HCLSIG BioRDF Subgroup/DERI HCLS KB
DERI Health Care and Life Science Knowledge Base
NOTE: THIS KB HAS BEEN DEPRECATED. THE INFORMATION HERE IS FOR HISTORIC PURPOSES. You can access the NEW HCLS KB at http://hcls.deri.org:8080/openrdf-sesame/repositories/hclskb We are no longer keeping this datasets updated but provided a catalogue of all linked life sciences dataset, described using the Vocabulary for Interlinked Dataset (VoiD) at http://hcls.deri.org/RoadMapEvaluation/ and queriable as a SPARQL endpoint at http://hcls.deri.org:8080/openrdf-sesame/repositories/roadmap
The knowledge base can be accessed through a SPARQL endpoint: http://hcls.deri.org/sparql
The contents of the knowledge base can also be explored through a faceted searching / browsing interface: http://srvgal14.deri.ie:8081/fct/
The HCLS Knowledge Base at DERI is a Virtuoso-based triplestore containing information relevant to life science, medicine and health care. It contains RDF/OWL data that was generated by current and previous participants of the W3C Semantic Web for Health Care and Life Science Interest Group. A major part of the HCLS Knowledge Base is comprised of a mirror of the Neurocommons Knowledge Base maintained by Science Commons.
The HCLS Knowledge Base contains over 400 million RDF statements.
If you have suggestions for relevant RDF/OWL data that should be added to the KB, please propose them to the mailing list public-semweb-lifesci@w3.org (requires prior registration).
How to query named graphs contained in the knowledge base
The HCLS Knowledge Base is divided into subsections (named graphs) which are listed below. To query a graph such as `http://hcls.deri.org/resource/graph/drugbank` you can use a SPARQL query such as
SELECT *
FROM <http://hcls.deri.org/resource/graph/drugbank>
WHERE {?s ?p ?o}
LIMIT 20
or, alternatively:
SELECT *
WHERE {
GRAPH <http://hcls.deri.org/resource/graph/drugbank>
{?s ?p ?o}
}
LIMIT 20
The latter syntax allows you to direct subqueries to different graphs, for example:
PREFIX owl: <http://www.w3.org/2002/07/owl#>
PREFIX go: <http://purl.org/obo/owl/GO#>
PREFIX obo: <http://www.geneontology.org/formats/oboInOwl#>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
select *
where {
graph <http://purl.org/science/graph/inferred-relations> {
?class rdfs:subClassOf go:GO_0008150
}
graph <http://purl.org/science/graph/obo/GO> {
?class rdfs:label ?name.
?class obo:hasDefinition ?def.
?def rdfs:label ?definition .
}
filter(regex(str(?name),"[Dd]endrite"))
}
Note that clicking on the URIs of the named graphs will not necessarily lead you anywhere. They are just used inside the triplestore as names for graphs, and might not resolve via HTTP.
Please try to keep the server load of your queries low. This can easily be accomplished by 1) restricting you queries to the named graphs you need, instead of querying the entire triplestore or a multitude of graphs, 2) uinge the LIMIT clause in your queries.
Named graphs contained in the HCLS Knowledge Base
Neurocommons Knowledge Base
Named graphs derived from the Neurocommons Knowledge Base are described in more detail on the Neurocommons RDF web page.
