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IMUNOLOGI Nugraha

The document summarizes key steps in the immune response process: 1. The immune response occurs in three phases - mechanical, chemical, and microbial barriers that provide initial protection from pathogens. 2. Antigens are processed and degraded into peptide fragments which are then presented on MHC molecules on cell surfaces to interact with T cells. 3. The immune response involves both innate and adaptive immunity. Adaptive immunity involves antigen presentation to T and B cells, followed by clonal expansion and production of antibodies or cytotoxic T cells to eliminate pathogens.

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47 views58 pages

IMUNOLOGI Nugraha

The document summarizes key steps in the immune response process: 1. The immune response occurs in three phases - mechanical, chemical, and microbial barriers that provide initial protection from pathogens. 2. Antigens are processed and degraded into peptide fragments which are then presented on MHC molecules on cell surfaces to interact with T cells. 3. The immune response involves both innate and adaptive immunity. Adaptive immunity involves antigen presentation to T and B cells, followed by clonal expansion and production of antibodies or cytotoxic T cells to eliminate pathogens.

Uploaded by

Danu Anggoro
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PPTX, PDF, TXT or read online on Scribd
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AAH NUGRAHA, SE, S.Si, Apt, M.

Sc

IMUNOLOGI DASAR
AAH NUGRAHA, SE, S.Si, Apt, M.Sc
Step of immune response

The response to an initial infection occurs in three phases

D.Purnomosari 4 11/20/2019
Mechanical

P Mucosal
a
t
h
o Chemical
g
e
n Ex.Epithelia

Microbial
Bacterial agents released by phagocytes on ingestion of
microorganism
Cytokine marker
for inflammation
 Jenis antigen.

 T : peptida (protein)
dinitrophenol, urushiol
 B : protein
non protein
Respon imun adaptif
Antigens di proses (degradasi)  fragmen peptida  MHC-T

T
Y
Fragmen peptida Ag + MHC
di permukaan
Soluble Soluble
Ag asing peptida
Ag asing di Ag MHC
permukaan sel Peptida Ag
di permukaan

proses antigen
(degradasi)

Respon Respon Respon Respon respon


Sel T (-) Sel T (-) Sel T (-) Sel T (-)
Sel T (+)
Presentasi Antigen
Jalur eksogen
Jalur endogen
B cell help

CD4 T
CD8 T ab
CTL TcR CD4
CD8 kill MHC II
TcR
MHC I
pathogen

Infeksi-virus /
sel tumor
dendritik/macrophag

MHC I restriction MHC II restriction


Katabolis antigen

M
M

Makrophag dan Melekat dipermukaan sel


*Listeria monocytogenes

Degradasi
M bakteri.
M
Fragmen peptida
antigen bakteri
diekspresikan di
permukaan
Internalisasi
sel
IMUNOGLOBULIN
SEL T DAN SEL B
REGULASI IMUNITAS
HUMORAL

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