptosis Homo sapiens h caspasePathway
TNF/Stress Related Signaling Homo sapiens h stressPathway
Inhibition of Cellular Proliferation by Gleevec Homo sapiens h gleevecpathway
Growth Hormone Signaling Pathway Homo sapiens h ghPathway
Lissencephaly gene (LIS1) in neuronal migration and development Homo sapiens h Lis1Pathway
Nitric Oxide Signaling Pathway Homo sapiens h nos1Pathway
Chaperones modulate interferon Signaling Pathway Homo sapiens h tidPathway
METS affect on Macrophage Differentiation Homo sapiens h etsPathway
TNFR1 Signaling Pathway Homo sapiens h tnfr1Pathway
uCalpain and friends in Cell spread Homo sapiens h ucalpainPathway
IL12 and Stat4 Dependent Signaling Pathway in Th1 Development Homo sapiens h IL12Pathway
IL 6 signaling pathway Homo sapiens h il6Pathway
Erythropoietin mediated neuroprotection through NF-kB Homo sapiens h eponfkbPathway
Role of Mitochondria in Apoptotic Signaling Homo sapiens h mitochondriaPathway
IL 3 signaling pathway Homo sapiens h il3Pathway
EPO Signaling Pathway Homo sapiens h epoPathway
Role of Ran in mitotic spindle regulation Homo sapiens h ranMSpathway
SODD/TNFR1 Signaling Pathway Homo sapiens h soddPathway
NO2-dependent IL 12 Pathway in NK cells Homo sapiens h no2il12Pathway
CD40L Signaling Pathway Homo sapiens h cd40Pathway
RNA polymerase III transcription Homo sapiens h RNApol3Pathway
TACI and BCMA stimulation of B cell immune responses Homo sapiens h tall1Pathway
Stat3 Signaling Pathway Homo sapiens h stat3Pathway
TSP-1 Induced Apoptosis in Microvascular Endothelial Cell Homo sapiens h tsp1Pathway
IFN gamma signaling pathway Homo sapiens h ifngPathway
HIV-1 Nef: negative effector of Fas and TNF Homo sapiens h HivnefPathway

0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6

-log10(adjusted p-value)

GSE38485 BioCarta_2016 divergence scatter (top100)

1.6
TSP-1 Induced Apoptosis in Microvascular Endothelial Cell Homo sapiens h tsp1Pathway
TACI and BCMA stimulation of B cell immune responses Homo sapiens h tall1Pathway
1.4
SODD/TNFR1 Signaling Pathway Homo sapiens h soddPathway

Role of Mitochondria in Apoptotic Signaling Homo sapiens h mitochondriaPathway

1.2
TNFR1 Signaling Pathway Homo sapiens h tnfr1Pathway
Manual -log10(adj. p)

1.0

0.8

0.6

0.4

0.2

0.0 METS affect

NitriconOxide
Macrophage
Role
Signaling
of Ran
Differentiation
Pathway
in mitotic
RNA
Homo
spindle
polymerase
Homo
CD40L
sapiens
regulation
sapiens
Signaling
hIIInos1Pathway
transcription
h Homo
etsPathway
Pathway
sapiens
Homo
Homo
h sapiens
ranMSpathway
sapienshhcd40Pathway
RNApol3Pathway
0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6
ML -log10(adj. p)
 GSE21138: Scatter of z-scores
5

3
ML score (z)

1
1 0 1 2 3 4
Manual score (z)
 GSE21138: Rank Rank Scatter
80

70

60

50
ML rank

40

30

20

10

0
0 10 20 30 40 50 60 70 80
Manual rank
 GSE21138: Distribution of disagreements

10

8
Gene count

0
0 1 2 3 4 5 6
|Z-score difference|
 |Z-score difference|

0
1
2
3
4
5
6

F4
0A

IP1
1
VA
L B
NM
U
01
01
TA
C1

SC
2
AIN
4
GSE21138: Top 10 disagreements

RA
P2

YO
6
 GSE21138: Jaccard overlap curve
1.0

0.8
Jaccard similarity

0.6

0.4

0.2

0.0
0 500 1000 1500 2000 2500 3000
Top-N genes
 GSE38485: Scatter of z-scores
7

4
ML score (z)

1 0 1 2 3
Manual score (z)
 GSE38485: Rank Rank Scatter
160

140

120

100
ML rank

80

60

40

20

0
0 20 40 60 80 100 120 140 160
Manual rank
 GSE38485: Distribution of disagreements
25

20
Gene count

15

10

0
0 1 2 3 4 5 6 7 8
|Z-score difference|
 |Z-score difference|

0
1
2
3
4
5
6
7
8

GIR
R
LG
1
IN3
B
FLN
A
RG
2
PS
2 9
2R
1A

SD
1
GSE38485: Top 10 disagreements

MF
B
F3
C1
 GSE38485: Jaccard overlap curve
1.0

0.8
Jaccard similarity

0.6

0.4

0.2

0.0
0 500 1000 1500 2000 2500 3000
Top-N genes