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In conclusion, we have proposed a six-deep-feature radiomics signature that have the potential to be an imag- ing biomarker for prediction of the OS in patients with GBM. It was demonstrated that the deep learning method can be incorporated into the state-of-the-art radiomics model to achieve a better performance. The proposed signature predicted the OS in GBM patients with better performance compared with conventional factors such as age and KPS. A nomogram was proposed for prediction of the probability of survival. Despite the limitations, the proposed radiomics model has the potential to facilitate the preoperative care of patients with GBM 解释

时间: 2024-04-27 19:22:03 浏览: 200
这段话总结了该研究的主要发现和贡献。研究提出了一个由六个深度特征组成的放射组学标记,具有成为GBM患者OS预测的成像生物标志物的潜力。研究表明,深度学习方法可以融入最新的放射组学模型,以实现更好的性能。与年龄和KPS等传统因素相比,所提出的标记对GBM患者的OS预测具有更好的性能。研究提出了一个预测生存概率的数学模型。尽管存在一些限制,但所提出的放射组学模型有望促进GBM患者的术前护理。诺模图也被提出用于预测生存概率。总之,该研究的结果表明,放射组学和深度学习方法可以被用于开发一种非侵入性的成像生物标志物,来预测GBM患者的生存期,并可能有助于为这些患者提供更好的治疗和护理。
相关问题

In our study the proposed radiomics signature performed better than traditional risk factors such as age and KPS. None of these clinical factors successfully stratified patients into groups with different prognostic risks. After combining the radiomics signature with clinical factors into a Cox regression model, the predictive power improved with C-index of 0.739 in validation data set. According to the radiomics signature and the two clinical risk factors, we drew a nomogram that can visually predict the probability of survival. According to the calibra- tion curve we can see that our nomogram had good predictive performance. 解释

这段话是在讲述一项医学研究,研究人员使用了一种叫做“放射组学签名”的方法来预测患者的预后风险,这种方法比传统的风险因素如年龄和身体状况评分(KPS)更有效。经过将放射组学签名与临床因素结合起来,研究人员得到了一种名为“诺模图”的预测模型,可以直观地预测患者的生存概率。通过校准曲线可以看出,这个诺模图的预测性能很好。总的来说,这项研究表明,放射组学签名可以作为一种有效的预测方法,可以帮助医生更准确地评估患者的预后风险。

精简下面表达:Existing protein function prediction methods integrate PPI networks and multivariate bioinformatics data to improve the performance of function prediction. By combining multivariate information, the interactions between proteins become diverse. Different interactions’ functions in functional prediction are various. Combining multiple interactions simply between two proteins can effectively reduce the effect of false negatives and increase the number of predicted functions, but it can also increase the number of false positive functions, which contribute to nonobvious enhancement for the overall functional prediction performance. In this article, we have presented a framework for protein function prediction algorithms based on PPI network and semantic similarity with the addition of protein hierarchical functions to them. The framework relies on diverse clustering algorithms and the calculation of protein semantic similarity for protein function prediction. Classification and similarity calculations for protein pairs clustered by the functional feature are more accurate and reliable, allowing for the prediction of protein function at different functional levels from different proteomes, and giving biological applications greater flexibility.The method proposed in this paper performs well on protein data from wine yeast cells, but how well it matches other data remains to be verified. Yet until now, most unknown proteins have only been able to predict protein function by calculating similarities to their homologues. The predictions result of those unknown proteins without homologues are unstable because they are relatively isolated in the protein interaction network. It is difficult to find one protein with high similarity. In the framework proposed in this article, the number of features selected after clustering and the number of protein features selected for each functional layer has a significant impact on the accuracy of subsequent functional predictions. Therefore, when making feature selection, it is necessary to select as many functional features as possible that are important for the whole interaction network. When an incorrect feature was selected, the prediction results will be somewhat different from the actual function. Thus as a whole, the method proposed in this article has improved the accuracy of protein function prediction based on the PPI network method to a certain extent and reduces the probability of false positive prediction results.

