Human Eye

 A human eyeball is like a simple camera!

 Sclera: outer walls, hard, like a light-tight box.
 Cornea and crystalline lens (eyelens): the two
lens system.
 Retina: at the back of eyeball, like the film.
 Iris: like diaphragms or stop in a camera.
 Pupil: camera aperture.
 Eyelid: lens cover.
Sclera (The white/non-transparent tissue surrounding the cornea)
Aqueous humor and Vitreous humor
 The Aqueous Humor is the clear liquid between the
cornea and the lens. It has the benefit of being fairly
homogenous and, as a result, the optical properties
are easily measured. (Le Grand, 1967)
 The space that it inhabits is called the anterior
chamber.
 The Vitreous Humor is the clear liquid between the
lens and the retina.
 The space that it fills is called the vitreous body.
Functions?
 Provides nourishment to the eyelens and cornea.
Cannot use the blood vessels:
 Will block the light.
 Easy for surgical transplant.

 Hold the shape of the eyeball.

Focusing
 The cornea and eyelens form a compound lens
system, producing a real inverted image on the
retina.
 From air to cornea (n=1.376): large bending, the main
focusing.
 From cornea to eyelens (n=1.406), less focusing power.
(Eyelens can develop white cloudiness when getting old:
Cataracts.)
 The eye has a limited depth of field. We cannot see
things close and far at the same time.
Accommodation
 The eye focusing is not done by change the distance
between the lens and retina. Rather, it is done by
changing the focal length of the eyelens! Ciliary
muscles help to change the shape of the lens:
accommodation.
 Muscles relax, long focal length, see objects far way;
Muscles tense, short focal length see objects close.
 Normal eyes can see 25cm to infinity, however, if the
cornea bulges too much or too little. The accommodation
does not help. (myopia or hyperopia)
The Iris
 When it is full open, it is about f/2 and f/3.
This happens at low light level.
 When the iris has a small opening, it can cut
down the light intensity by a factor of 20.
 However, the main function of stopping down
the iris is to increase the depth of field.
Retina Structure
 Light sensitive layer is made of photo-
receptors: rods (120 millions) and cones (7
millions) which absorb the light.
 Plexiform Layer: nerve cells that process
the signals generated by rods and cones and
relay them to the optical nerve.
 Choroid: carries mayor blood vessels to
nourish the retina and absorb the light so
that it will not be reflected back (dark
pupil!)
Rods and Cones
 Covers an area of 5 cm2. A baseball a mile
away gives an image covering one cone.
 Cones: for more precise vision, need strong
light. help to see colors. Mostly distributed
in the center of the retina (fovea).
 Rods: for peripheral and night vision.
Sensitive to light. Mostly distributed away
from fovea.
Sensitivity
 Cones: slow, fine grain, like color film.
 Need high level of light (photopic condition, day)
 High density, high resolution.
 Rods: fast, coarse grain, black & white film
 Low level of light (scotopic condition, at night)
No color is obvious.
 Adaptation: Changing of retina sensitivity.
Singal Processing
 Trace the signal through the retina:
 The retina is a seven-layered structure involved in
signal transduction.
 Light enters from the GCL side first, and must
penetrate all cell types before reaching the rods and
cones.
 The outer segments of the rods and cones transduce
the light and send the signal through the cell bodies of
the ONL and out to their axons.
 In the OPL photoreceptor axons contact the
dendrites of bipolar cells and horizontal
cells. Horizontal cells are interneurons
which aid in signal processing
 The bipolar cells in the INL process input
from photoreceptors and horizontal cells,
and transmit the signal to their axons.
 In the IPL, bipolar axons contact ganglion
cell dendrites and amacrine cells, another
class of interneurons.
 The ganglion cells of the GCL send their
axons through the OFL to the optic disk to
make up the optic nerve. They travel all the
way to the lateral geniculate nucleus.
Fovea
 The fovea defines the center of the retina, and
is the region of highest visual acuity. The
fovea is directed towards whatever object you
wish to study most closely - this sentence, at
the moment. In the fovea there are almost
exclusively cones, and they are at their
highest density.
Processing Time
 Latency: it takes a bit time for the cells in
retina to respond to a flash of light.
 Persistence of response: the response does
not stop at the instant the flash stops.
 1/25 second at low intensity, 1/50 second at high
intensity.
 The persistence allows as to see moving things
clearly.
Human Eye Diseases
The human eye is susceptible to various diseases and disorders
that can affect vision.
1. Refractive Errors
Myopia (Nearsightedness): Difficulty seeing distant objects

