ONCOLOGY
Definition & Scope
Oncology: Branch of medicine dealing with the study, diagnosis, treatment, and prevention
of cancer.
Cancer: Group of diseases characterized by uncontrolled cell growth, invasion of surrounding
tissues, and potential spread (metastasis).
Oncologist: Medical professional specializing in cancer care.
Key Concepts
Neoplasm: Abnormal tissue growth.
o Benign tumors: Non-cancerous, localized, slow-growing.
o Malignant tumors: Cancerous, invasive, capable of metastasis.
Carcinogenesis: Process of cancer development.
o Initiation → Promotion → Progression.
Metastasis: Spread of cancer cells to distant organs via blood or lymph.
Differentiation: Degree to which tumor cells resemble normal cells.
o Well-differentiated = less aggressive.
o Poorly differentiated (anaplastic) = more aggressive.
Types of Cancer
Carcinomas: Cancer of epithelial cells (e.g., breast, lung, colon).
Sarcomas: Cancer of connective tissue (bone, muscle).
Leukemias: Cancer of blood-forming tissues.
Lymphomas: Cancer of lymphatic system.
Melanomas: Cancer of pigment-producing cells.
Risk Factors
Genetic: Family history, inherited mutations (e.g., BRCA1/2).
Environmental: Radiation, carcinogens, pollution.
Lifestyle: Smoking, alcohol, poor diet, obesity.
Biological: Chronic infections (HPV, Hepatitis B/C, EBV).
Diagnosis
Screening tests: Pap smear, mammography, colonoscopy.
Biopsy: Gold standard for diagnosis.
Imaging: CT, MRI, PET scans.
Laboratory tests: Tumor markers (PSA, CA-125, AFP).
Treatment Modalities
Surgery: Removal of tumor.
Radiotherapy: Use of ionizing radiation to kill cancer cells.
Chemotherapy: Cytotoxic drugs targeting rapidly dividing cells.
Immunotherapy: Boosting immune system (checkpoint inhibitors, monoclonal antibodies).
Targeted therapy: Drugs aimed at specific molecular pathways (e.g., tyrosine kinase
inhibitors).
Hormonal therapy: For hormone-sensitive cancers (breast, prostate).
Palliative care: Symptom management, quality of life improvement.
Nursing & Supportive Care
Symptom management: Pain, fatigue, nausea, alopecia.
Psychosocial support: Counseling, patient education.
Monitoring: Side effects of therapy, infection prevention.
Rehabilitation: Physical therapy, nutritional support.
Quick Comparison Table
Aspect Benign Tumor Malignant Tumor
Growth rate Slow Rapid
Invasion Localized Invades surrounding tissue
Metastasis None Common
Differentiation Well-differentiated Poorly differentiated
Prognosis Usually favorable Often poor if untreated
Ethical & Public Health Considerations
Screening programs: Early detection saves lives.
Access to care: Equity in cancer treatment.
End-of-life care: Ethical issues in palliative and hospice care.
Prevention: Lifestyle modification, vaccination (HPV, Hepatitis B).