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Striatal network modeling in Huntington’s Disease

Fig 6

Heat maps showing goodness of fit measure, log(KL), (the lower the better), for multiple network simulations compared to different experimental datasets.

(a) Q175WT, (b) Q175Het, (c) Q175Hom, (d) YACWT, (e) YACHD, (g) R62WT, (h) R62HD, (f) restricted age YACWT dataset denoted ‘WT75’, (i) restricted age YACHD dataset denoted ‘HD12’. In each panel the x-axis shows network model inhibition, g_I, and the y-axis network model excitation, g_E. Note g_E is not equally spaced. Each small square, corresponding to a particular g_I, g_E pair, in each panel shows the KL distance, log(KL), for that network simulation from the particular experimental dataset. The bars on each panel show the log(KL) colourscale. (f,i) These two datasets are indicated by the pink arrows in Fig 11(a) and 11(b) and their spiking characteristics are shown in Figs 8, 9(a), 9(c) and 9(e). The crosses indicate the best fit model simulations whose spiking characteristics are shown in Figs 8, 9(b), 9(d) and 9(f).

doi: https://doi.org/10.1371/journal.pcbi.1007648.g006