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Jenis dan Efek Obat Antidepresi

This document discusses different types of antidepressant drugs, how they work, their side effects, and important considerations for their use. It covers tricyclic antidepressants which work by inhibiting neurotransmitter reuptake and blocking receptors; monoamine oxidase inhibitors which metabolize monoamines; and selective serotonin reuptake inhibitors which increase serotonin in synapses. Common side effects include dry mouth, blurred vision, weight gain, and hypotension. Drug interactions and contraindications in certain patient populations are also important to consider.

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43 views11 pages

Jenis dan Efek Obat Antidepresi

This document discusses different types of antidepressant drugs, how they work, their side effects, and important considerations for their use. It covers tricyclic antidepressants which work by inhibiting neurotransmitter reuptake and blocking receptors; monoamine oxidase inhibitors which metabolize monoamines; and selective serotonin reuptake inhibitors which increase serotonin in synapses. Common side effects include dry mouth, blurred vision, weight gain, and hypotension. Drug interactions and contraindications in certain patient populations are also important to consider.

Uploaded by

mengaku
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PPT, PDF, TXT or read online on Scribd

OBAT-OBAT ANTIDEPRESI

Penggolongan
-Obat anti depresi Trisiklik: Amitriptiline,
Imipramine,Clomipramine, Tianeptin,Opipramol
-Obat anti depresi Tetrasiklik: Maprotiline,
Mianserin,Amoxapine
-Noradrenergic Reuptake Inhibitors:Reboxetine
-Obat antidepresi MAOI-reversible: Moclobemide
-Obat antidepresi SSRI (Selective Serotonin
Reuptake Inhibitor): Sertraline, PAroxetine,
Fluoxetine
Trisiklik antidepressant
Cara Kerja:
-Menghambat ambilan neurotransmitter
-Penghambatan reseptor: serotonik, histamin,
alpha adrenegik
Side effect:
-Hipotensi dan dizzines (block alpha 1 adrenergic)
-dry mouth, blurred vision,memory disturbance
(muscharinic cholinergic receptor block)
-Sedasi dan weight gain (Histamin receptor block)

Overdosis:
Atropine Toxic Syndrome
Monoamine oxidase Inhibitors
Monoamine:
-Monoamine A
-Monoamine B
Monoamine oksidase A memetabolisme serotonin
dan epinefrine
Monoamine oksidases B memetabolisme protoxin
menjadi toxin kerusakan saraf
Side Effect: intracerebral hemorrhage (akibat
konsumsi makanan yang mengandung tiramin)

Interaksi obat: + SSRI Serotonin


malignant Syndrome
+ Obat sympathomimetic
Krisis Hipertensi
SSRI Antidepressant
Fluoxetine, sertraline, paroxetine, fluvoxamine
citalopram
Menggantikan fungsi TCA di klinik
Efek: Meningkatkan serotonin di sinaps
Indikasi: Depresi, bulimia nervosa, obsesif
kompulsif
Side effect:
-Brain
-spinal cord
-Gut
Perhatian Khusus
-Kepatuhan pasien dapt hilang karena adanya efek
samping
-Kontraindikasi penyakit jantung koroner pada usia
tua
-Trisikli antidepressant jangan diberikan pada ibu
hamil dan menyusui Teratogenik

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