本文提出了一种基于PPI网络和语义相似性,加上蛋白质分层功能的蛋白质功能预测算法框架,对酒葡萄酵母细胞的蛋白质数据表现出良好的效果,但其他数据的效果如何仍有待验证。此外,该框架中的功能特征选择的数量以及每个功能层中蛋白质特征的选择量,对于后续功能预测的准确度有很大影响。因此,在进行特征选择时,必须尽可能选择对整个交互网络重要的多种功能特征,从而提高蛋白质功能预测的准确性,减少错误预测的概率。
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检查下列语句的语法和拼写问题。Traditional network security situation prediction methods depend on the accuracy of historical situation value. Moreover, there are differences in correlation and importance among various network security factors. In order to solve these problems, a combined prediction model based on the temporal convolution attention network (TCAN) and bi-directional gate recurrent unit (BiGRU) network optimized by singular spectrum analysis (SSA) and improved quantum particle swarm optimization algorithm (IQPSO) was proposed. This model was first decomposed and reconstructed into a series of subsequences through the SSA of network security situation data. Next, a prediction model of TCAN-BiGRU was established for each subsequence, respectively. The TCN with relatively simple structure was used in the TCAN to extract features from the data. Besides, the improved channel attention mechanism (CAM) was used to extract important feature information from TCN. Afterwards, the before-after status of the learning situation value of the BiGRU neural network was used to extract more feature information from sequences for prediction. Meanwhile, an improved IQPSO was proposed to optimize the hyper-parameter of the BiGRU neural network. Finally, the prediction results of subsequence were superimposed to obtain the final predicted value. In the experiment, on the one hand, the IQPSO was compared with other optimization algorithms; and the results showed that the IQPSO has better optimization performance; on the other hand, the comparison with traditional prediction methods was performed through the simulation experiment and the established prediction model; and the results showed that the combined prediction model established has higher prediction accuracy.

Compared with homogeneous network-based methods, het- erogeneous network-based treatment is closer to reality, due to the different kinds of entities with various kinds of relations [22– 24]. In recent years, knowledge graph (KG) has been utilized for data integration and federation [11, 17]. It allows the knowledge graph embedding (KGE) model to excel in the link prediction tasks [18, 19]. For example, Dai et al. provided a method using Wasser- stein adversarial autoencoder-based KGE, which can solve the problem of vanishing gradient on the discrete representation and exploit autoencoder to generate high-quality negative samples [20]. The SumGNN model proposed by Yu et al. succeeds in inte- grating external information of KG by combining high-quality fea- tures and multi-channel knowledge of the sub-graph [21]. Lin et al. proposed KGNN to predict DDI only based on triple facts of KG [66]. Although these methods have used KG information, only focusing on the triple facts or simple data fusion can limit performance and inductive capability [69]. Su et al. successively proposed two DDIs prediction methods [55, 56]. The first one is an end-to-end model called KG2ECapsule based on the biomedical knowledge graph (BKG), which can generate high-quality negative samples and make predictions through feature recursively propagating. Another one learns both drug attributes and triple facts based on attention to extract global representation and obtains good performance. However, these methods also have limited ability or ignore the merging of information from multiple perspectives. Apart from the above, the single perspective has many limitations, such as the need to ensure the integrity of related descriptions, just as network-based methods cannot process new nodes [65]. So, the methods only based on network are not inductive, causing limited generalization [69]. However, it can be alleviated by fully using the intrinsic property of the drug seen as local information, such as chemical structure (CS) [40]. And a handful of existing frameworks can effectively integrate multi-information without losing induction [69]. Thus, there is a necessity for us to propose an effective model to fully learn and fuse the local and global infor- mation for improving performance of DDI identification through multiple information complementing.是什么意思