clearly.
Hyperopia (Farsightedness): Difficulty seeing nearby objects

clearly.
Astigmatism: Blurred vision due to irregular curvature of the

cornea or lens.
Presbyopia: Age-related difficulty in focusing on close objects.
2. Cataracts: Clouding of the eye's lens, leading
to blurry vision.

Causes: Aging, injury, or genetic disorders.

Treatment: Surgery to replace the cloudy lens

with an artificial one.
3. Glaucoma: Damage to the optic nerve, often
caused by increased pressure in the eye.
Symptoms: Loss of peripheral vision, halos
around lights, or total blindness if untreated.
Treatment: Medications, laser treatment, or
surgery to lower eye pressure.
4. Age-Related Macular Degeneration (AMD) :
Deterioration of the macula, which is responsible
for central vision.
Types: Dry AMD (gradual thinning of the
macula) and Wet AMD (abnormal blood vessel
growth).
Treatment: Lifestyle changes, medications, or
laser therapy.
5. Diabetic Retinopathy: Damage to the retina's
blood vessels caused by uncontrolled diabetes.
Symptoms: Blurred vision, floaters, and vision
loss.
Treatment: Controlling blood sugar levels, laser
treatment, or surgery.
6. Conjunctivitis (Pink Eye): Inflammation of
the conjunctiva, often due to infections or
allergies.
Symptoms: Redness, itching, discharge, or
tearing.
Treatment: Antibacterial, antiviral, or anti-
allergy medications.
7. Dry Eye Syndrome: Insufficient tear
production or poor tear quality.
Symptoms: Burning sensation, redness, or a
feeling of a foreign object in the eye.
Treatment: Artificial tears, medications, or
lifestyle changes
8. Retinal Detachment: The retina separates from
the underlying tissue, disrupting vision.
Symptoms: Sudden floaters, flashes of light, or a
shadow over part of the visual field.
Treatment: Emergency surgery to reattach the
retina.
9. Keratitis: Inflammation of the cornea caused
by infections, injuries, or prolonged contact lens
use.
Symptoms: Pain, redness, blurred vision, and
sensitivity to light.
Treatment: Antibacterial, antiviral, or antifungal
medications.
10. Uveitis: Inflammation of the uvea (middle
layer of the eye).
Symptoms: Eye redness, pain, blurred vision,
and light sensitivity.
Treatment: Steroids and immunosuppressive
drugs.
11. Amblyopia (Lazy Eye): Reduced vision in
one eye due to abnormal visual development
during childhood.
Treatment: Corrective glasses, patching the
stronger eye, or vision therapy.
12. Strabismus (Crossed Eyes) : Misalignment of
the eyes causing double vision or vision issues.
Treatment: Glasses, vision therapy, or surgery.
13. Corneal Ulcer: Open sore on the cornea,
often due to infections.
Symptoms: Pain, redness, tearing, and blurred
vision.
Treatment: Antimicrobial eye drops or surgery in
severe cases.
14. Night Blindness (Nyctalopia): Difficulty
seeing in low light or at night.
Causes: Vitamin A deficiency, retinitis
pigmentosa, or cataracts.
Treatment: Addressing the underlying cause.
 Prevention and General Eye Care
[Link] eye check-ups.

[Link] protective eyewear during activities.

[Link] chronic conditions like diabetes or

hypertension.
[Link] eyes from UV exposure.

[Link] a balanced diet rich in vitamins A,

C, and E.