- MeSH polyhierarchy represented using SKOS: `http://purl.org/science/graph/mesh/mesh-skos`
- MeSH qualified headings - defines one URI for each valid major/minor heading: `http://purl.org/science/graph/mesh/qualified-headings`
- Medline / NLM MeSH subject headings for all articles: `http://purl.org/science/graph/medline/subject-headings`
- Medline / title and year of publication for each article: `http://purl.org/science/graph/medline/titles-years`
- All OBO ontologies: There is one named graph for each OBO ontology and they cannot all be listed here for space reasons. The graph names are made up of http://purl.org/science/graph/obo/ concatenated with the acronym of the OBO ontology. For example, the graph name of the Gene Ontology is: `http://purl.org/science/graph/obo/GO`
- Galen ontology: `http://purl.org/science/graph/galen`
- W3C SKOS (Simple Knowledge Organization System) ontology: `http://purl.org/science/graph/skos`
- Supporting ontology for conversion of MeSH polyhierarchy to RDF: `http://purl.org/science/graph/mesh-eswc06`
- Ad hoc Science Commons ontology: `http://purl.org/science/graph/sciencecommons`
- BAMS (Brain Architecture Management System): `http://purl.org/science/graph/bams`
- Senselab: `http://purl.org/science/graph/senselab`
- PDSP Ki database of ligand-receptor interactions: `http://purl.org/science/graph/pdspki`
- NCI thesaurus: `http://purl.org/science/graph/nci-thesaurus`
- NCBI Gene Ontology annotations: `http://purl.org/science/graph/ncbi/goa`
- NCBI Homologene selection: `http://purl.org/science/graph/ncbi/homologene`
- NCBI Gene gene synonyms extraction: `http://purl.org/science/graph/ncbi/gene-info`
- Links from NCBI Gene to Medline: `http://purl.org/science/graph/ncbi/gene-pubmed`
- Addgene plasmid catalog: `http://purl.org/science/graph/addgene`
- Neurocommons text processing pilot: `http://purl.org/science/graph/neurocommons-text`
- ABA (Allen Brain Atlas): `http://purl.org/science/graph/aba`
- Reactome records (direct from RDB): `http://purl.org/science/graph/reactome`
- Transitive closure of subclass and part_of relations: `http://purl.org/science/graph/inferred-relations`
Linking Open Drug Data and BioRDF
Several Datasets generated by the Linking Open Drug Data project and the BioRDF group have been loaded into the knowledge base
- Dailymed: `http://hcls.deri.org/resource/graph/dailymed`
- DrugBank: `http://hcls.deri.org/resource/graph/drugbank`
- ClinicalTrials.gov / LinkedCT: `http://hcls.deri.org/resource/graph/linkedct`
- Diseasome: `http://hcls.deri.org/resource/graph/diseasome`
- SIDER: `http://hcls.deri.org/resource/graph/sider`
- Traditional Chinese Medicine: `http://hcls.deri.org/resource/graph/tcm`
- Gene lists from the BioRDF microarray demo: `http://hcls.deri.org/resource/graph/genelists`
aTags
See the aTag website for background information.
- aTag Pastebin (user-generated aTags): `http://hcls.deri.org/atag/data/pastebin.html` (triplestore is periodically and automatically updated with RDFa contained in source)
- aTags generated out of conclusion sections from PubMed abstracts: `http://purl.org/concept/assertion/` (further information)
- SIDER aTags (drug side-effect data from SIDER): `http://hcls.deri.org/atag/data/SIDER_atags.html`
- aTags about pharmacological effects of plants used in TCM: `http://hcls.deri.org/atag/data/tcm_atags.html`
DBpedia - OBO - MeSH mapping
See DBpedia - OBO mapping task page for background information.
- DBpedia - OBO mapping based on xrefs contained in the OBO ontologies (a few hundred seeAlso statements): `http://samwald.info/res/dbpedia_obo_mapping_based_on_xrefs.ttl`
- DBpedia - MeSH mapping based on xrefs in DBpedia (a few hundred seeAlso statements): `http://samwald.info/res/dbpedia_mesh_mapping.ttl`
DBpedia
A subset of DBpedia is contained within the HCLS Knowledge Base. This subset contains the english labels and short abstracts of all DBpedia entries, as well as the YAGO hierarchy. The rationale for including a subset of DBpedia is that it provides a huge taxonomy of entities that are relevant for the HCLS domain (among many other things).