润色下面英文:The controlled drug delivery systems, due to their precise control of drug release in spatiotemporal level triggered by specific stimulating factors and advantages such as higher utilization ratio of drug, less side-effects to normal tissues and so forth, provide a new strategy for the precise treatment of many serious diseases, especially tumors. The materials that constitute the controlled drug delivery systems are called “smart materials” and they can respond to the stimuli of some internal (pH, redox, enzymes, etc.) or external (temperature, electrical/magnetic, ultrasonic and optical, etc.) environments. Before and after the response to the specific stimulus, the composition or conformational of smart materials will be changed, damaging the original balance of the delivery systems and releasing the drug from the delivery systems. Amongst them, the photo-controlled drug delivery systems, which display drug release controlled by light, demonstrated extensive potential applications, and received wide attention from researchers. In recent years, photo-controlled drug delivery systems based on different photo-responsive groups have been designed and developed for precise photo-controlled release of drugs. Herein, in this review, we introduced four photo-responsive groups including photocleavage groups, photoisomerization groups, photo-induced rearrangement groups and photocrosslinking groups, and their different photo-responsive mechanisms. Firstly, the photocleavage groups represented by O-nitrobenzyl are able to absorb the energy of the photons, inducing the cleavage of some specific covalent bonds. Secondly, azobenzenes, as a kind of photoisomerization groups, are able to convert reversibly between the apolar trans form and the polar cis form upon different light irradiation. Thirdly, 2-diazo-1,2-naphthoquinone as the representative of the photo-induced rearrangement groups will absorb specific photon energy, carrying out Wolff rearrangement reaction. Finally, coumarin is a promising category photocrosslinking groups that can undergo [2+2] cycloaddition reactions under light irradiation. The research progress of photo-controlled drug delivery systems based on different photo-responsive mechanisms were mainly reviewed. Additionally, the existing problems and the future research perspectives of photo-controlled drug delivery systems were proposed.

Algorithm 1: The online LyDROO algorithm for solving (P1). input : Parameters V , {γi, ci}Ni=1, K, training interval δT , Mt update interval δM ; output: Control actions 􏰕xt,yt􏰖Kt=1; 1 Initialize the DNN with random parameters θ1 and empty replay memory, M1 ← 2N; 2 Empty initial data queue Qi(1) = 0 and energy queue Yi(1) = 0, for i = 1,··· ,N; 3 fort=1,2,...,Kdo 4 Observe the input ξt = 􏰕ht, Qi(t), Yi(t)􏰖Ni=1 and update Mt using (8) if mod (t, δM ) = 0; 5 Generate a relaxed offloading action xˆt = Πθt 􏰅ξt􏰆 with the DNN; 6 Quantize xˆt into Mt binary actions 􏰕xti|i = 1, · · · , Mt􏰖 using the NOP method; 7 Compute G􏰅xti,ξt􏰆 by optimizing resource allocation yit in (P2) for each xti; 8 Select the best solution xt = arg max G 􏰅xti , ξt 􏰆 and execute the joint action 􏰅xt , yt 􏰆; { x ti } 9 Update the replay memory by adding (ξt,xt); 10 if mod (t, δT ) = 0 then 11 Uniformly sample a batch of data set {(ξτ , xτ ) | τ ∈ St } from the memory; 12 Train the DNN with {(ξτ , xτ ) | τ ∈ St} and update θt using the Adam algorithm; 13 end 14 t ← t + 1; 15 Update {Qi(t),Yi(t)}N based on 􏰅xt−1,yt−1􏰆 and data arrival observation 􏰙At−1􏰚N using (5) and (7). i=1 i i=1 16 end With the above actor-critic-update loop, the DNN consistently learns from the best and most recent state-action pairs, leading to a better policy πθt that gradually approximates the optimal mapping to solve (P3). We summarize the pseudo-code of LyDROO in Algorithm 1, where the major computational complexity is in line 7 that computes G􏰅xti,ξt􏰆 by solving the optimal resource allocation problems. This in fact indicates that the proposed LyDROO algorithm can be extended to solve (P1) when considering a general non-decreasing concave utility U (rit) in the objective, because the per-frame resource allocation problem to compute G􏰅xti,ξt􏰆 is a convex problem that can be efficiently solved, where the detailed analysis is omitted. In the next subsection, we propose a low-complexity algorithm to obtain G 􏰅xti, ξt􏰆. B. Low-complexity Algorithm for Optimal Resource Allocation Given the value of xt in (P2), we denote the index set of users with xti = 1 as Mt1, and the complementary user set as Mt0. For simplicity of exposition, we drop the superscript t and express the optimal resource allocation problem that computes G 􏰅xt, ξt􏰆 as following (P4) : maximize 􏰀j∈M0 􏰕ajfj/φ − Yj(t)κfj3􏰖 + 􏰀i∈M1 {airi,O − Yi(t)ei,O} (28a) τ,f,eO,rO 17 ,建立了什么模型

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