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Bioreaction Engineering Basics

1) The document discusses concepts related to bioreaction engineering including wash out, steady state, and the maximum production rate. 2) It also covers topics in chemical reaction engineering like energy balance fundamentals, adiabatic reactors, and relating temperature and conversion or selectivity using user friendly equations. 3) Examples are provided for an adiabatic reactor with no work and a plug flow reactor model for a reversible reaction A ↔ B including mole balances, rate laws, stoichiometry and an energy balance.

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Khai Huynh
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89 views25 pages

Bioreaction Engineering Basics

1) The document discusses concepts related to bioreaction engineering including wash out, steady state, and the maximum production rate. 2) It also covers topics in chemical reaction engineering like energy balance fundamentals, adiabatic reactors, and relating temperature and conversion or selectivity using user friendly equations. 3) Examples are provided for an adiabatic reactor with no work and a plug flow reactor model for a reversible reaction A ↔ B including mole balances, rate laws, stoichiometry and an energy balance.

Uploaded by

Khai Huynh
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPT, PDF, TXT or read online on Scribd

Last time 3/6/08

D=v
o
/ V
Bioreaction Engineering
Wash Out:









1.) Neglect Death Rate and Cell Maintenance


2.) Steady State





Wash Out:
Maximum Production Rate =

Dividing by V

m
V
= DC
C
How does this figure relate to drinking a lot of
fluids when you have an infection or cold?


Lecture Thursday 3/11/08

Energy Balance Fundamentals
Adiabatic Reactors






User Friendly Equations Relate T and X or F
i
User Friendly Equations Relate T and X or F
i


Last Time 3/6/08
Intro to heat effects
D
a
d
C
a
c
B
a
b
A + +
Q

s
mol
F
i

0
mol
J
E
i

0
i
F
i
E
Rate of
energy
in by
flow
Rate of
energy
out by
flow
Heat
added
to the
system
Work
done
by the
system
Rate of
energy
accumulation
- - + =
( ) ( ) ( ) ( ) state) steady (at 0

0 0
=
= +

s J s J s J s J
dt
dE
W Q E F E F
sys
i i i i

Assumptions:
|
|
.
|

\
|
= + =
+ =
+ + =

mol
m
V V P F V P F
W
KE PE U E
i i i i
i i i i
3
0 0 0
~

~ ~
work flow
shaft work work flow
internal to compared small energies other

=0 =0
| |
| | | |
0
0
~ ~
0
~ ~
0 0
0 0 0 0
0 0 0 0 0
= +
= + + +
= + + +



S i i i i
S i i i i i i
S i i i i i i i i
W Q H F H F
W Q V P U F V P U F
W V P F V P F Q U F U F



( )
( )
( ) 0
0
0

0 0 0
0 0 0 0
0 0 0
0
0 0 0 0
= +
|
.
|

\
|

= +
|
.
|

\
|

= +
|
.
|

\
|
+
+ =
= =



S
i
i A i i i A
S i A i i A i i A
S i i A i i A
i A i
A i i i A i
W Q H
a
i
X F H H F
W Q XH
a
i
F H F H F
W Q H X
a
i
F H F
X a i F F
F F F F



u
u u
u u
u
u u
- Assuming no phase change during
reaction
- Assuming constant heat capacity
|
.
|

\
|
K mol
J

Pi
C
( ) ( ) ( ) ( ) ( )
R Pi R i i
T
T
Pi R i i
T T C T H T H dT C T H T H
R
+ = + =
}
0 0
Enthalpy of formation at temperature T
R
( ) ( ) | |
R P i R P i i i
T T C H T T C H H H + + =
0
0
0
( )
( ) ( ) ( )
R Pi i i
Pi i i
T T C H a i H a i
T T C H H
+ =
=

0
0 0
Heat of reaction at temperature T
( ) ( ) ( )
( ) ( ) | | 0
0 0 0
0 0 0 0 0
0
= + A + A
+ = A
+ = A
A + A = A =

S R P i A Pi i A
PA PB PC PD P
A B C D X
R P X RX i
W Q T T C H X F T T C F
C C
a
b
C
a
c
C
a
d
C
H H
a
b
H
a
c
H
a
d
H
T T C H T H H a i

u
Example Adiabatic and no work
( ) ( ) | |
( )
( ) | |

A
+ =
A
A A

=
A A =
= =
0
0
0
P
0
0
0
0
C neglecting
0 , 0
P i
X
R P X
Pi i
R P X Pi i
S
C
X H
T T
T T C H
T T C
X
T T C H X T T C
W Q
u
u
u

F
A0
cancels from remaining terms
Usually C
P
is small compared to
other terms
X X
T T
exothermic
endothermic
Example PFR A B
1) Mole balance
2) Rate Laws


3) Stoichiometry
4) Energy Balance
0 A
A
F
r
dV
dX
=
(

|
|
.
|

\
|

A
= = A
(

|
|
.
|

\
|
=
(

=
T T k
H
k k C
T T R
E
k k
k
C
C k r
X
C C P
C
B
A A
1 1
exp 0
1 1
exp
2
0
2
1
1
( ) X C C X C C
A B A A 0 0
1 = =

A
+ =
Pi i
X
C
X H
T T
u
0
0

A
+ =
Pi i
X
C
X H
T T
u
0
0
T
X
C
Adiabatic
equilibrium
conversion
C
C
eq
k
k
X
+
=
1

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