List of all graphs
Below is a list of all graphs contained in the triplestore, without further description. This includes the graphs detailed above.
http://www.openlinksw.com/schemas/virtrdf# http://srvgal14.deri.ie:8081/DAV http://www.w3.org/2002/07/owl# http://purl.org/concept/assertion/ http://samwald.info/res/dbpedia_mesh_mapping.ttl http://hcls.deri.org/resource/graph/dailymed http://hcls.deri.org/resource/graph/drugbank http://samwald.info/res/dbpedia_obo_mapping_based_on_xrefs.ttl http://purl.org/science/graph/inferred-relations http://purl.org/science/graph/obo/GO http://hcls.deri.org/atag/data/SIDER_atags.html http://sw.neurocommons.org/2007/aba-20070226 http://hcls.deri.org/resource/graph/dbpedia http://hcls.deri.org/resource/graph/diseasome http://hcls.deri.org/resource/graph/linkedct http://hcls.deri.org/resource/graph/medicare http://hcls.deri.org/resource/graph/sider http://purl.org/science/graph/addgene http://purl.org/science/graph/bams http://purl.org/commons/galen http://purl.org/science/graph/medline/subject-headings http://hcls.deri.org/atag/data/pastebin.html http://hcls.deri.org/atag/data/tcm_atags.html http://hcls.deri.org/atag/data/depression_atags_dumontier.ttl http://hcls.deri.org/resource/graph/tcm http://purl.org/science/graph/medline/titles-years http://purl.org/science/graph/mesh-eswc06 http://purl.org/science/graph/mesh/mesh-skos http://purl.org/science/graph/mesh/qualified-headings http://purl.org/science/graph/ncbi/gene-info http://purl.org/science/graph/ncbi/gene-pubmed http://purl.org/science/graph/ncbi/goa http://purl.org/science/graph/ncbi/homologene http://purl.org/science/graph/nci-thesaurus http://sw.neurocommons.org/2007/2007-03-15/pubmed-annotations http://purl.org/science/graph/obo/AAO http://purl.org/science/graph/obo/BILA http://purl.org/science/graph/obo/BOOTStrep http://purl.org/science/graph/obo/BSPO http://purl.org/science/graph/obo/BTO http://purl.org/science/graph/obo/CARO http://purl.org/science/graph/obo/CHEBI http://purl.org/science/graph/obo/CL http://purl.org/science/graph/obo/COG2GO http://purl.org/science/graph/obo/DDANAT http://purl.org/science/graph/obo/DOID http://purl.org/science/graph/obo/EC2GO http://purl.org/science/graph/obo/ECO http://purl.org/science/graph/obo/EGAD2GO http://purl.org/science/graph/obo/EHDA http://purl.org/science/graph/obo/EHDAA http://purl.org/science/graph/obo/EMAP http://purl.org/science/graph/obo/ENVO http://purl.org/science/graph/obo/EO http://purl.org/science/graph/obo/EV http://purl.org/science/graph/obo/FAO http://purl.org/science/graph/obo/FBbi http://purl.org/science/graph/obo/FBbt http://purl.org/science/graph/obo/FBcv http://purl.org/science/graph/obo/FBdv http://purl.org/science/graph/obo/FBsp http://purl.org/science/graph/obo/FIX http://purl.org/science/graph/obo/FMA http://purl.org/science/graph/obo/GENPROTECGO http://purl.org/science/graph/obo/GO_XP_INTERNAL http://purl.org/science/graph/obo/GO_XP_REGULATION http://purl.org/science/graph/obo/GRO http://purl.org/science/graph/obo/HAMAP2GO http://purl.org/science/graph/obo/IDO http://purl.org/science/graph/obo/IEV http://purl.org/science/graph/obo/IMR http://purl.org/science/graph/obo/INTERPRO2GO http://purl.org/science/graph/obo/MA http://purl.org/science/graph/obo/METACYC2GO http://purl.org/science/graph/obo/MFO http://purl.org/science/graph/obo/MI http://purl.org/science/graph/obo/MIPS2GO http://purl.org/science/graph/obo/MIRO http://purl.org/science/graph/obo/MO http://purl.org/science/graph/obo/MP http://purl.org/science/graph/obo/MPATH http://purl.org/science/graph/obo/MP_XP http://purl.org/science/graph/obo/MS http://purl.org/science/graph/obo/MULTIFUN2GO