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Primary Prevention of Cardiovascular Disease With A Mediterranean Diet Supplemented With Extra-Virgin Olive Oil or Nuts

The document summarizes a clinical trial showing that a Mediterranean diet supplemented with extra-virgin olive oil or nuts reduced cardiovascular events more than a low-fat diet in people at high risk. It provides study details, dietary recommendations, baseline characteristics, event estimates, and concludes that a Mediterranean diet lowered cardiovascular risk more than a reduced-fat diet.

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97 views9 pages

Primary Prevention of Cardiovascular Disease With A Mediterranean Diet Supplemented With Extra-Virgin Olive Oil or Nuts

The document summarizes a clinical trial showing that a Mediterranean diet supplemented with extra-virgin olive oil or nuts reduced cardiovascular events more than a low-fat diet in people at high risk. It provides study details, dietary recommendations, baseline characteristics, event estimates, and concludes that a Mediterranean diet lowered cardiovascular risk more than a reduced-fat diet.

Uploaded by

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Copyright
© © All Rights Reserved
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Download as PPTX, PDF, TXT or read online on Scribd

Original Article

Primary Prevention of Cardiovascular Disease


with a Mediterranean Diet Supplemented with
Extra-Virgin Olive Oil or Nuts
Ramón Estruch, M.D., Ph.D., Emilio Ros, M.D., Ph.D., Jordi Salas-Salvadó, M.D.,
Ph.D., Maria-Isabel Covas, [Link]., Ph.D., Dolores Corella, [Link]., Ph.D.,
Fernando Arós, M.D., Ph.D., Enrique Gómez-Gracia, M.D., Ph.D., Valentina Ruiz-
Gutiérrez, Ph.D., Miquel Fiol, M.D., Ph.D., José Lapetra, M.D., Ph.D., Rosa M.
Lamuela-Raventos, [Link]., Ph.D., Lluís Serra-Majem, M.D., Ph.D., Xavier
Pintó, M.D., Ph.D., Josep Basora, M.D., Ph.D., Miguel A. Muñoz, M.D., Ph.D., José
V. Sorlí, M.D., Ph.D., J. Alfredo Martínez, [Link]., M.D., Ph.D., Montserrat
Fitó, M.D., Ph.D., Alfredo Gea, [Link]., Ph.D., Miguel A. Hernán, M.D., Dr.P.H.,
Miguel A. Martínez-González, M.D., Ph.D., for the PREDIMED Study Investigators

N Engl J Med
Volume 378(25):e34
June 21, 2018
Study Overview
• This report includes the reanalysis of data from a clinical trial showing a
lower rate of cardiovascular events among persons assigned to a
Mediterranean diet supplemented with extra-virgin olive oil or nuts than
among those assigned to a low-fat diet.
Kaplan–Meier Estimates of the Cumulative Incidence of End-Point Events in the Total Study
Population.

Estruch R et al. N Engl J Med


2018;378:e34
Sensitivity Analyses of Each Mediterranean-Diet Group and the Control Group.

Estruch R et al. N Engl J Med 2018;378:e34


Sensitivity Analyses of the Combined Mediterranean-Diet Groups and the Control Group.

Estruch R et al. N Engl J Med 2018;378:e34


Summary of Dietary Recommendations to Participants in the Mediterranean-Diet Groups and the
Control-Diet Group.

Estruch R et al. N Engl J Med


2018;378:e34
Baseline Characteristics of the Participants, According to Intervention Group.

Estruch R et al. N Engl J Med 2018;378:e34


Estimates of Cardiovascular Events, According to Intervention Group.

Estruch R et al. N Engl J Med


2018;378:e34
Conclusions
• In this study involving persons at high cardiovascular risk, the incidence
of major cardiovascular events was lower among those assigned to a
Mediterranean diet supplemented with extra-virgin olive oil or nuts than
among those assigned to a reduced-fat diet.

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