http://purl.org/science/graph/obo/OBI http://purl.org/science/graph/obo/OBO_REL http://purl.org/science/graph/obo/OBO_REL_BFO_BRIDGE http://purl.org/science/graph/obo/PATO http://purl.org/science/graph/obo/PATO_BFO_BRIDGE http://purl.org/science/graph/obo/PFAM2GO http://purl.org/science/graph/obo/PLO http://purl.org/science/graph/obo/PO http://purl.org/science/graph/obo/PRINTS2GO http://purl.org/science/graph/obo/PRO http://purl.org/science/graph/obo/PRODOM2GO http://purl.org/science/graph/obo/PROSITE2GO http://purl.org/science/graph/obo/PW http://purl.org/science/graph/obo/ProPreO http://purl.org/science/graph/obo/REACTOM2GO http://purl.org/science/graph/obo/REX http://purl.org/science/graph/obo/RFAMGO http://purl.org/science/graph/obo/RO http://purl.org/science/graph/obo/SAO http://purl.org/science/graph/obo/SBO http://purl.org/science/graph/obo/SMART2GO http://purl.org/science/graph/obo/SO http://purl.org/science/graph/obo/SOPHARM http://purl.org/science/graph/obo/SO_XP http://purl.org/science/graph/obo/SPD http://purl.org/science/graph/obo/SPKW2GO http://purl.org/science/graph/obo/TADS http://purl.org/science/graph/obo/TAO http://purl.org/science/graph/obo/TGMA http://purl.org/science/graph/obo/TIGR2GO http://purl.org/science/graph/obo/TIGRFAMS2GO http://purl.org/science/graph/obo/TO http://purl.org/science/graph/obo/TO_XP http://purl.org/science/graph/obo/TRANS http://purl.org/science/graph/obo/TTO http://purl.org/science/graph/obo/UBERON http://purl.org/science/graph/obo/UMBBDENZYMEID2GO http://purl.org/science/graph/obo/UMBBDPATHWAYID2GO http://purl.org/science/graph/obo/UO http://purl.org/science/graph/obo/WBPhenotype http://purl.org/science/graph/obo/WBbt http://purl.org/science/graph/obo/WBls http://purl.org/science/graph/obo/WP_XP http://purl.org/science/graph/obo/XAO http://purl.org/science/graph/obo/YPO http://purl.org/science/graph/obo/ZEA http://purl.org/science/graph/obo/ZFA http://purl.org/science/graph/obo/biological_process_xp_cell http://purl.org/science/graph/obo/biological_process_xp_cellular_component http://purl.org/science/graph/obo/biological_process_xp_multi_organism_process http://purl.org/science/graph/obo/biological_process_xp_self http://purl.org/science/graph/obo/biological_process_xp_uber_anatomy http://purl.org/science/graph/obo/caro_to_bfo http://purl.org/science/graph/obo/cellular_component_xp_go http://purl.org/science/graph/obo/cellular_component_xp_self http://purl.org/science/graph/obo/go_to_chebi http://purl.org/science/graph/obo/habronattus_courtship http://purl.org/science/graph/obo/molecular_function_xp_regulators http://purl.org/science/graph/obo/ncbitaxon http://purl.org/science/graph/obo/oboInOwl http://purl.org/science/graph/obo/ro_proposed http://purl.org/science/graph/obo/ro_ucdhsc http://purl.org/science/graph/obo/bfo http://purl.org/science/graph/pdspki http://purl.org/science/graph/reactome http://purl.org/science/graph/sciencecommons http://purl.org/commons/hcls/senselab http://purl.org/science/graph/skos http://purl.org/science/graph/transitive-properties-direct http://purl.org/science/graph/transitive-properties-indirect http://purl.org/science/graph/temporary/original-subclassof-relations http://purl.org/science/graph/temporary/original-flattened-class-relations http://purl.org/science/graph/temporary/subclass-transitive
The list above was generated by the query described here.
TODO
- Create RDF descriptions about graphs inside the triplestore, expose them via the linked data interface if possible
- Identify datasets that could be added and add them to the KB.
- Make documentation wiki page (this page) more complete.